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See detailPhase Change Memories challenges: A material and process perspective
Maitrejean, S.; Ghezzi, G.; Gourvest, E. et al

in 2012 IEEE International Interconnect Technology Conference, IITC 2012 (2012)

Among all the new memories concepts, Phase Change Memories (PCM) is one of the most promising. However, various challenges remain. This paper reviews the materials and processes required to face these ... [more ▼]

Among all the new memories concepts, Phase Change Memories (PCM) is one of the most promising. However, various challenges remain. This paper reviews the materials and processes required to face these challenges. As an example, attention will be made on the effect of Phase change material composition on stability of the amorphous phase i.e. on the retention of the information. Additionally, it is showed how specific processes such as CVD or ALD can be developed in order to minimize the current required to amorphize the phase change material i.e. to reset the device. Finally, with the perspectives of the advanced integration nodes, experimental results on the effect of scaling on phase transformation are presented and discussed. © 2012 IEEE. [less ▲]

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See detailPhase closure image reconstruction for future VLTI instrumentation
Filho, Mercedes E; Renard, Stephanie; Garcia, Paulo et al

in Schöller, Markus; Danchi, William; Delplancke, Françoise (Eds.) Optical and Infrared Interferometry (2008, July 01)

Classically, optical and near-infrared interferometry have relied on closure phase techniques to produce images. Such techniques allow us to achieve modest dynamic ranges. In order to test the feasibility ... [more ▼]

Classically, optical and near-infrared interferometry have relied on closure phase techniques to produce images. Such techniques allow us to achieve modest dynamic ranges. In order to test the feasibility of next generation optical interferometers in the context of the VLTI-spectro-imager (VSI), we have embarked on a study of image reconstruction and analysis. Our main aim was to test the influence of the number of telescopes, observing nights and distribution of the visibility points on the quality of the reconstructed images. Our results show that observations using six Auxiliary Telescopes (ATs) during one complete night yield the best results in general and is critical in most science cases; the number of telescopes is the determining factor in the image reconstruction outcome. In terms of imaging capabilities, an optical, six telescope VLTI-type configuration and ~200 meter baseline will achieve 4 mas spatial resolution, which is comparable to ALMA and almost 50 times better than JWST will achieve at 2.2 microns. Our results show that such an instrument will be capable of imaging, with unprecedented detail, a plethora of sources, ranging from complex stellar surfaces to microlensing events. [less ▲]

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See detailPhase control for the stabilization of a photorefractive holographic camera in perturbed environments
Thizy, Cédric ULg; Georges, Marc ULg; Lemaire, philippe

in Hesselink, Lambertus; Feinberg, Jack (Eds.) Controlling Light with Light: Photorefractive Effects, Photosensitivity, Fiber Gratings, Photonic Materials and More (2007, October)

The holographic interferometer developed by CSL, and which uses a BSO crystal, exhibits a response time of a few seconds. This prevents us to properly record holograms under perturbated environmental ... [more ▼]

The holographic interferometer developed by CSL, and which uses a BSO crystal, exhibits a response time of a few seconds. This prevents us to properly record holograms under perturbated environmental conditions due to optical phase variations between reference and object beams. We present hereafter several active phase control strategies to overcome this problem [less ▲]

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See detailPhase control strategies for stabilization of photorefractive holographic interferometer
Thizy, Cédric ULg; Georges, Marc ULg; Lemaire, Philippe ULg et al

in Slangen, P.; Cerruti, C. (Eds.) Speckle06 : Speckles, From Grains to Flowers (2006, September)

A current problem encountered in holographic interferometry systems is the phase variations that arise from vibrations, from the use of optical fiber in one arm, by air convection or by unwanted movement ... [more ▼]

A current problem encountered in holographic interferometry systems is the phase variations that arise from vibrations, from the use of optical fiber in one arm, by air convection or by unwanted movement between the object and the measurement device. The holographic device developed by CSL based on photorefractive BSO crystals has the advantage of high resolution fringes with the capability of self-processing and indefinite reusability. The weakness of the technique is a response time that is often slow compared to external perturbations. For applications outside the laboratory, we decided to find solutions adapted to the holographic camera and which tend to limit or to eliminate the effect of such phase variations. An error signal is measured from one or another technique which measure the phase variations and which counteracts on an active element in the interferometer to stabilize the phase during recording. Different solutions have been analysed and are presented here. Interferograms were obtained with and without implementation of the phase control system that show the interest of such approach. Some of the system presented are only adapted to photorefractive holographic interferometry, making use of some crystal diffraction properties. Other systems can be used with other kind of interferometers. [less ▲]

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See detailPhase distribution measurements in metallic foam packing using X-ray radiography and micro-tomography
Calvo, Sébastien ULg; Beugre, Djomice Antoine ULg; Crine, Michel ULg et al

in Chemical Engineering & Processing (2009), 48(5), 1030-1039

Some structural and hydrodynamic properties of RCM-NCX-1116, a Ni-Cr metallic foam packing manufactured by Recemat International B.V (The Netherlands) are investigated using X-ray radiography and X-ray ... [more ▼]

