Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailIs 3 '-deoxy-3 '-[F-18] fluorothymidine ([F-18]-FLT) the next tracer for routine clinical PET after R [F-18]-FDG?
Couturier, Olivier; Léost, Françoise; Campone, Mario et al

in Bulletin du Cancer (2005), 92(9), 789-798

Positron emission tomography (PET) with {F-18}-FDG is nowfirmly established as a clinical tool in oncology. Its applications are however limited in some indications, due to the lack of specificity of its ... [more ▼]

Positron emission tomography (PET) with {F-18}-FDG is nowfirmly established as a clinical tool in oncology. Its applications are however limited in some indications, due to the lack of specificity of its uptake mechanism for tumors, or the low avidity of some cancer types such as prostate. Alternative tracers are thus being developed, in order to fill up this void. Proliferation as a biological target is particularly attractive in cancer imaging. From that perspective, fluorothymidine ({F-18}-FLT or FLT) has generated a strong interest among the scientific community, especially since the radiosynthesis process has been improved and simplified, thus making possible to envision a routine use for the tracer. This article aims at summarizing the status of the current scientific data regarding FLT The uptake mechanism of FLT is well known, relying on the thymidine kinase 1 (TK1) enzymatic activity, and thus on DNA synthesis, Preclinical studies have shown a clear relationship between tracer accumulation and level of tumor proliferation, even though DNA salvage pathwayss intervene in the process and may complicate the interpretation of the results. Several clinical studies suggest a good specificity for tumor, albeit with a lower sensitivity than with FDG. In all likelihood however, the future of FLT lies in the evaluation of antitumor response and possibly the pretherapeutic prognostic characterization, rather than in the diagnosis and staging of malignancies. Although the scientific data regarding this issue remain limited, initial results are encouraging. Further significant work remains to he done in order to fully assess the clinical performances of the tracer, on the one hand, and to determine its place relative to FDG and other emerging tracers, on the other hand. Until these studies are completed, FLT should he considered as a promising tracer, hut remaining at an experimental stage of its development. [less ▲]

Detailed reference viewed: 44 (1 ULiège)
Peer Reviewed
See detailIs 5-Hydroxytryptamine (serotonin) involved in the pathogenesis of canine idiopathic pulmonary fibrosis ?
Krafft, Emilie ULiege; Roels, Elodie ULiege; Laurila, HP et al

Poster (2014, September 20)

Detailed reference viewed: 21 (0 ULiège)
Full Text
Peer Reviewed
See detailIs 5-Hydroxytryptamine (serotonin) involved in the pathogenesis of idiopathic pulmonary fibrosis in dogs ?
Krafft, Emilie ULiege; Roels, Elodie ULiege; Laurila et al

in Proceedings of the 23th ECVIM Meeting (2013, September)

Detailed reference viewed: 30 (8 ULiège)
Full Text
Peer Reviewed
See detailIs a low-mass top quark ruled out?
Cudell, Jean-René ULiege; Halzen, F.; He, X. G. et al

in Physics Letters B (1987), 196

Detailed reference viewed: 5 (1 ULiège)
Full Text
Peer Reviewed
See detailIs a Memoryless Motion Detection Truly Relevant for Background Generation with LaBGen?
Laugraud, Benjamin ULiege; Van Droogenbroeck, Marc ULiege

in Advanced Concepts for Intelligent Vision Systems (2017, September)

The stationary background generation problem consists in generating a unique image representing the stationary background of a given video sequence. The LaBGen background generation method combines a ... [more ▼]

The stationary background generation problem consists in generating a unique image representing the stationary background of a given video sequence. The LaBGen background generation method combines a pixel-wise median filter and a patch selection mechanism based on a motion detection performed by a background subtraction algorithm. In our previous works related to LaBGen, we have shown that, surprisingly, the frame difference algorithm provides the most effective motion detection on average. Compared to other background subtraction algorithms, it detects motion between two frames without relying on additional past frames, and is therefore memoryless. In this paper, we experimentally check whether the memoryless property is truly relevant for LaBGen, and whether the effective motion detection provided by the frame difference is not an isolated case. For this purpose, we introduce LaBGen-OF, a variant of LaBGen leverages memoryless dense optical flow algorithms for motion detection. Our experiments show that using a memoryless motion detector is an adequate choice for our background generation framework, and that LaBGen-OF outperforms LaBGen on the SBMnet dataset. We further provide an open-source C++ implementation of both methods at http://www.telecom.ulg.ac.be/labgen. [less ▲]

