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See detailOutcome of pregnancy in women with inflammatory bowel disease treated with antitumor necrosis factor therapy.
Schnitzler, François ULg; Fidder, Herma; Boukerroucha, Meriem ULg et al

in Inflammatory Bowel Diseases (2011), 17(9), 1846-1854

BACKGROUND:: Infliximab (IFX) and adalimumab (ADA) are attractive treatment options in patients with inflammatory bowel disease (IBD) also during pregnancy but there is still limited data on the benefit ... [more ▼]

BACKGROUND:: Infliximab (IFX) and adalimumab (ADA) are attractive treatment options in patients with inflammatory bowel disease (IBD) also during pregnancy but there is still limited data on the benefit/risk profile of IFX and ADA during pregnancy. METHODS:: This observational study assessed pregnancy outcomes in 212 women with IBD under antitumor necrosis factor alpha (TNF) treatment at our IBD unit. Pregnancy outcomes in 42 pregnancies with direct exposure to anti-TNF treatment (35 IFX, 7 ADA) were compared with that in 23 pregnancies prior to IBD diagnosis, 78 pregnancies before start of IFX, 53 pregnancies with indirect exposure to IFX, and 56 matched pregnancies in healthy women. RESULTS:: Thirty-two of the 42 pregnancies ended in live births with a median gestational age of 38 weeks (interquartile range [IQR] 37-39). There were seven premature deliveries, six children had low birth weight, and there was one stillbirth. One boy weighed 1640 g delivered at week 33, died at age of 13 days because of necrotizing enterocolitis. A total of eight abortions (one patient wish) occurred in seven women. Trisomy 18 was diagnosed in one fetus of a mother with CD at age 37 under ADA treatment (40 mg weekly) and pregnancy was terminated. Pregnancy outcomes after direct exposure to anti-TNF treatment were not different from those in pregnancies before anti-TNF treatment or with indirect exposure to anti-TNF treatment but outcomes were worse than in pregnancies before IBD diagnosis. CONCLUSIONS:: Direct exposure to anti-TNF treatment during pregnancy was not related to a higher incidence of adverse pregnancy outcomes than IBD overall. (Inflamm Bowel Dis 2011;). [less ▲]

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See detailThe outcome of the EC pharmaceutical sector inquiry
Petit, Nicolas ULg

in Concurrences : Revue des Droits de la Concurrence (2009), (3),

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See detailOutcome of the living kidney donor
DELANAYE, Pierre ULg; WEEKERS, Laurent ULg; DUBOIS, Bernard ULg et al

in Nephrology Dialysis Transplantation (2012), 27(1), 41-50

Renal transplantation from living kidney donors is still relatively marginal in most of the European countries. However, this source of kidney grafts may help to overcome in part the organ donor shortage ... [more ▼]

Renal transplantation from living kidney donors is still relatively marginal in most of the European countries. However, this source of kidney grafts may help to overcome in part the organ donor shortage of cadaveric donors. The living donor strategy implies correct and objective information about donation risks and completely free acceptance of the living candidate of the donation. In this paper, we reviewed the consequences of kidney donation on the living donor health, considering very short term (linked to the surgery), short term (effect of nephrectomy on glomerular filtration rate) and long term (risk of mortality, chronic kidney disease, proteinuria and hypertension) consequences of kidney donation. [less ▲]

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See detailOutcome prediction in asymptomatic degenerative MR: the usefulness of exercise BNP.
Magne, Julien ULg; Mahjoub, H; Pibarot, P et al

Conference (2012)

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See detailOutcomes and lessons from the PROactive study.
SCHEEN, André ULg

in Diabetes Research & Clinical Practice (2012), epub ahead of print

Beyond improvement of glucose control, thiazolidinediones exert pleiotropic effects, which may contribute to some cardiovascular protection. PROactive ("PROspective pioglitAzone Clinical Trial In ... [more ▼]

