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See detailPericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation
Fuxe, J.; Tabruyn, Sébastien ULg; Colton, K. et al

in American Journal of Pathology (2011), 178(6), 2897-909

Blood vessel leakiness is an early, transient event in acute inflammation but can also persist as vessels undergo remodeling in sustained inflammation. Angiopoietin/Tie2 signaling can reduce the leakiness ... [more ▼]

Blood vessel leakiness is an early, transient event in acute inflammation but can also persist as vessels undergo remodeling in sustained inflammation. Angiopoietin/Tie2 signaling can reduce the leakiness through changes in endothelial cells. The role of pericytes in this action has been unknown. We used the selective PDGF-B-blocking oligonucleotide aptamer AX102 to determine whether disruption of pericyte-endothelial crosstalk alters vascular leakiness or remodeling in the airways of mice under four different conditions: i) baseline, ii) acute inflammation induced by bradykinin, iii) sustained inflammation after 7-day infection by the respiratory pathogen Mycoplasma pulmonis, or iv) leakage after bradykinin challenge in the presence of vascular stabilization by the angiopoietin-1 (Ang1) mimic COMP-Ang1 for 7 days. AX102 reduced pericyte coverage but did not alter the leakage of microspheres from tracheal blood vessels at baseline or after bradykinin; however, AX102 exaggerated leakage at 7 days after M. pulmonis infection and increased vascular remodeling and disease severity at 14 days. AX102 also abolished the antileakage effect of COMP-Ang1 at 7 days. Together, these findings show that pericyte contributions to endothelial stability have greater dependence on PDGF-B during the development of sustained inflammation, when pericyte dynamics accompany vascular remodeling, than under baseline conditions or in acute inflammation. The findings also show that the antileakage action of Ang1 requires PDGF-dependent actions of pericytes in maintaining endothelial stability. [less ▲]

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See detailPeridontitis as a potential risk factor for coronary heart disease and stroke
Geerts, Sabine ULg; Legrand, Victor; Rompen, Eric ULg

Poster (1997)

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See detailLe "péril jaune" en RDC : mythe ou réalité ?
Wintgens, Sophie ULg; Kabamba, Bob ULg

in Santander, Sébastian (Ed.) L’Afrique, nouveau terrain de jeu des émergents (2014)

L’influence de la Chine en république démocratique du Congo (RDC) se caractérise par son caractère tardif mais fulgurant, au regard d’une présence chinoise historiquement forte en Afrique subsaharienne ... [more ▼]

L’influence de la Chine en république démocratique du Congo (RDC) se caractérise par son caractère tardif mais fulgurant, au regard d’une présence chinoise historiquement forte en Afrique subsaharienne. Son implantation offensive en RDC résulte d’une convergence d’intérêts entre un État chinois en quête de matières premières et de terres arables pour assurer son développement économique et sa stabilité politique, et un État congolais en (re)construction résolument acquis, depuis l’élection du président Joseph Kabila, au modèle de développement chinois fondé sur la séparation volontaire entre objectifs économiques et réformes politiques (prêts inconditionnés, aide déliée). En consacrant l’accroissement rapide des relations commerciales sino-congolaises, le partenariat stratégique Chine-Afrique, scellé en 2006 lors du troisième Forum de coopération sino-africain, participe plus largement de la remise en cause du rôle des puissances traditionnellement influentes dans la région. Au-delà de la concurrence économique induite vis-à-vis des États-Unis, du Japon et des institutions financières internationales au sein desquelles elle est largement représentée, l’Europe assiste plus singulièrement à la remise en question de son leadership régional et à la dépréciation normative de sa politique développementale. Entre émancipation et hégémonie, cet article vise à mettre au jour les enjeux stratégiques inhérents à l’impact du "facteur chinois" en RDC. [less ▲]

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See detailPerilimbal pocket technique for surgical repositioning of prolapsed nictitans gland in dogs
Prémont, Johanna ULg; Monclin, Sébastien ULg; Farnir, Frédéric ULg et al

in Veterinary Record : Journal of the British Veterinary Association (2012)

The objective of this prospective study was to investigate the success rate, practicality and complications of a new perilimbal pocket technique for the replacement of prolapsed nictitans gland in 30 dogs ... [more ▼]

