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See detailIP licensing and insolvency - Belgium
Kaesmacher, Dominique; Vanbrabant, Bernard ULiege; Vandewynckel, Simone et al

in AIPPI yearbook 2014 (2014, September)

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See detailIP Sustainable pig production : economic aspects
Berti, Fabio ULiege

Scientific conference (2011)

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See detailIpad et Kindle sont sur un bateau
Habrand, Tanguy ULiege

Article for general public (2011)

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See detailIPCAPS: an R package for iterative pruning to capture population structure
Chaichoompu, Kridsadakorn ULiege; Abegaz Yazew, Fentaw; Tongsima, Sissades et al

in Bioinformatics : Application Notes (in press)

Resolving population genetic structure is challenging, especially when dealing with closely related populations. Although Principal Component Analysis (PCA)-based methods and genomic var- iation with ... [more ▼]

Resolving population genetic structure is challenging, especially when dealing with closely related populations. Although Principal Component Analysis (PCA)-based methods and genomic var- iation with single nucleotide polymorphisms (SNPs) are widely used to describe shared genetic an- cestry, improvements can be made targeting fine-level population structure. This work presents an R package called IPCAPS, which uses SNP information for resolving possibly fine-level population structure. The IPCAPS routines are built on the iterative pruning Principal Component Analysis (ipP- CA) framework to systematically assign individuals to genetically similar subgroups. Our tool is able to detect and eliminate outliers in each iteration to avoid misclassification. It can be extended to de- tect subtle subgrouping in patients as well. In addition, IPCAPS supports different measurement scales for variables used to identify substructure. Hence, panels of gene expression and methylation data can be accommodated. [less ▲]

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See detailIPHAS and the symbiotic stars . II. New discoveries and a sample of the most common mimics
Corradi, R. L. M.; Valentini, Marica ULiege; Munari, U. et al

in Astronomy and Astrophysics (2010), 509

Context. Knowledge of the total population of symbiotic stars in the Galaxy is important for understanding basic aspects of stellar evolution in interacting binaries and the relevance of this class of ... [more ▼]

Context. Knowledge of the total population of symbiotic stars in the Galaxy is important for understanding basic aspects of stellar evolution in interacting binaries and the relevance of this class of objects in the formation of supernovae of type Ia. <BR /> Aims: In a previous paper, we presented the selection criteria needed to search for symbiotic stars in IPHAS, the INT Hα survey of the Northern Galactic plane. IPHAS gives us the opportunity to make a systematic, complete search for symbiotic stars in a magnitude-limited volume. <BR /> Methods: Follow-up spectroscopy at different telescopes worldwide of a sample of sixty two symbiotic star candidates is presented. <BR /> Results: Seven out of nineteen S-type candidates observed spectroscopically are confirmed to be genuine symbiotic stars. The spectral type of their red giant components, as well as reddening and distance, were computed by modelling the spectra. Only one new D-type symbiotic system, out of forty-three candidates observed, was found. This was as expected (see discussion in our paper on the selection criteria). The object shows evidence for a high density outflow expanding at a speed ≥65 km s[SUP]-1[/SUP]. Most of the other candidates are lightly reddened classical T Tauri stars and more highly reddened young stellar objects that may be either more massive young stars of HAeBe type or classical Be stars. In addition, a few notable objects have been found, such as three new Wolf-Rayet stars and two relatively high-luminosity evolved massive stars. We also found a helium-rich source, possibly a dense ejecta hiding a WR star, which is surrounded by a large ionized nebula. <BR /> Conclusions: These spectroscopic data allow us to refine the selection criteria for symbiotic stars in the IPHAS survey and, more generally, to better understand the behaviour of different Hα emitters in the IPHAS and 2MASS colour-colour diagrams. Based on observations obtained at; the 2.6 m Nordic Optical Telescope operated by NOTSA; the 2.5 m INT and 4.2 m WHT telescopes of the Isaac Newton Group of Telescopes in the Spanish Observatorio del Roque de Los Muchachos of the Instituto de Astrofísica de Canarias; the 2.3 m ANU telescope at Siding Spring Observatory, Australia; the Asiago 1.82 m telescope of the INAF Astronomical Observatory of Padova, Italy; and the 2.1 m telescope at San Pedro Martir, Mexico. Some of the INT spectra incorporated into this paper were obtained as part of a CCI International Time Programme awarded to the IPHAS collaboration. This publication makes use of data products from the Two Micron All Sky Survey, which is a joint project of the University of Massachusetts and the Infrared Processing and Analysis Center/California Institute of Technology, funded by the National Aeronautics and Space Administration and the National Science Foundation. This research has also made use of the SIMBAD database, operated at CDS, Strasbourg, France. [less ▲]

