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See detailPersistency of lactation yields: A review
Gengler, Nicolas ULg

in Interbull Bulletin (1996), 12

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See detailPersistent atrial standstill in familial Ebstein's anomaly.
Pierard, Luc ULg; Henrard, L.; Demoulin, J. C.

in British heart journal (1985), 53(6), 594-7

Persistent atrial standstill occurred in a father and his youngest son with familial Ebstein's anomaly. In both cases routine electrocardiograms showed no atrial electrical activity and cross sectional ... [more ▼]

Persistent atrial standstill occurred in a father and his youngest son with familial Ebstein's anomaly. In both cases routine electrocardiograms showed no atrial electrical activity and cross sectional echocardiograms showed inferior displacement of the septal tricuspid leaflet and tethering of the tricuspid leaflets to the right ventricle. The father had a cerebral embolism and died of a myocardial infarction. Necropsy showed attachment of the septal tricuspid leaflet below the membranous septum. On serial histological examination fibrofatty infiltration of the right atrial wall, the atrioventricular node, and the inferior part of the His bundle up to the bifurcation was present. The son had haemodynamic and electrophysiological findings consistent with mild Ebstein's anomaly and persistent atrial standstill, for which permanent cardiac pacing was necessary. The persistent atrial standstill with slow escape rhythm was most probably a consequence of the abnormalities in both the atrial wall and the His bundle which, together with the abnormal attachment of the tricuspid valve, may be features of the same congenital cardiac anomaly. [less ▲]

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See detailPersistent hyperplastic primary vitreous: MRI.
Kuker, W.; RAMAEKERS, Vincent ULg

in Neuroradiology (1999), 41(7), 520-2

Persistent hyperplastic primary vitreous (PHPV), a developmental cause of leukocoria, is due to incomplete regression of the fetal blood supply to the eye. We report the MRI features of PHPV of the dorsal ... [more ▼]

Persistent hyperplastic primary vitreous (PHPV), a developmental cause of leukocoria, is due to incomplete regression of the fetal blood supply to the eye. We report the MRI features of PHPV of the dorsal type to facilitate differential diagnosis from other causes of leukocoria, namely retinoblastoma, which may have major therapeutic consequences. [less ▲]

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See detailPersistent hypocoagulability in patients with septic shock predicts greater hospital mortality: impact of impaired thrombin generation.
MASSION, Paul ULg; PETERS, Pierre ULg; LEDOUX, Didier ULg et al

in Intensive Care Medicine (2012), 38(8), 1326-35

PURPOSE: Sepsis induces hypercoagulability, hypofibrinolysis, microthrombosis, and endothelial dysfunction leading to multiple organ failure. However, not all studies reported benefit from anticoagulation ... [more ▼]

PURPOSE: Sepsis induces hypercoagulability, hypofibrinolysis, microthrombosis, and endothelial dysfunction leading to multiple organ failure. However, not all studies reported benefit from anticoagulation for patients with severe sepsis, and time courses of coagulation abnormalities in septic shock are poorly documented. Therefore, the aim of this prospective observational cohort study was to describe the coagulation profile of patients with septic shock and to determine whether alterations of the profile are associated with hospital mortality. METHODS: Thirty-nine patients with septic shock on ICU admission were prospectively included in the study. From admission to day 7, analytical coagulation tests, thrombin generation (TG) assays, and thromboelastometric analyses were performed and tested for association with survival. RESULTS: Patients with septic shock presented on admission prolongation of prothrombin time, activated partial thromboplastin time (aPTT), increased consumption of most procoagulant factors as well as both delay and deficit in TG, all compatible with a hypocoagulable state compared with reference values (P < 0.001). Time courses revealed a persistent hypocoagulability profile in non-survivors as compared with survivors. From multiple logistic regression, prolonged aPTT (P = 0.007) and persistence of TG deficit (P = 0.024) on day 3 were strong predictors of mortality, independently from disease severity scores, disseminated intravascular coagulation score, and standard coagulation tests on admission. CONCLUSIONS: Patients with septic shock present with hypocoagulability at the time of ICU admission. Persistence of hypocoagulability assessed by prolonged aPTT and unresolving deficit in TG on day 3 after onset of septic shock is associated with greater hospital mortality. [less ▲]