Beyond improvement of glucose control, thiazolidinediones exert pleiotropic effects, which may contribute to some cardiovascular protection. PROactive ("PROspective pioglitAzone Clinical Trial In macroVascular Events") has provided valuable, although controversial, information on the impact of pioglitazone on cardiovascular outcomes in a high-risk population of patients with type 2 diabetes and established macrovascular disease. Since 2005, there has been much debate on the relative value of the statistically non-significant 10% reduction in the quite challenging primary composite endpoint (combining cardiovascular disease-driven and procedural events in all vascular beds) versus the statistically significant 16% decrease in the more robust and conventional main secondary endpoint (all-cause mortality, myocardial infarction, and stroke) observed with pioglitazone. Revisiting PROactive deserves much interest following the report of inconclusive results on cardiovascular efficacy and safety of rosiglitazone in RECORD, the withdrawal (limitation) of rosiglitazone because of cardiovascular safety concern, the recent publication of a statement positioning pioglitazone in type 2 diabetes and the near availability of cheaper generics of pioglitazone. Although subanalyses may have more limited value from a statistical viewpoint, they nonetheless can provide valuable information on the drug efficacy/safety profile and clinical insights into which patients might benefit most (in terms of cardiovascular outcomes) from pioglitazone therapy. [less ▲]

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See detailOutcomes from the MACSUR grassland model inter-comparison with the model CARAIB
Minet, Julien ULg; Laloy, Eric; Tychon, Bernard ULg et al

Conference (2014, October 15)

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See detailOutcomes in patients undergoing multivessel percutaneous coronary intervention using sirolimus-eluting stents: a report from the e-SELECT registry.
Cuculi, Florim; Banning, Adrian P.; Abizaid, Alexander et al

in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology (2011), 7(8), 962-8

AIMS: Performing percutaneous coronary intervention (PCI) to multiple coronary lesions during the same procedure has potential economic and social advantages. However comprehensive outcome data of real ... [more ▼]

AIMS: Performing percutaneous coronary intervention (PCI) to multiple coronary lesions during the same procedure has potential economic and social advantages. However comprehensive outcome data of real world practice in a large population is limited. We aimed to compare short- and long-term outcomes between patients with multivessel coronary artery disease who either underwent single- or multivessel PCI within the e-SELECT registry. METHODS AND RESULTS: The e-SELECT registry combines data collected at 320 medical centres in 56 countries where patients received CYPHER Select(R) or CYPHER Select(R) Plus sirolimus-eluting stent (SES). Rates of myocardial infarction and major adverse cardiac event (MACE) (defined as any death, myocardial infarction or target lesion revascularisation) were compared between patients undergoing single-vessel versus multivessel PCI. A total of 15,147 patients who satisfied the inclusion criteria were included in the e-SELECT registry. Two thousand two hundred and seventy-eight (2,278) subjects (15%) underwent multivessel PCI and 12,869 (85%) had single-vessel PCI. The mean age was higher in the multivessel PCI group (63 vs. 62 years, p<0.001) and there was a higher prevalence of diabetes mellitus (32.4 vs. 30.0%, p=0.02). Lesions were more complex in the single-PCI group while pre- and post-dilatation were less common in the multivessel PCI group. Myocardial infarction within the first 30 days post PCI was more common in the multivessel PCI group (1.9 vs. 0.8%, p<0.001) and most of the infarctions were periprocedural (1.3 vs. 0.6%, p=0.001). Mortality and myocardial infarction at one-year were higher in the multivessel PCI group resulting in a significantly higher MACE (6.1 vs. 4.6%, p=0.005). CONCLUSIONS: Overall procedural and one year outcomes were excellent for both single- and multivessel procedures. However despite lower lesion complexity, performing multivessel PCI was associated with higher rates of periprocedural myocardial infarction and MACE when compared to single-vessel PCI in the e-SELECT registry. [less ▲]

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See detailOutcomes of adults with active or progressive hematological malignancies at time of allogeneic stem cell transplantation : a survey from the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
Chevallier, P.; Labopin, M.; Milpied, N. et al

in Bone Marrow Transplantation (2014), 49

Previous data suggested that allo-SCT might be an effective therapy in the setting of chemo-refractory/relapsed diseases because of the potent long-term immune-mediated tumor control. This retrospective ... [more ▼]

