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See detailpH-sensitive micellar systems for controlled drug delivery: synthesis and structural characterization by small-angle neutron scattering
Joset, Arnaud ULg; Jérôme, Christine ULg; Brulet, Annie et al

Poster (2009, March)

The aim of the project is the preparation of micellar nanocarriers made of biocompatibles copolymers and their structural analysis by Small Angle Neutron Scattering (SANS). These micelles could be used in ... [more ▼]

The aim of the project is the preparation of micellar nanocarriers made of biocompatibles copolymers and their structural analysis by Small Angle Neutron Scattering (SANS). These micelles could be used in drug delivery applications to fight cancer1. The hydrophobic polycaprolactone (PCL) core is intended to incorporate the drug. The corona of hydrophilic polyethylene oxide (PEO) stabilizes the nanocarriers with respect to the plasma proteins. The pH in the neighborhood of the tumoral cells is lower than in the healthy cells. We incorporated a pH-sensitive sequence of poly(2-vinylpyridine) (P2VP). As a result, these micelles are expected to deliver their drug near the cancerous cells without affecting the healthy cells. When the pH is acidic, the P2VP is protonated and the chains are repulsive. The micellar size is then larger than in basic pH, when the P2VP is precipitated on the PCL core. We prepared PCL65-b-P2VP31 / PCL65-b-PEO114 and PCL32-b-P2VP52 / PCL36-b-PEO114 50:50 mixtures of diblocks copolymers. The resulting mixed micelles are analyzed by SANS. We developed a theoretical model with a spherical water-free PCL core. The PEO corona is described as consisting of gaussian chains with a thickness estimated as twice the chain gyration radius, Rg. We propose two alternatives for handling the P2VP zone. The P2VP molecules are either assumed to be Gaussian chains or they fill a shell of thickness L with possible water penetration.The fitting of the models to the experimental scattering cross sections leads to important structural parameters like the aggregation number, the core radius, the gyration radius and the thickness of the P2VP shell. [less ▲]

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See detailpH-sensitive micellar systems for controlled drug delivery: synthesis and structural characterization by small-angle neutron scattering
Joset, Arnaud ULg; Jérôme, Christine ULg; Brulet, Annie et al

Poster (2009, May 14)

The aim of the project is the preparation of micellar nanocarriers made of biocompatibles copolymers and their structural analysis by Small Angle Neutron Scattering (SANS). These micelles could be used in ... [more ▼]

The aim of the project is the preparation of micellar nanocarriers made of biocompatibles copolymers and their structural analysis by Small Angle Neutron Scattering (SANS). These micelles could be used in drug delivery applications to fight cancer1. The hydrophobic polycaprolactone (PCL) core is intended to incorporate the drug. The corona of hydrophilic polyethylene oxide (PEO) stabilizes the nanocarriers with respect to the plasma proteins. The pH in the neighborhood of the tumoral cells is lower than in the healthy cells. We incorporated a pH-sensitive sequence of poly(2-vinylpyridine) (P2VP). As a result, these micelles are expected to deliver their drug near the cancerous cells without affecting the healthy cells. When the pH is acidic, the P2VP is protonated and the chains are repulsive. The micellar size is then larger than in basic pH, when the P2VP is precipitated on the PCL core. We prepared PCL65-b-P2VP31 / PCL65-b-PEO114 and PCL32-b-P2VP52 / PCL36-b-PEO114 50:50 mixtures of diblocks copolymers. The resulting mixed micelles are analyzed by SANS. We developed a theoretical model with a spherical water-free PCL core. The PEO corona is described as consisting of gaussian chains with a thickness estimated as twice the chain gyration radius, Rg. We propose two alternatives for handling the P2VP zone. The P2VP molecules are either assumed to be Gaussian chains or they fill a shell of thickness L with possible water penetration.The fitting of the models to the experimental scattering cross sections leads to important structural parameters like the aggregation number, the core radius, the gyration radius and the thickness of the P2VP shell. [less ▲]

