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See detailIs Sino-Nasal Outcome Test 22 (SNOT-22) an Appropriate Outcome Measure for Septorhinoplasty?
Goodson, Alexandre; POIRRIER, Anne-Lise ULiege; Ahluwalia, Suki et al

Poster (2012)

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See detailIs steroid 16alpha-hydroxylase supported by more than one mono-oxygenase.
Kremers, Pierre ULiege; Pasleau, Françoise ULiege; Gielen, Jacques

in Biochemical and Biophysical Research Communications (1978)

Steroid-16α-hydroxylase activities have been measured in normal and induced rat livers using four different substrates. The male/female activity ratio as well as the induction factor vary with the ... [more ▼]

Steroid-16α-hydroxylase activities have been measured in normal and induced rat livers using four different substrates. The male/female activity ratio as well as the induction factor vary with the substrate indicating that steroid-16α-hydroxylase activity is a heterogenous enzyme. Experiments using specific inhibitors led to the conclusion that steroid-16α-hydroxylase is supported by at least two cytochrome P-450 forms, different from the cytochrome P-448. [less ▲]

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See detailIs supercritical fluid chromatography hyphenated to massspectrometry suitable for the quality control of vitamin D3 oilyformulations?
Andri, Bertyl ULiege; Dispas, Amandine ULiege; Klinkenberg, Régis et al

in Journal of Chromatography. A (2017), 1515

Nowadays, many efforts are devoted to improve analytical methods regarding efficiency, analysis timeand greenness. In this context, Supercritical Fluid Chromatography (SFC) is often regarded as a ... [more ▼]

Nowadays, many efforts are devoted to improve analytical methods regarding efficiency, analysis timeand greenness. In this context, Supercritical Fluid Chromatography (SFC) is often regarded as a goodalternative over Normal Phase Liquid Chromatography (NPLC). Indeed, modern SFC separations arefast, efficient with suitable quantitative performances. Moreover, the hyphenation of SFC to mass spec-trometry (MS) provides additional gains in specificity and sensitivity. The present work aims at thedetermination of vitamin D3 by SFC-MS for routine Quality Control (QC) of medicines specifically. Basedon the chromatographic parameters previously defined in SFC-UV by Design of Experiments (DoE) andDesign Space methodology, the method was adapted to work under isopycnic conditions ensuring a base-line separation of the compounds. Afterwards, the response provided by the MS detector was optimizedby means of DoE methodology associated to desirability functions. Using these optimal MS parameters,quantitative performances of the SFC-MS method were challenged by means of total error approachmethod validation. The resulting accuracy profile demonstrated the full validity of the SFC-MS method. It was indeed possible to meet the specification established by the European Medicines Agency (EMA) (i.e. 95.0 − 105.0% of the API content) for a dosing range corresponding to at least 70.0-130.0% of theAPI content. These results highlight the possibility to use SFC-MS for the QC of medicine and obviouslysupport the switch to greener analytical methods. [less ▲]

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See detailIs system resilience maintained at the expense of individual resilience?
Nyssen, Anne-Sophie ULiege; Berastegui, Pierre ULiege

in Braithwaite, Jeffrey; Wears, Robert; Hollnagel, Erik (Eds.) Resilient Health Care III: Reconciling Work-As-Imagined and Work-As-Done (2016)

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See detailIs territorial sensitivities method acceptable in the territorial intelligence approaches?
Schmitz, Serge ULiege

in Girardot, Jean Jacques; Mihai, Pascaru; Ileana, Ioan (Eds.) International Conference of territorial intelligence, Alba Iulia 2006, Papers on Region, Identity and sustainable development (2007)

The territorial sensitivities method was proposed as a tool to collect senses of places and meanings of landscape features. It was presented as an alternative of the traditional participation process to ... [more ▼]

The territorial sensitivities method was proposed as a tool to collect senses of places and meanings of landscape features. It was presented as an alternative of the traditional participation process to take into account the inhabitants’ meanings in physical planning projects. The method is based on the comparison of an “objective” inventory of localisable changes and those collected in the speech of the inhabitants. Analysing which changes are mentioned but also which ones are absent contributes to grasp the places appropriation. After a short presentation of the method, the paper asks about the acceptability of this one in the context of the territorial intelligence. Is it suitable to join non participative empathic methods in the set of tools of the territorial intelligence? [less ▲]

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See detailIs the (E)-ß-farnesene only volatile terpenoid in aphids?
Francis, Frédéric ULiege; Vandermoten, Sophie ULiege; Verheggen, François ULiege et al

in Journal of Applied Entomology (2005), 129

Herbivore insects use a broad range of chemical cues to locate their host to feed or to oviposit. Whether several plant volatiles are effective allelochemicals for insects, the latter also emit molecules ... [more ▼]

