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See detailPermis de conduire : du retrait à la substitution - Rôle du laboratoire de Toxicologie
DENOOZ, Raphael ULg

Scientific conference (2012, December)

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See detailLe permis unique
Pâques, Michel ULg

in X (Ed.) Liber Amicorum Michel Melchior, Liège, Strasbourg, Bruxelles : parcours des droits de l’homme (2010)

The single permit is the authorization required by law in Wallonia when the project requires both planning permission and environmental permit. The single permit is remarkable administrative ... [more ▼]

The single permit is the authorization required by law in Wallonia when the project requires both planning permission and environmental permit. The single permit is remarkable administrative simplification. Indeed, one procedure is applicable mediated by the different administrations. Some problems of scope have been resolved. This procedure in effect since 2002 is a success. [less ▲]

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See detailPermutation based methods for comparing quality of life between observed treatments
Moerkerke, Beatrijs; Goetghebeur, Els; Van Steen, Kristel ULg et al

in Statistics in Medicine (2005), 24(24), 4055-66

Quality of life is becoming an important outcome for the comparison of aggressive therapies. To measure quality of life (QOL), questionnaires have been designed that ask patients about symptoms and ... [more ▼]

Quality of life is becoming an important outcome for the comparison of aggressive therapies. To measure quality of life (QOL), questionnaires have been designed that ask patients about symptoms and functionality in several aspects of daily life. Primary analyses of such questionnaires typically focus on a summary statistic, such as a sum score or a single global question. This avoids inflated type I errors or loss of power due to multiple testing of individual items. In return, specific questions and answers that initially mattered to the patient may unfortunately get buried. To avoid reduced specificity and interpretability for both patients and physicians, we propose to also analyse all original questions. In this paper, we seek to detect items of the QOL questionnaire that differ significantly over observed treatments even in the face of multiple testing. We sequentially build a model that combines features which additionally discriminate between treatments. To achieve this, we draw on insights gained in the field of statistical genetics where one is often confronted with a vast amount of predictors, e.g. of a genotypic nature. Specifically, we adopt a permutation based approach to evaluate the null distribution of the maximum of many correlated test statistics and use it to build a regression model that explains QOL differences between treatment arms. We apply the new methodology to analyse QOL data in an observational study of four different treatments of breast cancer. We discover that a single question captures most of the observed treatment differences in this population. [less ▲]

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See detailLes pérogatives respectives du Parlement et du Gouvernement des entités fédérées en fin de législature, et au début de la législature suivante
Behrendt, Christian ULg

Report (2011)

Cette étude expose les prérogatives respectives du Parlement et du Gouvernement, au sein des entités fédérées belges, en fin de législature et au début de la législture suivante.

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See detailPeroxidase activity, ethylene production, lignification and growth limitation in shoots of a nonrooting mutant of tobacco
Faivre-Rampant, Odile; Kevers, Claire ULg; Bellini, Catherine et al

in Plant Physiology & Biochemistry (1998), 36(12), 873-877

The rooting recalcitrant rac Nicotiana tabacum cv Xanthi mutant has been multiplied in vitro under the form of shoots in parallel to wild-type. rac Shoots grew at a lower rate and did not root whatever ... [more ▼]

The rooting recalcitrant rac Nicotiana tabacum cv Xanthi mutant has been multiplied in vitro under the form of shoots in parallel to wild-type. rac Shoots grew at a lower rate and did not root whatever the treatments when compared to those of wild-type shoots. They were characterized by a higher lignin level, a higher total specific peroxidase activity with higher activity of both acidic and basic isoperoxidases (although missing and supernumerary isoenzymes were observed), and higher ethylene production. These observations might be causally related to growth inhibitions as similar incidences have been noted in different stress-induced growth limitation, through cell wall rigidification and auxin catabolism. The relationship between these aspects and rooting recalcitrance remains to be explored. (C) Elsevier, Paris. [less ▲]

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See detailPeroxidase-Catalysed Oxidation of Different Dibenzazepine Derivatives
Liégeois, Jean-François ULg; Rogister, F.; Delarge, J. et al

in Archiv der Pharmazie (1995), 328(2), 109-12

According to a recent hypothesis suggesting the potential role of free radical formation in the clozapine-induced agranulocytosis, we have evaluated the susceptibility to the peroxidase-mediated oxidation ... [more ▼]