The objective of this prospective study was to investigate the success rate, practicality and complications of a new perilimbal pocket technique for the replacement of prolapsed nictitans gland in 30 dogs (44 eyes). A first incision was made in the bulbar conjunctiva, 2-3 mm from and parallel to the infero-nasal limbus, a second incision on the bulbar aspect of the nictitating membrane (NM), 2-3 mm parallel to the free edge. The gland was returned to its normal position by suturing the subconjunctival tissues of the NM to the episcleral tissues, using four to six interrupted horizontal mattress sutures. The English bulldog, Neapolitan mastiff, great dane and American cocker spaniel were commonly presented. Nictitans gland prolapse occurred prior to one year of age in 83.3 per cent of dogs, and unilaterally in 15 patients. The procedure was easy to perform, and had a 90.9 per cent success rate, with minimal complications. The median duration of follow-up, conducted by ophthalmic examination or telephone contact with the owners, was 21.5 months. Tear production and ocular health were not affected in 17 eyes with at least six months follow-up. There was a statistically significant increase between preoperative and postoperative Schirmer tear test-1 measurements. [less ▲]

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See detailPérils de la copie : les cas de l’Estoire del Saint Graal, du Merlin et de la Suite Vulgate
Combes, Annie ULg

in Cahiers de Civilisation Médiévale (in press)

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See detailLe périmètre irrigué de la Vallée du Kou: Diagnostic des efficiences hydro-agricole et élaboration des calendriers d'irrigation à l'aide de SIMIS (étude de cas)
Wellens, Joost ULg; Nitcheu, Martial

Report (2009)

La vallée du Kou a été depuis le milieu des années 70, le lieu d’un développement rapide de l’irrigation. Reconnue comme une excellente plaine à vocation agricole notamment pour la riziculture, en raison ... [more ▼]

La vallée du Kou a été depuis le milieu des années 70, le lieu d’un développement rapide de l’irrigation. Reconnue comme une excellente plaine à vocation agricole notamment pour la riziculture, en raison de ses importantes potentialités hydrauliques le périmètre irrigué de la vallée du Kou revêt une importance majeure dans les économies des communautés rurales et urbaines situées à proximité. D’une superficie totale aménagée de 1.260 ha, l’aménagement dudit périmètre à vocation rizicole a été réalisé de 1969 à 1970 dans le cadre de l’autosuffisance alimentaire. Malheureusement, ce périmètre est aujourd’hui peu performant à cause de la réduction progressive des surfaces emblavées au fil des années et de la faible productivité. De 7 t/ha environ de paddy par campagne pendant les premières années après l’aménagement, les rendements sont passés à 4 t/ha dans les dernières années. Actuellement, en station d’essai, les rendements atteignent 7 à 8 t/ha. Cela montre donc clairement les possibilités d’accroître les rendements sur les périmètres irrigués. Les causes principales de cette contre performance sont des pénuries en eau chroniques due à une intensification des utilisateurs en amont du périmètre et la mauvaise gestion de l’eau sur le périmètre. La question de la gestion de l’eau d’irrigation devient alors primordiale. C’est dans ce sens qu’il a été jugé nécessaire d'entreprendre une stratégie d'amélioration de la gestion de l'irrigation sur le périmètre. Après avoir élaboré un diagnostic des efficiences en irrigation, le logiciel SIMIS a été mis en place afin de proposer des scénarii d’irrigation fiables et équitables. [less ▲]

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See detailPerinatal care in Belgium
Battisti, Oreste ULg

Conference given outside the academic context (1990)

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See detailPerinatal depression in adolescent mothers : a public health concern
Noirhomme-Renard, Florence ULg; Tancredi, Annalisa; Gosset, Christiane ULg

Poster (2011, September)

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See detailPerinatal Group B Streptococcal Disease : Prevention strategies
Melin, Pierrette ULg

Conference (2006, February)

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See detailPerinatal Group B Streptococcal Disease Prevention, Interactive session
Melin, Pierrette ULg

Conference (2002, November 23)

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See detailPerinatal Group B Streptococcal infections
Melin, Pierrette ULg

Conference (2005, February)

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See detailPerinatal growth hormone (GH) physiology : effect of GH-releasing factor on maternal and fetal secretion of pituitary and placental GH.
De Zegher, F.; Vanderschueren-Lodeweyckx, M.; Spitz, B. et al

in Journal of Clinical Endocrinology and Metabolism (1990), 71(2), 520-522

To study regulation of the secretion of human pituitary GH (hGH) and placental GH (hPGH) in the pregnant woman and human fetus, the GH-releasing factor Sermorelin [GRF-(l–29)-NH2] was administered to ... [more ▼]