Herbivore insects use a broad range of chemical cues to locate their host to feed or to oviposit. Whether several plant volatiles are effective allelochemicals for insects, the latter also emit molecules which have infochemical role. The (E)-beta-farnesene (EBF) is a well-known aphid alarm pheromone commonly found in all previously tested species. Analysis of the released molecules from 23 aphid species, mainly collected on their natural host plant from May to July, was performed by gas chromatography–mass spectrometry. While EBF was identified as the main volatile substance in 16 species, alone or associated with other molecules, the alarm pheromone was only a minor component of the volatile molecule pattern of five other species. Moreover, two species, Euceraphis punctipennis and Drepanosiphum platanoides, did not release EBF at all but other terpenes were identified. This original observation raised the question on the utility and the source of the non-EBF volatiles. Are these potential infochemical substances produced by the aphid or only absorbed from the host plant? Here we determined that terpenes released by insects were not only provided by the host plants. Indeed, Megoura viciae emitted additional molecules than the ones from several aphid species reared on the same host plant. Moreover, no systematic relation between the feeding behaviour of the aphid species and the volatile releases was observed. Aphid terpene composition and proportion would provide reliable cues to identify the emitting organism, plant or insect. The next step of this work will be to determine the infochemical role of terpenes found in the range of tested aphid samples to better understand the relations between the different tritrophic levels. [less ▲]

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See detailIs the ADA/EASD algorithm for the management of type 2 diabetes (January 2009) based on evidence or opinion? A critical analysis.
Schernthaner, G.; Barnett, A. H.; Betteridge, D. J. et al

in Diabetologia (2010)

The ADA and the EASD recently published a consensus statement for the medical management of hyperglycaemia in patients with type 2 diabetes. The authors advocate initial treatment with metformin ... [more ▼]

The ADA and the EASD recently published a consensus statement for the medical management of hyperglycaemia in patients with type 2 diabetes. The authors advocate initial treatment with metformin monotherapy and lifestyle modification, followed by addition of basal insulin or a sulfonylurea if glycaemic goals are not met (tier 1 recommendations). All other glucose-lowering therapies are relegated to a secondary (tier 2) status and only recommended for selected clinical settings. In our view, this algorithm does not offer physicians and patients the appropriate selection of options to individualise and optimise care with a view to sustained control of blood glucose and reduction both of diabetes complications and cardiovascular risk. This paper critically assesses the basis of the ADA/EASD algorithm and the resulting tiers of treatment options. [less ▲]

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See detailIs the arbitrary symmetrical?
Badir, Sémir ULiege

in Semiotica (2017)

Arbitrariness is commonly seen as a major concept in Saussure’s thought, and it even receives the status of a “principle” in his theory. It is not only the characteristic feature of the relation between ... [more ▼]

Arbitrariness is commonly seen as a major concept in Saussure’s thought, and it even receives the status of a “principle” in his theory. It is not only the characteristic feature of the relation between the signifier and the signified (the semiological relation is arbitrary), but moreover it is constitutive of this very relation (the relation is semiological because it is arbitrary; there is a so-called “semiological relation” established between a signifier and a signified because of the principle of arbitrariness). And when linguists and other Saussurean interpreters comment on the concept of arbitrariness, they usually imply a binary relation: the semiological relation is arbitrary due to the fact that the signifier is arbitrarily chosen vis-à-vis the signified, and vice versa. I will be questioning the latter assertion in this paper. In my opinion, the symmetry of the semiological relation has not been properly demonstrated. The signifier can be seen as arbitrary with regard to the signified, but no reason has been provided to recognize the converse. Instead a number of arguments can be put forth to see arbitrariness as a concept that implies a non-symmetrical relation. [less ▲]

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See detailIs the aroma compound g-decalactone produced by yeast in response to a membrane-rigidifying stress induced by the biotransformation medium?
Aguedo, Mario ULiege; Beney, L.; Waché, Y. et al

in Chemické Listy (2003, June), 97

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See detailIs the baboon model appropriate for endometriosis studies?
Dehoux, Jean-Paul; Defrère, Silvie; Squifflet, Jean et al

in Fertility and Sterility (2011), 96(3), 728-7333

Objective To determinethe prevalence of spontaneous endometriosis andthe incidence of induced endometriosis after endocervical canal resection in baboons. Design Induction and follow-up of endometriosis ... [more ▼]