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See detailIpilimumab induces simultaneous regression of melanocytic naevi and melanoma metastases
LIBON, Florence ULiege; ARRESE ESTRADA, Jorge ULiege; RORIVET, A. et al

in Clinical & Experimental Dermatology (2012), (4452), 1-4

Background : Ipilimumab blocks cytotoxic T-lymphocyte-associated antigen (CTLA)-4, potentiating the antimelanoma T-cell host reponse. Ipilimumab has been shown to improve overall survival in patients with ... [more ▼]

Background : Ipilimumab blocks cytotoxic T-lymphocyte-associated antigen (CTLA)-4, potentiating the antimelanoma T-cell host reponse. Ipilimumab has been shown to improve overall survival in patients with previously treated metastatic melanoma. CTLA-4 antibodies generate immune responses to the melanoma-associated antigens Melan-A, NY-ESO-1 and glycoprotein (gp) 100 in metastatic melanoma. Digital epiluminescence microscopy (DELM) is a noninvasive method permitting the monitoring of the morphology of melanocytic lesions over time. Observation : A 50-year-old man with metastatic melanoma received four ipilimumab injections after failure of dacarbazine chemotherapy. Positron emission tomography revealed regression of pulmonary metastases, and simultaneously, DELM showed regression of several melanocytic naevi. On histological examination of the regressing naevi, prominent CD8+, CD4+ and CD45R0 lichenoid lymphohistiocytic infiltrates were seen, whereas nonregressing naevi were almost free of inflammatory infiltrate. Conclusion : Expression of melanoma-associated antigens in benign melanocytic naevi may explain the induction of naevus regression by ipilimumab. DELM could represent a valuable noninvasive method to monitor ipilimumab efficacy. [less ▲]

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See detailIpilimumab, a promising immunotherapy with increased overall survival in metastatic melanoma?
PIERARD, Gérald ULiege; Aubin, Francois; Humbert, Philippe

in Dermatology Research and Practice (2012), 2012

Malignant melanoma (MM) is one of the most aggressive skin cancer. The therapeutic options remain limited for advanced MM, and those directed to the neoplastic cells have not brought major survival ... [more ▼]

Malignant melanoma (MM) is one of the most aggressive skin cancer. The therapeutic options remain limited for advanced MM, and those directed to the neoplastic cells have not brought major survival advantage so far. Immunotherapy is another targeted option. Ipilimumab, a monoclonal antibody directed to CTLA-4 present on cytotoxic T cells boosts immunity, particularly its anti-MM activity. Under treatment, the overall survival of patients with MM metastases is moderately but significantly increased. The immuno-related adverse effects may be severe and life threatening. [less ▲]

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See detailIPM in Asia - A review of existing projects in the Philippines and Indonesia
Wynn, Nigel R.; Schiffers, Bruno ULiege; Seghers, N. et al

in Agro-Chemicals News in Brief (1997), XX(2), 1-18

Integrated Pest Management means a pest management system that, in the context of the associated environment and the population dynamics of the pest species, utilizes ail suitable techniques and methods ... [more ▼]

Integrated Pest Management means a pest management system that, in the context of the associated environment and the population dynamics of the pest species, utilizes ail suitable techniques and methods in as compatible a manner as possible and maintains the pest populations at levels below those causing economically unacceptable damage or 1055. FAO-Code- of Conduct 1984. [less ▲]

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See detailIpNose : Electronic nose for remote bad odour monitoring system in landfill sites.
Perera, A.; Pardo, T.; Sundi, T. et al

in Proceedings of the 8th conference Eurodeur (2001)

Electronic noses are intelligent instruments that are able to classify and quantify different gas/odours. Here we suggest the integration of a small form factor computer inside the electronic nose. This ... [more ▼]

Electronic noses are intelligent instruments that are able to classify and quantify different gas/odours. Here we suggest the integration of a small form factor computer inside the electronic nose. This concept allows us to easily provide remote connectivity, large data storage and complex signal processing. The evolution of this technology will permit distributed sensing with applications to agriculture and environment. Proposed instrument allows incoming connections for remote control of bad odours in landfill sites. Preliminary approach to this application using commercial sensors and mixture model pattern recognition scheme is exposed. [less ▲]

