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See detailPresurgical octreotide treatment in acromegaly
Stevenaert, Achille ULg; Beckers, Albert ULg

in 3rd International pituitary congress - Abstract book (1993)

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See detailPresurgical octreotide treatment in acromegaly
Stevenaert, Achille ULg; Beckers, Albert ULg

in Journal of Endocrinological Investigation (1993), 16(1-8), 137

See detailPresurgical Octreotide Treatment in Acromegaly : does it improve surgical cure rate?
Stevenaert, Achille ULg; Lenelle, Jacques ULg; Martin, Didier ULg et al

in 10th European Congress of Neurosurgery - Abstract book (1995)

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See detailPresurgical octreotide treatment in acromegaly.
Stevenaert, Achille ULg; Harris, A. G.; Kovacs, K. et al

in Metabolism : Clinical and Experimental (1992), 41(9 Suppl. 2), 51-8

The aim of this study was to determine the role of octreotide administration in acromegalic patients as a preparation for selective adenomectomy using transsphenoidal route. Octreotide was administered ... [more ▼]

The aim of this study was to determine the role of octreotide administration in acromegalic patients as a preparation for selective adenomectomy using transsphenoidal route. Octreotide was administered for 3 to 6 weeks before surgery in 12 patients and for 4 to 39 months in 25 patients. The clinical response was judged as excellent or good in 10 of 12 patients from group I and in 23 of 25 patients from group II. Marked reduction (ie, greater than 50% of initial values) in serum growth hormone (GH) levels was seen in all patients, with levels to less than 5 micrograms/L in 68% of patients and less than 2 micrograms/L in 27%. Insulin-like growth factor 1 (IGF-1) levels decreased to within normal limits in half the cases. During long-term treatment, an escape phenomenon could be seen. Varying degrees of tumor shrinkage were seen in more than 50% of cases. During surgery, with regard to the relative ease or difficulty in removing the tumor, the consistency of the tumor and the separation of normal from pathological tissue, no significant difference was observed between patients given octreotide and those from control series. Morphological changes in adenomatous tissue were rather small. The surgical outcome was similar in the pretreated series as in the control series, except in enclosed adenomas, which showed a tendency to a higher success rate. Since octreotide improves both the clinical condition and hormonal parameters and induces varying degrees of tumor shrinkage, it is potentially useful as an adjunct to surgery. Morphological data suggest that octreotide exercises a functional inhibitory effect on GH release. [less ▲]

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See detailPresurgical Octreotide: Treatment in Acromegaly
Stevenaert, Achille ULg; Beckers, Albert ULg

in Metabolism : Clinical and Experimental (1996), 45(8 Suppl. 1), 72-4

One hundred seventy-two acromegalics who were operated on using the trans-sphenoidal approach underwent long-term follow-up evaluation. Sixty-four received 100 micrograms octreotide subcutaneously three ... [more ▼]

One hundred seventy-two acromegalics who were operated on using the trans-sphenoidal approach underwent long-term follow-up evaluation. Sixty-four received 100 micrograms octreotide subcutaneously three times daily: for 3 to 6 weeks before surgery in 14 patients (group 1); and for 3 to 9 months in 41 and for 13 to 39 months in nine (n = 50, group 2). In 18 group 2 patients, the dose was increased stepwise to 500 micrograms three times daily because of incomplete suppression of growth hormone (GH)/insulin-like growth factor-1 (IGF-1). Tumor shrinkage was seen in 60% within 3 weeks, being nearly maximal by 3 to 4 months. More group 2 patients had greater than 25% tumor shrinkage (14 of 48 v 1 of 14 in group 1). Clinical response was excellent or good in 89%. Decrease in soft-tissue swelling and weight loss, and improved vitality, performance, carbohydrate metabolism, and cardiovascular function, facilitated anesthetic and surgical management; tumor removal was easy in virtually all cases. In all 64 patients, GH levels decreased by > or = 50%, and to < 2 micrograms/L in three of 14 patients initially and 25 of 50 patients after more prolonged treatment. IGF-1 levels decreased to normal in seven of 14 group 1 and 31 of 50 group 2 patients. Light and electron microscopy showed that adenomatous tissue exposed to octreotide had lysosomal accumulation, amyloid deposition, mild to moderate perivascular fibrosis, and moderate size reduction in both cytoplasmic and nuclear areas, with virtually no cellular complications. Remission with enclosed adenomas was greater (p < .05) than for the 108 patients not treated with octreotide; there was no difference for invasive adenomas. Octreotide use for 3 to 4 months before surgery can be recommended. [less ▲]

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See detailPresurgical Sandostatin treatment in acromegaly.
Stevenaert, Achille ULg; Beckers, Albert ULg

Conference (1991)

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See detailPrêt public et droit d’auteur : le "droit de prêt", c’est pour bientôt
Habrand, Tanguy ULg

Article for general public (2006)