Objective To determinethe prevalence of spontaneous endometriosis andthe incidence of induced endometriosis after endocervical canal resection in baboons. Design Induction and follow-up of endometriosis in baboons, which is one of the primate species that develop spontaneous endometriosis. Forty-one baboons were checked for the presence of spontaneous endometriosis. We then attempted to induce endometriosis in 30 of them by endocervical canal resection. Setting Institute of Primate Research, Nairobi, Kenya, and Catholic University of Louvain, Brussels, Belgium. Animal(s) Forty-one baboons were checked for spontaneous endometriosis and 30 of them were used to develop a model of induced endometriosis. Intervention(s) A total of 41 baboons underwent diagnostic laparoscopy for 10 months. In a first step, 30 of this number subsequently underwent endocervical canal resection. In a second step, 20 of the 30 underwent uterine horn resection. Main Outcome Measure(s) Follow-up by laparoscopy. Result(s) Two of the 41 baboons were diagnosed with spontaneous endometriosis (4.8%). Twelve months after the surgical procedure to induce endometriosis, 8 of 29 animals presented with endometriotic lesions diagnosed by using laparoscopy and confirmed by histologic examination. The incidence of induced endometriosis in our model was thus 27.6%. In 2 baboons, endometriosis disappeared over time, resulting in a final rate of 20.7% (6/29). Conclusion(s) The rate of spontaneous endometriosis is very low (4.8%). Endometriosis can be induced (with a rate of just 27.6%) by endocervical canal resection to stimulate retrograde menstruation. [less ▲]

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See detailIs the behaviour of grazing cattle influenced by the presence of a hedge in the pasture?
Vandermeulen, Sophie ULiege; Yando, Emile; Marche, Christian et al

Poster (2014, February 07)

The interest in using shrubs and trees as forage for cattle is raising in temperate regions, along with the environmental measures promoting hedges along pasture. This study aimed at determining the ... [more ▼]

The interest in using shrubs and trees as forage for cattle is raising in temperate regions, along with the environmental measures promoting hedges along pasture. This study aimed at determining the influence of the presence of a woody hedge on grazing cattle behavior as well as the evolution of this behavior during the grazing season. Twelve heifers were set to graze a standard ryegrass and clover meadow during the grazing season of 2013. The animals were divided in 2 groups : one with a free access to a hedge composed by 10 temperate shrub and tree species, the other with no access to a hedge (control). Their behavior (grazing, browsing and other activities) was monitored during 14h d-1 replicated 3d week-1 during 3 periods (May, July and September). Results suggest that both season and presence of a hedge have an influence on the behavior of heifers. Grazing, resting and rumination varied between the two groups in each period (P<0.05). The time spent browsing was influenced by the season (P<0.001); the heifers with an access to the hedge could browse 19.3% of the total time in May against 5.9 and 5.4% in July and September. Both control and experimental heifers grazed more with the progressing season, but the animals without the hedge grazed always more than the heifers that could graze and browse (49.6 vs 43.0%). In conclusion, browsing woody species represents a significant part of the time spent for forage ingestion, and variation in this behavior over the whole grazing season requires to investigate the influence of both pasture and browse availability and composition. [less ▲]

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See detailIs the bowshock of the runaway massive star HD 195592 a Fermi source?
del Valle, M.; Romero, G.E.; De Becker, Michaël ULiege

in Astronomy and Astrophysics (2013), 550

HD 195592 is an O-type super-giant star, known as a well-established runaway. Recently, a Fermi gamma-ray source (2FGL J2030.7+4417) with a position compatible with that of HD 195592 has been reported ... [more ▼]

HD 195592 is an O-type super-giant star, known as a well-established runaway. Recently, a Fermi gamma-ray source (2FGL J2030.7+4417) with a position compatible with that of HD 195592 has been reported. Our goal is to explore the scenario where HD 195592 is the counterpart of the Fermi gamma-ray source modeling the non-thermal emission produced in the bowshock of the runaway star. We calculate the spectral energy distribution of the radiation produced in the bowshock of HD 195592 and we compare it with Fermi observations of 2FGL J2030.7+4417. We present relativistic particle losses and the resulting radiation of the bowshock of HD 195592 and show that the latter is compatible with the detected gamma-ray emission. We conclude that the Fermi source 2FGL J2030.7+4417 might be produced, under some energetic assumptions, by inverse Compton up-scattering of photons from the heated dust in the bowshock of the runaway star. HD 195592 might therefore be the very first object detected belonging to the category of gamma-ray emitting runaway massive stars, whose existence has been recently predicted. [less ▲]

