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See detailPeroxisomal β-oxidation and Production of γ-decalactone by the Yeast Rhodotorula aurantiaca
Alchihab, Mohamed ULg; Dubois Dauphin, Robin ULg; Aguedo, Mario ULg et al

in Notulae Botanicae Horti Agrobotanici Cluj-Napoca (2010), 2

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See detailPeroxisome proliferator-activated receptor-gamma1 is dephosphorylated and degraded during BAY 11-7085-induced synovial fibroblast apoptosis
Relic, Biserka ULg; Benoit, Valerie; Franchimont, Nathalie et al

in Journal of Biological Chemistry (2006), 281(32), 597-604

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) plays a central role in whole body metabolism by regulating adipocyte differentiation and energy storage. Recently, however, PPAR-gamma has ... [more ▼]

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) plays a central role in whole body metabolism by regulating adipocyte differentiation and energy storage. Recently, however, PPAR-gamma has also been demonstrated to affect proliferation, differentiation, and apoptosis of different cell types. As we have previously shown that BAY 11-7085-induced synovial fibroblast apoptosis is prevented by PPAR-gamma agonist 15d-PGJ2; the expression of PPAR-gamma in these cells was studied. Both PPAR-gamma1 and PPAR-gamma2 isoforms were cloned from synovial fibroblast RNA, but only PPAR-gamma1 was detected by Western blot, showing constitutive nuclear expression. Within minutes of BAY 11-7085 treatment, a PPAR-gamma1-specific band was shifted into a form of higher mobility, suggesting dephosphorylation, as confirmed by phosphatase treatment of cell extracts. Of interest, BAY 11-7085-induced PPAR-gamma1 dephosphorylation was followed by PARP and caspase-8 cleavage as well as by PPAR-gamma1 protein degradation. PPAR-gamma1 dephosphorylation was followed by the loss of PPAR-DNA binding activity ubiquitously present in synovial fibroblast nuclear extracts. Unlike the phosphorylated form, dephosphorylated PPAR-gamma1 was found in insoluble membrane cell fraction and was not ubiquitinated before degradation. PPAR-gamma1 dephosphorylation coincided with ERK1/2 phosphorylation that accompanies BAY 11-7085-induced synovial fibroblasts apoptosis. 15d-PGJ2, PGD2, and partially UO126, down-regulated ERK1/2 phosphorylation, protected cells from BAY 11-7085-induced apoptosis, and reversed both PPAR-gamma dephosphorylation and degradation. Furthermore, PPAR-gamma antagonist BADGE induced PPAR-gamma1 degradation, ERK1/2 phosphorylation, and synovial fibroblasts apoptosis. The results presented suggest an anti-apoptotic role for PPAR-gamma1 in synovial fibroblasts. Since apoptotic marker PARP is cleaved after PPAR-gamma1 dephosphorylation but before PPAR-gamma1 degradation, dephosphorylation event might be enough to mediate BAY 11-7085-induced apoptosis in synovial fibroblasts. [less ▲]

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See detailPerpectives économiques du transport de conteneurs par bateaux fluvio-maritimes à partir de ports d'intérieur
Marchal, Jean ULg

in Bulletin de l'Association Technique Maritime et Aéronautique (1986)

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See detailLes perquisitions dans les cabinets d'avocats. Les usages à l'épreuve de la jurisprudence de la cour européenne des droits de l'homme
Jacobs, Ann ULg

in Het Strafrecht bedreven. Liber Amicorum Alain De Nauw. (2011)

Les usages en matière de perquisitions dans les cabinets d'avocats divisent auteurs et jurisprudence à plus d'un titre. Analyse sous l'angle de la Convention européenne des droits de l'homme.

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See detailLes perquisitions dans les cabinets d’avocats. Les usages à l’épreuve de la jurisrpudence de la Cour européenne des droits de l’homme
Jacobs, Ann ULg

in Deruyck, Filip (Ed.) Het strafrecht bedreven, Liber amicorum Alain De Nauw (2011)

Confrontation de la législation et de la jurisprudence belges en matière de perquisition dans les cabinets d'avocat avec la jurisprudence de la Cour européenne des droits de l'homme

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See detailPerquisitions et droits de la défense : une remise en question des pratiques par la Cour européenne des droits de l’homme ?
Jacobs, Ann ULg

in Revue de Droit Pénal et de Criminologie (2004)

Confrontation de la jurisprudence belge en matière de perquisitions à la jurisprudence de la Cour européenne des droits de l'homme, en particulier sous l'angle des mentions du mandat de perquisition et du ... [more ▼]

Confrontation de la jurisprudence belge en matière de perquisitions à la jurisprudence de la Cour européenne des droits de l'homme, en particulier sous l'angle des mentions du mandat de perquisition et du déroulement de la perquisition. [less ▲]

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See detailPERS - Doctoraat onderzoekt de kwaliteit van leven bij alzheimer
Missotten, Pierre ULg

in Contactblad van het Academisch Centrum voor Huisartsgeneeskunde van de K.U.Leuven (2012)

