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See detailPathogenicity and thermotolerance of entomopathogenic fungi for the control of the scab mite, Psoroptes ovis.
Lekimme, Mireille ULg; Focant, Charles ULg; Farnir, Frédéric ULg et al

in Experimental & Applied Acarology (2008), 46(1-4), 95-104

Psoroptes ovis is responsible for a highly contagious skin condition, both in sheep and cattle. This parasite has a marked economical impact in the sheep and cattle industry. Biological control is ... [more ▼]

Psoroptes ovis is responsible for a highly contagious skin condition, both in sheep and cattle. This parasite has a marked economical impact in the sheep and cattle industry. Biological control is considered as a realistic alternative to chemotherapeutic control. Laboratory experiments were carried out to evaluate the pathogenicity and the thermotolerance of twelve isolates of entomopathogenic fungi from four genera (Beauveria Vuillemin, Metarhizium Sorokin, Paecilomyces Bainier and Verticillium Nees). The pathogenicity was evaluated by the survival of P. ovis females after exposure to 10(6) to 10(8) conidia ml(-1) in humidity chambers. Results revealed intra- and interspecies differences. All isolates with the exception of B. bassiana IHEM3558 and V. lecanii MUCL8672 induced 50% mortality within 2 days at the highest concentration. At this concentration the entire mite population became infected with all isolates but B. bassiana IHEM3558; however, only four isolates gave rise to 100% infected cadavers at the lowest concentration. The thermotolerance of each isolate was evaluated by measuring its growth on an artificial medium kept between 25 and 37.5 degrees C. All isolates were able to grow up to 30 degrees C but only two, M. anisopliae IHEM18027 and Paecilomyces farinosus MUCL18885, tolerated temperatures up to 35 degrees C. These two isolates could be considered as good candidates for further use as biopesticide taking into account their virulence and thermotolerance. Other critical factors linked with the implementation of this type of biocontrol in P. ovis infected animals are discussed. [less ▲]

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See detailPathogenicity of Aspergillus clavatus produced in a fungal biofilm bioreactor toward Culex quinquefasciatus (Diptera: Culicidae)
Seye, Fawrou; Bawin, Thomas ULg; Boukraa, Slimane ULg et al

in Journal of Pesticide Science (2014), 39(3), 127-132

Many entomopathogenic fungi have been demonstrated to be potential agents for efficiently controlling mosquito populations. In the present study, we investigated a bioreactor system to produce metabolites ... [more ▼]

Many entomopathogenic fungi have been demonstrated to be potential agents for efficiently controlling mosquito populations. In the present study, we investigated a bioreactor system to produce metabolites and conidia by combining technological advantages of submerged and solid-state fermentations. The efficiency of fungal products was tested toward mosquitoes. Aspergillus clavatus (Eurotiales: Trichocomaceae) was grown by semi-solid-state fermentation in a bioreactor for up to 7 days. Depending on conidial doses (2.5×10^7, 5×10^7, 7.5×10^7, 10×10^7 and 12.5×10^7 conidia/mL), mortality ranged from 37.2±15.0 to 86.3±5.0% toward larvae and from 35.8±2.0 to 85.2±1.5% toward adults. The metabolites (10, 20, 40, 60, 80 and 100% v/v) yielded mortality from 23.7±15.0 to 100.0±0.1% toward larvae, and two sprayed volumes (5 and 10 mL) reached 45.5±1.4 and 75.6±2.6% mortality, respectively, toward adults. [less ▲]

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See detailPathogenicity of pap-negative avian Escherichia coli isolated from septicaemic lesions
Stordeur, P.; Bree, A.; Mainil, Jacques ULg et al

in Microbes & Infection (2004), 6(7), 637-645

Recent studies by DNA-DNA hybridisation assays conducted on a large collection of Escherichia coli strains isolated from chickens, ducks and turkeys suffering from colibacillosis, showed that 76% of the ... [more ▼]

Recent studies by DNA-DNA hybridisation assays conducted on a large collection of Escherichia coli strains isolated from chickens, ducks and turkeys suffering from colibacillosis, showed that 76% of the strains were negative for the presence of the pap gene cluster. The objective of this paper was to study the virulence associated with the avian E. coli strains negative for the P fimbriae, but carrying the f17 or the afa-8 gene cluster coding for adhesins associated with strains pathogenic for mammals. Three strains carrying the f17 fimbriae and three carrying the afa-8 adhesin-encoding gene cluster were studied in three in vivo experimental models of avian colibacillosis: subcutaneous inoculation of 1-day-old chicks, inoculation of specific-pathogen-free (SPF) chickens via the intra-thoracic air sac, and intra-tracheal inoculation of axenic chickens. The results showed that the six P-negative E. coli isolates carrying the f17 or the afa-8 gene cluster were lethal for 1-day-old chicks. They were also able to reproduce clinical signs and lesions of colibacillosis (aerosacculitis, pericarditis, perihepathitis), with bacteraemia and septicaemia, in SPF chickens inoculated via the thoracic air sacs as well as in axenic chickens inoculated by the intra-tracheal route. Further studies with f17 and afa-8 allelic mutants constructed by disruption must be performed to confirm a role of F17 fimbrial and Afa-VIII afimbrial adhesins in the pathogenesis of avian colibacillosis. (C) 2004 Elsevier SAS. All rights reserved. [less ▲]

