Leerdoelen en testformaat : De Europese Talencertificaten : Certificaat Nederlands
; Vromans, Joseph
Book published by Weiterbildungs-Testsysteme (1999)Detailed reference viewed: 28 (0 ULg)
De leerkrachten en de pedagogisch-didaktische Vernieuwing
de Landsheere, Gilbert
in Doceo (1972), 182
Het ware ongetwijfeld interessant hier ook enkele experimentele demonstraties over weerstanden tegen de vernieuwing te beschrijven. In dit korte bestek is dat echter niet mogelijk. Besluitend wil ik: een ... [more ▼]
Het ware ongetwijfeld interessant hier ook enkele experimentele demonstraties over weerstanden tegen de vernieuwing te beschrijven. In dit korte bestek is dat echter niet mogelijk. Besluitend wil ik: een onvoorwaardelijke waarschuwing laten horen. In onze veranderende samenleving, die zich resoluut en snel verwetenschappelijkt, trachten de opvoedingsdeskundigen soms met een onthutsende goede wil. de school in de vernieuwing in te schakelen. Slecht geïnformeerd, onvoldoende uitgerust met onderzoeksmethodes, slagen zij er niet altijd in een onderscheid te maken tussen de pedagogische mythe en de realiteit, tussen goedkope beweringen en wetenschap. Het getuigt van een ontzettende naïviteit te geloven dat de pedagogisch-didactische wetenschap op alle vragen kan antwoorden, alle problemen kan oplossen. Maar zo maar zonder meer aanvaarden dat de school verder kan evolueren naar haar echte rol in de maatschappij, zonder de beslissingen te doen steunen op strenge studies of de resultaten van de vernieuwingen te onderwerpen aan objectieve evaluaties, getuigt van een niet minder grote naïviteit. Ons land heeft een zeer dringende nood aan een net van onderzoekscentra van hoog niveau. Deze centra moeten zowel op gedetacheerde leerkrachten als academisch geschoolden, inspecteurs en administratieve mensen een beroep doen. Een school in ontwikkeling, deel uitmakend van een samenleving in wording, heeft klaarziende en getrainde geesten nodig. Avonturiers moeten uitgeschakeld worden. [less ▲]Detailed reference viewed: 20 (9 ULg)
De Leeuw van Waterloo. Een trefpunt van verleden, heden en toekomst
in Tollebeek, Jo (Ed.) België, een parcours van hennering. Plaatsen van geschiedenis en expansie (2008)Detailed reference viewed: 41 (3 ULg)
LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes.
; ; et al
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2017)
Reduced SIRT1 activity and levels during osteoarthritis (OA), promotes gradual loss of cartilage. Loss of cartilage matrix is accompanied by an increase in matrix metalloproteinase (MMP) 13, partially ... [more ▼]
Reduced SIRT1 activity and levels during osteoarthritis (OA), promotes gradual loss of cartilage. Loss of cartilage matrix is accompanied by an increase in matrix metalloproteinase (MMP) 13, partially because of enhanced LEF1 transcriptional activity. In this study, we assessed the role of SIRT1 in LEF1-mediated MMP13 gene expression in human OA chondrocytes. Results showed that MMP13 protein levels and enzymatic activity decreased significantly during SIRT1 overexpression or activation by resveratrol. Conversely, MMP13 gene expression was reduced in chondrocytes transfected with SIRT1 siRNA or treated with nicotinamide (NAM), a sirtuin inhibitor. Chondrocytes challenged with IL-1beta, a cytokine involved in OA pathogenesis, enhanced LEF1 protein levels, and gene expression, resulting in increased MMP13 gene expression; however, overexpression of SIRT1 during IL-1beta challenge impeded LEF1 levels and MMP13 gene expression. Previous reports showed that LEF1 binds to the MMP13 promoter and transactivates its expression, but we observed that SIRT1 repressed LEF1 protein and mRNA expression, ultimately reducing LEF1 transcriptional activity, as judged by luciferase assay. Finally, mouse articular cartilage from Sirt1-/- presented increased LEF1 and MMP13 protein levels, similar to human OA cartilage. Thus, demonstrating for the first time that SIRT1 represses MMP13 in human OA chondrocytes, which appears to be mediated, at least in part, through repression of the transcription factor LEF1, a known modulator of MMP13 gene expression.-Elayyan, J. Lee, E.-J., Gabay, O., Smith, C. A., Qiq, O., Reich, E., Mobasheri, A., Henrotin, Y., Kimber, S. J., Dvir-Ginzberg, M. LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes. [less ▲]Detailed reference viewed: 11 (2 ULg)
Left atrial dysfunction as a correlate of heart failure symptoms in hypertrophic cardiomyopathy.
