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See detailMembrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases
Chabottaux, Vincent; Sounni, Nor Eddine ULg; Pennington, C. J. et al

in Cancer Research (2006), 66(10), 5165-5172

Membrane-type matrix metalloproteinases (MT-MMP) constitute a subfamily of six distinct membrane-associated MMPs. Although the contribution of MT1-MMP during different steps of cancer progression has been ... [more ▼]

Membrane-type matrix metalloproteinases (MT-MMP) constitute a subfamily of six distinct membrane-associated MMPs. Although the contribution of MT1-MMP during different steps of cancer progression has been well documented, the significance of other MT-MMPs is rather unknown. We have investigated the involvement of MT4-MMP, a glycosylphosphatidylinositol-anchored protease, in breast cancer progression. Interestingly, immunohistochemical analysis shows that MT4-MMP production at protein level is strongly increased in epithelial cancer cells of human breast carcinomas compared with normal epithelial cells. Positive staining for MT4-MMP is also detected in lymph node metastases. In contrast, quantitative reverse transcription-PCR analysis reveals similar MT4-MMP mRNA levels in human breast adenocarcinomas and normal breast tissues. Stable transfection of MT4-MMP cDNA in human breast adenocarcinoma MDA-MB-231 cells does not affect in vitro cell proliferation or invasion but strongly promotes primary tumor growth and associated metastases in RAG-1 immunodeficient mice. We provide for the first time evidence that MT4-MMP overproduction accelerates in vivo tumor growth, induces enlargement of i.t. blood vessels, and is associated with increased lung metastases. These results identify MT4-MMP as a new putative target to design anticancer strategies. [less ▲]

Detailed reference viewed: 78 (24 ULg)
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See detailMembrane-type matrix metalloproteinase-1 expression at the site of human placentation
Nawrocki, B.; Polette, M. E.; Marchand, V. et al

in Placenta (1996), 17(8), 565-72

Human trophoblast implantation is a highly regulated process of invasion that requires action of proteolytic enzymes to degrade extracellular matrix components of the endometrium. Among these enzymes ... [more ▼]

Human trophoblast implantation is a highly regulated process of invasion that requires action of proteolytic enzymes to degrade extracellular matrix components of the endometrium. Among these enzymes, matrix metalloproteinases (MMPs) seem to be particularly important in this degradative process. We previously showed that gelatinase A is extensively expressed in vivo in the human placenta. A new MMP, MT-MMP-1 (membrane-type matrix metalloproteinase-1), which is thought to activate progelatinase A, has recently been described. In this study, we examined the expression of MT-MMP-1, by immunohistochemistry and in situ hybridization, in human placental bed biopsies taken during the first trimester of gestation. Human first trimester intermediate trophoblasts synthesized MT-MMP-1 mRNAs and the protein. The MT-MMP-1 pattern of distribution in placental beds was similar to that of gelatinase A, suggesting a pivotal role for MT-MMP-1 in placentation, perhaps by activating progelatinase A. [less ▲]

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See detailA Membrane-Type-1 Matrix Metalloproteinase (MT1-MMP) - Discoidin Domain Receptor 1 Axis Regulates Collagen-Induced Apoptosis in Breast Cancer Cells.
Assent, Delphine; Bourgot, Isabelle ULg; Hennuy, Benoît ULg et al

in PloS one (2015), 10(3), 0116006

During tumour dissemination, invading breast carcinoma cells become confronted with a reactive stroma, a type I collagen-rich environment endowed with anti-proliferative and pro-apoptotic properties. To ... [more ▼]

