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See detailKNN-MDR: a learning approach for improving interactions mapping performances in genome wide association studies
Abo Al Chamlat, Sinan ULg; Farnir, Frédéric ULg

in BMC Bioinformatics (2017), 18

Background Finding epistatic interactions in large association studies like genome-wide association studies (GWAS) with the nowadays-available large volume of genomic data is a challenging and largely ... [more ▼]

Background Finding epistatic interactions in large association studies like genome-wide association studies (GWAS) with the nowadays-available large volume of genomic data is a challenging and largely unsolved issue. Few previous studies could handle genome-wide data due to the intractable difficulties met in searching a combinatorial explosive search space and statistically evaluating epistatic interactions given a limited number of samples. Our work is a contribution to this field. We propose a novel approach combining K-Nearest Neighbors (KNN) and Multi Dimensional Reduction (MDR) methods for detecting gene-gene interactions as a possible alternative to existing algorithms, e especially in situations where the number of involved determinants is high. After describing the approach, a comparison of our method (KNN-MDR) to a set of the other most performing methods (i.e., MDR, BOOST, BHIT, MegaSNPHunter and AntEpiSeeker) is carried on to detect interactions using simulated data as well as real genome-wide data. Results Experimental results on both simulated data and real genome-wide data show that KNN-MDR has interesting properties in terms of accuracy and power, and that, in many cases, it significantly outperforms its recent competitors. Conclusions The presented methodology (KNN-MDR) is valuable in the context of loci and interactions mapping and can be seen as an interesting addition to the arsenal used in complex traits analyses. [less ▲]

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See detailKnock-down of the COX3 and COX17 gene expression of cytochrome c oxidase in the unicellular green alga Chlamydomonas reinhardtii.
Remacle, Claire ULg; Coosemans, Nadine ULg; Jans, Frédéric ULg et al

in Plant Molecular Biology (2010), 74(3), 223-2363

The COX3 gene encodes a core subunit of mitochondrial cytochrome c oxidase (complex IV) whereas the COX17 gene encodes a chaperone delivering copper to the enzyme. Mutants of these two genes were isolated ... [more ▼]

The COX3 gene encodes a core subunit of mitochondrial cytochrome c oxidase (complex IV) whereas the COX17 gene encodes a chaperone delivering copper to the enzyme. Mutants of these two genes were isolated by RNA interference in the microalga Chlamydomonas. The COX3 mRNA was completely lacking in the cox3-RNAi mutant and no activity and assembly of complex IV were detected. The cox17-RNAi mutant presented a reduced level of COX17 mRNA, a reduced activity of the cytochrome c oxidase but no modification of its amount. The cox3-RNAi mutant had only 40% of the wild-type rate of dark respiration which was cyanide-insensitive. The mutant presented a 60% decrease of H(2)O(2) production in the dark compared to wild type, which probably accounts for a reduced electron leakage by respiratory complexes III and IV. In contrast, the cox17-RNAi mutant showed no modification of respiration and of H(2)O(2) production in the dark but a two to threefold increase of H(2)O(2) in the light compared to wild type and the cox3-RNAi mutant. The cox17-RNAi mutant was more sensitive to cadmium than the wild-type and cox3-RNAi strains. This suggested that besides its role in complex IV assembly, Cox17 could have additional functions in the cell such as metal detoxification or Reactive Oxygen Species protection or signaling. Concerning Cox3, its role in Chlamydomonas complex IV is similar to that of other eukaryotes although this subunit is encoded in the nuclear genome in the alga contrary to the situation found in all other organisms. [less ▲]

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See detailKnock-out. Tres historias de boxeo.
London, Jack; Willson, Patricia ULg

Book published by Libros del Zorro Rojo (2011)

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See detailKnowing the past to anticipate the future: soil charcoal as a proxy to model forest evolution
Morin, Julie ULg; Biwolé, Achille; Bourland, Nils et al

Poster (2014, October)

Tropical forests of Central Africa constitute the second most important block of moist forest of the world. However little is known about their past evolution. Indeed, determining the past specific ... [more ▼]

Tropical forests of Central Africa constitute the second most important block of moist forest of the world. However little is known about their past evolution. Indeed, determining the past specific composition of these forests could allow modeling their evolution over time and providing data about their resilience capacity facing global change. To do this, we performed a pedoanthracological analysis in the semi-deciduous forests of southeastern Cameroon. We excavated test pits in 53 plots of botanical inventory along a gradient of vegetation, quantified wood charcoals by layers of 10 cm, identify the species present in charcoals, dated the charcoals by the radiocarbon method, then built up sequences including present forest composition. Results show that repeated fire events occurred across the study area during the last 2500 years. These disturbances are likely human-induced regarding evidence of anthropogenic activities (e.g. potsherds). Nonetheless the past specific composition does not strongly differ from the current one except for the oldest layers related to the major dry climatic event of 2500 BP. We conclude that moist forests have a good resilience capacity regarding moderate disturbances but were and will be deeply impacted by climate change. [less ▲]