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See detailIPOPv2 : Photoionization of Ni XIV - a test case
Delahaye, F.; Palmeri, P.; Quinet, Pascal ULiege et al

in European Astronomical Society Publications Series (2013), 63

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See detailThe iPot Project: improved potato monitoring in Belgium using remote sensing and crop growth modelling
Piccard, I.; Nackaerts, K.; Gobin, A. et al

Poster (2015, April)

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See detailiPot: Improved potato monitoring in Belgium using remote sensing and crop growth modelling
Piccard, Isabelle; Gobin, Anne; Curnel, Yannick et al

Poster (2016, April)

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See detailiPot: Industrial Potato monitoring for the Belgian potato sector using remote sensing and crop growth modelling
Wellens, Joost ULiege

in Qu, Dongyu (Ed.) Develop Together for a Better Future (2015 Beijing World Potato Congress) (2015, July)

The Belgian potato processing industry has known a spectacular growth during the last decades. The companies active in this sector (most of them family owned enterprises) have succeeded – together with ... [more ▼]

The Belgian potato processing industry has known a spectacular growth during the last decades. The companies active in this sector (most of them family owned enterprises) have succeeded – together with primary producers and traders – to grow from 500.000 tons of processed potatoes in 1990 till 3.650.000 tons of raw material in 2012. When considering the production (in tons) per habitant, Belgium is ranked on the 4th place with a production of 395 tons per 1.000 inhabitants. Nowhere in the world are higher yields obtained than in Belgium. To keep up its position on the forefront of innovation, the potato processing industries are continuously looking at promising novel technologies that could improve business processes at any stage of growth. The close follow up of parcels on the land as form above is becoming an important tool to improve the quantity and the quality of the potato crop, and reduce the risks in order to plan the storage, packaging or processing and as such to strengthen the competiveness of the Belgian potato in a global market. The iPot project, financed by the Belgian Science Policy Office (BELSPO), aims to provide the Belgian potato sector, represented by Belgapom, with near real time information on field condition (weather-soil) and crop development, and with early yield estimates, derived from a combination of satellite images and crop growth models. Satellite images are used since long for crop monitoring at regional level by the public sector. Traditionally, low to medium resolution images, with pixel sizes from 250m to 1km are used for providing information on crop growth and development, and on yield at regional scale. However, the recent launch of constellations of high resolution optical sensors (DMC, Sentinel-2) offering spatially detailed information (20m pixel size) at high frequency (every 2 to 3 days) and at low cost, is creating a (r)evolution in the world of crop monitoring. Automatic processing chains have been developed to derive vegetation indices (NDVI) and biophysical parameters (fAPAR, LAI, fCover). Maps are being derived on a regular basis with for each pixel the actual development stage of the potato crop. This on-line scanning of the growth (phenology) is expected to result in an increased performance of crop growth models and better yield predictions. Once the data for crop phenology are incorporated into the model (B-CGMS), the yield data collected at the parcel level will be assimilated into the model using optimization algorithms to minimize the discrepancies between observed and simulated yield time series in order to improve further yield estimations. The combination of these new earth observation and modelling techniques arose the interest of a new type of users, mainly from the private sector (agro-industry, agricultural insurers, etc.). The iPot project aims to bridge the gap between the latest research efforts regarding crop growth monitoring and the industry. An intuitive web based geo-information platform is being developed to allow both the Belgian potato industry and research centers to access, analyze and combine the data with their own field observations in closed collaboration with the farmers, for improved decision-making. [less ▲]

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See detailLes IPP au très long cours: le problème est-il uniquement économique?
Vanmeerbeek, Marc ULiege; Louis, Edouard ULiege

in Revue Médicale de Liège (2006), 61(5-6), 483-7

Proton pump inhibitors are among the most prescribed drugs in Belgium, due to the high prevalence of gastrooesophageal reflux disease and significant impairment of health-related well-being. Short-term ... [more ▼]

Proton pump inhibitors are among the most prescribed drugs in Belgium, due to the high prevalence of gastrooesophageal reflux disease and significant impairment of health-related well-being. Short-term and long-term efficacy is superior to that of H2-receptor antagonists. Long-term safety is established. Empirical short-term treatment of symptomatic patients under 50 years of age without alarm signs is acceptable, but endoscopic investigation should always be performed before starting a long-term treatment. Doses for management of low-grade oesophagitis may be tailored to the patient's response. Continuous maintenance of full-dose is recommended for high grade oesophagitis. Surgical alternative is to be discussed with patients. Efficacy and mean cost for insurance plans are comparable. Endoscopic procedures are not yet sufficiently evaluated to be considered. Simple lifestyle advice is still useful. The burden of proton pump inhibitors cost is acceptable if they are prescribed at adequate doses. Cost-effective drugs should be chosen first. [less ▲]

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See detailL’IPP régionalisé après la sixième réforme de l’Etat
Bourgeois, Marc ULiege; Donea, M.-P.