To study regulation of the secretion of human pituitary GH (hGH) and placental GH (hPGH) in the pregnant woman and human fetus, the GH-releasing factor Sermorelin [GRF-(l–29)-NH2] was administered to pregnant women at term (n = 5), just before elective cesarean section; saline was administered in control studies (n = 5). The effects of GRF-(1–29)-NH2 administration on maternal and fetal serum concentrations of hGH and GRF-(l–29)-NH2 and maternal serum levels of hPGH were evaluated at birth. The mean time span between injection and birth was 20 min (range, 15–25 min). Cord serum hGH concentrations were similar in infants of GRF-(1–29)-NH2-injected mothers and control infants. GRF-(l–29)-NH2 elicited a consistent but small rise in maternal hGH serum concentrations (P = 0.08), whereas hPGH concentrations remained unaltered. Finally, GRF-(l–29)-NH2 concentrations were undetectable in cord serum, but readily detectable in concomitantly obtained maternal serum. In conclusion, these data suggest that hGH secretion in the pregnant woman at term is suppressed at the pituitary level, that GRF does not affect hPGH secretion, and that fetal hGH secretion is independent of circulating maternal GRF, probably because of lack of transplacental GRF passage. [less ▲]

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See detailPERINATAL INFECTIONS - The GBS successful practices in prevention
MELIN, Pierrette ULg

Conference (2012, October 20)

Updated information on the most common infectious diseases that the mother may transmit to her infant during pregnancy, at birth or by breast feeding the infant. Most of the emphasis is directed to ... [more ▼]

Updated information on the most common infectious diseases that the mother may transmit to her infant during pregnancy, at birth or by breast feeding the infant. Most of the emphasis is directed to preventive measures, screening when interventions are available, and the detailed analysis of interventions during the preconceptional period, antenatal care, perinatal care and maternal and neonatal care after birth. The strategic approach for prevention is illustrated with the group B streptococci story. This information emphasizes the basic knowledge of the pathogen, the disease, the burden of problems caused by the disease in the mother and her offspring, epidemiological aspects, and how to manage the disease. Most of the emphasis is directed to screening-based preventive measures and new approaches to improve the accuracy and predictive values of screening are discussed. An update of the developments of a group B streptococcal vaccine is briefly presented. [less ▲]

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See detailPerineal herpes simplex infection in bedridden geriatric patients.
Nikkels, Arjen ULg; Pierard, Gérald ULg

in American Journal of Clinical Dermatology (2007), 8(2), 79-83

BACKGROUND: Herpes simplex virus (HSV) lesions are prone to reactivation and recurrence in response to various local or systemic triggering factors. OBJECTIVE: To study the characteristics of five ... [more ▼]

BACKGROUND: Herpes simplex virus (HSV) lesions are prone to reactivation and recurrence in response to various local or systemic triggering factors. OBJECTIVE: To study the characteristics of five bedridden geriatric patients who presented with herpetic recurrences on the buttocks, gluteal cleft, and perianal region during hospitalization. METHODS: Data were gathered regarding age, gender, reason for hospitalization, localization of lesions, clinical presentation, previous clinical diagnosis and topical treatments, immune status and immunosuppressant drug intake, as well as prior history of labial or genital herpes. A skin biopsy was taken for histologic examination and immunohistochemical viral identification. Viral culture and viral serology were performed and data regarding antiviral therapy were recorded. RESULTS: The five patients (three women, two men) were aged >80 years and hospitalized for either severe drug-induced renal insufficiency (one case), severe pneumonia (two cases), or stroke causing restricted mobility (two cases). Numerous well demarcated, painful ulcerations developed in the perianal region of these patients, and one patient also presented with some vesicular lesions. The lesions had been confused with mycotic and/or bacterial infections for 10-14 days. No inguinal lymphadenopathies were present and there was no fever. None of the patients had a previous history of recurrent labial or genital HSV infections or HIV infection. Histology was suggestive of HSV infection in two of five patients. Immunohistochemistry identified HSV type I (three patients) and HSV type II (two patients) infections. Viral culture with immunofluorescence viral identification revealed HSV type I in one of the four patients in whom a swab for viral culture was taken. Serology revealed past HSV infection. All lesions cured gradually after 10-14 days of intravenous acyclovir (aciclovir) treatment. CONCLUSION: Herpetic lesions of the perineal region represent a rare complication in bedridden geriatric patients in the absence of a previous history of HSV infections at the same site. Common traits of patients with this condition were the presence of numerous ulcerated lesions, prolonged time course, and confinement to bed. The latter probably modifies the skin condition, which triggers viral reactivation and favors cutaneous extension of the infection. Complementary diagnostic methods for viral detection and identification are mandatory. [less ▲]

