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See detailMalignant cell attachment to endothelium of ex vivo perfused human umbilical vein. Modulation by platelets, plasma and fibronectin.
Lewalle, J. M.; Castronovo, Vincenzo ULg; Goffinet, G. et al

in Thrombosis Research (1991), 62(4), 287-98

The success of blood-born metastatic spread depends upon a key event: the tumor cell arrest and attachment to the host organ vasculature. In the present study, we have investigated interactions between ... [more ▼]

The success of blood-born metastatic spread depends upon a key event: the tumor cell arrest and attachment to the host organ vasculature. In the present study, we have investigated interactions between several normal and cancer cell lines and vascular endothelium in a model of ex vivo perfusion of human umbilical vein. In this system, hydrodynamic parameters are monitored and endothelial cells are kept in their original environment known to modulate their phenotype. Metastatic tumor cell adhesion to the perfused endothelium was found to be significantly higher than that of normal cells tested. Platelets and soluble plasma factors including fibronectin promoted tumor cell arrest and adhesion to endothelium. Altogether our results indicate that the ex vivo perfusion of human umbilical vein allows the study of the interactions between malignant tumor cells, circulating plasma or blood cells and the endothelium during blood-born metastatic spread. [less ▲]

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See detailMalignant Hyperthermia and Severe Hypoglycemia after Reexposure to Halothane
Bichel, T.; Canivet, Jean-Luc ULg; Damas, Pierre ULg et al

in Acta Anaesthesiologica Belgica (1994), 45(1), 23-7

A four year child presented with an episode of malignant hyperthermia induced by reexposure to halothane. The episode was associated with early onset of a severe hypoglycemia and liver enzymatic ... [more ▼]

A four year child presented with an episode of malignant hyperthermia induced by reexposure to halothane. The episode was associated with early onset of a severe hypoglycemia and liver enzymatic perturbances. Etiology of these perturbances is hard to state precisely in this clinical context, but a hepatic toxicity of halothane and/or by dantrolene is considered. [less ▲]

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See detailMalignant melanoma
Paquet, Philippe ULg; Hustinx, Roland ULg; Rigo, Pierre ULg et al

in Oehr, Peter; Biersack, Hans_jürgen; Coleman, Edward R (Eds.) PET and PET-CT in Oncology (2003)

PET and PET-CT in Oncology describes the principles of positron emission tomography and is a useful resource for incorporating the technique in clinical practice. In a clear and straightforward fashion ... [more ▼]

PET and PET-CT in Oncology describes the principles of positron emission tomography and is a useful resource for incorporating the technique in clinical practice. In a clear and straightforward fashion, this heavily-illustrated text offers instructive information and overviews of the basic principles of PET and PET-CT as well as the routine clinical PET scanning procedures for all important oncological indications. It is designed to serve as a reference work for specialists in nuclear medicine and radiology (including therapy planning) and for oncologists. It also provides student and physicians in other medical specialities with a general introduction to the effective integration of this modern technique into routine clinical diagnostics. Above all, this volume illustrates the importance of PET and PET-CT in comparison with other imaging techniques. [less ▲]

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See detailMalignant melanoma and its stromal nonimmune microecosystem.
PIERARD, Gérald ULg; Franchimont, Claudine ULg; Delvenne, Philippe ULg

in Journal of Oncology (2012), 2012

In recent years, rapid advances were reached in the understanding of a series of biologic signals influencing cutaneous malignant melanoma (CMM) cells. CMM is in close contact with a peculiar dermal ... [more ▼]

In recent years, rapid advances were reached in the understanding of a series of biologic signals influencing cutaneous malignant melanoma (CMM) cells. CMM is in close contact with a peculiar dermal extracellular matrix (ECM). Stromal cells store and release various structural ECM components. The impact on CMM growth and progression is mediated through strong and long-lasting effects of ECM products. This paper summarizes some peculiar aspects of the peri-CMM stroma showing intracytoplasmic loads in Factor XIIIa, CD34, versican, and alpha (IV) collagen chains. The restricted peri-CMM skin territory exhibiting such changes corresponds to the area showing neoangiogenesis and extravascular unicellular metastatic spread. The latter inconspicuous migratory CMM cells possibly correspond to CMM stem cells or to CMM cells with aberrant HOX gene expression. Their presence is associated with an increased risk for metastases in the regional sentinel lymph nodes. In conclusion, the CMM-stroma connection appears crucial to the growth regulation, invasiveness and initial metastatic spread of CMM cells. Although much remains to be learned in this field, the active intervention of the peri-CMM stroma is likely involved in the inconspicuous early metastatic migration of CMM cells. [less ▲]

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See detailMalignant Melanoma Staging Using Whole-Body Positron Emission Tomography
Paquet, Philippe ULg; Hustinx, Roland ULg; Rigo, Pierre ULg et al

in Melanoma Research (1998), 8(1), 59-62

The correct staging of potentially metastatic melanoma is essential for an appropriate therapeutic attitude. Current methods include computed tomography, magnetic resonance imaging, ultrasonography and ... [more ▼]

The correct staging of potentially metastatic melanoma is essential for an appropriate therapeutic attitude. Current methods include computed tomography, magnetic resonance imaging, ultrasonography and scintigraphy. Another tool is whole-body positron tomography using the radiopharmaceutical 2-fluorine-18-fluoro-2-deoxy-D-glucose as an emitter because it accumulates inside neoplasms, especially melanoma. We report two cases of malignant melanoma in which computed tomography and magnetic resonance imaging suggested visceral metastatic spread. In contrast, whole-body positron emission tomography indicated the absence of metastases, and this was confirmed by histological examination of the organs where metastases were suspected. Whole-body positron emission tomography appears to have high specificity and sensitivity for clinical melanoma staging. [less ▲]

