The role of thymic cryptocrine signals in developmental immunology and neuroimmunomodulation

Conference given outside the academic context (1992)

Role of Tir and Intimin in the virulence of rabbit enteropathogenic Escherichia coli (REPEC) of serotype O103:H2

in Infection and Immunity (2000), 68

Role of tumor-associated lipogenesis in the formation and composition of membrane microdomains

Conference (2006)

The role of varicella zoster virus immediate-early proteins in latency and their potential use as components of vaccines

in Gershon, A. A.; Calisher, C. H.; Arvin, A. M. (Eds.) Immunity to and Prevention of Herpes Zoster (2001)

Varicella zoster virus immediate-early (IE) proteins are intracellular regulators of viral gene expression. Some of them (IE62 and IE63) are found in large amounts in infected cells but are also ... [more ▼]

Varicella zoster virus immediate-early (IE) proteins are intracellular regulators of viral gene expression. Some of them (IE62 and IE63) are found in large amounts in infected cells but are also components of the virion tegument. Several IE and early genes are transcribed during latency, while late genes are not. Recently, we demonstrated the presence of protein IE 63 in dorsal root ganglia of persistently infected rats as well as in normal human ganglia; other IE proteins have been found since in human ganglia. Cell-mediated immunity (CMI) to IE 62 has been evidenced. We found both humoral immunity and CMI to IE 63 in immune adults. In elderly zoster-free individuals, CMI to IE 63 remained high. The differences in the CMI to IE 63 among young adults, elderly people and immunocompromized patients have to be analyzed according to their status relative to zoster, to determine whether the decrease in CMI, particularly to IE proteins, could be responsible for viral reactivation and for the onset of shingles. Hopefully, the waning of the CMI to VZV IE 63 and perhaps to other IE proteins could become a predictive marker for herpes zoster and reimmunization, not only with the vaccine strain, but also with purified IE proteins could help prevent zoster at old age. [less ▲]

The role of VZV immediate-early proteins in latency and their potential as component of vaccines

Conference (1999)

Role of western lowland gorilla (Gorilla gorilla gorilla Savage & Wyman, 1847) on the dynamics of tropical logged forest ecosystems

Poster (2012, February 08)

The western lowland gorilla (Gorilla gorilla gorilla Savage & Wyman) (WLG) which is considered as a critically endangered species by IUCN, could play a fundamental function in seeds dispersal of several ... [more ▼]

The western lowland gorilla (Gorilla gorilla gorilla Savage & Wyman) (WLG) which is considered as a critically endangered species by IUCN, could play a fundamental function in seeds dispersal of several plant species. This could be related to its frugivorous diet, its stomach capacity and the long gut retention time of the ingested food, its extensive daily path length, and its ability to swallow seeds of variable sizes. In addition, this animal tends to deposit most of ingested seeds in suitable habitats (especially logging gaps and old logging roads) for light-demanding plant development. This research will be conducted within the moist evergreen forest of Central Gabon in a logging concession granted to the company CEB Precious Woods. A preliminary study was undertaken as a Master thesis. It was aiming at obtaining a first insight of interactions between WLG and timber exploitation in Central Gabon and at assessing the extent to which they may benefit of each other. WLG abundances were estimated in unlogged and logged sites in the concession, and nesting behavior described. Seeds dispersed during the study period (February-May) by WLG were identified through fecal analysis. Relatively high WLG abundances were observed in the concession. WLG were found to nest preferentially in open areas and to frequently use old logging road network for nesting and feeding. Sixteen species were observed to be dispersed by WLG. Seeds of the most abundant species, Santiria trimera, were subjected to four treatments: (1) passed seeds, (2) passed seeds in fecal matrix, (3) seeds surrounded by fresh pulp and (3) seeds extracted from fresh fruits. The germination successes of S. trimera were significantly higher after gut passage partly thanks to fruit pulp removal. Our PhD study aims to characterize the functional ecology of WLG in tropical forests dynamics, especially regarding logging biotopes. Our research will be organized in three parts: (1) the survey of gorilla populations in the study area coupled with the characterization of their nests and habitats, (2) the study of dispersed species and of the effect of passage through gorilla gut on seed germination, (3) the estimate of dispersal distances for the species Santiria trimera (Burseraceae) by using molecular markers. Data for the second and third parts will be collected in one site selected thanks to the results of the survey for its high gorilla density, to assess the following assumptions: (1) gorillas favor the regeneration of many plant species, including timber trees; (2) they improve the genetic diversity and limit the genetic structure by widening the genetic pool and dispersing diasporas on large distances. If these hypotheses are accepted, sylvicultural practices may be adapted so as to take advantage from the presence of gorilla population. [less ▲]

Role of western lowland gorilla (Gorilla gorilla gorilla) to dispersal and regeneration of commercial trees in South-East Cameroon

Poster (2011, December 01)

The role of working memory in language and communication disorders

in Stemmer, Brigitte; Whitaker, Harry (Eds.) The Handbook of Neurolinguistics (1998)

Role of γδ T cells in HPV-induced cancer progression

Poster (2012, June 22)

Le rôle philosophique du concept d’inconscient

in Studia Europaea (2010, June 10)