Some structural and hydrodynamic properties of RCM-NCX-1116, a Ni-Cr metallic foam packing manufactured by Recemat International B.V (The Netherlands) are investigated using X-ray radiography and X-ray micro-tomography. Local values of porosity and pore diameters are measured on a foam sample 3D image obtained with a Skyscan-1172 high-resolution desk-top micro-CT system operated at 100 kV. Structural parameters computed on tomography images agree well with manufacturer data. Hydrodynamic tests are performed in a flat rectangular column packed with a sheet of metallic foam packing. Measurements are realized with a single-phase flow of liquid as well as with a counter-current flow of gas and liquid. Dynamic and static liquid holdup distributions and liquid radial spreading coefficient are measured on 2D radiographic images of the bed obtained with the high energy large scale ULG 420 kV scanner operated in the radiographic mode at 420 kV. Pressure drop measurements are successfully compared to experimental results reported in literature, as well as to the literature model predictions and to values computed using an in-house Lattice Boltzmann CFD simulation code. (C) 2009 Elsevier B.V. All rights reserved. [less ▲]

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See detailPhase distribution measurements in metallic foam using x-ray radiography and micro-tomography
Toye, Dominique ULg; Aferka, Saïd ULg; Calvo, Sébastien ULg et al

in Johansen, G. A.; Mc Cann, H. (Eds.) Proceedings of the 5th World Congress on Industrial Process Tomography, Bergen, Norway, September 6-9, 2007 (CD-ROM) (2007)

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See detailPhase equilibria of the Lyngdal granodiorite (Norway): Implications for the origin of metaluminous ferroan granitoids
Bogaerts, Michel; Scaillet, Bruno; Vander Auwera, Jacqueline ULg

in Journal of Petrology (2006), 47

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See detailPhase equivalent chains of Darboux transformations in scattering theory
Samsonov, B. F.; Stancu, Floarea ULg

in Physical Review C (2002), 66(3), 034001

We propose a procedure based on phase equivalent chains of Darboux transformations to generate local potentials satisfying the radial Schrodinger equation and sharing the same scattering data. For ... [more ▼]

We propose a procedure based on phase equivalent chains of Darboux transformations to generate local potentials satisfying the radial Schrodinger equation and sharing the same scattering data. For potentials related by a chain of transformations, an analytic expression is derived for the Jost function. It is shown how the same system of S-matrix poles can be differently distributed between poles and zeros of a Jost function that corresponds to different potentials with equal phase shifts. The concept of shallow and deep phase equivalent potentials is analyzed in connection with distinct distributions of poles. It is shown that phase equivalent chains do not violate the Levinson theorem. The method is applied to derive a shallow and a family of deep phase equivalent potentials describing the S-1(0) partial wave of the nucleon-nucleon scattering. [less ▲]

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See detailPhase formation during aging of Zn-12% Al and Zn-27% Al alloys at 100°C.
Terziev, L.; Rachev, P.; Lecomte-Beckers, Jacqueline ULg et al

in Zeitschrift für Metallkunde (1990), 81[6]

The phase formation during ageing of ZrH2 wt% AI and Zna27 wt.% AI alloys at 100 O has been studied by means of transmission electron microscopy and electron diffraction. No formation of ellipsoidal ... [more ▼]

The phase formation during ageing of ZrH2 wt% AI and Zna27 wt.% AI alloys at 100 O has been studied by means of transmission electron microscopy and electron diffraction. No formation of ellipsoidal precipitates of GP 2 and c4 phase bas been observed. Precipitation of hexagonal phases occurs generally on account of the a phase. The <011> habitus plane of a new phase q has been found. The q phase has been distinguished from the metastable Qm using Moire patterns [less ▲]

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See detailPhase I trial of oral mTOR inhibitor everolimus in combination with trastuzumab and vinorelbine in pre-treated patients with HER2-overexpressing metastatic breast cancer
Jerusalem, Guy ULg; Fasolo, Angelica; Dieras, Véronique et al

in Breast Cancer Research and Treatment (2011), 125(2), 447-455

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See detailA phase I trial of sunitinib, a tyrosine kinase inhibitor (TKI) combined with ionizing irradiation in rectal cancer
Coucke, Philippe ULg

in Belgian Journal of Medical Oncology [=BJMO] (2009), 3(3), 117

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See detailA phase I trial of sutent, a tyrosine kinase inhibitor combined with ionizing irradiation in rectal cancer: protocol KIRC 08-01
COUCKE, Philippe ULg

in Belgian Journal of Medical Oncology [=BJMO] (2010), 4(2), 65-66

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See detailPhase I/II studies to evaluate safety and immunogenicity of a recombinant gp350 Epstein-Barr virus vaccine in healthy adults
Moutschen, Michel ULg; Leonard, Philippe ULg; Sokal, E. M. et al

in Vaccine (2007), 25(24), 4697-4705

Two double-blind randomised controlled studies (phase I and I/II) were performed to assess for the first time the safety and immunogenicity of a recombinant subunit gp350 Epstein-Barr virus (EBV) vaccine ... [more ▼]