; ; et al
in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography (2010), 23(10), 1090-8
BACKGROUND: Hypertrophic cardiomyopathy (HCM) represents a generalized myopathic process affecting both ventricular and atrial myocardium. We aimed to assess left atrial (LA) function by two-dimensional ... [more ▼]
BACKGROUND: Hypertrophic cardiomyopathy (HCM) represents a generalized myopathic process affecting both ventricular and atrial myocardium. We aimed to assess left atrial (LA) function by two-dimensional speckle tracking echocardiography and its relation with left ventricular (LV) function and clinical status in patients with HCM. METHODS: We prospectively enrolled 37 consecutive patients with HCM and 37 normal subjects with similar age and gender distribution. Longitudinal LV strain (epsilon) and LA epsilon and strain rate (Sr) parameters (systolic, early diastolic, and late diastolic during atrial contraction) were assessed. RESULTS: Peak LAepsilon and LA Sr parameters were significantly lower in patients compared with controls (P </= .001 for all). In patients, all LA function parameters correlated with LVepsilon (P < .003 for all). Indexed LA volume, LA function parameters, and mitral regurgitation degree were the main correlates of New York Heart Association class; late diastolic strain rate during atrial contraction was the only independent predictor of symptomatic status. CONCLUSION: In patients with HCM, LA function is significantly reduced and related to LV dysfunction. Moreover, LA booster pump function emerged as an independent correlate of heart failure symptoms in this setting. [less ▲]Detailed reference viewed: 19 (2 ULg)
Left atrial function and remodelling in aortic stenosis.
; Magne, Julien ; et al
in European Journal of Echocardiography (2011), 12(4), 299-305
AIMS: The present study sought to determine the relationship between left atrial (LA) volume (structural changes) and LA function as assessed by strain rate imaging in patients with aortic stenosis (AS ... [more ▼]
AIMS: The present study sought to determine the relationship between left atrial (LA) volume (structural changes) and LA function as assessed by strain rate imaging in patients with aortic stenosis (AS). <br />METHODS AND RESULTS: The study consisted of a total of 64 consecutive patients with severe AS (<1 cm²) and 20 healthy control subjects. The phasic LA volumes and function (tissue Doppler-derived strain) were assessed in all patients. As compared with healthy controls, all strain-derived parameters of LA function were reduced in patients with AS. Conversely, only indexed LA passive volume (increased) (7.6 ± 3.8 vs. 10.5 ± 5.1 ml/m², P= 0.02) and LA active fraction (decreased) (43 ± 6.7 vs. 31 ± 13.3%, P< 0.001) (volume-based parameters) were significantly different between AS and controls. In AS, LA volume-derived function parameters were poorly correlated with LA strain parameters. In fact, by multivariable analysis, no LA phasic strain parameters emerged as independently associated with LA phasic volume parameters. <br />CONCLUSIONS: In AS, changes in LA function did not parallel changes in LA size. Furthermore, the increase in LA volume does not necessarily reflect the presence of intrinsic LA dysfunction [less ▲]Detailed reference viewed: 25 (7 ULg)
Left atrial function: pathophysiology, echocardiographic assessment, and clinical applications.