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See detailPersévérances - Programme de recherche de formation et d'action pour lutter contre le harcèlement moral au travail - Projets diffusion et évaluation
Italiano, Patrick ULg; Vella, Sonia; Vivegnis, Aurelie

Report (2007)

Rapport concernant la diffusion et l'évaluation par des professionnel du secteur des outils de diagnostic et d'intervention sur le harcèlement moral au travail

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See detailPersistance des troubles psychologiques et comportementaux de la démence
Squelard, Gilles ULg; Adam, Stéphane ULg; Missotten, Pierre ULg et al

Poster (2010, October)

est considérable. Actuellement, la sélection d’un traitement dépend de la nature du trouble et de son intensité. La connaissance de leur persistance s’avère importante pour la sélection et l’organisation ... [more ▼]

est considérable. Actuellement, la sélection d’un traitement dépend de la nature du trouble et de son intensité. La connaissance de leur persistance s’avère importante pour la sélection et l’organisation du traitement. Objectifs: Evaluer la persistance des troubles psychologiques et comportementaux dans une population de sujets déments suivis longitudinalement. Méthodes: Nous avons sélectionné 104 sujets déments issus de l’étude Qualidem (Paquay et al., 2004). Tous les sujets sont institutionnalisés et présentent des perturbations cognitives (score MMSE<20). Les troubles psychologiques et comportementaux ont été évalués à 12 mois d’intervalle avec le Neuropsychiatric Inventory (Cummings et al., 1997). Résultats: Les perturbations les plus persistantes sont les idées délirantes (62%), et l’agitation (67%). Le risque de rechute est moins important pour la dépression (54%), les hallucinations (44%), l’exaltation de l’humeur (43%), l’apathie (48%), l’irritabilité (52%), et le comportement moteur aberrant (52%). L’anxiété (38%), la désinhibition (39%), les troubles du sommeil (39%) et de l’appétit (38%) sont les moins persistants. Conclusion: La nature persistante de l’agitation et des idées délirantes suggère que le traitement de ces perturbations doit être prolongé. La nature ponctuelle de l’anxiété, la désinhibition et des troubles de l’appétit et du sommeil suggère qu’un traitement à court terme est plus approprié pour ces perturbations. Ces résultats sont à interpréter par rapport à la définition des troubles induite par le NPI. [less ▲]

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See detailPersistence and dispersion of an introduced population of Alpine Newt (Triturus alpestris) in the limestone plateau of Larzac (Southern France)
Denoël, Mathieu ULg

in Revue d'Ecologie (La Terre et la Vie) (2005), 60(2), 139-148

Persistence and dispersion of an introduced population of Alpine Newt (Triturus alpestris) in the limestone plateau of Larzoc (southern France). - The study of introduced populations is interesting to ... [more ▼]

Persistence and dispersion of an introduced population of Alpine Newt (Triturus alpestris) in the limestone plateau of Larzoc (southern France). - The study of introduced populations is interesting to better understand the geographic distribution and adaptability of species in different environments. The recent finding of an Alpine Newt population (Triturus alpestris) in the limestone plateau of Larzac (Department of Herault, France) provides the opportunity to examine the success of this species in the French supra-Mediterranean environment, Indeed, this species is absent from southern France although present in a large part of France and in northern Spain. The introduction site and all water bodies within a 2.5 km radius were surveyed between spring and autumn 2003. Because of the introduction date and the life expectancy of newts, all observed individuals are descendants of the introduced animals. They persist and breed in the study site despite the coexistence with Palmate Newts (Tri-turus helveticus). Body condition decreases in summer in these two species, but was lower in Alpine Newt males than in Palmate Newt males in autumn. Alpine Newts were found in only one of the other nine ponds, indicating a 1.5 km dispersion. Few Alpine Newts were present at this site, but reproduction was effective. These results show that the Alpine Newt can survive in southern France despite the presence of other newt species, but that the dispersion speed and rate towards other ponds are low. [less ▲]

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See detailPersistence of an intact endometrial matrix and vessels structure in women exposed to VA-2914, a selective progesterone receptor modulator.
Ravet, Stéphanie ULg; Munaut, Carine ULg; Blacher, Silvia ULg et al

in Journal of Clinical Endocrinology and Metabolism (2008), 93(11), 4525-31

Background: VA-2914 is a selective progesterone receptor modulator with potential contraceptive activity that induces amenorrhea, whereas progestins cause endometrial spotting and bleeding. This abnormal ... [more ▼]

Background: VA-2914 is a selective progesterone receptor modulator with potential contraceptive activity that induces amenorrhea, whereas progestins cause endometrial spotting and bleeding. This abnormal bleeding due to progestins is a consequence of focal stromal proteolysis by an increase in naked vessel size and density. Objective: Our objective was to quantify the effects of VA-2914 on endometrial vascularization, fibrillar matrix, and vascular endothelial growth factor (VEGF)-A expression in endometrial biopsies from 41 women before and after 12 wk daily treatment with a placebo, or 2.5, 5, or 10 mg VA-2914. Methods: Collagen fibrillar network was stained by silver impregnation. Vessel area, density, and structure were quantified with a computer-assisted image analysis system after double immunostaining using an anti-von Willebrand factor (endothelial cells) and an anti- smooth muscle actin (vascular smooth muscle cells) marker antibody. VEGF-A mRNAs were quantified by RT-PCR and localized by immunohistochemistry. Results: The endometrial vessels, collagen network, and mRNA levels of VEGF-A were identical during the luteal phase at baseline and in VA-2914 treated women. VEGF-A distribution was unchanged. Conclusions: VA-2914 does not alter the endometrial matrix and cells, and does not modify the endometrial vessel morphology as compared with baseline biopsies. [less ▲]

