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See detailPath Similarity Evaluation using Bloom Filters
Donnet, Benoît ULg; Gueye, Bamba,; Kaafar, Mohamed Ali

in Computer Networks (2012), 56(2), 858-869

The performance of several Internet applications often relies on the measurability of path similarity between different participants. In particular, the performance of content distribution networks mainly ... [more ▼]

The performance of several Internet applications often relies on the measurability of path similarity between different participants. In particular, the performance of content distribution networks mainly relies on the awareness of content sources topology information. It is commonly admitted nowadays that, in order to ensure either path redundancy or efficient content replication, topological similarities between sources is evaluated by exchanging raw traceroute data, and by a hop by hop comparison of the IP topology observed from the sources to the several hundred or thousands of destinations. In this paper, based on real data we collected, we advocate that path similarity comparisons between different Internet entities can be much simplified using lossy coding techniques, such as Bloom filters, to exchange compressed topology information. The technique we introduce to evaluate path similarity enforces both scalability and data confidentiality while maintaining a high level of accuracy. In addition, we demonstrate that our technique is scalable as it requires a small amount of active probing and is not targets dependent. [less ▲]

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See detailPathbase: a database of mutant mouse pathology
Schofield, P. N.; Bard, J. B. L.; Booth, C. et al

in Nucleic Acids Research (2004), 32(Sp. Iss. SI), 512-515

Pathbase is a database that stores images of the abnormal histology associated with spontaneous and induced mutations of both embryonic and adult mice including those produced by transgenesis, targeted ... [more ▼]

Pathbase is a database that stores images of the abnormal histology associated with spontaneous and induced mutations of both embryonic and adult mice including those produced by transgenesis, targeted multagenesis and chemical mutagenesis. Images of normal mouse histology and strain-dependent background lesions are also available. The database and the images are publicly accessible (http://www.pathbase.net) and linked by anatomical site, gene and other identifiers to relevant databases; there are also facilities for public comment and record annotation. The database is structured around a novel ontology of mouse disorders (MPATH) and provides high-resolution downloadable images of normal and diseased tissues that are searchable through orthogonal ontologies for pathology, developmental stage, anatomy and gene attributes (GO terms), together with controlled vocabularies for type of genetic manipulation or mutation, genotype and free text annotation for mouse strain and additional attributes. The database is actively curated and data records assessed by pathologists in the Pathbase Consortium before publication. The database interface is designed to have optimal browser and platform compatibility and to interact directly with other web-based mouse genetic resources. [less ▲]

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See detailPathbase: A new reference resource and database for laboratory mouse pathology
Schofield, P. N.; Bard, J. B. L.; Boniver, Jacques ULg et al

in Radiation Protection Dosimetry (2004), 112(4 Sp. Iss. SI), 525-528

Pathbase (http://www.pathbase.net) is a web accessible database of histopathological images of laboratory mice, developed as a resource for the coding and archiving of data derived from the analysis of ... [more ▼]

Pathbase (http://www.pathbase.net) is a web accessible database of histopathological images of laboratory mice, developed as a resource for the coding and archiving of data derived from the analysis of mutant or genetically engineered mice and their background strains. The metadata for the images, which allows retrieval and interoperability with other databases, is derived from a series of orthogonal ontologies and controlled vocabularies. One of these controlled vocabularies, MPATH, was developed by the Pathbase Consortium as a formal description of the content of mouse histopathological images. The database currently has over 1000 images on-line with 2000 more under curation and presents a paradigm for the development of future databases dedicated to aspects of experimental biology. [less ▲]

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See detailPathogenèse de l'endométriose
Nisolle, Michelle ULg; Alvarez Gonzalez, Maria-Luz ULg; Colombo, M. et al

in Gynécologie Obstétrique & Fertilité (2007), 35(9), 898-903

Endometriosis, defined by the development of endometrial tissue outside the uterus, is a benign disease responsible for infertility and pelvic pain. The diagnosis based on a detailed gynecological history ... [more ▼]

Endometriosis, defined by the development of endometrial tissue outside the uterus, is a benign disease responsible for infertility and pelvic pain. The diagnosis based on a detailed gynecological history and a careful clinical examination should be done as early as possible in order to treat patients correctly. Medical treatment is not appropriate in all cases and surgical treatment should be proposed but morbidity is related to the severity of the lesion. Ectopic implantation of endometrial cells needs complex interactions between host tissue and epithelial endometrial cells. The conditions for the development of endometriosis are estrogeno-dependent growth of endometrial cells, induction of angiogenesis and lymphangiogenesis. Principal cellular and molecular factors of angiogenesis, lymphangiogenesis and fibrosis should be identified in order to develop new therapeutic strategies of endometriosis. [less ▲]