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See detailKnowledge about physical activity among older adults: Short term effects of a neighbourhood environment internet-based intervention
Mouton, Alexandre ULg; Rompen, Jérôme ULg; Cloes, Marc ULg

Poster (2013, May)

Purpose. Despite the numerous health benefits, population physical activity levels are low and decline with age. Few studies exposed that a better knowledge about physical activity could encourage people ... [more ▼]

Purpose. Despite the numerous health benefits, population physical activity levels are low and decline with age. Few studies exposed that a better knowledge about physical activity could encourage people to become physically active, which constitute a critical health challenge for older people. Moreover, neighbourhood environment internet-based interventions are recommended to promote physical activity. Therefore, the main purpose of this study was to explore the effects of a neighbourhood environment internet-based intervention on knowledge about physical activity among older adults. Methods. At baseline, 87 older adults (60.69 ± 7.85 years) from the same district were assigned to an intervention (n = 41) or a control (n = 46) group. The two months intervention was composed of a comprehensive physical activity promotion website, with an emphasis on neighbourhood environment contents, and a monthly personalized email based on the stage of change theory. Physical activity knowledge was assessed by questionnaires at baseline, after one and two month of the intervention, and after one month follow-up. Results. After the intervention, knowledge of the physical activity recommendations significantly improved in the intervention group (p = 0.032), while the control group remained unchanged. Besides, knowledge about environmental opportunities for physical activity increased slightly only in the intervention group. Conclusions. These findings suggest that a neighbourhood environment internet-based intervention can result in modest improvements of the physical activity knowledge in older adults. Further research should focus on alternative ways to improve the knowledge about local opportunities for physical activity and its relationship with long term effects on behaviour change. [less ▲]

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See detailKnowledge and beliefs of health care professionals performing thrust spinal manipulations on these techniques: A preliminary study
Demoulin, Christophe ULg; TOUSSAINT, Geoffrey ULg; Grosdent, Stéphanie ULg et al

in Vleeming, Andry (Ed.) 9th Interdisciplinary World Congress on Low Back and Pelvic Girdle Pain - Progress in Evidence based diagnosis and treatment (2016, November)

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See detailKnowledge and its value
Janvier, Antoine ULg; Leclercq, Bruno ULg

Conference (2011, December 09)

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See detailThe Knowledge of Man in the Works of Christopher Isherwood
Maes-Jelinek, Hena ULg

in Revue des Langues Vivantes = Tijdschrift voor Levende Talen (1960), 26(5), 341-360

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See detailKnowledge of the Concept Light Rail Transit: Determinants of the Cognitive Mismatch between Actual and Perceived Knowledge
Creemers, Lieve; Cools, Mario ULg; Tormans, Hans et al

in Proceedings of the 13th International Conference on Travel Behaviour Research (2012)

The Flemish public transport company “De Lijn” is planning the development of a new Light Rail network for medium range distance trips (10 to 40km). A challenge exists in the fact that the concept of ... [more ▼]

The Flemish public transport company “De Lijn” is planning the development of a new Light Rail network for medium range distance trips (10 to 40km). A challenge exists in the fact that the concept of Light Rail Transit (LRT) is relatively unknown in Flanders. Therefore this paper explores the knowledge of the concept ‘Light Rail Transit’ among the Flemish population. To investigate the knowledge, two separate binary logit models are estimated to explore the determinants of the overall actual knowledge and the determinants of a cognitive mismatch. The results show that age, sex, public transit use, household size, bicycle ownership and weekly number of shopping activities contribute significantly to the overall actual knowledge of the LRT-concept. Besides, cognitive mismatch is only significantly affected by age and gender. Moreover, the results reveal a serious lack of knowledge of the concept of LRT. Consequently, a successful implementation of the LRT-system in Flanders may be jeopardized and thus it is of crucial importance to raise the level of knowledge. A first option is knowledge acquisition based on experience of the transit network. In this view, it can be a good idea to develop “travel-one-day-for-free” marketing actions. Second, it is important to provide information to the travelers by contriving information campaigns based on the determinants identified by the models. How the campaigns should be constructed from an intrinsic and psychological point of view and deliberating between the methods of communication to reach the various target groups are some important considerations for further research. [less ▲]