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See detailPathogenicity test of the fungus Aspergillus clavatus on aphid Acyrthosiphon pisum (Aphididae)
Seye, Fawrou; Bawin, Thomas ULg; Delvigne, Frank ULg et al

Poster (2012, August 19)

Pea aphid is a pest of many cultivated and wild plants, but also a vector of several viral diseases. To control this pest, the most widely used methods are physical, chemical and more recently an ... [more ▼]

Pea aphid is a pest of many cultivated and wild plants, but also a vector of several viral diseases. To control this pest, the most widely used methods are physical, chemical and more recently an integrated approach that includes biological control. With the use of pathogenic agents against insects, the use of entomopathogenic fungi is one of the most promising. The present study demonstrated the possibility of using an entomopathogenic fungus Aspergillus clavatus against aphids. In laboratory conditions (8/16 photoperiod, average temperature 25°C), the insects were in contact with different concentrations ranging from 10^2 to 10^4 spores/cm2 deposited on filter paper in Petri dishes, or applied directly to young plants with doses ranging from 10^4 to 10^6 spores/ml. In 24 hours, mortality was 0 to 31.5% in Petri dishes. For treatment plants, the cumulative mortality in 5 days was 55 to 79%. Microscopic observations showed that the aphids were infected by contact and fungus has a mycosis effect. From these preliminary results, investigations should be made to study the action of the fungus on the reproduction of aphids. Therefore, A. clavatus could be introduced along with other fungi found in the literature as a biological control agent against aphids. [less ▲]

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See detailPathogénie cellulaire et moléculaire du stress oxydatif dans l'ostéo-arthropathie dégénérative équine
Schneider, Nicole ULg

Doctoral thesis (2007)

L’ostéo-arthropathie dégénérative affecte fréquemment les chevaux, et particulièrement le cheval de trait ardennais (Lejeune et al., 2002). Les nombreuses recherches consacrées à cette pathologie montrent ... [more ▼]

L’ostéo-arthropathie dégénérative affecte fréquemment les chevaux, et particulièrement le cheval de trait ardennais (Lejeune et al., 2002). Les nombreuses recherches consacrées à cette pathologie montrent un phénomène inflammatoire et un déséquilibre entre la production des enzymes dégradant le cartilage et l’intensité du processus de régénération (Landoni et al., 1996). On observe donc des dégâts à la surface du cartilage : f ibrillation, érosion, ulcération, formation d’ostéophytes, sclérose de l’os sous-chondral et remodelage ostéochondral (Reboul et al., 1996). Tous les éléments anatomiques sont concernés, avec une libération de médiateurs par les chondrocytes et les synoviocytes : cytokines, métalloprotéases, prostanoïdes (Cadore et Donabedian, 1997), leucotriènes, et espèces activées de l’oxygène et de l’azote (RNOS : reactive nitrogen and oxygen species). La formation des RNOS est souvent invoquée en relation avec des phénomènes d’anoxie-réoxygénation cycliques, liés au trauma ou à la surcharge articulaire, à un épanchement ou à un oedème de la capsule articulaire. Les travaux consacrés à la production des RNOS dans l’articulation l’attribuent habituellement aux chondrocytes et des observations biochimiques récentes ont révélé une augmentation des concentrations sanguines d’un produit oxydé caractéristique de la dégradation du cartilage, signe d’un métabolisme oxydant intra-articulaire (Lejeune et al., 2007). Peu de travaux sont consacrés à l’étude directe d’une production d’espèces radicalaires par les chondrocytes et les synoviocytes. L’objectif du travail était donc d’étudier la capacité des chondrocytes et des synoviocytes articulaires équins à produire des RNOS sous l’effet de l’anoxieréoxygénation. Il nécessitait la mise au point d’un modèle de culture des chondrocytes équins (Sanchez et al., 2002), d’un modèle de culture des synoviocytes équins (Georgescu et al., 1988) et d’un modèle de co-culture chondrocytes-synoviocytes pour imiter les interactions entre ces deux types cellulaires dans l’articulation où les chondrocytes matures sont nourris par diffusion à partir du liquide synovial à basse tension en oxygène (Grimshaw et Mason, 2000). Pour induire l’activité oxydante, nous avons soumis les cellules en culture à plusieurs cycles d’anoxie-réoxygénation, sur base de l’hypothèse qu’un traumatisme aigu ou chronique peut modifier le débit sanguin dans la membrane synoviale et initier des cycles d’anoxie-réoxygénation (par oedème et hypoxie tissulaire transitoire), avec une production intra-articulaire de RNOS, capables de déclencher des dommages tissulaires participant au développement de la pathologie articulaire. Pour tenir compte des conditions en oxygène existant dans l’articulation et du rôle du glucose ajouté au milieu de culture dans la résistance à l’anoxie, les chondrocytes ont été cultivés avec des concentrations variables en glucose (0, 1 et 4,5 g/l de milieu), combinées aux tensions d’oxygène de 1 % (hypoxie), 5 % (équivalent à la normoxie in vivo) et 21 % (condition hyperoxique prise comme référence par rapport à la littérature internationale). L’étude du métabolisme oxydant est effectuée en mesurant la consommation d’oxygène [oxymétrie mesurant la réponse mitochondriale (Mouithys- Mickalad et al., 2002)], la production globale de RNOS [estimée par la mesure de l’éthylène, produit par l’attaque d’un substrat par les RNOS (Deby-Dupont et al., 2005)] et la production d’espèces radicalaires [par résonance paramagnétique électronique (RPE) couplée au « spin trapping »] [less ▲]