Detailed reference viewed: 135 (16 ULg)
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See detailPathogenesis and management of acute pulmonary embolism
D'Orio, Vincenzo ULg; MENDES, P; SAAD, G et al

in Acta Clinica Belgica (1989), 44

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See detailPathogenesis of abdominal aortic aneurysm (AAA) formation.
Limet, Raymond ULg; Richelle, Betty ULg; VERLOES, Alain ULg et al

in Acta Chirurgica Belgica (1998), 98(5), 195-8

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See detailPathogenesis of dermatophytosis
Vermout, Sandy; Tabart, Jeremy; Baldo, Aline ULg et al

in Mycopathologia (2008), 166(5-6), 267-275

Despite the superficial localization of most dermatophytosis, host-fungus relationship in these infections is complex and still poorly elucidated. Though many efforts have been accomplished to ... [more ▼]

Despite the superficial localization of most dermatophytosis, host-fungus relationship in these infections is complex and still poorly elucidated. Though many efforts have been accomplished to characterize secreted dermatophytic proteases at the molecular level, only punctual insights have been afforded into other aspects of the pathogenesis of dermatophytosis, such as fungal adhesion, regulation of gene expression during the infection process, and immunomodulation by fungal factors. However, new genetic tools were recently developed, allowing a more rapid and high-throughput functional investigation of dermatophyte genes and the identification of new putative virulence factors. In addition, sophisticated in vitro infection models are now used and will open the way to a more comprehensive view of the interactions between these fungi and host epidermal cells, especially keratinocytes. [less ▲]

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See detailPathogenesis of migraine: the biobehavioural and hypoxia theories reconciled.
Schoenen, Jean ULg

in Acta Neurologica Belgica (1994), 94(2), 79-86

The recent pathophysiological data obtained in migraine patients during and between attacks are reviewed in this article. They suggest that the headache in migraine is due to activation of the trigemino ... [more ▼]

The recent pathophysiological data obtained in migraine patients during and between attacks are reviewed in this article. They suggest that the headache in migraine is due to activation of the trigemino-vascular system. While this can be found in other headache disorders, the process leading ultimately to trigemino-vascular activation appears to characterize migraine. Between attacks, the migrainous brain has two functional abnormalities: a habituation defect in sensory processing, probably related to dysfunctioning transmitter (serotonin, noradrenaline) systems and a reduced mitochondrial energy reserve. Both abnormalities may be genetically determined and concur to favour biochemical shifts leading to the migraine attack as a primary protective mechanism of the brain. Such a model of migraine pathogenesis reconciles the biobehavioural and hypoxia theories and opens new therapeutic perspectives. [less ▲]

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See detailPathogenesis, latency and reactivation of infections by herpesviruses
Thiry, Etienne ULg; Dubuisson, J.; Pastoret, Paul-Pierre ULg

in Revue Scientifique et Technique (International Office of Epizootics) (1986), 5

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See detailPathogenic and molecular characterization of Pythium species inducing root rot symptoms of common bean in Rwanda
Nzungize, J.; Geps, P.; Buruchara, R. et al

in African Journal of Microbiology Research [=AJMR] (2011), 5

Detailed reference viewed: 32 (5 ULg)
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See detailPathogenic aspects of VTEC infections in ruminants
Goffaux, F; China, B; Stordeur, P et al

in Duffy, G; Garvey, P; McDowell, DA (Eds.) Verocytotoxigenic Escherichia coli (2001)

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See detailPathogenic role of matrix metalloproteases and their inhibitors in asthma and chronic obstructive pulmonary disease and therapeutic relevance of matrix metalloproteases inhibitors
Cataldo, Didier ULg; Guéders, Maud ULg; Rocks, Natacha ULg et al

in Cellular and Molecular Biology (2003), 49(6), 875-884

Matrix metalloproteinases (MMPs) are an at least 23 member family of calcium and zinc dependent enzymes implicated in many physiological and pathological processes. Asthma, chronic obstructive pulmonary ... [more ▼]