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See detailKnowledge of the concept Light Rail Transit: Exploring its relevance and identification of the determinants of various knowledge levels
Creemers, Lieve; Tormans, Hans; Bellemans, Tom et al

in Transportation Research. Part A : Policy & Practice (2015), 74

This paper explores the knowledge of the concept ‘Light Rail Transit’ (LRT) in the context of implementing a Light Rail system in a (sub)-urban region. To this end, three models are estimated: a first ... [more ▼]

This paper explores the knowledge of the concept ‘Light Rail Transit’ (LRT) in the context of implementing a Light Rail system in a (sub)-urban region. To this end, three models are estimated: a first model to explore the role of knowledge on modal choice, a second one to identify the determinants of the level of knowledge and a third model to identify the determinants of a cognitive mismatch between actual (real) knowledge and perceived knowledge. The first model (a negative binomial regression model) underlines the significant relation between knowledge of the concept LRT and modal choice. Given the lack of knowledge of the concept ‘Light Rail Transit’ revealed by the descriptive results, it is of crucial importance to raise the level of knowledge. Knowledge acquisition can be based on transit experiences and information provision. To explore how information campaigns should be constructed and which target groups should be approached, the factors influencing travelers’ knowledge and the determinants of a cognitive mismatch are identified by a Multinomial Logit Model (MNL-model) and a binary logit model. The results show that various socio-economic variables as well as socio-psychological variables are significantly influencing actual knowledge and significantly influencing a cognitive mismatch. Among these variables, employment, gender, perception of ticket price of Public Transit (PT) and expectations with regard to seat availability in the LRT-vehicle are the most influential ones. [less ▲]

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See detailKnowledge structures involved in episodic future thinking
D'Argembeau, Arnaud ULg

in Feeney, A.; Thompson, V. A. (Eds.) Reasoning as memory (2015)

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See detailKnowledge transfer from Belgian government to medical doctors
MORTELMANS, Katrien; REMMEN, Roy; BERKEIN, Philip et al

Conference (2014, October 02)

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See detailKnowledge Transfer in Human Science : is it relevant ?
Morant, Michel ULg

Conference given outside the academic context (2011)

The presentation aims at explaining what are the ways for transferring knowledge in human sciences, in comparison with tech transfer in physical or biotech sciences.

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See detailKnowledge Transfer in Regulatory Analytical Sciences through the Implementation of Communities of Practice
Jesionkowska, Joanna; Denis, Brigitte ULg; Taylor, Philip

in Proceedings of the conference In Doctoral Consortium - DC3K, (IC3K 2014) (2014, October)

Promoting affiliation between scientists is relatively easy, but creating larger organisational structures is more difficult, due to traditions of scientific independance, difficulties of sharing implicit ... [more ▼]

Promoting affiliation between scientists is relatively easy, but creating larger organisational structures is more difficult, due to traditions of scientific independance, difficulties of sharing implicit knowledge, and formal organisational barrers. Hence there is a need to research possibilities given by Communities of practice. This paper presents a research projet (doctoral thesis) whose goal is to implement Communities of Practice (CoP) in order to sustain knowledge transfer in regulatory analytical sciences. [less ▲]

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See detailKnowledge without Judgement: Lotze, Brentano, and Cook Wilson
Boccaccini, Federico ULg

Conference (2013)

Detailed reference viewed: 36 (0 ULg)
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See detailKnowledge work: organising mental health care networks in Belgium
Thunus, Sophie ULg; Cerfontaine, Gaëtan ULg; Schoenaers, Frédéric ULg

in Freeman, Richard; Sturdy, Steven (Eds.) Knowledge in policy - Embodied-Inscribed-Enacted (2014)

This chapter analyses the production of knowledge in mental health care networks during a policy process that took place in Belgium between 2007 and 2010.By drawing on a case study of the horizontal pilot ... [more ▼]

This chapter analyses the production of knowledge in mental health care networks during a policy process that took place in Belgium between 2007 and 2010.By drawing on a case study of the horizontal pilot ‘Adults: General Psychiatry’ (AGP) – the discussion of different local pilots in adult general psychiatry – this chapter sets out to investigate empirically: how practitioners embodied knowledge of the new practices; how they came to enact that knowledge in the course of cross-project discussions; and how they coped with its inscription in a proposal for structural reform. At the same time, by also drawing on Actor-Network Theory (ANT) and the sociology of translation (Callon, 1999; Latour, 2007; Freeman, 2009), the discussion shows how ANT and the phenomenology of embodied, inscribed and enacted knowledge complement each another. [less ▲]

Detailed reference viewed: 79 (14 ULg)