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See detailPathogénie de la maladie d'Alzheimer: les mécanismes moléculaires et cellulaires
Govaerts, L.; Schoenen, Jean ULg; Bouhy, D.

in Revue Médicale de Liège (2007), 62(4), 209-16

Alzheimer's disease is worldwide the leading cause of dementia in the elderly. Senile plaques and neurofibrillary tangles are together with neuronal loss and cortical atrophy characteristic ... [more ▼]

Alzheimer's disease is worldwide the leading cause of dementia in the elderly. Senile plaques and neurofibrillary tangles are together with neuronal loss and cortical atrophy characteristic neuropathological features of the disease. Senile plaques contain beta-amyloid (Abeta) peptide which is produced by cleavage of the amyloid precursor protein (APP) by beta- and gamma-secretases. Neurofibrillary tangles are twisted helicoidal strands of hyperphosphorylated tau protein, a microtubule-associated protein. Both pathogenic arms which we describe are interrelated and Abeta deposition seems to potentiate tau pathology. Tangle and plaque formation is influenced by various factors including reciprocal interactions, genetic factors, inflammation and reactive oxygen species. A better understanding of the cellular and molecular cascade which leads to the neuropathological lesions of Alzheimer's disease has led to novel disease-modifying treatment strategies. They yield varying, though encouraging, results and target various stages of the pathological process. Future cooperation between basic, clinical and pharmacological research should allow the development in a foreseeable future of strategies that can halt, or even prevent, this devastating disorder. [less ▲]

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See detailPathogénie et épidémiologie de l'infection par le virus BVD
Nettleton, P. F.; Barlow, R. M.; Gardiner, A. C. et al

in Annales de Médecine Vétérinaire (1985), 129

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See detailPathologic aspects of carotid plaques : surgical and clinical significance
Van Damme, Hendrik ULg; Martin, Didier ULg; Demoulin, J. et al

Conference (1988, June)

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See detailPathologic aspects of carotid plaques : surgical and clinical significance
Van Damme, Hendrik ULg; Martin, Didier ULg; Demoulin, J. et al

Conference (1988, October)

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See detailPathologic features and mechanisms of hypoxemia in adult respiratory distress syndrome
Lamy, Maurice ULg; Fallat, R.; Koeniger, E. et al

in American Review of Respiratory Disease (1976), 114

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See detailPathologic fracture following humeral bone tumor in a mare
Bolen, Géraldine ULg; Péters, F.; Heimann, M. et al

Poster (2003)

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See detailPathological and clinical features of a large brazilian family harboring a frameshift mutation in the aryl hydrocarbon receptor interacting protein gene
Naves, L. A.; Azevedo, M. F.; Casulari, L. A. et al

in XIV Simposo Internacinal de Neuroendocrinologia - Endocrinologia and Metabologia - Arquivos Brasileiros de Endocrinologia e Metabologia : Fevereiro 2008, 52, suplemento 1 (2008)

