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See detailLipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKK epsilon-dependent lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF
GATOT, Jean-Stéphane ULg; Gioia, Romain ULg; Chau, Tieu-Lan ULg et al

in Journal of Biological Chemistry (2007), 282(43), 31131-31146

Type I interferon gene induction relies on IKK-related kinase TBK1 and IKK epsilon-mediated phosphorylations of IRF3/7 through the Toll-like receptor-dependent signaling pathways. The scaffold proteins ... [more ▼]

Type I interferon gene induction relies on IKK-related kinase TBK1 and IKK epsilon-mediated phosphorylations of IRF3/7 through the Toll-like receptor-dependent signaling pathways. The scaffold proteins that assemble these kinase complexes are poorly characterized. We show here that TANK/ITRAF is required for the TBK1- and IKK epsilon-mediated IRF3/7 phosphorylations through some Toll-like receptor-dependent pathways and is part of a TRAF3-containing complex. Moreover, TANK is dispensable for the early phase of double-stranded RNA-mediated IRF3 phosphorylation. Interestingly, TANK is heavily phosphorylated by TBK1-IKK epsilon upon lipopolysaccharide stimulation and is also subject to lipopolysaccharide- and TBK1-IKK epsilon-mediated Lys(63)-linked polyubiquitination, a mechanism that does not require TBK1-IKK epsilon kinase activity. Thus, we have identified TANK as a scaffold protein that assembles some but not all IRF3/7-phosphorylating TBK1-IKK epsilon complexes and demonstrated that these kinases possess two functions, namely the phosphorylation of both IRF3/7 and TANK as well as the recruitment of an E3 ligase for Lys63-linked polyubiquitination of their scaffold protein, TANK. [less ▲]

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See detailLIPOSOME CONTAINING ESTETROL FOR THE TREATMENT OF ISCHEMIA DISEASES IN PREMATURE BABIES
Palazzo, Claudio ULg; Karim, Reatul ULg; Mawet, Marie et al

Poster (2015, April 14)

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See detailLiposome electrokinetic chromatography based in vitro model for early screening of the drug-induced phospholipidosis risk.
Wang, Tingting; Feng, Ying; Jin, Xiaohan et al

in Journal of pharmaceutical and biomedical analysis (2014), 96

Drug-induced phospholipidosis (PLD) is a storage disorder of lysosomes characterized by the excessive accumulation of phospholipids as a result of improper medical treatments. Although few evidences have ... [more ▼]

Drug-induced phospholipidosis (PLD) is a storage disorder of lysosomes characterized by the excessive accumulation of phospholipids as a result of improper medical treatments. Although few evidences have supported that PLD can induce significant pathological consequences, this potential toxicity indeed can put off the drug discovery process. In this research, a high-throughput liposome electrokinetic chromatography (LEKC) method was validated to evaluate the PLD risk of drug candidates by screening drug-phospholipid interaction, which correlates to the phospholipidosis inducing risk. A statistical analysis based on the Spearman's correlation test showed that the retention factors (log k) of the tested drugs in the LEKC system and the literature reported in vivo and in vitro PLD data were highly correlated. In order to investigate the predictability of LEKC, the effect of liposome composition such as the molar ratio of phospholipids and the addition of cholesterol were also discussed in this study. The results indicated that the LEKC method could offer a fast, reliable and cost-effective screening tool for early prediction of the PLD inducing potential of drug candidates. [less ▲]

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See detailLiposome surface charge influence on skin penetration behaviour
Gillet, Aline ULg; Compère, Philippe ULg; Lecomte, Frédéric ULg et al

in International Journal of Pharmaceutics (2011), 411(1-2), 223-231

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See detailLiposomes and parameters affecting their skin penetration behaviour
Gillet, Aline ULg; Evrard, Brigitte ULg; Piel, Géraldine ULg

in Journal of Drug Delivery Science and Technology [=JDDST] (2011), 21

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See detailLiposomes entrapping apigenin for the treatment of glioblastoma
Karim, Reatul ULg; Palazzo, Claudio ULg; Dubois, Nadège ULg et al

Poster (2015, April 17)

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See detailLiposomes loaded with diglyceride ester of methotrexate and mephalan: sutdies on stability and hemocompatibilit
Kuznetsova, N; Sevrin, Chantal ULg; Lespineux, David et al

Poster (2009, September 28)