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See detailIs the cerebral cortex hyperexcitable or hyperresponsive in migraine?
Coppola, G.; Pierelli, F.; Schoenen, Jean ULiege

in Cephalalgia : An International Journal of Headache (2007), 27(12), 1429-1439

Although migraineurs appear in general to be hypersensitive to external stimuli, they maybe also have increased daytime sleepiness and complain of fatigue. Neurophisiological studies between attacks have ... [more ▼]

Although migraineurs appear in general to be hypersensitive to external stimuli, they maybe also have increased daytime sleepiness and complain of fatigue. Neurophisiological studies between attacks have shown that for a number of different sensory modalities the migrainous brain is characterised by a lack of habituation of evoked responses. Whether this is due to increased cortical hyperexcitability, possibly due to decreased inhibition, or to an abnormal responsivity of the cortex due a decreased preactivation level remains disputed. Studies using transcranial magnetic stimulation in particular have yielded contradictory results. We will review here the available data on cortical excitability obtained with different methodological approaches in patients over the migraine cycle. We will show that these data congruently indicate that the sensory cortices of migraineurs react excessively to repetitive, but not to single, stimuli and that the controversy above hyper- versus hypo-excitability is merely a semantic misunderstanding. Describing the migrainous brain as 'hyperresponsive' would fit most of the available data. Deciphering the precise cellular and molecular underpinnings of this hyperresponsivity remains a challenge for future research. We propose, as a working hypothesis, that a thalamo-cortical dysrhythmia might be the culprit. [less ▲]

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See detailIs the CXC-Chemokine CXCL8 involved in the breed predisposition of west highland white terrier to canine idiopathic pulmonary fibrosis ?
Roels, Elodie ULiege; Krafft, Emilie ULiege; Laurila, HP et al

in Proceedings of the 23th ECVIM Meeting (2013, September)

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See detailIs the Darwin´s “Abominable Mystery” still a mystery?
Cascales-Miñana, Borja ULiege; Cleal, Chris J.; Gerrienne, Philippe ULiege

in Proceedings of the XXXI Annual Meeting of the Spanish Society of Palaeontology (abstract book) (2015, October)

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See detailIs the decrease of central venous compliance the factor responsible for salt sensitivity?
Krzesinski, Jean-Marie ULiege; Rorive, Georges ULiege

in Journal of Hypertension (Supplement) (1986), 4

To detect the possible mechanisms of salt sensitivity, blood pressure (BP), renal biological and red blood cell (RBC) ionic fluxes, responses were studied in 20 normotensive males (<30 years old), after ... [more ▼]

To detect the possible mechanisms of salt sensitivity, blood pressure (BP), renal biological and red blood cell (RBC) ionic fluxes, responses were studied in 20 normotensive males (<30 years old), after acute isotonie saline infusion (1 litre in less than 30 min). Salt sensitivity was considered to be present if mean supine BP increased by more than 9 mmHg when the salt diet, which was applied each time for 1 week, increased from less than 20 mmol/l NaCI per day to more than 340 mmol/l. Three subgroups were defined: eight salt-sensitives (SS), 10 salt-resistants (SR) and two patients with only a very slight BP increase. ln each group (SS or SR), the same percentage of family history of hypertension was noted (60%). During the normal diet (± 170 mmol/l NaCl per day), vascular resistances were lower , and creatinine clearance higher in SS (26 ± 8 units, and 122 ± 6 ml/min, respectively) than in SR (48 ± 1 units and 102 ± 1 ml/min). As other markers of greater salt overloading could not be detected in SS, these differences could be due to higher cardiac volume ejection in SS than in SR (heart rate was the same in the two populations. During acute salt loading, mean BP rase in SS (tram 88 ± 6 to 93 ± 7 mmHg), while it decreased in SR (from 85 ± 10 to 81 ± 10 mmHg, P < 0.05). During the same period RBC Na+K+-ATPase activity decreased more in SS (from 3970 ± 715 to 3312 ± 452 umol/l cell per h) than in SR (from 4430 ± 550 to 4300 ± 520). Moreover, during chronic oral salt loading (> 340 mmol/l NaCl per day) , SS showed a greater BP increase during noradrenaline (NE) infusion (10 ± 6 mmHg for 60 ng/min per kg NA) than in SR (5 ± 3 mmHg, P < 0.02). In conclusion, salt sensitivity is already present in young normotensives. It could be due to a higher sympathetic venous tone , which in turn would increase cardiac output and secretio n of a plasma Na+K+-pump inhibitor. [less ▲]

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