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See detailPersistent infection of thymic epithelial cells with coxsackievirus B4 results in a decreased expression of insulin-like growth factor 2
Jaïdane, Hela; Caloone, Delphine; Lobert, Pierre-Emmanuel et al

in Journal of Virology (2012), 86

It has been hypothesized that a disturbance of central self-tolerance to islet β-cell may play a role in the enteroviral pathogenesis of type 1 diabetes. Whether enteroviruses can induce an impaired ... [more ▼]

It has been hypothesized that a disturbance of central self-tolerance to islet β-cell may play a role in the enteroviral pathogenesis of type 1 diabetes. Whether enteroviruses can induce an impaired expression of β-cell self-antigens in thymic epithelial cells has been investigated in a murine thymic epithelial (MTE) cell line. This cell line was permissive to the diabetogenic strain CV-B4 E2 and spontaneously expressed type 2 insulin-like growth factor (Igf2), the dominant self-antigen of the insulin family. In this model, a persistent replication of CV-B4 E2 was obtained as attested by the prolonged detection of intracellular positive and negative-strand viral RNA by RT-PCR, and capsid protein VP1 by IF and by the release of infectious particles in culture supernatant fluids. The chronic stage of the infection was characterized by a low proportion of VP1-positive cells (1-2%) whereas many cells harbored enteroviral RNA as displayed by RT-PCR without extraction applied directly on a few cells. Igf2 mRNA and IGF-2 protein were dramatically decreased in CV-B4 E2-infected MTE cultures compared with mock-infected cultures, whereas housekeeping and Il6 genes expression were maintained and Igf1 mRNA was decreased but at a lower extent. Inoculation of CV-B3-, CV-B4 JVB- or Echovirus 1 resulted in a low level of IGF-2 in culture supernatant fluids as well, whereas HSV-1 stimulated the production of the protein. Thus, a persistent infection of a thymic epithelial cell line with enteroviruses, like CV-B4 E2 can result in a disturbed production of IGF-2, a protein involved in central self-tolerance towards islet β-cells. [less ▲]

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See detailPersistent Ischemic Mitral Regurgitation After Annuloplasty can be Predicted by Pre-operative Echocardiography.
Magne, Julien ULg; Pibarot, P; Dagenais, F et al

Conference (2006)

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See detailPersistent Ischemic Mitral Regurgitation After Annuloplasty can be Predicted by Pre-operative Echocardiography.
Sénéchal, M; Magne, Julien ULg; Pibarot, P et al

Conference (2006)

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See detailPersistent low levels of serum hCG: please do not miss phantom hCG! (pseudohypergonadotropinemia syndrome)
VALDES SOCIN, Hernan Gonzalo ULg; SYRIOS, Petros ULg; GADISSEUR, Romy ULg et al

in Acta Clinica Belgica (2013), 68(6), 465

Introduction: Beyond pregnancy, persistent low levels of hCG may be associated with various benign and malignant conditions, i.e. quiescent gestational trophoblastic disease (QTD), raised pituitary hCG or ... [more ▼]