Matrix metalloproteinases (MMPs) are an at least 23 member family of calcium and zinc dependent enzymes implicated in many physiological and pathological processes. Asthma, chronic obstructive pulmonary disease (COPD) and emphysema are diseases associated with an inflammation of the airways and lung parenchyma. In this review, we focus on the role played by MMPs in the pathogenesis of inflammation, airway remodelling and alveolar destruction, depicting the observational studies in humans and the experimental studies in animal models. During the course of asthma, MM P-2,-8,-9 and TIMP-1 are expressed at baseline and the allergen exposure or exacerbations of the disease lead to an increase of MMP-9 secretion being at this time much higher than that of TIMP-1, allowing temporarily a matrix damage, possibly followed by abnormal repair. Animal models suggest a predominant role for MMP-9 and MMP-12 in the pathogenesis of pulmonary inflammation and link an absence of MMP-2 to an increased parenchymal inflammation. In COPD and emphysema, human studies indicate an over-secretion of MMP-2,-8,-9 and animal models point out MMP-1 and MMP-12 as being key players in the pathogenesis of emphysema. Taken together, these data identify specific MW inhibition as appropriate target for therapeutic intervention in asthma or COPD/emphysema. They also strongly argue against the widespread use of large spectrum non specific inhibitors that could be detrimental. [less ▲]

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See detailPathogenic Tracks in Fatigue Syndromes
Moutschen, Michel ULg; Triffaux, Jean-Marc ULg; Demonty, Jean ULg et al

in Acta Clinica Belgica (1994), 49(6), 274-89

This review analyses the recent literature devoted to two related fatigue syndromes: chronic fatigue syndrome (CFS) and acute onset postviral fatigue syndrome (PVFS). The articles are grouped into five ... [more ▼]

This review analyses the recent literature devoted to two related fatigue syndromes: chronic fatigue syndrome (CFS) and acute onset postviral fatigue syndrome (PVFS). The articles are grouped into five pathogenic tracks: infectious agents, immune system, skeletic muscle, hypothalamo-pituitary-adrenal (HPA) axis and psychiatric factors. Although a particular infectious agent is unlikely to be responsible for all CFS cases, evidence is shown that host-parasite relationships are modified in a large proportion of patients with chronic fatigue. Antibody titres against infectious agents are often elevated and replication of several viruses could be increased. Chronic activation of the immune system is also observed and could be due to the reactivation of persistent or latent infectious agents such as herpes viruses (i.e. HHV-6) or enteroviruses. It could also be favorised by an impaired negative feedback of the HPA axis on the immune system. A model is proposed where the abnormalities of the HPA axis are primary events and are mainly responsible for a chronic activation of the immune system which in turn induces an increased replication of several viruses under the control of cellular transcription factors. These replicating viruses together with cytokines such as TNF-alpha would secondarily induce functional disorders of muscle and several aspects of asthenia itself. [less ▲]

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See detailPathogenicity and thermotolerance of entomopathogenic fungi for the control of the scab mite, Psoroptes ovis.
Lekimme, Mireille ULg; Focant, Charles ULg; Farnir, Frédéric ULg et al

in Experimental & Applied Acarology (2008), 46(1-4), 95-104

Psoroptes ovis is responsible for a highly contagious skin condition, both in sheep and cattle. This parasite has a marked economical impact in the sheep and cattle industry. Biological control is ... [more ▼]

Psoroptes ovis is responsible for a highly contagious skin condition, both in sheep and cattle. This parasite has a marked economical impact in the sheep and cattle industry. Biological control is considered as a realistic alternative to chemotherapeutic control. Laboratory experiments were carried out to evaluate the pathogenicity and the thermotolerance of twelve isolates of entomopathogenic fungi from four genera (Beauveria Vuillemin, Metarhizium Sorokin, Paecilomyces Bainier and Verticillium Nees). The pathogenicity was evaluated by the survival of P. ovis females after exposure to 10(6) to 10(8) conidia ml(-1) in humidity chambers. Results revealed intra- and interspecies differences. All isolates with the exception of B. bassiana IHEM3558 and V. lecanii MUCL8672 induced 50% mortality within 2 days at the highest concentration. At this concentration the entire mite population became infected with all isolates but B. bassiana IHEM3558; however, only four isolates gave rise to 100% infected cadavers at the lowest concentration. The thermotolerance of each isolate was evaluated by measuring its growth on an artificial medium kept between 25 and 37.5 degrees C. All isolates were able to grow up to 30 degrees C but only two, M. anisopliae IHEM18027 and Paecilomyces farinosus MUCL18885, tolerated temperatures up to 35 degrees C. These two isolates could be considered as good candidates for further use as biopesticide taking into account their virulence and thermotolerance. Other critical factors linked with the implementation of this type of biocontrol in P. ovis infected animals are discussed. [less ▲]