Previous data suggested that allo-SCT might be an effective therapy in the setting of chemo-refractory/relapsed diseases because of the potent long-term immune-mediated tumor control. This retrospective study aimed to analyze the outcome of adult patients who received allo-SCT in a chemo-refractory/relapsed status. The series included 840 patients with active or progressive disease at the time of transplant. Median age was 50 years. With a median follow-up of 40 months, 3-year OS, disease-free survival (DFS), and non-relapse mortality rates were 29±2, 23±2, and 30±2%, respectively. At the last follow-up, 252 patients (30%) were still alive (of whom 201 were in CR (24%). In a Cox multivariate analysis, the use of a reduced-intensity conditioning (RIC) before allo-SCT and use of an HLA-identical sibling donor remained independently associated with a better OS (hazard ratio (HR)¼0.82; 95% confidence interval (CI), 0.69–0.98, P¼0.03; and HR¼0.79; 95% CI, 0.66–0.93, P¼0.006, respectively). Also, a diagnosis of myelodysplastic syndrome/myeloproliferative disorder, Hodgkin lymphoma and non-Hodgkin lymphoma compared with acute leukemia had a favorable impact on OS (HR¼0.55; 95% CI, 0.45–0.68, Po0.0001; HR¼0.49; 95% CI, 0.31–0.75, P¼0.001; and HR¼0.47; 95% CI, 0.35–0.63, Po0.0001, respectively). In conclusion, this study suggests that allo-SCT may be of benefit in some subgroups of patients with active or progressive hematological malignancies at the time of allo-SCT. [less ▲]

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See detailOUTCOMES OF LIVER TRANSPLANTATION USING DONATIONS AFTER CIRCULATORY DEATH : A SINGLE-CENTER EXPERIENCE
MEURISSE, Nicolas ULg; VANDEN BUSSCHE, S; JOCHMANS, I et al

in Transplantation Proceedings (2012), 44

Introduction Orthotopic liver transplantation (OLT) (LTx) using donation after circulatory death (DCD) donors is increasingly performed, but still considered to risk of poorer outcomes compared with ... [more ▼]

Introduction Orthotopic liver transplantation (OLT) (LTx) using donation after circulatory death (DCD) donors is increasingly performed, but still considered to risk of poorer outcomes compared with standard donations after brain death (DBD)-OLT. Therefore we reviewed our results of DCD-OLT. Patients and Methods Between 2003 and 2010, we performed 30 DCD-OLT (6% of all OLT). We retrospectively reviewed medical records of donors and recipients after DCD versus DBD-OLT to analyze biliary complications, retransplantation rates, and patient/graft survivals. Results Median donor age was similar for DCD and DBD-OLT: 51 versus 53 years (P = .244). Median donor warm ischemia time (stop ventilation to cold perfusion in DCD donors) was 24 minutes. Median cold ischemia time was shorter for DCD (6 hours 54 minutes) compared with DBD-OLT (8 hours 36 minutes; P < .0001). Median laboratory model of end-stage liver disease score was 15 for DCD, and 16 for DBD-OLT (P = .59). Median post-OLT Aspartate Aminotransferase (AST) peak was higher after DCD: 1178 versus DBD-OLT 651 IU/L (P = .005). The incidence of nonanastomotic strictures was different: 33.3% for DCD versus 12.5% for DBD-OLT (P = .001). The overall retransplantation rate was 3% after both DCD and DBD-OLT. After DCD-LTx actuarial 1, 3- and 5-year patient survivals were 93, 85 and 85%, and corresponding graft survivals, 90%, 82%, and 82% respectively, and not different compared with DBD-OLT: 88%, 78%, and 72% (P = .348) and 85%, 74%, and 68% (P = .524) respectively. Conclusion Despite substantial ischemic injury (high peak AST and biliary strictures) short- and long-term survival after DCD-OLT was comparable to DBD-OLT. Rapid donor surgery, careful donor and recipient selection, as well as short warm and cold ischemia times are key factors to optimize outcomes after DCD-OLT. However, strategies to reduce biliary complications remain warranted. [less ▲]

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See detailOutdoor comfort and Urban design decision-making
Reiter, Sigrid ULg

Scientific conference (2008, October 29)

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See detailOutil d'aide à l'optimisation de l'enveloppe de bâtiment, au stade de l'esquisse d'avant-projet
Hauglustaine, Jean-Marie ULg

Conference (2001, June)