Detailed reference viewed: 181 (22 ULiège)
Peer Reviewed
See detailIs a new definition of intermodal transport interesting for transferring flows from road to more environmentally friendly modes?
Mostert, Martine ULiege; Limbourg, Sabine ULiege; Caris, An

Conference (2017, July)

Road remains the most used mode in Europe. Even if it is appreciated for its responsiveness, flexibility, and quickness, road transport is however responsible for negative impacts on its environment like ... [more ▼]

Road remains the most used mode in Europe. Even if it is appreciated for its responsiveness, flexibility, and quickness, road transport is however responsible for negative impacts on its environment like air pollution or climate change. Intermodal freight transport i.e. the transportation of goods using two or more modes of transport, in the same loading unit, without handling of the goods themselves is identified by the European Commission as an interesting solution for limiting the negative impacts of transport. In the classical conception of intermodal transport, pre- and post-haulage travels are supposed to be short, and to be performed by road transport, whereas the long-haul travel is done using rail or inland waterways (IWW). The objective of this study is to determine the impact on intermodal attractiveness of allowing other combinations of modes than the classical road-rail/IWW-road combination, during an intermodal travel. The goal is to determine the flow distribution of goods between direct transportation by road, rail or IWW, and any combination of these modes using intermodal transport. The novelty consists in taking into account three modes of transport in a mixed integer programming model, and to allow the transfer from any mode to any other at intermodal terminals where these modes coexist. For testing the hypothesis of intermodal transport attractiveness on medium to long distance, the model is applied to experimental data at the European level. [less ▲]

Detailed reference viewed: 28 (2 ULiège)
Full Text
Peer Reviewed
See detailIs a renal abnormality of sodium excretion the marker of genetic predisposition to hypertension?
Krzesinski, Jean-Marie ULiege; Goffard, A.; Warling, X. et al

in Clinical & Experimental Hypertension (1989), A11(7), 1391

Detailed reference viewed: 10 (0 ULiège)
Full Text
Peer Reviewed
See detailIs adult translocation a credible way to accelerate the recolonization process of Chondrostoma nasus in a rehabilitated river?
Ovidio, Michaël ULiege; Hanzen, Céline; Gennotte, Vincent ULiege et al

in Cybium (2016), 40(1), 43-49

The decline of the patrimonial rheophilic nase, Chondrostoma nasus (Linnaeus, 1758) populations was mainly caused by construction of dams and hydroelectric power-plants, together with the straightening ... [more ▼]

The decline of the patrimonial rheophilic nase, Chondrostoma nasus (Linnaeus, 1758) populations was mainly caused by construction of dams and hydroelectric power-plants, together with the straightening and artificialization of the river banks and water pollution. In this study, we tested the hypothesis whether the translocation of few adult nase individuals from a river stretch to another upstream may be a credible way to accelerate the recolonization process of the species in the Amblève River (Southern Belgium). In February and March 2011, just before their spawning period, eight adult nases (462-509 mm; 1546-2002 g; presumed males and females) were captured in the lower part of the River Amblève. Fin clip samples were stored in alcohol for further genetic analysis. They were equipped with a 14 g radio transmitter and translocated upstream in a 18 km river stretch, where the species had disappeared since decades due to river anthropization. They were manually located two to five times/week using mobile receivers until maximum June 2012 (n = 977 locations). River temperature and flow were hourly recorded during the entire tracking period. The tagged nase individuals displayed various mobility patterns, exploited different areas of the river stretch, occupied longitudinal home ranges from 3.4 to 36.1 km (one individual finally left the new river stretch) and travelled total distances from 12.2 to 186.6 km. The tagged individuals were most of the times apart from one to another, but most individuals grouped together in potential spawning areas in late March-early April 2011, suggesting an attempt to reproduce. In September 2011, electric fishing in two potential detected spawning sites allowed to capture 16 juvenile (0+) nases, demonstrating the existence of spawning activity in the newly occupied river stretch. Individual genetic characterization was performed in 2014 in order to reveal a possible direct lineage between juveniles and adults. Allelic distribution of 22 microsatellite markers unambiguously identified the 16 juveniles as full-sib progeny descending from two of the translocated adults. This demonstrated that the adult nases succeeded to find spawning areas and that progeny found raised-up from the translocated individuals. [less ▲]