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See detailPeriod 2 regulates neural stem/progenitor cell proliferation in the adult hippocampus.
Borgs, Laurence ULg; Beukelaers, Pierre ULg; Vandenbosch, Renaud ULg et al

in BMC Neuroscience (2009), 10

BACKGROUND: Newborn granule neurons are generated from proliferating neural stem/progenitor cells and integrated into mature synaptic networks in the adult dentate gyrus of the hippocampus. Since light ... [more ▼]

BACKGROUND: Newborn granule neurons are generated from proliferating neural stem/progenitor cells and integrated into mature synaptic networks in the adult dentate gyrus of the hippocampus. Since light/dark variations of the mitotic index and DNA synthesis occur in many tissues, we wanted to unravel the role of the clock-controlled Period2 gene (mPer2) in timing cell cycle kinetics and neurogenesis in the adult DG. RESULTS: In contrast to the suprachiasmatic nucleus, we observed a non-rhythmic constitutive expression of mPER2 in the dentate gyrus. We provide evidence that mPER2 is expressed in proliferating neural stem/progenitor cells (NPCs) and persists in early post-mitotic and mature newborn neurons from the adult DG. In vitro and in vivo analysis of a mouse line mutant in the mPer2 gene (Per2Brdm1), revealed a higher density of dividing NPCs together with an increased number of immature newborn neurons populating the DG. However, we showed that the lack of mPer2 does not change the total amount of mature adult-generated hippocampal neurons, because of a compensatory increase in neuronal cell death. CONCLUSION: Taken together, these data demonstrated a functional link between the constitutive expression of mPER2 and the intrinsic control of neural stem/progenitor cells proliferation, cell death and neurogenesis in the dentate gyrus of adult mice. [less ▲]

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See detailA period and a prediction for the Of ? p spectrum alternator HD 191612
Walborn, Nolan R.; Howarth, Ian D.; Rauw, Grégor ULg et al

in Astrophysical Journal (2004), 617(1, Part 2), 61-64

The observational picture of the enigmatic O-type spectrum variable HD 191612 has been sharpened substantially. A symmetrical, low-amplitude light curve with a period near 540 days has recently been ... [more ▼]

The observational picture of the enigmatic O-type spectrum variable HD 191612 has been sharpened substantially. A symmetrical, low-amplitude light curve with a period near 540 days has recently been reported from Hipparcos photometry. This period satisfies all of the spectroscopy since at least 1982, including extensive new observations during 2003 and 2004, and it has predicted the next transition during 2004 September - October. Measurements of the Ha equivalent width reveal a sharp emission peak in the phase diagram, in contrast to the apparently sinusoidal light curve. The He II absorption-line strength is essentially constant, while He I varies strongly, possibly filled in by emission in the O6 state, thus producing the apparent spectral type variations. The O8 state appears to be the "normal" one. Two intermediate O7 observations have been obtained, which fall at the expected phases, but these are the only modern observations of the transitions so far. The period is too long for rotation or pulsation; although there is no direct evidence as yet for a companion, a model in which tidally induced oscillations drive an enhanced wind near periastron of an eccentric orbit appears promising. Further observations during the now predictable transitions may provide a critical test. Ultraviolet and X-ray observations during both states will likely also prove illuminating. [less ▲]

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See detailPeriod and Spectroscopic Orbit of TU Hor
Duerbeck, H. W.; Surdej, Anna ULg; Surdej, Jean ULg

in Astronomy and Astrophysics. Supplement Series (1979), 36

Abstract image available at: http://esoads.eso.org/abs/1979A&AS...36..283D

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See detailPeriod doubling as a means of representing multiply instantiated entities
Sougné, Jacques ULg

in Gernsbacher, Morton Ann; Derry, Sharon J. (Eds.) Proceedings of the Twentieth Annual Conference of the Cognitive Science Society (1998)

Detailed reference viewed: 14 (2 ULg)