Introduction: Beyond pregnancy, persistent low levels of hCG may be associated with various benign and malignant conditions, i.e. quiescent gestational trophoblastic disease (QTD), raised pituitary hCG or false positive elevation caused by circulating heterophilic antibodies. This situation requires a clinico-biological approach in order to avoid misunderstandings that could lead to inappropriate diagnostic or therapeutic attitudes. Observation: A 23 years old woman (GOPO status) consulted his gynaecologist because of persistent abdominal pain. She was diagnosed of having trophoblastic disease on the basis of persistently positive human chorionic gonadotropin (hCG) test (Roche Modular) results, in the absence of pregnancy. Persistent low levels of hCG (around 10 U/L) were detected in her plasma. The patient underwent a trial with methotrexate chemotherapy. Abdominal pain was unrelieved whereas plasma hCG was 8.9 U/L. A serology test for Chlamydia indicated persistent infection and a course of antibiotic treatment was underwent without any relief. A laparoscopic exploration ruled out any trophoblastic residue or pelvic adherences. The patient was referred to the Endocrine Unit for further pituitary and hormonal investigations. Plasma and urine samples were sent to Biology Service to exclude a false hCG positive value. While low levels of hCG were detected in serum by assay, no significant hCG was detected in the urine (0,1 U/L). When serum was treated with HBT tube for the detection of heterophilic antibodies, hCG levels were 0.98 U/L. After mouse serum treatment, hCG was not further detected in our patient, indicating the presence of phantom hCG due to the presence of human anti mouse heterophilic antibodies. Conclusions: Textbooks on obstetrics and gynecology emphasize the importance of plasma hCG testing in patients with trophoblastic diseases. The ability of laboratory measurements to guide the clinician appropriately in every circumstance is limited. Caution should be exercised when clinical findings and laboratory results are discordant. Current protocols for the diagnosis and treatment of trophoblastic disease should include a compulsory test for hCG in urine and a test for heterophilic antibodies when appropriate. In this case report, we demonstrated that phantom hCG, was caused by heterogenous human anti mouse antibodies. [less ▲]

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See detailPersistent negative T waves in the infarct-related leads as an independent predictor of poor long-term prognosis after acute myocardial infarction
Lancellotti, Patrizio ULg; Gerard, P. L.; Kulbertus, Henri ULg et al

in American Journal of Cardiology (2002), 90(8), 833-837

This study sought to determine the long-term prognostic significance of persistent or transient, negative T waves in infarct-related leads. After acute myocardial infarction (AMI), QRS and T wave ... [more ▼]

This study sought to determine the long-term prognostic significance of persistent or transient, negative T waves in infarct-related leads. After acute myocardial infarction (AMI), QRS and T wave alterations may resolve. No clinical study has investigated the prognostic importance of persistent versus transient negative T waves. We studied 147 consecutive patients with first AMI and greater than or equal to2 negative T waves in the infarct-related leads on the electrocardiogram. One hundred twenty patients developed Q waves. Patients were followed clinically for 60 +/- 21 months. T-wave normalization was observed early (before hospital discharge) in 34 patients and late (at 4 +/- 1 months) in 65. Thirty patients had Q-wave regression. Adverse outcome occurred in 57 patients. There were 23 hard events (cardiac death in 12 patients and nonfatal AMI in 11). Patients with early or late T-wave normalization had similar event-free survival curves that diverged rapidly from that of patients with persistent negative T waves, who had a worse outcome (p <0.0001). Patients with or without Q-wave regression had similar survival curves. Using multivariate Cox regression analysis, higher end-systolic volume (hazard ratio [HR] 1.01, p = 0.007), the presence of multivessel disease (HR 3.33, p = 0.009), and persistent negative T waves (HR 2.92, p = 0.024) predicted hard events. Persistent negative T waves 4 months after first AMI were independently associated with a worse outcome, whereas Q-wave regression has no long-term prognostic importance. (C) 2002 by Excerpta Medica, Inc. [less ▲]

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See detailPersistent organic pollutants and methoxylated PBDEs in harbour porpoises from the North Sea from 1990 until 2008. Young wildlife at risk?
Weijs, Liesbeth; van Elk, Cornelis; Das, Krishna ULg et al

in Science of the Total Environment (2010), 409

n the European North Sea, harbour porpoises are top predators with relatively long life spans and a limited capacity for metabolic biotransformation of contaminants compared to some other marine mammal ... [more ▼]