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See detailLiposomes loaded with diglyceride esters of methotrexate and melphalan: studies on stability and hemocompatibility
Kuznetsova, N; Kandyba, A; Bovin, N et al

in Proceedings of the International Liposome Society 2009 Meeting (2009, December 12)

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See detailLiposomes loaded with diglyceride esters of methotrexate and mephalan studies on stability and hemocompatibility
Kuznetsova, N; Kandyba, A.K.; Bovin, N et al

in European Cells and Materials (2010, November 03), 20(3), 152

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See detailLiposomes loaded with diglyceride esters of methotrexate and mephalan studies on stability and hemocompatibility
Kuznetsova, N; Kandyba, A.K; Bovin, N et al

Poster (2010, August 24)

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See detailThe lipoxygenase metabolic pathway in plants: potential for industrial production of natural green leaf volatiles
Gigot, Cédric ULg; Ongena, Marc ULg; Fauconnier, Marie-Laure ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2010), 14(3), 451-460

Lipoxygenase enzymatic pathway is a widely studied mechanism in the plant kingdom. Combined actions of three enzymes: lipase, lipoxygenase (LOX) and hydroperoxide lyase (HPL) convert lipidic substrates ... [more ▼]

Lipoxygenase enzymatic pathway is a widely studied mechanism in the plant kingdom. Combined actions of three enzymes: lipase, lipoxygenase (LOX) and hydroperoxide lyase (HPL) convert lipidic substrates such as C18:2 and C18:3 fatty acids into short chain volatiles. These reactions, triggered by cell membrane disruptions, produce compounds known as Green Leaf Volatiles (GLVs) which are C6 or C9-aldehydes and alcohols. These GLVs are commonly used as flavors to confer a fresh green odor of vegetable to food products. Therefore, competitive biocatalytic productions have been developed to meet the high demand in these natural flavors. Vegetable oils, chosen for their lipidic acid profile, are converted by soybean LOX and plant HPL into natural GLVs. However this second step of the bioconversion presents low yield due to the HPL instability and the inhibition by its substrate. This paper will shortly describe the different enzymes involved in this bioconversion with regards to their chemical and enzymatic properties. Biotechnological techniques to enhance their production potentialities will be discussed along with their implication in a complete bioprocess, from the lipid substrate to the corresponding aldehydic or alcoholic flavors. [less ▲]

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See detailLipoxygenase pathway and antioxidant system in salt-stressed tomato seedlings (Lycopersicon esculentum Mill.).
Delaplace, Pierre ULg; Frettinger, P.; Ghanem, M. E. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2009), 13

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See detailLes lipoxygénases du soja.
Fauconnier, Marie-Laure ULg; Marlier, M.

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1997), 1(2), 125-141

Dans cet article de synthèse, les auteurs font le point sur les connaissances actuelles dans le domaine des lioxygénases du soja. Une attention particulière est portée à la compréhension des mécanismes ... [more ▼]

Dans cet article de synthèse, les auteurs font le point sur les connaissances actuelles dans le domaine des lioxygénases du soja. Une attention particulière est portée à la compréhension des mécanismes réactionnels (substrats, inhibiteurs, site actif, etc.). Le rôle physiologique ainsi que l'utilisation de cet enzuyme dans les industries agroalimentaires et en biotechnologie sont également abordés. [less ▲]

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See detailLipschitz robust control from off-policy trajectories
Fonteneau, Raphaël ULg; Ernst, Damien ULg; Boigelot, Bernard ULg et al

in Proceedings of the 53rd IEEE Conference on Decision and Control (IEEE CDC 2014) (2014)

We study the minmax optimization problem introduced in [Fonteneau et al. (2011), ``Towards min max reinforcement learning'', Springer CCIS, vol. 129, pp. 61-77] for computing control policies for batch ... [more ▼]

We study the minmax optimization problem introduced in [Fonteneau et al. (2011), ``Towards min max reinforcement learning'', Springer CCIS, vol. 129, pp. 61-77] for computing control policies for batch mode reinforcement learning in a deterministic setting with fixed, finite optimization horizon. First, we state that the $\min$ part of this problem is NP-hard. We then provide two relaxation schemes. The first relaxation scheme works by dropping some constraints in order to obtain a problem that is solvable in polynomial time. The second relaxation scheme, based on a Lagrangian relaxation where all constraints are dualized, can also be solved in polynomial time. We theoretically show that both relaxation schemes provide better results than those given in [Fonteneau et al. (2011)] [less ▲]

Detailed reference viewed: 81 (13 ULg)