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See detailPathogenicity of Aspergillus clavatus produced in a fungal biofilm bioreactor toward Culex quinquefasciatus (Diptera: Culicidae)
Seye, Fawrou; Bawin, Thomas ULg; Boukraa, Slimane ULg et al

in Journal of Pesticide Science (2014), 39(3), 127-132

Many entomopathogenic fungi have been demonstrated to be potential agents for efficiently controlling mosquito populations. In the present study, we investigated a bioreactor system to produce metabolites ... [more ▼]

Many entomopathogenic fungi have been demonstrated to be potential agents for efficiently controlling mosquito populations. In the present study, we investigated a bioreactor system to produce metabolites and conidia by combining technological advantages of submerged and solid-state fermentations. The efficiency of fungal products was tested toward mosquitoes. Aspergillus clavatus (Eurotiales: Trichocomaceae) was grown by semi-solid-state fermentation in a bioreactor for up to 7 days. Depending on conidial doses (2.5×10^7, 5×10^7, 7.5×10^7, 10×10^7 and 12.5×10^7 conidia/mL), mortality ranged from 37.2±15.0 to 86.3±5.0% toward larvae and from 35.8±2.0 to 85.2±1.5% toward adults. The metabolites (10, 20, 40, 60, 80 and 100% v/v) yielded mortality from 23.7±15.0 to 100.0±0.1% toward larvae, and two sprayed volumes (5 and 10 mL) reached 45.5±1.4 and 75.6±2.6% mortality, respectively, toward adults. [less ▲]

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See detailPathogenicity of pap-negative avian Escherichia coli isolated from septicaemic lesions
Stordeur, P.; Bree, A.; Mainil, Jacques ULg et al

in Microbes & Infection (2004), 6(7), 637-645

Recent studies by DNA-DNA hybridisation assays conducted on a large collection of Escherichia coli strains isolated from chickens, ducks and turkeys suffering from colibacillosis, showed that 76% of the ... [more ▼]

Recent studies by DNA-DNA hybridisation assays conducted on a large collection of Escherichia coli strains isolated from chickens, ducks and turkeys suffering from colibacillosis, showed that 76% of the strains were negative for the presence of the pap gene cluster. The objective of this paper was to study the virulence associated with the avian E. coli strains negative for the P fimbriae, but carrying the f17 or the afa-8 gene cluster coding for adhesins associated with strains pathogenic for mammals. Three strains carrying the f17 fimbriae and three carrying the afa-8 adhesin-encoding gene cluster were studied in three in vivo experimental models of avian colibacillosis: subcutaneous inoculation of 1-day-old chicks, inoculation of specific-pathogen-free (SPF) chickens via the intra-thoracic air sac, and intra-tracheal inoculation of axenic chickens. The results showed that the six P-negative E. coli isolates carrying the f17 or the afa-8 gene cluster were lethal for 1-day-old chicks. They were also able to reproduce clinical signs and lesions of colibacillosis (aerosacculitis, pericarditis, perihepathitis), with bacteraemia and septicaemia, in SPF chickens inoculated via the thoracic air sacs as well as in axenic chickens inoculated by the intra-tracheal route. Further studies with f17 and afa-8 allelic mutants constructed by disruption must be performed to confirm a role of F17 fimbrial and Afa-VIII afimbrial adhesins in the pathogenesis of avian colibacillosis. (C) 2004 Elsevier SAS. All rights reserved. [less ▲]

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See detailPathogenicity test of the fungus Aspergillus clavatus on aphid Acyrthosiphon pisum (Aphididae)
Seye, Fawrou; Bawin, Thomas ULg; Delvigne, Frank ULg et al

Poster (2012, August 19)

Pea aphid is a pest of many cultivated and wild plants, but also a vector of several viral diseases. To control this pest, the most widely used methods are physical, chemical and more recently an ... [more ▼]

Pea aphid is a pest of many cultivated and wild plants, but also a vector of several viral diseases. To control this pest, the most widely used methods are physical, chemical and more recently an integrated approach that includes biological control. With the use of pathogenic agents against insects, the use of entomopathogenic fungi is one of the most promising. The present study demonstrated the possibility of using an entomopathogenic fungus Aspergillus clavatus against aphids. In laboratory conditions (8/16 photoperiod, average temperature 25°C), the insects were in contact with different concentrations ranging from 10^2 to 10^4 spores/cm2 deposited on filter paper in Petri dishes, or applied directly to young plants with doses ranging from 10^4 to 10^6 spores/ml. In 24 hours, mortality was 0 to 31.5% in Petri dishes. For treatment plants, the cumulative mortality in 5 days was 55 to 79%. Microscopic observations showed that the aphids were infected by contact and fungus has a mycosis effect. From these preliminary results, investigations should be made to study the action of the fungus on the reproduction of aphids. Therefore, A. clavatus could be introduced along with other fungi found in the literature as a biological control agent against aphids. [less ▲]