; Lancellotti, Patrizio ; et al
in Heart (2011), 97(23), 1982-9Detailed reference viewed: 32 (7 ULg)
Left atrial thrombus in a newborn with dilated cardiomyopathy
Rigo, Vincent ; ; Rigo, Jacques
in Edition Spéciale SBP, Vol 1 (2008, February 29)Detailed reference viewed: 34 (0 ULg)
The left atrium: an old 'barometer' which can reveal great secrets.
Lancellotti, Patrizio ;
in European journal of heart failure (2014)Detailed reference viewed: 14 (3 ULg)
« Left Behind »? Le rôle des non-migrants dans les dynamiques de soins transnationales
in Bousetta, Hassan; Gsir, Sonia; Jacquemain, Marc (Eds.) et al Villes connectées Pratiques transnationales, dynamiques identitaires et diversité culturelle (2016)Detailed reference viewed: 27 (7 ULg)
Left Behind? A Case Study of Immobile Populations in the Senegalese River Basin
Conference (2014, August)
The Senegalese River Basin has undergone environmental transformations in recent decades that, in combination with poor infrastructure and inadequate resources, has affected the livelihood strategies and ... [more ▼]
The Senegalese River Basin has undergone environmental transformations in recent decades that, in combination with poor infrastructure and inadequate resources, has affected the livelihood strategies and mobility patterns of its residents. As a low-lying city near the mouth of the Senegal River, Saint-Louis is highly vulnerable to flooding. Furthermore, the vulnerability of the city can be attributed to coastal land degradation, high and increasing population density and inadequate infrastructure to manage wastewater, household waste, rain and river water (Dia 2007). In a complex web of migration drivers that include, but are not exclusively linked to, environmental drivers (Black et al. 2011), the region has seen migration out of rural and coastal areas for urban centers and other regions in Senegal. Yet, even if migration is understood as one potential adaptation strategy, not everyone leaves his or her community of origin. In keeping with the themes of this panel, this qualitative case study, conducted in the summer of 2014, explores who stays and why. Furthermore, it asks how the migration of some affects the vulnerability of those who stay. This paper explores alternative hypotheses regarding the impact of migration on communities of origin. Echoing the migration and development debates (de Haas 2009), but expanding them to include the specificities of climate change and, more broadly, environmental transformations, I present data from in-depth interviews with the immobile – shifting the public and academic focus from migrants to those ‘left behind’. This paper explores the relationship between the movers and the stayers within family and household configurations, in which the migration of some may allow others to stay (e.g. through remittances or through the alleviation of pressure on local resources), or may deplete the capital necessary to adapt effectively to environmental changes (e.g. the ‘brain drain’). [less ▲]Detailed reference viewed: 80 (7 ULg)
Left inferior frontal cortex is involved in probabilistic serial reaction time learning
Peigneux, Philippe ; Maquet, Pierre ; Van der Linden, Martial et al
in Brain and Cognition (1999), 40(1), 215-219
Cerebral blood flow was estimated using positron emission tomography and H2O15 infusions in 12 volunteers while they were trained on the probabilistic serial reaction time task developed by Jimenez ... [more ▼]
Cerebral blood flow was estimated using positron emission tomography and H2O15 infusions in 12 volunteers while they were trained on the probabilistic serial reaction time task developed by Jimenez, Mender, and Cleeremans (1996). Participants' reaction rimes to predictable and nonpredictable stimuli showed increasing sensitivity to the: probabilistic constraints set by previous elements of the sequence. Analysis by statistical parametric mapping showed a significant interaction between participants' performance and time effect in the left inferior frontal cortex. Our results provide the first evidence of this cerebral area being involved in the processing of contextual information in a probabilistic sequence learning task. [less ▲]Detailed reference viewed: 35 (2 ULg)
The left intraparietal sulcus and verbal short-term memory: Focus of attention or serial order ?