n the European North Sea, harbour porpoises are top predators with relatively long life spans and a limited capacity for metabolic biotransformation of contaminants compared to some other marine mammal species. As such, they are exposed to a mixture of persistent pollutants, such as polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), DDT and metabolites (DDXs), hexachlorobenzene (HCB) and chlordanes (CHLs) that bioaccumulate in their tissues. We report here on the levels of persistent organic pollutants and of the naturally-produced methoxylated PBDEs (MeO-PBDEs) in blubber, liver and kidney of harbour porpoise neonates (n = 3), calves (n = 15), juveniles (n = 6) and adults (n = 4) of the southern North Sea. Concentrations of almost all contaminant classes decrease slightly in all age groups over the period 1990–2008. For some classes (e.g. PCBs and DDXs) however, levels seem to increase little in harbour porpoise calves. In all animals, blubber had the highest concentrations, followed by liver and kidney, whereas liver and kidney were the preferred tissues for several compounds, such as octa- and deca-PCBs. Our data suggest that harbour porpoises calves are exposed to higher or comparable concentrations of POPs and of MeO-PBDEs and somewhat different patterns of selected POPs than adults, potentially placing them, and the entire population, at a disproportionate risk for exposure-related health effects. [less ▲]

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See detailPersistent organic pollutants in wild seabass (Dicentrarchus labrax) from the Northeast atlantic coastal regions and relationship with thyroid hormone levels
Schnitzler, Joseph ULg; Thomé, Jean-Pierre ULg; Das, Krishna ULg

Poster (2008, October 30)

Polychlorinated biphenyls (PCBs) and organochlorine pesticides like Dichloro-Diphenyl-Trichloroethane (DDTs), Hexachlorocyclohexanes (HCHs), Aldrin and Dieldrin were analysed in the muscle of sea bass ... [more ▼]

Polychlorinated biphenyls (PCBs) and organochlorine pesticides like Dichloro-Diphenyl-Trichloroethane (DDTs), Hexachlorocyclohexanes (HCHs), Aldrin and Dieldrin were analysed in the muscle of sea bass (Dicentrarchus labrax) sampled in coastal regions near several important European river mouths (Garonne, Charente, Loire, Seine and Scheldt). These organochlorinated compounds are known to influence the endocrine system of many fish species and mammals and are thus qualified as endocrine disrupters. To highlight a potentially harmful effect of these compounds on the thyroid function of these fishes, we measured the muscular concentrations of thyroid hormones T3 and T4 by Radio-Immuno-Assay. The contamination levels were as follows: the highest concentrations were measured in individuals collected from the coastal region near the Scheldt > Seine > Loire > Charente and the lowest levels were observed in sea bass from coastal regions near the Garonne (from 2422 to 6188 ng.g-1 lw). The measured levels were generally higher than those reported in literature in sea bass from other regions in the Mediterranean Sea. Contamination patterns were different depending on the sampling area and thus the river input of pollutants. The multivariate statistical analysis revealed a significant relationship between the measured persistent organic pollutants and thyroid hormones in muscle. We cannot exclude the assumption that an endocrine disruption of the thyroid related to these pollutants could be the origin of these modifications of the thyroid hormone concentrations. [less ▲]

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See detailPersistent Organochlorine Pollutants with Endocrine Activity and Blood Steroid Hormone Levels in Middle- Aged Men
Emeville, Elise; Giton, Frank; Giusti, Arnaud ULg et al

in PLoS ONE (2013), 8(6), 66460

Abstract Background: Studies relating long-term exposure to persistent organochlorine pollutants (POPs) with endocrine activities (endocrine disrupting chemicals) on circulating levels of steroid hormones ... [more ▼]

Abstract Background: Studies relating long-term exposure to persistent organochlorine pollutants (POPs) with endocrine activities (endocrine disrupting chemicals) on circulating levels of steroid hormones have been limited to a small number of hormones and reported conflicting results. Objective: We examined the relationship between serum concentrations of dehydroepiandrosterone, dehydroepiandrosterone sulphate, androstenedione, androstenediol, testosterone, free and bioavailable testosterone, dihydrotestosterone, estrone, estrone sulphate, estradiol, sex-hormone binding globulin, follicle-stimulating hormone, and luteinizing hormone as a function of level of exposure to three POPs known to interfere with hormone-regulated processes in different way: dichlorodiphenyl dichloroethene (DDE), polychlorinated biphenyl (PCB) congener 153, and chlordecone. Methods: We collected fasting, morning serum samples from 277 healthy, non obese, middle-aged men from the French West Indies. Steroid hormones were determined by gas chromatography-mass spectrometry, except for dehydroepiandrosterone sulphate, which was determined by immunological assay, as were the concentrations of sex-hormone binding globulin, follicle-stimulating hormone and luteinizing hormone. Associations were assessed by multiple linear regression analysis, controlling for confounding factors, in a backward elimination procedure, in multiple bootstrap samples. Results: DDE exposure was negatively associated to dihydrotestosterone level and positively associated to luteinizing hormone level. PCB 153 was positively associated to androstenedione and estrone levels. No association was found for chlordecone. Conclusions: These results suggested that the endocrine response pattern, estimated by determining blood levels of steroid hormones, varies depending on the POPs studied, possibly reflecting differences in the modes of action generally attributed to these compounds. It remains to be investigated whether this response pattern is predictive of the subsequent occurrence of disease. [less ▲]