During tumour dissemination, invading breast carcinoma cells become confronted with a reactive stroma, a type I collagen-rich environment endowed with anti-proliferative and pro-apoptotic properties. To develop metastatic capabilities, tumour cells must acquire the capacity to cope with this novel microenvironment. How cells interact with and respond to their microenvironment during cancer dissemination remains poorly understood. To address the impact of type I collagen on the fate of tumour cells, human breast carcinoma MCF-7 cells were cultured within three-dimensional type I collagen gels (3D COL1). Using this experimental model, we have previously demonstrated that membrane type-1 matrix metalloproteinase (MT1-MMP), a proteinase overexpressed in many aggressive tumours, promotes tumour progression by circumventing the collagen-induced up-regulation of BIK, a pro-apoptotic tumour suppressor, and hence apoptosis. Here we performed a transcriptomic analysis to decipher the molecular mechanisms regulating 3D COL1-induced apoptosis in human breast cancer cells. Control and MT1-MMP expressing MCF-7 cells were cultured on two-dimensional plastic plates or within 3D COL1 and a global transcriptional time-course analysis was performed. Shifting the cells from plastic plates to 3D COL1 activated a complex reprogramming of genes implicated in various biological processes. Bioinformatic analysis revealed a 3D COL1-mediated alteration of key cellular functions including apoptosis, cell proliferation, RNA processing and cytoskeleton remodelling. By using a panel of pharmacological inhibitors, we identified discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase specifically activated by collagen, as the initiator of 3D COL1-induced apoptosis. Our data support the concept that MT1-MMP contributes to the inactivation of the DDR1-BIK signalling axis through the cleavage of collagen fibres and/or the alteration of DDR1 receptor signalling unit, without triggering a drastic remodelling of the transcriptome of MCF-7 cells. [less ▲]

Detailed reference viewed: 38 (5 ULg)
See detailMembre du jury du GPWE
Cornet, Annie ULg

Diverse speeche and writing (2013)

Detailed reference viewed: 9 (0 ULg)
See detailmembre rebelle
Claes, Hubert; Andrianne, Robert ULg

Book published by Roularta Books (2005)

Detailed reference viewed: 20 (1 ULg)
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See detailMême galvaudé, le terme ‘politique’ ne suggère-t-il pas le pouvoir ?
Grandjean, Geoffrey ULg

Conference given outside the academic context (2012)

Detailed reference viewed: 5 (0 ULg)
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See detailMême le silence a une fin
Claisse, Frédéric ULg

Article for general public (2011)

Detailed reference viewed: 42 (14 ULg)
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See detailMémento de conception mécanique
Debongnie, Jean-François ULg

Book published by DEBONGNIE (JEAN-FRANCOIS) (2013)

Normal numbers. Tolerances. Alloy designation. Antifriction bearings. Journal bearings. Assembling of a shaft and a hub. Bolts. Welds. Riveted joints. Shafts. Fatigue. Hertzian contacts. Wear. Belts ... [more ▼]

Normal numbers. Tolerances. Alloy designation. Antifriction bearings. Journal bearings. Assembling of a shaft and a hub. Bolts. Welds. Riveted joints. Shafts. Fatigue. Hertzian contacts. Wear. Belts. Gearings. Illustrated lexicon. [less ▲]

Detailed reference viewed: 837 (59 ULg)
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See detailMemento of useful tips and tricks for HP50g
Merciadri, Luca ULg

E-print/Working paper (2009)

This document presents a short list of math. important commands on HP50g. There is not much documentation about HP50g on Internet, so it completes the user’s manual.

Detailed reference viewed: 317 (18 ULg)
See detailMémoire
Brédart, Serge ULg; Van der Linden, Martial ULg

in Rondal, Jacques (Ed.) Introduction à la psychologie scientifique (1999)

Detailed reference viewed: 47 (12 ULg)
See detailMémoire à ciel ouvert. Une histoire de l’Espagne : 1931-1981
Molina Marmol, Maïté ULg; Muñoz, Ángeles

Book published by Territoires de la Mémoire (2014)

Detailed reference viewed: 57 (10 ULg)
See detailMémoire à court terme / mémoire de travail : développements théoriques récents
Majerus, Steve ULg

Scientific conference (2012, October 12)

Detailed reference viewed: 30 (1 ULg)
See detailLa mémoire à court terme : un défi à long terme.
Majerus, Steve ULg

Conference (2011, November 18)

Detailed reference viewed: 3 (2 ULg)
See detailMémoire à court terme et langage : modèles théoriques actuels.
Majerus, Steve ULg

Conference (2002, September 28)

Detailed reference viewed: 14 (0 ULg)
See detailMémoire à court terme et langage : modèles théoriques récents et implications cliniques.
Majerus, Steve ULg

Scientific conference (2008, May 23)

Detailed reference viewed: 8 (0 ULg)
See detailMémoire à court terme et langage.
Majerus, Steve ULg

Conference (2012, June)

Detailed reference viewed: 7 (2 ULg)
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See detailMémoire à court terme et pathologies du langage
Poncelet, Martine ULg; Majerus, Steve ULg; Van der Linden, Martial ULg

in Rééducation Orthophonique (2001), 208

Detailed reference viewed: 71 (12 ULg)