Two double-blind randomised controlled studies (phase I and I/II) were performed to assess for the first time the safety and immunogenicity of a recombinant subunit gp350 Epstein-Barr virus (EBV) vaccine in 148 healthy adult volunteers. All candidate vaccine formulations had a good safety profile and were well tolerated, with the incidence of solicited and unsolicited symptoms within a clinically acceptable range. One serious adverse event was reported in the phase I trial which was considered to be of suspected relationship to vaccination. The gp350 vaccine formulations were immunogenic and induced gp350-specific antibody responses (including neutralising antibodies). (c) 2007 Elsevier Ltd. All rights reserved. [less ▲]

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See detailPhase I/II trial of immunogenicity of a human papillomavirus (HPV) type 16 E7 protein-based vaccine in women with oncogenic HPV-positive cervical intraepithelial neoplasia
Hallez, Sophie; Simon, Philippe; Maudoux, Frédéric et al

in Cancer Immunology, Immunotherapy (2004), 53(7), 642-650

Purpose: Infection with oncogenic human papillomavirus (HPV) and HPV-16 in particular is a leading cause of anogenital neoplasia. High-grade intraepithelial lesions require treatment because of their ... [more ▼]

Purpose: Infection with oncogenic human papillomavirus (HPV) and HPV-16 in particular is a leading cause of anogenital neoplasia. High-grade intraepithelial lesions require treatment because of their potential to progress to invasive cancer. Numerous preclinical studies have demonstrated the therapeutic potential of E7-directed vaccination strategies in mice tumour models. In the present study, we tested the immunogenicity of a fusion protein (PD-E7) comprising a mutated HPV-16 E7 linked to the first 108 amino acids of Haemophilus influenzae protein D, formulated in the GlaxoSmithKline Biologicals adjuvant AS02B, in patients bearing oncogenic HPV-positive cervical intraepithelial neoplasia (CIN). Methods: Seven patients, five with a CIN3 and two with a CIN1, received three intramuscular injections of adjuvanted PD-E7 at 2-week intervals. Three additional CIN1 patients received a placebo. CIN3 patients underwent conization 8 weeks postvaccination. Cytokine flow cytometry and ELISA were used to monitor antigen-specific cellular and antibody responses from blood taken before and after vaccine or placebo injection. Results: Some patients had preexisting systemic IFN-gamma CD4(+) (1/10) and CD8(+) (5/10) responses to PD-E7. Vaccination, not placebo injection, elicited systemic specific immune responses in the majority of the patients. Five vaccinated patients (71%) showed significantly increased IFN-gamma CD8(+) cell responses upon PD-E7 stimulation. Two responding patients generated long-term T-cell immunity toward the vaccine antigen and E7 as well as a weak H. influenzae protein D (PD)-directed CD4(+) response. All the vaccinated patients, but not the placebo, made significant E7- and PD-specific IgG. Conclusions: The encouraging results obtained from this study performed on a limited number of subjects justify further analysis of the efficacy of the PD-E7/AS02B vaccine in CIN patients. [less ▲]

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See detailPhase I/IIclinical trial of local GM-CSF application in patients with cervical HPV-associated low grade squamous intraepithelial lesions
Hubert, Pascale ULg; Doyen, Jean ULg; Chapelle, X. et al

Conference (2007)

Background: Quantitative and functional alterations of professional antigen-presenting cells (APC) in SIL suggest that these lesions may have a diminished capacity to capture viral antigens. Moreover, GM ... [more ▼]

Background: Quantitative and functional alterations of professional antigen-presenting cells (APC) in SIL suggest that these lesions may have a diminished capacity to capture viral antigens. Moreover, GM-CSF (whose production is decreased in HPV-transformed keratinocytes) is an essential factor for the migration of APC in cervical (pre)neoplastic lesions formed in vitro and transplanted in vivo on mouse. In this study we performed a phase I/II clinical trial in order to determine whether a local application of GM-CSF on cervical low-grade squamous intraepithelial lesions (LSIL) might increase the recruitment of APC into the epithelium and indirectly the viral antigen presentation to the immune system. Methods: Fifteen patients with LSIL (10 GM-CSF and 5 placebo) were enrolled in this study. Patients received 4 GM-CSF applications (or placebo gel) and were followed during 6-7 months. APC infiltration was quantified by immunostaining with anti-CD1a mAb. Cellular immune response was evaluated by using an IFN-gamma intracellular staining on PBMC stimulated in vitro with the E7 HPV16 protein and L1 HPV16 Virus-like particles (VLP). Hybrid capture was performed to semi-quantify the viral DNA in cervical brush specimens. Results: GM-CSF applications were well tolerated in all patients. No difference in the cytological/histological and viral parameters assessed at 2 and 6 months after the last application was observed between the GM-CSF and the placebo group. An increased number of CD1a+ APC was observed in 6/10 patients treated by GM-CSF compared to 1/5 patient in the placebo group. There was an increased immune response against HPV in the GM-CSF group showed by NK and T cells producing IFN-gamma. [less ▲]

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