According to a recent hypothesis suggesting the potential role of free radical formation in the clozapine-induced agranulocytosis, we have evaluated the susceptibility to the peroxidase-mediated oxidation of different dibenzazepine analogues. On the one hand, compounds with an arylamine group such as clozapine or isoclozapine present a high reactivity in the horseradish peroxidase or myeloperoxidase systems and, on the other hand, fluperlapine, though known to induce agranulocytosis, and other dibenzothiazepine and dibenzoxazepine derivatives appear insensitive to oxidation. Consequently, among tricyclic derivatives, the way of diaryloxa- and diarylthiazepine compounds could be an alternative for the development of safer drugs such as antipsychotics. [less ▲]

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See detailPeroxisomal and mitochondrial status of two murine oligodendrocytic cell lines (158N, 158JP): potential models for the study of peroxisomal disorders associated with dysmyelination processes
Baarine, Mauhamad; Ragot, Kevin; Genin, Emmanuelle ULg et al

in Journal of Neurochemistry (2009), 111

In some neurodegenerative disorders (leukodystrophies) characterized by myelin alterations, the defect of peroxisomal functions on myelin-producing cells (oligodendrocytes) are poorly understood. The ... [more ▼]

In some neurodegenerative disorders (leukodystrophies) characterized by myelin alterations, the defect of peroxisomal functions on myelin-producing cells (oligodendrocytes) are poorly understood. The development of in vitro models is fundamental to understanding the physiopathogenesis of these diseases. We characterized two immortalized murine oligodendrocyte cell lines: a normal (158N) and a jimpy (158JP) cell line mutated for the proteolipid protein PLP/DM20. Fluorescence microscopy, flow cytometry, and western blotting analysis allow to identify major myelin proteins (PLP colocalizing with mitochondria; myelin basic protein), oligodendrocyte (CNPase and myelin oligodendrocyte glycoprotein), and peroxisomal markers [adrenoleukodystrophy protein, PMP70, acyl-CoA oxidase 1 (ACOX1), l-peroxisomal bifunctional enzyme, and catalase]. Using electron microscopy, peroxisomes were identified in the two cell lines. Gene expression (ATP-binding cassette, Abcd1, Abcd2, Abcd3, and Acox1) involved in peroxisomal transport or beta-oxidation of fatty acids was evaluated using quantitative PCR. 4-phenylbutyrate treatment increases expression of ACOX1, l-peroxisomal bifunctional enzyme, PLP, myelin oligodendrocyte glycoprotein, and CNPase, mainly in 158N cells. In both cell lines, 4-phenylbutyrate-induced ACOX1 and catalase activities while only Abcd2 gene was up-regulated in 158JP. Moreover, the higher mitochondrial activity and content observed in 158JP were associated with higher glutathione content and increased basal production of reactive oxygen species revealing different redox statuses. Altogether, 158N and 158JP cells will permit studying the relationships between peroxisomal defects, mitochondrial activity, and oligodendrocyte functions. [less ▲]

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See detailPeroxisomal β-oxidation and Production of γ-decalactone by the Yeast Rhodotorula aurantiaca
Alchihab, Mohamed ULg; Dubois Dauphin, Robin ULg; Aguedo, Mario ULg et al

in Notulae Botanicae Horti Agrobotanici Cluj-Napoca (2010), 2

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See detailPeroxisome proliferator-activated receptor-gamma1 is dephosphorylated and degraded during BAY 11-7085-induced synovial fibroblast apoptosis
Relic, Biserka ULg; Benoit, Valerie; Franchimont, Nathalie et al

in Journal of Biological Chemistry (2006), 281(32), 597-604

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) plays a central role in whole body metabolism by regulating adipocyte differentiation and energy storage. Recently, however, PPAR-gamma has ... [more ▼]