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See detailPathogénie cellulaire et moléculaire du stress oxydatif dans l'ostéo-arthropathie dégénérative équine
Schneider, Nicole ULg

Doctoral thesis (2007)

L’ostéo-arthropathie dégénérative affecte fréquemment les chevaux, et particulièrement le cheval de trait ardennais (Lejeune et al., 2002). Les nombreuses recherches consacrées à cette pathologie montrent ... [more ▼]

L’ostéo-arthropathie dégénérative affecte fréquemment les chevaux, et particulièrement le cheval de trait ardennais (Lejeune et al., 2002). Les nombreuses recherches consacrées à cette pathologie montrent un phénomène inflammatoire et un déséquilibre entre la production des enzymes dégradant le cartilage et l’intensité du processus de régénération (Landoni et al., 1996). On observe donc des dégâts à la surface du cartilage : f ibrillation, érosion, ulcération, formation d’ostéophytes, sclérose de l’os sous-chondral et remodelage ostéochondral (Reboul et al., 1996). Tous les éléments anatomiques sont concernés, avec une libération de médiateurs par les chondrocytes et les synoviocytes : cytokines, métalloprotéases, prostanoïdes (Cadore et Donabedian, 1997), leucotriènes, et espèces activées de l’oxygène et de l’azote (RNOS : reactive nitrogen and oxygen species). La formation des RNOS est souvent invoquée en relation avec des phénomènes d’anoxie-réoxygénation cycliques, liés au trauma ou à la surcharge articulaire, à un épanchement ou à un oedème de la capsule articulaire. Les travaux consacrés à la production des RNOS dans l’articulation l’attribuent habituellement aux chondrocytes et des observations biochimiques récentes ont révélé une augmentation des concentrations sanguines d’un produit oxydé caractéristique de la dégradation du cartilage, signe d’un métabolisme oxydant intra-articulaire (Lejeune et al., 2007). Peu de travaux sont consacrés à l’étude directe d’une production d’espèces radicalaires par les chondrocytes et les synoviocytes. L’objectif du travail était donc d’étudier la capacité des chondrocytes et des synoviocytes articulaires équins à produire des RNOS sous l’effet de l’anoxieréoxygénation. Il nécessitait la mise au point d’un modèle de culture des chondrocytes équins (Sanchez et al., 2002), d’un modèle de culture des synoviocytes équins (Georgescu et al., 1988) et d’un modèle de co-culture chondrocytes-synoviocytes pour imiter les interactions entre ces deux types cellulaires dans l’articulation où les chondrocytes matures sont nourris par diffusion à partir du liquide synovial à basse tension en oxygène (Grimshaw et Mason, 2000). Pour induire l’activité oxydante, nous avons soumis les cellules en culture à plusieurs cycles d’anoxie-réoxygénation, sur base de l’hypothèse qu’un traumatisme aigu ou chronique peut modifier le débit sanguin dans la membrane synoviale et initier des cycles d’anoxie-réoxygénation (par oedème et hypoxie tissulaire transitoire), avec une production intra-articulaire de RNOS, capables de déclencher des dommages tissulaires participant au développement de la pathologie articulaire. Pour tenir compte des conditions en oxygène existant dans l’articulation et du rôle du glucose ajouté au milieu de culture dans la résistance à l’anoxie, les chondrocytes ont été cultivés avec des concentrations variables en glucose (0, 1 et 4,5 g/l de milieu), combinées aux tensions d’oxygène de 1 % (hypoxie), 5 % (équivalent à la normoxie in vivo) et 21 % (condition hyperoxique prise comme référence par rapport à la littérature internationale). L’étude du métabolisme oxydant est effectuée en mesurant la consommation d’oxygène [oxymétrie mesurant la réponse mitochondriale (Mouithys- Mickalad et al., 2002)], la production globale de RNOS [estimée par la mesure de l’éthylène, produit par l’attaque d’un substrat par les RNOS (Deby-Dupont et al., 2005)] et la production d’espèces radicalaires [par résonance paramagnétique électronique (RPE) couplée au « spin trapping »] [less ▲]

Detailed reference viewed: 33 (7 ULg)