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See detailPathological Aspects of Carotid Plaques: Surgical and Clinical Significance
VAN DAMME, Hendrik ULg; Demoulin, J.C.; Limet, Raymond ULg

in VASA. Supplementum (1991), 32

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See detailPathological Findings in Two Fin Whales (Balaenoptera Physalus) with Evidence of Morbillivirus Infection
Jauniaux, Thierry ULg; Charlier, G.; Desmecht, M. et al

in Journal of Comparative Pathology (2000), 123(2-3, Aug-Oct), 198-201

Two immature female fin whales stranded on the Belgian and French coastlines, were examined post mortem. The main gross findings were massive parasitic infestation, associated with a large thrombus in one ... [more ▼]

Two immature female fin whales stranded on the Belgian and French coastlines, were examined post mortem. The main gross findings were massive parasitic infestation, associated with a large thrombus in one whale, and severe emaciation. Microscopical investigations revealed multinucleated syncytia with large intranuclear inclusion bodies in various tissues, and positive immunolabelling for morbillivirus antigens. Other evidence of morbillivirus infection was provided by the demonstration of specific viral structures in syncytia and in cell cultures, and the detection of neutralizing antibodies to canine distemper virus. To the authors>> knowledge, this is the first firm report of morbillivirus infection in baleen whales. [less ▲]

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See detailPathological investigations on guillemots (Uria aalge) stranded on the Belgian coast during the winter of 1993-94
Jauniaux, Thierry ULg; Brosens, L.; Meire, P. et al

in Veterinary Record : Journal of the British Veterinary Association (1998), 143(14), 387-390

Pathological investigations were carried out on 67 guillemots (Uria aalge) washed up on the Belgian coast between November 1993 and March 1994. Emaciation and acute haemorrhagic gastroenteropathy were ... [more ▼]

Pathological investigations were carried out on 67 guillemots (Uria aalge) washed up on the Belgian coast between November 1993 and March 1994. Emaciation and acute haemorrhagic gastroenteropathy were observed in more than 70 per cent of the birds. There was no statistical relationship between the level of oil contamination and the severity of the lesions. Differences in bodyweight were accounted for by age, sex, emaciation, and acute haemorrhagic gastroenteropathy. The birds had a severe weight deficit but the concentrations of pollutants were below acutely toxic levels. [less ▲]

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See detailPathological investigations on sperm whales stranded on Belgian and Dutch coasts
Jauniaux, Thierry ULg; Brosens, L.; Jacquinet, E. et al

in Sperm whale deaths in the North Sea Science and management (1995)

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See detailPathological survey of dead marine mammals along the Belgian seashore
Jauniaux, Thierry ULg; Borrens, M.; Coignoul, Freddy ULg

in proceeding of the annual conference (1991)

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See detailPathologie : La maîtrise des cycles chez les petits ruminants
Hanzen, Christian ULg

Learning material (2014)

Objectif général : Ce chapitre est le second des deux consacrés à l’anoestrus (l’anoestrus pubertaire et du postpartum dans l’espèce bovine ; l’anoestrus saisonnier des petits ruminants). Ce chapitre ... [more ▼]

Objectif général : Ce chapitre est le second des deux consacrés à l’anoestrus (l’anoestrus pubertaire et du postpartum dans l’espèce bovine ; l’anoestrus saisonnier des petits ruminants). Ce chapitre décrit plus spécifiquement l’anoestrus saisonnier propre aux petits ruminants. Une fois défini l’anoestrus saisonnier et son mécanisme hormonal, sont passés en revue les divers traitements hormonaux (progestagènes, prostaglandines, mélatonine) ou zootechniques (mâle, alimentation, photopériode) [less ▲]

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See detailPathologie : Les pathologies de la reproduction du mâle
Hanzen, Christian ULg

Learning material (2014)

Objectif général : Le présent chapitre est consacré aux diverses pathologies qui de manière directe ou indirecte contribuent à réduire voire à supprimer la fertilité normale du mâle dans les espèces ... [more ▼]

Objectif général : Le présent chapitre est consacré aux diverses pathologies qui de manière directe ou indirecte contribuent à réduire voire à supprimer la fertilité normale du mâle dans les espèces bovine, ovine et caprine. Celles relatives à l’étalon et au verrat font l’objet d’un chapitre plus spécifique. Elles sont pour la facilité présentées selon leur localisation anatomique. Sont également synthétisées les affections liées à des modifications de l'instinct sexuel. [less ▲]

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See detailPathologie bovine : transport de l’oxygène et solutions salines
Gustin, Pascal ULg; Cambier, Carole ULg; Frans, A. et al

in Agricontact (1998), 302

Detailed reference viewed: 17 (1 ULg)