Detailed reference viewed: 156 (26 ULiège)
Full Text
Peer Reviewed
See detailIs Aggregation Of Beta-Amyloid Peptides A Mis-Functioning Of A Current Interaction Process?
Festy, F.; Lins, Laurence ULiege; Peranzi, G. et al

in Biochimica et Biophysica Acta-Protein Structure and Molecular Enzymology (2001), 1546(2), 356-64

In a previous study, Hughes et al. [Proc. Natl. Acad. Sci. USA 93 (1996) 2065-2070] demonstrated that the amyloid peptide is able to interact with itself in a two-hybrid system and that interaction is ... [more ▼]

In a previous study, Hughes et al. [Proc. Natl. Acad. Sci. USA 93 (1996) 2065-2070] demonstrated that the amyloid peptide is able to interact with itself in a two-hybrid system and that interaction is specific. They further supported that the method could be used to define the sequences that might be important in nucleation-dependent aggregation. The sequence of the amyloid peptide can be split into four clusters, two hydrophilic (1-16 and 22-28) and two hydrophobic (17-21 and 29-42). We designed by molecular modeling and tested by the two-hybrid approach, series of mutations spread all over the sequence and changing the distribution of hydrophobicity and/or the spatial hindrance. In the two-hybrid assay, interaction of native Abeta is reproduced. Screening of mutations demonstrates that the C-domain (residues 29-40 (42)), the median domain (residues 17-22) and the N-domain (1-16) are all crucial for interaction. This demonstrates that almost all fragments of the amyloid peptide but a loop (residues 23-28) and the C-term amino acid are important for the native interaction. We support that the folded three-dimensional (3D) structure is the Abeta-Abeta interacting species, that the whole sequence is involved in that 3D fold which has a low secondary structure propensity and a high susceptibility to mutations and thus should have a low stability. The native fold of Abeta could be stabilized in Abeta-Abeta complexes which could in other circumstances facilitate the nucleation event of aggregation that leads to the formation of stable senile plaques. [less ▲]

Detailed reference viewed: 12 (0 ULiège)
Full Text
Peer Reviewed
See detailIs Alzheimer's disease a disconnection syndrome? Evidence from a crossmodal audio-visual illusory experiment
Delbeuck, Xavier; Collette, Fabienne ULiege; Van der Linden, Martial ULiege

in Neuropsychologia (2007), 45(14), 3315-3323

In Alzheimer's disease (AD), loss of connectivity in the patient's brain has been evidenced by a range of electrophysiological and neuroimaging studies. However, few neuropsychological research projects ... [more ▼]

In Alzheimer's disease (AD), loss of connectivity in the patient's brain has been evidenced by a range of electrophysiological and neuroimaging studies. However, few neuropsychological research projects have sought to interpret the cognitive modifications following the appearance of AD in terms of a disconnection syndrome. In this paper, we sought to investigate brain connectivity in AD via the study of a crossmodal effect. More precisely, we examined the integration of auditory and visual speech information (the McGurk effect) in AD patients and matched control subjects. Our results revealed impaired crossmodal integration during speech perception in AD, which was not associated with disturbances in the separate processing of auditory and visual speech stimuli. In conclusion, our data suggest the occurrence of a specific, audio-visual integration deficit in AD, which might be the consequence of a connectivity breakdown and corroborate the observation from other studies of crossmodal deficits between the auditory and visual modalities in this population. (C) 2007 Elsevier Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 113 (6 ULiège)
Full Text
See detailIs Ambrosia artemisiifolia L. able to expand its invaded range northward in Western Europe?
Ortmans, William ULiege; Mahy, Grégory ULiege; Monty, Arnaud ULiege

Conference (2016, September 13)

Ambrosia artemisiifolia L. (common ragweed, Asteraceae) is an invasive weed causing a health crisis in Europe, due to its highly allergenic pollen. In Western Europe the invaded range covers most of ... [more ▼]