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See detailLe prétendu séisme de Tongres vers 600 : une invention hagiographique
Alexandre, Pierre ULg

in Ciel et Terre (1989), 105

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See detailPrétest, suivi et contrôle de la performance des produits nouveaux
Choffray, Jean-Marie ULg

in P. Joffre et Y. Simon (Ed.) Encyclopédie des Sciences de Gestion (1999)

L’objet de cet article est de présenter un ensemble cohérent de concepts et de modèles utiles en matière de prétest, de suivi et de contrôle de la performance d’un produit nouveau. L’approche suivie est ... [more ▼]

L’objet de cet article est de présenter un ensemble cohérent de concepts et de modèles utiles en matière de prétest, de suivi et de contrôle de la performance d’un produit nouveau. L’approche suivie est résolument modulaire, orientée-objet, de telle sorte que le lecteur puisse construire son propre système à partir du problème auquel il est confronté: évaluation pré-lancement, suivi en phase d’introduction et de croissance, et contrôle du marketing-mix au cours de l’étape de développement du marché. Le kit proposé rassemble les modèles de diffusion, les modèles d’intensité de réachat, les fonctions de réponse et l’analyse dynamique des coûts. Ces outils conservent leur pertinence quel que soit le couple produit-marché considéré: grande consommation, durable, industriel et/ou service. [less ▲]

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See detailPretherapeutic assessment of cerebral aneuvrysms with arterially enhanced spiral CT
Vanderschelden, P.; Flandroy, P.; Dondelinger, Robert ULg et al

Conference (1995, November 26)

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See detailPretransplant helper T-lymphocyte determination in bone marrow donors: acute graft-versus-host disease prediction and relation with long-term survival
Winandy, Marie ULg; Lewalle, Philippe; Deneys, Véronique et al

in British Journal of Haematology (1999), 105

Helper T-lymphocyte precursor (HTLp) frequency from 19 allogeneic bone marrow donors was tested to detect weak antigenic differences with the recipient, and then compared to the outcome. HTLp frequency ... [more ▼]

Helper T-lymphocyte precursor (HTLp) frequency from 19 allogeneic bone marrow donors was tested to detect weak antigenic differences with the recipient, and then compared to the outcome. HTLp frequency was estimated in limiting dilution cultures, and HLA-DR and CD 80 expression by stimulating cells was measured by flow cytometry. 12/19 patients experienced acute graft-versus-host disease (aGVHD) grade II–IV. A good correlation was found between high pretransplant HTLp frequency and grade II–IV aGVHD (median: 1/55848 PBMNC for II–IV GVHD versus 1/ 184346 for 0–I GVHD; P¼0·008). Sensitivity was 82%, specificity 63%, negative predictive value 71% and positive predictive value 75%. Long-term survivors also had a lower HTLp median frequency (1/143354) when compared with patients who died as a result of the transplant procedure (1/22100, P < 0·001). No correlation was found between HTLp frequency and HLA-DR or CD80 expression by patient’s cells. We conclude that HTLp frequency estimation can predict, although poorly, acute GVHD risk and long-term survival. [less ▲]

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See detailPretreatment And Enzymatic Hydrolysis Of Miscanthus x giganteus: Influence Of Process Parameters
Vanderghem, Caroline ULg; Brostaux, Yves ULg; Jacquet, Nicolas ULg et al

Poster (2010, September 21)

Miscanthus x giganteus is a perennial grass which grows rapidly and gives high yields of biomass per hectare. It can be grown in poor quality soil and is non invasive. Due to its high cellulose and ... [more ▼]

Miscanthus x giganteus is a perennial grass which grows rapidly and gives high yields of biomass per hectare. It can be grown in poor quality soil and is non invasive. Due to its high cellulose and hemicellulose content, it has attracted considerable attention as a possible energy crop to produce bioethanol. Pretreatment of lignocellulosic biomass is a key step to unlocking the protective structures so that the enzymatic hydrolysis of the carbohydrate fraction to monosugars can be achieved more easily and with greater yield. In this study, Miscanthus x giganteus was delignified by a chemical pre-treatment process using a mixture of formic acid/acetic acid (1). The treated material was then hydrolyzed. By means of Box-Behnken experimental design and response surface methodology we investigated the effect of cooking time (60, 120 and 180 min), formic acid/acetic acid/water concentration (20/60/20, 30/50/20 and 40/40/20) and temperature (80, 90 and 107°C) on the residual Klason lignin content and the % of digestibility. The optimal pretreatment process parameters were identified. [less ▲]

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See detailPretreatment minimal staging for non-small cell lung cancer: an updated consensus report
Goldstraw; Rocmansb; Ball et al

in Lung Cancer (1994), 11(supp 3), 1-4

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See detailPretreatment minimal staging for non-small cell lung cancer: an updated consensus report
Barthelemy, Nicole ULg; Goldstraw; Rocmans et al

in Lung Cancer (1994), 11(3),

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See detailPretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium
Bartunek, Joseph; Croissant, J. D.; Wijns, William et al

in American Journal of Physiology - Heart and Circulatory Physiology (2007), 292(2), 1095-1104