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See detailPh. Vendrix (éd.), « Grétry et l’Europe de l’opéra comique »
Pirenne, Christophe ULg

in Contrepoint (1992), 1

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See detailPh. Vendrix (éd.), « L’opéra comique en France au XVIIIe siècle »
Pirenne, Christophe ULg

in Contrepoint (1992), 1

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See detailPhagocytose immune et non immune
Malaise, Michel ULg

in Revue Médicale de Liège (1991), 46(9), 486-503

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See detailPhalangeal osteosonogrammetry study: age-related changes, diagnostic sensitivity, and discrimination power. The Phalangeal Osteosonogrammetry Study Group.
Wuster, C; Albanese, C; De Aloysio, D et al

in Journal of Bone and Mineral Research (2000), 15(8), 1603-14

Phalangeal osteosonogrammetry was introduced as a method for bone tissue investigation in 1992. It is based on the measure of the velocity of ultrasound (amplitude-dependent speed of sound [AD-SoS]) and ... [more ▼]

Phalangeal osteosonogrammetry was introduced as a method for bone tissue investigation in 1992. It is based on the measure of the velocity of ultrasound (amplitude-dependent speed of sound [AD-SoS]) and on the interpretation of the characteristics of the ultrasound signal. In this study we have collected a database of 10,115 subjects to evaluate the performance of AD-SoS and to develop a parameter that is able to quantify the signal characteristics: ultrasound bone profile index (UBPI). The database only includes females of which 4.5% had documented vertebral osteoporotic fractures, 16% lumbar spine dual X-ray absorptiometry (DXA), and 6% hip DXA. The analysis of the ultrasound signal has shown that with aging the UBPI, first wave amplitude (FWA), and signal dynamics (SDy) follow a trend that is different from the one observed for AD-SoS; that is, there is no increase during childhood. In the whole population, the risk of fracture per SD decrease for AD-SOS was odds ratio (OR) 1.71 (CI, 1.58-1.84). The AD-SoS in fractured subjects was significantly lower than in a group of age-matched nonfractured subjects (p < 0.0001). In a small cohort of hip-fractured patients UBPI proved to be lower than in a control age-matched group (p < 0.0001). When the World Health Organization (WHO) working group criteria were applied to this population to identify the T score value for osteoporosis, for AD-SoS we found a T score of -3.2 and for UBPI we found a T score of -3.14. Sixty-six percent of vertebral fractures were below the AD-SoS -3.2 T score and 62% were below UBPI -3.14. We observed the highest incidence of fractures (63.6%) among subjects with AD-SoS who had both DXA T score values below the threshold. We conclude from this study that ultrasound investigation at the hand phalanges is a valid methodology for osteoporosis assessment. It has been possible to quantify signal changes by means of UBPI, a parameter that will improve the possibility of investigating bone structure. [less ▲]

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See detailPhân bố, đặc điểm và năng suất sinh sản của lợn Bản nuôi tại Hòa Bình
Vu Dinh, Ton; Phan Dang, Thang ULg

in Journal of Science and Development (2009), 7(2), 180-185

Ban swine is raised by households of ethnic minorities, especially Muong, in the remote communes of Hoa Binh province. This breed has several advantages such as good resistance to diseases, good quality ... [more ▼]

Ban swine is raised by households of ethnic minorities, especially Muong, in the remote communes of Hoa Binh province. This breed has several advantages such as good resistance to diseases, good quality of meat. This research was conducted from July 2007 to June 2008 to determine characteristics, distribution, reproductive performance of this swine breed through by the conventional method of survey such as recording body weight data and measuring the length and chest size on weekly and monthly bases. Ban swine has a black color of coat with white feet and belly. Their hairs are long and hard. They have small and erected ears, small face, long mouth, and weak back. The age at first farrowing was 13 months. The reproductive performance was low with a litter size of 5.58 for the first litter and 9.06 for the fourth (P<0.05). The average birth weight was 0.43 kg, weaning weight at 86.33 days of age was 5.05 kg. The farrowing interval was very long (241 days) with 40.46 days from weaning to re-breeding The average monthly gain was 1.49 kg for the suckling period. Feed Converson Ratio (FCR) up to weaning was very high (19 kg concentrate and 57.4 kg of forage/kg live weight). [less ▲]

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See detailPhân cấp quản lý và Chương trình Xóa đói giảm nghèo
Mai, Lan Phương; Nguyễn, Mậu Dũng; Lebailly, Philippe ULg

in Faculté d'Economie et Développement rural (Ed.) Nông nghiệp, nông dân , nông thôn : trong quá trình công nghiệp hóa và đô thị hóa ớ Việt Nam (2012)