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) plays a central role in whole body metabolism by regulating adipocyte differentiation and energy storage. Recently, however, PPAR-gamma has also been demonstrated to affect proliferation, differentiation, and apoptosis of different cell types. As we have previously shown that BAY 11-7085-induced synovial fibroblast apoptosis is prevented by PPAR-gamma agonist 15d-PGJ2; the expression of PPAR-gamma in these cells was studied. Both PPAR-gamma1 and PPAR-gamma2 isoforms were cloned from synovial fibroblast RNA, but only PPAR-gamma1 was detected by Western blot, showing constitutive nuclear expression. Within minutes of BAY 11-7085 treatment, a PPAR-gamma1-specific band was shifted into a form of higher mobility, suggesting dephosphorylation, as confirmed by phosphatase treatment of cell extracts. Of interest, BAY 11-7085-induced PPAR-gamma1 dephosphorylation was followed by PARP and caspase-8 cleavage as well as by PPAR-gamma1 protein degradation. PPAR-gamma1 dephosphorylation was followed by the loss of PPAR-DNA binding activity ubiquitously present in synovial fibroblast nuclear extracts. Unlike the phosphorylated form, dephosphorylated PPAR-gamma1 was found in insoluble membrane cell fraction and was not ubiquitinated before degradation. PPAR-gamma1 dephosphorylation coincided with ERK1/2 phosphorylation that accompanies BAY 11-7085-induced synovial fibroblasts apoptosis. 15d-PGJ2, PGD2, and partially UO126, down-regulated ERK1/2 phosphorylation, protected cells from BAY 11-7085-induced apoptosis, and reversed both PPAR-gamma dephosphorylation and degradation. Furthermore, PPAR-gamma antagonist BADGE induced PPAR-gamma1 degradation, ERK1/2 phosphorylation, and synovial fibroblasts apoptosis. The results presented suggest an anti-apoptotic role for PPAR-gamma1 in synovial fibroblasts. Since apoptotic marker PARP is cleaved after PPAR-gamma1 dephosphorylation but before PPAR-gamma1 degradation, dephosphorylation event might be enough to mediate BAY 11-7085-induced apoptosis in synovial fibroblasts. [less ▲]

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See detailPerpectives économiques du transport de conteneurs par bateaux fluvio-maritimes à partir de ports d'intérieur
Marchal, Jean ULg

in Bulletin de l'Association Technique Maritime et Aéronautique (1986)

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See detailLes perquisitions dans les cabinets d'avocats. Les usages à l'épreuve de la jurisprudence de la cour européenne des droits de l'homme
Jacobs, Ann ULg

in Het Strafrecht bedreven. Liber Amicorum Alain De Nauw. (2011)

Les usages en matière de perquisitions dans les cabinets d'avocats divisent auteurs et jurisprudence à plus d'un titre. Analyse sous l'angle de la Convention européenne des droits de l'homme.

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See detailLes perquisitions dans les cabinets d’avocats. Les usages à l’épreuve de la jurisrpudence de la Cour européenne des droits de l’homme
Jacobs, Ann ULg

in Deruyck, Filip (Ed.) Het strafrecht bedreven, Liber amicorum Alain De Nauw (2011)

Confrontation de la législation et de la jurisprudence belges en matière de perquisition dans les cabinets d'avocat avec la jurisprudence de la Cour européenne des droits de l'homme

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See detailPerquisitions et droits de la défense : une remise en question des pratiques par la Cour européenne des droits de l’homme ?
Jacobs, Ann ULg

in Revue de Droit Pénal et de Criminologie (2004)

Confrontation de la jurisprudence belge en matière de perquisitions à la jurisprudence de la Cour européenne des droits de l'homme, en particulier sous l'angle des mentions du mandat de perquisition et du ... [more ▼]

Confrontation de la jurisprudence belge en matière de perquisitions à la jurisprudence de la Cour européenne des droits de l'homme, en particulier sous l'angle des mentions du mandat de perquisition et du déroulement de la perquisition. [less ▲]

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See detailPERS - Doctoraat onderzoekt de kwaliteit van leven bij alzheimer
Missotten, Pierre ULg

in Contactblad van het Academisch Centrum voor Huisartsgeneeskunde van de K.U.Leuven (2012)

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See detailPersévérances - Programme de recherche de formation et d'action pour lutter contre le harcèlement moral au travail - Projets diffusion et évaluation
Italiano, Patrick ULg; Vella, Sonia; Vivegnis, Aurelie

Report (2007)

Rapport concernant la diffusion et l'évaluation par des professionnel du secteur des outils de diagnostic et d'intervention sur le harcèlement moral au travail

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See detailPersistance des troubles psychologiques et comportementaux de la démence
Squelard, Gilles ULg; Adam, Stéphane ULg; Missotten, Pierre ULg et al