The in vivo cardiac differentiation and functional effects of unmodified adult bone marrow mesenchymal stem cells (MSCs) after myocardial infarction (MI) is controversial. We postulated that ex vivo ... [more ▼]

The in vivo cardiac differentiation and functional effects of unmodified adult bone marrow mesenchymal stem cells (MSCs) after myocardial infarction (MI) is controversial. We postulated that ex vivo pretreatment of autologous MSCs using cardiomyogenic growth factors will lead to cardiomyogenic specification and will result in superior biological and functional effects on cardiac regeneration of chronically infarcted myocardium. We used a chronic dog MI model generated by ligation of the coronary artery (n = 30). Autologous dog bone marrow MSCs were isolated, culture expanded, and specified into a cardiac lineage by adding growth factors, including basic FGF, IGF-1, and bone morphogenetic protein-2. Dogs underwent cell injection > 8 wk after the infarction and were randomized into two groups. Group A dogs (n = 20) received MSCs specified with growth factors (147 +/- 96 x 10(6)), and group B (n = 10) received unmodified MSCs (168 +/- 24 x 10(6)). After the growth factor treatment, MSCs stained positive for the early muscle and cardiac markers desmin, antimyocyte enhancer factor-2, and Nkx2-5. In group A dogs, prespecified MSCs colocalized with troponin I and cardiac myosin. At 12 wk, group A dogs showed a significantly larger increase in regional wall thickening of the infarcted territory (from 22 +/- 8 to 32 +/- 6% in group A; P < 0.05 vs. baseline and group B, and from 19 +/- 7 to 21 +/- 7% in group B, respectively) and a decrease in the wall motion score index (from 1.60 +/- 0.05 to 1.35 +/- 0.03 in group A; P < 0.05 vs. baseline and group B, and from 1.58 +/- 0.07 vs. 1.56 +/- 0.08 in group B, respectively). The biological ex vivo cardiomyogenic specification of adult MSCs before their transplantation is feasible and appears to improve their in vivo cardiac differentiation as well as the functional recovery in a dog model of the chronically infarcted myocardium. [less ▲]

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See detailPretreatments and enzymatic hydrolysis of Miscanthus x giganteus for oligosaccharides production: delignification degree and characterisation of the hydrolysis products
Vanderghem, Caroline ULg; Jacquet, Nicolas ULg; Blecker, Christophe ULg et al

Poster (2010, February 04)

The aim of the present study is to compare two delignification methods (formic/acetic acid1 and soaking in aqueous ammonia) on Miscanthus x giganteus and to assess the suitability to produce cellobiose ... [more ▼]

The aim of the present study is to compare two delignification methods (formic/acetic acid1 and soaking in aqueous ammonia) on Miscanthus x giganteus and to assess the suitability to produce cellobiose and other oligosaccharides after enzymatic hydrolysis. Oligosaccharides have recently gotten attention for their health benefits. Two methods were compared in order to quantify lignin: the acid detergent lignin method (procedure of Van Soest most commonly employed by animal scientist and agronomists for analysis of forages) and the Klason lignin procedure. Lignin concentrations in raw material determined by both methods were different; Klason lignin value (23.5%) was greater than the acid detergent lignin concentration (12.9%). Possible reasons of these results will be discussed. Pretreatment by the formic/acid mixture showed a better deliginification rate compared to the soaking in aqueous ammonia method. Results were based on Klason lignin. Analysis of the structural carbohydrates revealed that untreated miscanthus was mainly composed of glucose and xylose. Extracted pulps by both delignification methods were hydrolysed by commercial cellulases and hemicellulases. A major challenge is the characterisation of complex mixtures of lignocellulosic hydrolysates. In this study, the hydrolysis products were separated and quantified by highperformance anion exchange chromatography with pulsed amperometric detection (HPAECPAD). This method was successfully applied to the quantitative analysis of monosaccharides (glucose and xylose) and disaccharides (cellobiose and xylobiose) formed by the enzymatic hydrolysis of pretreated miscanthus. The influence of the pretreatments on the oligosaccharides yields will be presented. [less ▲]

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See detail'Pretty Happy!'
Delville, Michel ULg

in Literary Review (2002), 46(1), 196-199

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See detailPretzelosity TMD and Quark Orbital Angular Momentum
Lorce, Cédric ULg; Pasquini, B.

in Physics Letters B (2012), B710

We study the connection between the quark orbital angular momentum and the pretzelosity transverse momentum dependent parton distribution function. We discuss the origin of this relation in quark models ... [more ▼]

We study the connection between the quark orbital angular momentum and the pretzelosity transverse momentum dependent parton distribution function. We discuss the origin of this relation in quark models, identifying as key ingredient for its validity the assumption of spherical symmetry for the nucleon in its rest frame. Finally we show that the individual quark contributions to the orbital angular momentum obtained from this relation cannot be interpreted as the intrinsic contributions, but include the contribution from the transverse centre of momentum which cancels out only in the total orbital angular momentum. [less ▲]

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