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See detailPhân cấp quản lý và Chương trình xóa đói, giảm nghèo (Truờng hợp nghiên cứu tại tinh Hòa Bình)
Mai, Lan Phuong ULg; Nguyen Mau, Dung; Lebailly, Philippe ULg

in Trường đại học nông nghiêp Hà Nội (Université d'Agriculture de Hanoi, Faculté d'Economie et de Développement rural) (Ed.) Nông nghiệp, nông dân, nông thôn : trong quá trình công nghiệp hóa và đô thị Hóa ở Việt Nam (2012)

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See detail„Das Phantastische ist nur eine Dimension des Wirklichen“ [Erika Tunner]
Pontzen, Alexandra ULg

in Jean-Marie Paul, Jean-Marie (Ed.) Dimensionen des Phantastischen . Studien zu E.T.A. Hoffmann. (1998)

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See detail„Das Phantastische und das Groteske. Zu ihrem Zusammenwirken in E.T.A. Hoffmanns Nachtstücken“. [Dominique Iehl]
Pontzen, Alexandra ULg

in Paul, Jean-Marie (Ed.) Dimensionen des Phantastischen . Studien zu E.T.A. Hoffmann (1998)

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See detailPhantom program analysis to assess the variability in PET image quantification between different PET-CT centres
Guiot, Thomas; Vanderlinden, Bruno; Wimana, Zéna et al

in European Journal of Nuclear Medicine and Molecular Imaging (2011, October), 38(S2), 172

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See detailPharma clinics le medicament du mois. L'esomeprazole
Louis, Edouard ULg

in Revue Médicale de Liège (2002), 57(9), 610-2

Esomeprazole is the last PPI registered on the Belgian market. It is the stable s-isomer of omeprazole. It has a better pharmacokinetic profile than omeprazole (racemate), allowing also better clinical ... [more ▼]

Esomeprazole is the last PPI registered on the Belgian market. It is the stable s-isomer of omeprazole. It has a better pharmacokinetic profile than omeprazole (racemate), allowing also better clinical performances. Esomeprazole is the first PPI shown superior to omeprazole in acute and chronic treatment of gastro-esophageal reflux disease. Controlled trials with this drug have also allowed to define new cost-effective strategies, such as on demand treatment for endoscopy-negative gastro-esophageal reflux and one week treatment of Helicobacter pylori positive duodenal ulcer. [less ▲]

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See detailPharma clinics le medicament du mois. Le nebivolol (Nobiten).
Scheen, André ULg

in Revue Médicale de Liège (2001), 56(11), 788-91

Nebivolol (Nobiten, Menarini) is a new beta-blocker recommended for the management of essential hypertension, at a dose of 5 mg once daily. It is administered as a racemic mixture of equal proportions of ... [more ▼]

Nebivolol (Nobiten, Menarini) is a new beta-blocker recommended for the management of essential hypertension, at a dose of 5 mg once daily. It is administered as a racemic mixture of equal proportions of d- and l-enantiomers. As a lipophilic agent, it is metabolised in the liver and transformed in several active metabolites, essentially via the CYP 2D6, an isoform of cytochrome P450 characterized by a genetic polymorphism. Nebivolol is highly specific for beta-1 adrenergic receptors; it is devoid of intrinsic sympathomimetic or membrane stabilising activity. Interestingly enough, it appears to have nitric oxide-mediated vasodilatory effects which might explain its favourable haemodynamic profile. Several comparative trials demonstrated an antihypertensive activity that was similar or slightly superior to that observed with various other reference antihypertensive agents. Nebivolol has an additive antihypertensive effect in combination with hydrochlorothiazide. All studies reported that the drug has a good clinical and biological tolerance profile. Therefore, nebivolol may be recommended as an alternative first-line treatment option for the management of patients with mild to moderate essential hypertension. [less ▲]

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See detailPharma clinics. Comment je traite ... la sténose d'artère rénale
Krzesinski, Jean-Marie ULg; Turatzinze, Léopold

in Revue Médicale de Liège (1999), 54(9), 719-721

Renal artery stenosis is mainly due to atherosclerosis, but also to fibromuscular dysplasia. Treatment can consist eisther of angioplasty (± stent) or of surgical revascularization. Hypertension induced ... [more ▼]

Renal artery stenosis is mainly due to atherosclerosis, but also to fibromuscular dysplasia. Treatment can consist eisther of angioplasty (± stent) or of surgical revascularization. Hypertension induced by atherosclerotic disease is rarely cured, but more easily controlled. The renal function is often improved and thus this disease must be searched in the presence of renal insufficiency of unknown cause or refractory hypertension. [less ▲]

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