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See detailMalignant melanoma: from cell kinetics to micrometastases.
QUATRESOOZ, Pascale ULg; PIERARD, Gérald ULg

in American Journal of Clinical Dermatology (2011), 12(2), 77-86

Malignant melanoma (MM) micrometastases are basically seen in three locations inside the peritumoral dermis. They are localized (i) inside the interstitial sector of the dermal stroma; (ii) abutted to the ... [more ▼]

Malignant melanoma (MM) micrometastases are basically seen in three locations inside the peritumoral dermis. They are localized (i) inside the interstitial sector of the dermal stroma; (ii) abutted to the external surface of the microvasculature; and (iii) more rarely present inside vascular channels. Single-cell and paucicellular micrometastases may be disclosed using immunohistochemistry even in the absence of larger microsatellites, which represent micronodular nests of metastatic cells. The presence of microsatellites is frequently tied to markers of MM aggressiveness including thickness and the Ki-67 index. Micrometastases may be present in the same conditions, but even as early as thin MM showing a small growth fraction. Microsatellites as well as micrometastases appear to predict locoregional extension and decreased relapse-free interval, but not distant metastasis and overall survival. These considerations have implications for patient care since patients with microsatellites and micrometastases are now included in the clinical stage III category of the disease. Their implication as a prognostic factor is not fully dependent on or linked to other markers of MM aggressiveness. [less ▲]

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See detailMalignant prolactinoma discovered by D2 receptor imaging.
Petrossians, Patrick ULg; de Herder, W.; Kwekkeboom, D. et al

in Journal of Clinical Endocrinology and Metabolism (2000), 85(1), 398-401

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See detailMalignant solitary fibrous tumor of the pleura: report of a case with cytogenetic analysis
Defraigne, Jean-Olivier ULg; Hermans, Gilberte ULg; Dome, Florence ULg et al

in Virchows Archiv (2003), 442(4), 388-392

The majority of solitary fibrous tumors (SFTs) of the pleura are benign, but 10-30% locally recur or metastasize. Pathogenic factors relevant to the determinism of their biological properties are largely ... [more ▼]

The majority of solitary fibrous tumors (SFTs) of the pleura are benign, but 10-30% locally recur or metastasize. Pathogenic factors relevant to the determinism of their biological properties are largely unknown. Cytogenetic data on SFTs of the pleura are sparse. We report herein a case of a malignant SFT of the pleura where successful karyotyping was obtained from the primary and recurrent tumors. The initial karyotype showed two abnormal clones: 48, XY; +8; +8; del(9)(q22; q32) [19] and 46, XY, t(1; 16)(q25;p 12) [7]. Culture of the recurrent tumor yielded one clone identical to the dominant clone of the initial karyotype. Demonstration of a recurrent abnormal karyotype largely supports its relevance to the malignant clone and suggests a role of supernumerary chromosome(s) 8 in the determinism of malignant behavior in SFT. [less ▲]

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See detailMalingering in expertise context: How to better understand the victimology process?
Blavier, Adelaïde ULg; Thiltges, Esther ULg; Wertz, Céline ULg

Conference (2012, May 11)

In forensic context, the psychological or psychiatric assessment occurs in a particular and different way than the usual practice in psychotherapy, and malingering has a specific dimension in this context ... [more ▼]

In forensic context, the psychological or psychiatric assessment occurs in a particular and different way than the usual practice in psychotherapy, and malingering has a specific dimension in this context. This article focuses on malingering in situations of damages compensations. We analyse this behaviour through the study of the victimisation process, the family influence, the existent psychological tests and the examiner’s role. The injured persons are placed or place their-self in a victim position that seems to be a factor involved in their reconstruction process and by this way, in the use of malingering. The family has also a strong influence on the management of the traumatic incident and by this way, on the (conscious or unconscious) choice of malingering, particularly for children (by example, in the Munchausen by proxy syndrome). Finally, our study shows how the examiner’s role and attitude are central in the functioning and the interaction of the two mechanisms (management of the event/reconstruction by the victim and malingering). Although psychological tests can be used in order to discover malingering, a meticulous assessment, empathy, and neutral and benevolent attention are indispensable elements in order to assure authentic complaints and thus to prevent malingering. [less ▲]

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See detailMalitrah : une formation en alternance dans l'enseignement professionnel spécial de plain exercice : présentation d'un projet
Beckers, Jacqueline ULg

in Revue de la Direction Générale de l’Organisation des Etudes (1991), 2

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See detailMallarmé
Durand, Pascal ULg

in Polet J.-Cl. (Ed.) Patrimoine littéraire européen : Renaissances nationales et conscience universelle (1832-1885) (1999)

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See detailMallarmé (1842-1898)
Durand, Pascal ULg

in Kalifa, Dominique; Thérenty, Marie-Eve; Vaillant, Alain (Eds.) et al La civilisation du journal. Une histoire culturelle et littéraire de la presse au XIXe siècle (2012)

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See detailMallarmé : du sens des formes au sens des formalités
Durand, Pascal ULg

Conference given outside the academic context (2008)

Detailed reference viewed: 9 (0 ULg)
See detailMallarmé : du sens des formes au sens des formalités
Durand, Pascal ULg

Scientific conference (2008, November 05)

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See detailMallarmé : formalisme poétique et formalités sociales
Durand, Pascal ULg

Conference given outside the academic context (2008)

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See detailMallarmé : le retour des choses
Durand, Pascal ULg

Conference (2016, June 09)

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See detailMallarmé : retour du même, presque autre
Durand, Pascal ULg

in Critique (2005), 695

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See detailMallarmé à Oxford : “Fiction” des Lettres et réflexivité sociale
Durand, Pascal ULg

Scientific conference (2015, June 05)

Detailed reference viewed: 55 (5 ULg)