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See detailPersistence of decomposition odour in soil analysed by GC×GC-TOFMS
Perreault, K; Stefanuto, Pierre-Hugues ULg; Stuart, B et al

Conference (2014, May 22)

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See detailPersistence of Scattering Centers
Verly, Jacques ULg; Dudgeon, Dan E.

Scientific conference (1993)

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See detailPersistency of lactation yields: A review
Gengler, Nicolas ULg

in Interbull Bulletin (1996), 12

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See detailPersistent atrial standstill in familial Ebstein's anomaly.
Pierard, Luc ULg; Henrard, L.; Demoulin, J. C.

in British heart journal (1985), 53(6), 594-7

Persistent atrial standstill occurred in a father and his youngest son with familial Ebstein's anomaly. In both cases routine electrocardiograms showed no atrial electrical activity and cross sectional ... [more ▼]

Persistent atrial standstill occurred in a father and his youngest son with familial Ebstein's anomaly. In both cases routine electrocardiograms showed no atrial electrical activity and cross sectional echocardiograms showed inferior displacement of the septal tricuspid leaflet and tethering of the tricuspid leaflets to the right ventricle. The father had a cerebral embolism and died of a myocardial infarction. Necropsy showed attachment of the septal tricuspid leaflet below the membranous septum. On serial histological examination fibrofatty infiltration of the right atrial wall, the atrioventricular node, and the inferior part of the His bundle up to the bifurcation was present. The son had haemodynamic and electrophysiological findings consistent with mild Ebstein's anomaly and persistent atrial standstill, for which permanent cardiac pacing was necessary. The persistent atrial standstill with slow escape rhythm was most probably a consequence of the abnormalities in both the atrial wall and the His bundle which, together with the abnormal attachment of the tricuspid valve, may be features of the same congenital cardiac anomaly. [less ▲]

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See detailPersistent hyperplastic primary vitreous: MRI.
Kuker, W.; RAMAEKERS, Vincent ULg

in Neuroradiology (1999), 41(7), 520-2

Persistent hyperplastic primary vitreous (PHPV), a developmental cause of leukocoria, is due to incomplete regression of the fetal blood supply to the eye. We report the MRI features of PHPV of the dorsal ... [more ▼]

Persistent hyperplastic primary vitreous (PHPV), a developmental cause of leukocoria, is due to incomplete regression of the fetal blood supply to the eye. We report the MRI features of PHPV of the dorsal type to facilitate differential diagnosis from other causes of leukocoria, namely retinoblastoma, which may have major therapeutic consequences. [less ▲]

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See detailPersistent hypocoagulability in patients with septic shock predicts greater hospital mortality: impact of impaired thrombin generation.
MASSION, Paul ULg; PETERS, Pierre ULg; LEDOUX, Didier ULg et al

in Intensive Care Medicine (2012), 38(8), 1326-35

PURPOSE: Sepsis induces hypercoagulability, hypofibrinolysis, microthrombosis, and endothelial dysfunction leading to multiple organ failure. However, not all studies reported benefit from anticoagulation ... [more ▼]

PURPOSE: Sepsis induces hypercoagulability, hypofibrinolysis, microthrombosis, and endothelial dysfunction leading to multiple organ failure. However, not all studies reported benefit from anticoagulation for patients with severe sepsis, and time courses of coagulation abnormalities in septic shock are poorly documented. Therefore, the aim of this prospective observational cohort study was to describe the coagulation profile of patients with septic shock and to determine whether alterations of the profile are associated with hospital mortality. METHODS: Thirty-nine patients with septic shock on ICU admission were prospectively included in the study. From admission to day 7, analytical coagulation tests, thrombin generation (TG) assays, and thromboelastometric analyses were performed and tested for association with survival. RESULTS: Patients with septic shock presented on admission prolongation of prothrombin time, activated partial thromboplastin time (aPTT), increased consumption of most procoagulant factors as well as both delay and deficit in TG, all compatible with a hypocoagulable state compared with reference values (P < 0.001). Time courses revealed a persistent hypocoagulability profile in non-survivors as compared with survivors. From multiple logistic regression, prolonged aPTT (P = 0.007) and persistence of TG deficit (P = 0.024) on day 3 were strong predictors of mortality, independently from disease severity scores, disseminated intravascular coagulation score, and standard coagulation tests on admission. CONCLUSIONS: Patients with septic shock present with hypocoagulability at the time of ICU admission. Persistence of hypocoagulability assessed by prolonged aPTT and unresolving deficit in TG on day 3 after onset of septic shock is associated with greater hospital mortality. [less ▲]

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