Majerus, Steve ; Poncelet, Martine ; Van der Linden, Martial et al
in Neuroimage (2006), 32(2), 880-891
One of the most consistently activated regions during verbal short-term memory (STM) tasks is the left intraparietal sulcus (IPS). However, its precise role remains a matter of debate. While some authors ... [more ▼]
One of the most consistently activated regions during verbal short-term memory (STM) tasks is the left intraparietal sulcus (IPS). However, its precise role remains a matter of debate. While some authors consider the IPS to be a specific store for serial order information, other data suggest that it serves a more general function of attentional focalization. In the current fMRI experiment, we investigated these two hypotheses by presenting different verbal STM conditions that probed recognition for word identity or word order and by assessing functional connectivity of the left IPS with distant brain areas. If the IPS has a role of attentional focalization, then it should be involved in both order and item conditions, but it should be connected to different brain regions, depending on the neural substrates involved in processing the different types of information (order versus phonological/orthographic) to be remembered in the item and order STM conditions. We observed that the left IPS was activated in both order and item STM conditions but for different reasons: during order STM, the left IPS was functionally connected to serial/temporal order processing areas in the right IPS, premotor and cerebellar cortices, while during item STM, the left IPS was connected to phonological and orthographic processing areas in the superior temporal and fusiform gyri. Our data support a position considering that the left IPS acts as an attentional modulator of distant neural networks which themselves are specialized in processing order or language representations. More generally, they strengthen attention-based accounts of verbal STM. [less ▲]Detailed reference viewed: 112 (15 ULg)
Left Main Coronary Dissection after Mild Chest Trauma. Favorable Evolution with Fibrinolytic and Surgical Therapies
; Limet, Raymond ; Trotteur, Geneviève et al
in CHEST (1988), 93(1), 213-4
A 32-year-old woman had acute anterior myocardial infarction after a mild chest trauma (automobile accident). Unstable angina recurred shortly after admission, and extensive dissection of the left ... [more ▼]
A 32-year-old woman had acute anterior myocardial infarction after a mild chest trauma (automobile accident). Unstable angina recurred shortly after admission, and extensive dissection of the left coronary artery was demonstrated. Medical therapy including systemic fibrinolysis was started but clinical stabilization and good long-term result was achieved only by aortocoronary bypass grafting. [less ▲]Detailed reference viewed: 6 (0 ULg)
Left ventricular apex-dimension loops in acute myocardial infarction.
Pierard, Luc ; ;
in The American journal of cardiology (1984), 54(6), 526-9
Apex-dimension loops may provide useful information in patients with acute myocardial infarction because incoordinate contraction and relaxation can be demonstrated. The method could allow assessment of ... [more ▼]
Apex-dimension loops may provide useful information in patients with acute myocardial infarction because incoordinate contraction and relaxation can be demonstrated. The method could allow assessment of the effects of therapeutic interventions. Fifty consecutive patients with AMI in the coronary care unit within 48 hours after the onset of their symptoms were studied. Simultaneous recordings of the echocardiogram and apexcardiogram, which were of an adequate quality for analysis, were obtained in only 7 patients (success rate 14%). In all these patients, incoordinate relaxation was demonstrated. A major practical drawback of the method is the time needed for recording the basic data requiring 2 investigators. Therefore, because of the low success rate and difficulties in obtaining simultaneous recordings, apex-dimension loops are not practical in most patients with acute myocardial infarction. [less ▲]Detailed reference viewed: 2 (0 ULg)
Left ventricular assist device as bridge to liver transplantation in a patient with propionic acidemia and cardiogenic shock.
; ; et al
in Journal of Pediatrics (2011)Detailed reference viewed: 26 (4 ULg)
Left Ventricular Contractile Reserve in Asymptomatic Degenerative Mitral Regurgitation: Evaluation and Impact on Outcome.
Magne, Julien ; ; et al
Conference (2012)Detailed reference viewed: 8 (1 ULg)