Conference (2015)

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See detailL’IPP régionalisé après la sixième réforme de l’Etat
Bourgeois, Marc ULiege

Conference (2015)

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See detailipPCA clustering to find substructures in populations or patient collections
Chaichoompu, Kridsadakorn ULiege

Scientific conference (2014, December 02)

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See detailIpriflavone has no effect on bone metabolism and causes lymphopenia in osteopenic women
Alexandersen, P; Toussaint, A; Reginster, Jean-Yves ULiege et al

in Journal of Bone and Mineral Research (2000), 15(S1), 198

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See detailIpriflavone in prevention and treatment of postmenopausal and senile osteoporosis
Reginster, Jean-Yves ULiege

in Osteoporosis News (1996), 4

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See detailIpriflavone in the treatment of postmenopausal osteoporosis: a randomized controlled trial.
Alexandersen, P; Toussaint, André ULiege; Christiansen, C et al

in JAMA : Journal of the American Medical Association (2001), 285(11), 1482-8

CONTEXT: Data on the efficacy and safety of ipriflavone for prevention of postmenopausal bone loss are conflicting. OBJECTIVES: To investigate the effect of oral ipriflavone on prevention of ... [more ▼]

CONTEXT: Data on the efficacy and safety of ipriflavone for prevention of postmenopausal bone loss are conflicting. OBJECTIVES: To investigate the effect of oral ipriflavone on prevention of postmenopausal bone loss and to assess the safety profile of long-term treatment with ipriflavone in postmenopausal osteoporotic women. DESIGN AND SETTING: Prospective, randomized, double-blind, placebo-controlled, 4-year study conducted in 4 centers in Belgium, Denmark, and Italy from August 1994 to July 1998. PARTICIPANTS: Four hundred seventy-four postmenopausal white women, aged 45 to 75 years, with bone mineral densities (BMDs) of less than 0.86 g/cm(2). INTERVENTIONS: Patients were randomly assigned to receive ipriflavone, 200 mg 3 times per day (n = 234), or placebo (n = 240); all received 500 mg/d of calcium. MAIN OUTCOME MEASURES: Efficacy measures included spine, hip, and forearm BMD and biochemical markers of bone resorption (urinary hydroxyproline corrected for creatinine and urinary CrossLaps [Osteometer Biotech, Herlev, Denmark] corrected for creatinine), assessed every 6 months. Laboratory safety measures and adverse events were recorded every 3 months. RESULTS: Based on intent-to-treat analysis, after 36 months of treatment, the annual percentage change from baseline in BMD of the lumbar spine for ipriflavone vs placebo (0.1% [95% confidence interval (CI), -7.9% to 8.1%] vs 0.8% [95% CI, -9.1% to 10.7%]; P =.14), or in any of the other sites measured, did not differ significantly between groups. The response in biochemical markers was also similar between groups (eg, for hydroxyproline corrected for creatinine, 20.13 mg/g [95% CI, 18.85-21.41 mg/g] vs 20.67 mg/g [95% CI, 19.41-21.92 mg/g]; P =.96); urinary CrossLaps corrected for creatinine, 268 mg/mol (95% CI, 249-288 mg/mol) vs 268 mg/mol (95% CI, 254-282 mg/mol); P =.81. The number of women with new vertebral fracture was identical or nearly so in the 2 groups at all time points. Lymphocyte concentrations decreased significantly (500/microL (0.5 x 10(9)/L]) in women treated with ipriflavone. Thirty-one women (13.2%) in the ipriflavone group developed subclinical lymphocytopenia, of whom 29 developed it during ipriflavone treatment. Of these, 15 (52%) of 29 had recovered spontaneously by 1 year and 22 (81%) of 29 by 2 years. CONCLUSIONS: Our data indicate that ipriflavone does not prevent bone loss or affect biochemical markers of bone metabolism. Additionally, ipriflavone induces lymphocytopenia in a significant number of women. [less ▲]

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