Ambrosia artemisiifolia L. (common ragweed, Asteraceae) is an invasive weed causing a health crisis in Europe, due to its highly allergenic pollen. In Western Europe the invaded range covers most of central and southern France, and northern Italy. Northwards beyond the edge of this range, occurrence of casual population have been described for years, but these populations do not appear to become invasive, and the species does not seem to spread. This situation raises the following question: Has the invaded range reached a limit or will the species continue its invasion northwards? To answer this question, we followed two complementary approaches. First we set up an experimental garden in Belgium, 250 km north to the current invaded range, to see if the local climate allows the completion of the species reproduction cycle. Second, we performed an in situ measurement campaign in 12 population located beyond the edge, within the range but near the margin, and in the center of the invaded range. The aim of this campaign was to test whether the species had reduced plant performance towards range margins. The results showed that the species is able to establish populations with high growth rates in Belgium. Furthermore, the species expressed similar performance across the considered areas, even beyond the current invasion front. No evidence of processes constraining the invasion was found, which suggests a great potential for invasion north to the current invaded range. In this uncertain situation, awareness actions should be considered in the northern countries. [less ▲]

Detailed reference viewed: 50 (12 ULiège)
Full Text
See detailIs Ambrosia artemisiifolia L. able to expand its invaded range northward in Western Europe?
Ortmans, William ULiege; Mahy, Grégory ULiege; Monty, Arnaud ULiege

Poster (2016, April 19)

Ambrosia artemisiifolia L. (common ragweed, Asteraceae) is an invasive weed causing a health crisis in Europe, due to its highly allergenic pollen. In Western Europe the invaded range covers most of ... [more ▼]

Ambrosia artemisiifolia L. (common ragweed, Asteraceae) is an invasive weed causing a health crisis in Europe, due to its highly allergenic pollen. In Western Europe the invaded range covers most of central and southern France, and northern Italy. Northwards beyond the edge of this range, occurrence of casual population have been described for years, but these populations do not appear to become invasive, and the species does not seem to spread. This situation raises the following question: Has the invaded range reached a limit or will the species continue its invasion northwards? To answer this question, we followed two complementary approaches. First we set up an experimental garden in Belgium, 250 km north to the current invaded range, to see if the local climate allows the completion of the species reproduction cycle. Second, we performed an in situ measurement campaign in 12 population located beyond the edge, within the range but near the margin, and in the center of the invaded range. The aim of this campaign was to test whether the species had reduced plant performance towards range margins. The results showed that the species is able to establish populations with high growth rates in Belgium. Furthermore, the species expressed similar performance across the considered areas, even beyond the current invasion front. No evidence of processes constraining the invasion was found, which suggests a great potential for invasion north to the current invaded range. In this uncertain situation, awareness actions should be considered in the northern countries. [less ▲]

Detailed reference viewed: 49 (11 ULiège)
Full Text
Peer Reviewed
See detailIs an alcoholic fixative fluid used for manual liquid-based cytology accurate to perform HPV tests?
Garbar, Christian; Mascaux, Corinne; De Graeve, Philippe et al

in Pathology and Laboratory Medicine International (2012), 4

Detailed reference viewed: 14 (0 ULiège)
Full Text
Peer Reviewed
See detailIs an evidence-based approach unrealistic in NSCLC?
Coucke, Philippe ULiege; Barthelemy, Nicole ULiege; Bosquee, Léon ULiege et al

in Belgian Journal of Medical Oncology [=BJMO] (2008), volume 2(6), 326-333

Summary Non-small cell lung cancer (NSCLC) is a heterogeneous tumour. A wide variety of treatment options is currently available. Surgery remains the mainstay of curative treatment and an operative ... [more ▼]

Summary Non-small cell lung cancer (NSCLC) is a heterogeneous tumour. A wide variety of treatment options is currently available. Surgery remains the mainstay of curative treatment and an operative approach will be selected in function of disease stage, tumour resectability and performance status of the patient. Adjuvant chemotherapy is considered standard at least for stage II and III disease. In stage III disease, resectability should be decided in function of the cytological/histological confirmation of N2 disease. If N2-disease cannot be highlighted at work-up, the patients are submitted to surgery followed by adjuvant chemotherapy. If patients are staged pN0-pN1 after surgery, ostoperative radiotherapy should not be given. However, if pN2 is discovered at surgery, there might be a place for postoperative radiotherapy but this still needs confirmation. In case of cytological/histological confirmation of pN2 disease prior to surgery, patients should not be operated but treated with a combination of oncomitant chemoradiotherapy. This treatment algorithm will be evaluated by reviewing the published evidence issued from randomized controlled trials. [less ▲]