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See detailPersistent organochlorine pollutants, dioxins and polychlorinated biphenyls
Scippo, Marie-Louise ULg; Eppe, Gauthier ULg; Saegerman, Claude ULg et al

in Contaminant and Residue Analysis, Comprehensive Analytical Chemistry of Elsevier (2008)

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See detailPersistent right aortic arch associated with an aberrant left subclavian artery arising from a patent ductus arteriosus in a puppy
Rizza, Maïlis ULg; Claeys, Stéphanie ULg; Billen, Frédéric ULg et al

Poster (2013, August 31)

PERSISTENT RIGHT AORTIC ARCH ASSOCIATED WITH AN ABERRANT LEFT SUBCLAVIAN ARTERY ARISING FROM A PATENT DUCTUS ARTERIOSUS IN A PUPPY Rizza M.*, Claeys S.**, Billen F.***, Mc Entee K. ***, Bolen G ... [more ▼]

PERSISTENT RIGHT AORTIC ARCH ASSOCIATED WITH AN ABERRANT LEFT SUBCLAVIAN ARTERY ARISING FROM A PATENT DUCTUS ARTERIOSUS IN A PUPPY Rizza M.*, Claeys S.**, Billen F.***, Mc Entee K. ***, Bolen G.* *Diagnostic Imaging Section, **Small Animal Surgery Section, ***Small Animal Internal Medicine Section, Department of Clinical Sciences (Companion Animal and Equides), Faculty of Veterinary Medicine, University of Liege, Belgium. Introduction Vascular anomalies develop during foetal development and single or multiple aberrant vessels can be present. Persistent right aorta arch (PRAA) represents over 90% of described vascular ring anomalies and can be accompanied by a left ligamentum arteriosum or a patent left ductus arteriosus (approximately 10% of patients) that causes oesophageal entrapment and secondary sub-obstruction. Radiography is an effective means of detecting vascular ring anomalies when oesophageal dilation and left-sided tracheal displacement are visible. Computed tomography angiography (CTA) is necessary to confirm the nature and the patency of the vascular anomalies present and to identify which of the identified anomalies is causing the clinical signs. Materials and methods A 3.5-month-old, male French Bulldog was presented for regurgitation and vomiting since weaning. Besides a low body score, physical exam was unremarkable. Hypoglycemia was observed on routine blood analysis. Thoracic radiographs and CTA of the thorax were performed. Results The radiographs revealed severe oesophageal dilation cranial to the base of the heart and a ventral and left-sided tracheal displacement. A congenital oesophageal diverticulum secondary to a vascular anomaly was suspected. CTA showed multiple vascular anomalies. A PRAA was observed. An aberrant right subclavian artery (ARSA) was identified originating from the PRAA next to the brachiocephalic trunk. A patent left-to-right patent ductus arteriosus (PDA) was detected between the aorta and the pulmonary trunk and an aberrant left subclavian artery (ALSA) originated from the PDA. The oesophagus was compressed between the PDA and the trachea and was dilated cranially to this narrowing. Endoscopy revealed severely esophageal distension cranially to an extraluminal stenosis. Surgery was performed to ligate and cut the PDA. Discussion Seven types of vascular ring anomaly are described: types I - III have a PRAA, type IV has a double aortic arch, and types V -VII have a left aortic arch with combinations of persistent right ligamentum arteriosum and right subclavian arteries. In the patient described here, the vascular ring anomalies are a novel variant of the defined types. To the authors’ knowledge, an ALSA originating from a PDA has not been described previously. The severe compression of the oesophagus with severe dilation cranial to the heart was caused by the PDA and was resolved by surgical intervention. In conclusion, CTA is necessary to determine which vascular anomalies are present and to identify which of these anomalies is responsible for the clinical signs. This technique enables accurate pre-operative planning. Pownder S. Scrivani PV. Non-selective computed tomography angiography of a vascular ring anomaly in a dog. J Vet Cardiol. 2008 Dec;10(2):125-8 Henjes CR, Nolte I, Wefstaedt P. Multidetector-row computed tomography of thoracic aortic anomalies in dogs and cats: patent ductus arteriosus and vascular rings. BMC Vet Res. 2011 Sep 23;7:57 [less ▲]