L'étude a pour but d'introduire, au stade de l'esquisse, une méthode rationnelle d'aide à la conception de l'enveloppe d'un bâtiment, avec pour double objectif de respecter les coûts (de construction et d ... [more ▼]

L'étude a pour but d'introduire, au stade de l'esquisse, une méthode rationnelle d'aide à la conception de l'enveloppe d'un bâtiment, avec pour double objectif de respecter les coûts (de construction et d'usage) et d'améliorer la performance énergétique du projet (réglementaire et consommations). Respectant le contexte multicritère et multi-acteurs propre à tout projet d'architecture, un outil interactif a été développé, qui propose, aux acteurs d'un projet, de définir le projet qu'ils souhaitent en répondant à un questionnaire et/ou en dessinant l'esquisse, à main levée. Une procédure d'optimisation utilisant un algorithme génétique permet également de déterminer : pour un seul acteur, le projet optimal, défini par la combinaison de paramètres, qui présente des performances lui offrant la meilleure satisfaction possible ; pour un ensemble d'acteurs, le meilleur compromis entre les scénarios spécifiés, résultant de la combinaison des valeurs de paramètres, qui, à la fois, maximise les performances du projet, et donne, à tous les acteurs, la plus égale et la plus grande satisfaction possible. [less ▲]

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See detailUn outil d’aide à la décision pour la gestion des chablis en Région wallonne (Belgique)
Riguelle, Simon ULg; Hebert, Jacques ULg; Jourez, Benoît ULg

Poster (2009, June 30)

The poster highlights the main steps leading to the development of a decision-support tool for storm damage management by the forest sector at a regional scale.

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See detailUn outil d'aide à la décision pour la gestion des chablis en Région wallonne
Riguelle, Simon ULg; Hebert, Jacques ULg; Jourez, Benoît ULg

in Innovations Agronomiques (2009), (6), 113-123

In order to efficiently manage post-storm damages, we developed a computer software that would be used as a decision support system by the public authorities to make the best decisions as soon as possible ... [more ▼]

In order to efficiently manage post-storm damages, we developed a computer software that would be used as a decision support system by the public authorities to make the best decisions as soon as possible after the storm, as well by showing an overview of the present situation as by comparing efficiency of several prospective simulations. The model was built on the basis of previous windthrow events in Europe and its parameters were defined after a full literature review. The system dynamics approach was used to simulate the complex scheme composed by post-storm management operations (inventory, selling, harvesting, transport and transformation). Thirty parameters can be modified by the operator to simulate the crisis situation. The main entry system is the amount of damage, which can be estimated in a very short time (3 days) by using the regional forest inventory network. The first results showed a great potential to predict evolution of a windthrow crisis and the bottlenecks which have to be solved to improve post-storm management. Of course, a validation in real conditions should confirm tool efficiency and possibility to extend its scale. [less ▲]

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See detailUn outil d'aide à la décision pour la gestion des chablis en Région wallonne.
Riguelle, Simon ULg; Jourez, Benoît ULg; Hebert, Jacques ULg

in Silva Belgica (2009), 116(5), 34-38

Depuis 1990, la forêt wallonne a été épargnée par les violentes tempêtes qui ont dévasté les massifs forestiers de l’Europe de l’Ouest ces dernières décennies (1999, 2005, 2007, 2009). Néanmoins, il ne ... [more ▼]

Depuis 1990, la forêt wallonne a été épargnée par les violentes tempêtes qui ont dévasté les massifs forestiers de l’Europe de l’Ouest ces dernières décennies (1999, 2005, 2007, 2009). Néanmoins, il ne saurait en être éternellement ainsi, c’est pourquoi les pouvoirs publics régionaux et les professionnels de la filière bois ont décidé de se préparer dès maintenant à gérer une future catastrophe de grande ampleur. Dans cette optique, le DEMNA et la FUSAGx ont développé des procédures et des outils susceptibles d’aider les gestionnaires de crise à réagir efficacement dans l’urgence et à définir la meilleure stratégie opérationnelle pour valoriser les bois chablis. [less ▲]

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See detailUn outil d’optimisation des structures orthotropes intégré à l’avant-projet
Rigo, Philippe ULg

in Construction Métallique (2000)

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See detailOutil de diagnostic de gestion des âges
Cornet, Annie ULg

Conference given outside the academic context (2008)

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