Detailed reference viewed: 42 (11 ULiège)
Peer Reviewed
See detailIs Anosognosia in Alzheimer disease also observed for behavioural and personality changes?
Feyers, Dorothée ULiege; Bastin, Christine ULiege; Jaspar, Mathieu ULiege et al

Poster (2010, May 28)

Anosognosia is a frequent manifestation in Alzheimer disease (AD) but its extent is not yet clearly established. While anosognosia for memory deficit has been widely reported, no study has simultaneously ... [more ▼]

Anosognosia is a frequent manifestation in Alzheimer disease (AD) but its extent is not yet clearly established. While anosognosia for memory deficit has been widely reported, no study has simultaneously explored anosognosia for personality and behaviour changes. We have tackled this question with 20 AD patients and 20 matched elderly subjects (ES). Participants (AD and ES) assessed their personality and their reactions in social situation both in current (S1) and past (S1_bef) time period. Assessment of these characteristics was also performed by relatives of the participants (R2 and R2_bef). Mann-Whitney test (p<0.05) were performed between discrepancy scores (calculated by comparing answers of subjects and relatives) obtained for AD and ES. A specific measure of anosognosia was also calculated by comparing S1 and R2. Statistical analyses demonstrated (1) that relatives of AD patients report more personality and behavioural changes across time (S1-S1_bef) than relatives of ES (R2–R2_bef); (2) that self-reported changes were not significantly different between AD patients and ES; (3) that anosognosia (S1-R2) was observed in AD patients for personality changes only. Results obtained support the hypothesis that anosognosia does not affect all domain in AD. Indeed, even if AD patients are no more able to assess their current personality, they perceive adequately their current reactions in social situations. [less ▲]

Detailed reference viewed: 59 (5 ULiège)
Full Text
Peer Reviewed
See detailIs anthracene cofactor or spectator for the thermolysis of anthracenyl acylnitroso cycloadducts in the presence of a diene?
Monbaliu, Jean-Christophe ULiege; Marchand-Brynaert, Jacqueline; Peeters, Daniel

in Tetrahedron Letters (2009), 50

Detailed reference viewed: 14 (0 ULiège)
Full Text
Peer Reviewed
See detailIs aprotinin worth the risk in total hip replacement?
Janssens, Marc ULiege; Joris, Jean ULiege

in Anesthesiology (1994), 81(2), 518-519

Detailed reference viewed: 9 (0 ULiège)
Full Text
Peer Reviewed
See detailIs artemisinin the only antiplasmodial compound in the Artemisia annua tea infusion? An in vitro study.
Mouton, Julia; Jansen, Olivia ULiege; Frederich, Michel ULiege et al

in Planta Medica (2013), 79(6), 468-70

In our ongoing investigation into Artemisia annua for the treatment of malaria, we decided to study the possibility that synergism might enhance the efficacy of artemisinin. Our main objective was to test ... [more ▼]

In our ongoing investigation into Artemisia annua for the treatment of malaria, we decided to study the possibility that synergism might enhance the efficacy of artemisinin. Our main objective was to test tea infusions and nonpolar extracts prepared from different A. annua varieties against Plasmodium falciparum in vitro in order to determine if synergism will increase the effectiveness of artemisinin in the samples as compared to pure artemisinin. We found that the IC50 of artemisinin in the tea and nonpolar extracts was not significantly different to the IC50 of pure artemisinin. We could show that the year and country of harvest or storage conditions did not have any influence on the activity and that it narrowly followed the concentration of artemisinin in all the extracts. In conclusion, based on these in vitro results, artemisinin seems to be the only active antiplasmodial compound in A. annua. [less ▲]

Detailed reference viewed: 56 (10 ULiège)
Peer Reviewed
See detailIs automatic disinfection between each endoscopy mandatory? Jury opinion
Delwaide, Jean ULiege; Pelckmans, P.; Defrance, P. et al

in Acta Gastro-Enterologica Belgica (1998), 61(4), 429-430

Detailed reference viewed: 14 (0 ULiège)