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See detailPersistent tumor 18F-FDG uptake after a few cycles of polychemotherapy is predictive of treatment failure in non-Hodgkin's lymphoma.
Jerusalem, Guy ULg; Beguin, Yves ULg; Fassotte, Marie-France ULg et al

in Haematologica (2000), 85(6), 613-8

BACKGROUND AND OBJECTIVE: Early recognition of the ineffectiveness of chemotherapy could result in lower cumulative drug toxicity and tumor burden at the start of salvage therapy, which might improve ... [more ▼]

BACKGROUND AND OBJECTIVE: Early recognition of the ineffectiveness of chemotherapy could result in lower cumulative drug toxicity and tumor burden at the start of salvage therapy, which might improve clinical outcome. Therefore, we studied the value of (18)F-FDG PET for early evaluation of response in patients with non-Hodgkin's lymphoma (NHL). DESIGN AND METHODS: We studied 28 patients by (18)F-FDG PET after a median of 3 cycles of polychemotherapy. The presence or absence of abnormal (18)F-FDG uptake was correlated to clinical outcome (median follow-up: 17.5 months, range 4-47 months). RESULTS: Five of 28 patients still had increased (18)F-FDG uptake in one or more sites previously shown to be involved by lymphoma at baseline evaluation. Only one of these five patients entered complete remission (CR), whereas among the 23 patients with negative (18)F-FDG PET studies, two died of toxicity during chemotherapy and all the others entered clinical CR (p<0.00001). All five patients with and 7/21 patients without residual abnormal (18)F-FDG uptake relapsed or reprogressed (positive predictive value for relapse: 100%, negative predictive value: 67%). By Kaplan-Meier analysis, progression-free survival (PFS) at 1 and 2 years was respectively 20+/-18% and 0% for (18)F-FDG PET positive patients and 81+/-9% and 62+/-12% for (18)F-FDG PET negative patients (p=0.0001). Overall survival (OS) at 1 and 2 years was respectively 20+/-18% and 0% for (18)F-FDG PET positive and 87+/-7% and 68+/-11% for (18)F-FDG PET negative patients (p<0.0001). INTERPRETATION AND CONCLUSIONS: Persistent tumoral (18)F-FDG uptake after a few cycles of polychemotherapy is predictive of CR, PFS and OS in NHL. Further studies are warranted to determine whether (18)F-FDG PET has a predictive value independent from conventional prognostic factors. However, the sensitivity of qualitative (18)F-FDG PET imaging in identifying patients with a poor outcome was insufficient. Earlier evaluation after only one cycle of chemotherapy and quantitative analysis might increase the sensitivity of 18F-FDG PET is predicting treatment failure. [less ▲]

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See detailPersistent varicella-zoster virus infection in the nervous system: in vitro and in vivo models
Sadzot-Delvaux, Catherine ULg; Merville, Marie-Paule ULg; Bourdon-Wouters, C. et al

in Acta Neurologica Belgica (1988), 88

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See detailThe Person and Justice in Tunisian Souq: A Reflection upon the Linkages Between Justice, Impartiality and Respect for the Person
Nachi, Mohamed ULg

in DUPRET, Baudouin (Ed.) Standing Trial. Law and the Person in the Modern Middle East (2004)

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