Poster (2010, October)

est considérable. Actuellement, la sélection d’un traitement dépend de la nature du trouble et de son intensité. La connaissance de leur persistance s’avère importante pour la sélection et l’organisation ... [more ▼]

est considérable. Actuellement, la sélection d’un traitement dépend de la nature du trouble et de son intensité. La connaissance de leur persistance s’avère importante pour la sélection et l’organisation du traitement. Objectifs: Evaluer la persistance des troubles psychologiques et comportementaux dans une population de sujets déments suivis longitudinalement. Méthodes: Nous avons sélectionné 104 sujets déments issus de l’étude Qualidem (Paquay et al., 2004). Tous les sujets sont institutionnalisés et présentent des perturbations cognitives (score MMSE<20). Les troubles psychologiques et comportementaux ont été évalués à 12 mois d’intervalle avec le Neuropsychiatric Inventory (Cummings et al., 1997). Résultats: Les perturbations les plus persistantes sont les idées délirantes (62%), et l’agitation (67%). Le risque de rechute est moins important pour la dépression (54%), les hallucinations (44%), l’exaltation de l’humeur (43%), l’apathie (48%), l’irritabilité (52%), et le comportement moteur aberrant (52%). L’anxiété (38%), la désinhibition (39%), les troubles du sommeil (39%) et de l’appétit (38%) sont les moins persistants. Conclusion: La nature persistante de l’agitation et des idées délirantes suggère que le traitement de ces perturbations doit être prolongé. La nature ponctuelle de l’anxiété, la désinhibition et des troubles de l’appétit et du sommeil suggère qu’un traitement à court terme est plus approprié pour ces perturbations. Ces résultats sont à interpréter par rapport à la définition des troubles induite par le NPI. [less ▲]

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See detailPersistence and dispersion of an introduced population of Alpine Newt (Triturus alpestris) in the limestone plateau of Larzac (Southern France)
Denoël, Mathieu ULg

in Revue d'Ecologie (La Terre et la Vie) (2005), 60(2), 139-148

Persistence and dispersion of an introduced population of Alpine Newt (Triturus alpestris) in the limestone plateau of Larzoc (southern France). - The study of introduced populations is interesting to ... [more ▼]

Persistence and dispersion of an introduced population of Alpine Newt (Triturus alpestris) in the limestone plateau of Larzoc (southern France). - The study of introduced populations is interesting to better understand the geographic distribution and adaptability of species in different environments. The recent finding of an Alpine Newt population (Triturus alpestris) in the limestone plateau of Larzac (Department of Herault, France) provides the opportunity to examine the success of this species in the French supra-Mediterranean environment, Indeed, this species is absent from southern France although present in a large part of France and in northern Spain. The introduction site and all water bodies within a 2.5 km radius were surveyed between spring and autumn 2003. Because of the introduction date and the life expectancy of newts, all observed individuals are descendants of the introduced animals. They persist and breed in the study site despite the coexistence with Palmate Newts (Tri-turus helveticus). Body condition decreases in summer in these two species, but was lower in Alpine Newt males than in Palmate Newt males in autumn. Alpine Newts were found in only one of the other nine ponds, indicating a 1.5 km dispersion. Few Alpine Newts were present at this site, but reproduction was effective. These results show that the Alpine Newt can survive in southern France despite the presence of other newt species, but that the dispersion speed and rate towards other ponds are low. [less ▲]

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See detailPersistence of an intact endometrial matrix and vessels structure in women exposed to VA-2914, a selective progesterone receptor modulator.
Ravet, Stéphanie ULg; Munaut, Carine ULg; Blacher, Silvia ULg et al

in Journal of Clinical Endocrinology and Metabolism (2008), 93(11), 4525-31

Background: VA-2914 is a selective progesterone receptor modulator with potential contraceptive activity that induces amenorrhea, whereas progestins cause endometrial spotting and bleeding. This abnormal ... [more ▼]

Background: VA-2914 is a selective progesterone receptor modulator with potential contraceptive activity that induces amenorrhea, whereas progestins cause endometrial spotting and bleeding. This abnormal bleeding due to progestins is a consequence of focal stromal proteolysis by an increase in naked vessel size and density. Objective: Our objective was to quantify the effects of VA-2914 on endometrial vascularization, fibrillar matrix, and vascular endothelial growth factor (VEGF)-A expression in endometrial biopsies from 41 women before and after 12 wk daily treatment with a placebo, or 2.5, 5, or 10 mg VA-2914. Methods: Collagen fibrillar network was stained by silver impregnation. Vessel area, density, and structure were quantified with a computer-assisted image analysis system after double immunostaining using an anti-von Willebrand factor (endothelial cells) and an anti- smooth muscle actin (vascular smooth muscle cells) marker antibody. VEGF-A mRNAs were quantified by RT-PCR and localized by immunohistochemistry. Results: The endometrial vessels, collagen network, and mRNA levels of VEGF-A were identical during the luteal phase at baseline and in VA-2914 treated women. VEGF-A distribution was unchanged. Conclusions: VA-2914 does not alter the endometrial matrix and cells, and does not modify the endometrial vessel morphology as compared with baseline biopsies. [less ▲]

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