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Peer Reviewed
See detailNEMA NU1-2001 performance tests of Philips Brightview SPECT cameras
Seret, Alain ULg

in European Journal of Nuclear Medicine and Molecular Imaging (2009, October), 36(S2), 408

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See detailNEMA NU1-2001 performance tests of two Philips Brightview cameras
Seret, Alain ULg

Poster (2009, May)

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See detailNEMA NU4-2008 Image Quality Performance Report for the microPET Focus 120 and for Various Transmission and Reconstruction Methods
Bahri, Mohamed Ali ULg; Plenevaux, Alain ULg; Warnock, Geoffrey ULg et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (2009), 50

This work aimed to evaluate the image quality and accuracy of attenuation and scatter corrections provided with the microPET Focus 120 scanner using the National Electrical Manufacturers Association NU4 ... [more ▼]

This work aimed to evaluate the image quality and accuracy of attenuation and scatter corrections provided with the microPET Focus 120 scanner using the National Electrical Manufacturers Association NU4-2008 image quality phantom. Methods: Attenuation correction was obtained from transmission measurements using either a 68Ge or a 57Copoint source. Fully correctedemission images were reconstructed using Fourier rebinning (FORE) and filtered backprojection (FBP). For attenuation data obtained with the 57Co source, fully corrected emission images were also reconstructed using FORE and 2-dimensional (2D) ordered-subset expectation maximization (OSEM), 3-dimensional (3D) filtered backprojection (3DRP), 3D OSEM, and 3D maximum a posteriori methods. The mean activity, the coefficients of variation (COVs) of the uniform slices, the recovery coefficients (RCs) for hot rods, and the spillover ratio (SOR) for nonemittingwater and air compartments were measured. Results: For 57Co-based attenuation correction, the mean activity value differed by less than 3% from the true activity.Measuring the attenuation with 68Ge resulted in lower reconstructed activity and higher COV. On the basis of 57Co measurements, the SORs for air and water nonemitting compartments were the closest to zero for attenuation correction. The RC measured on emission images corrected for attenuation but not for scatter did not show any significant difference linked to the transmissionmethod. However, higherRCswere noted for transmission measurement with 68Ge in coincidence with windowing when emission data were corrected for attenuation and scatter. This resulted from a lower mean value in the uniform area. 2D and 3DRP reconstructionmethods showed little effect on themean activity value, whereas iterative 3D methods gave 7%higher values. Higher RCs were found with iterative reconstruction than with FBP and 3DRP. However, the SOR seemed to be optimal with FBP. SORs were higher with iterative methods and decreased with the number of iterations. Conclusion: For studies of small rodents with the Focus 120, 57Co transmission seems to be the most suitable method for attenuation correction. FORE and 2D reconstruction methods appear to be a good compromise between overall image quality and reconstruction time: OSEM provides the largest contrasts, but FBP provides superior attenuation and scatter correction. [less ▲]

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See detailNEMA NU4-2008 Performance Evaluation for the MicroPET FOCUS 120 and Iodine-124
Taleb, Dounia ULg; Bahri, Mohamed Ali ULg; Warnock, Geoffrey ULg et al

in IEEE proceedings of ANIMMA 2011 (2012, March 12)

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See detailNEMA NU4-2008 performance evaluation for the microPET Focus 120 and iodine-124
Taleb, Dounia ULg

Conference (2011, June 09)

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See detailNematocidal compounds from the seeds of Balanites aegyptiaca isolation and structure elucidation.
Gnoula, C.; Guissou, P.; Duez, P. et al

in International Journal of Pharmacology (2007), 3(3), 280-284

A study was conducted to characterize the anthelmintic activity and to isolate the main nematocidal agent of B. aegyptiaca plant. The anthelmintic activity was evaluated in vitro by means of an original ... [more ▼]

A study was conducted to characterize the anthelmintic activity and to isolate the main nematocidal agent of B. aegyptiaca plant. The anthelmintic activity was evaluated in vitro by means of an original anthelmintic assay using Caenorhabditis elegans as a biological model. Fluorescence microscopy was used for the determination of the percentage of worm death. The structure elucidation was based on NMR, mass spectroscopic analysis and chemical methods. A bioassay-directed fractionation of the aqueous extract of B. aegyptiaca led to the isolation of balanitin-7 (also named diosgenin 3beta-O-beta-D-xylopyranosyl-(1->3)-beta-D-glucopyranosyl-(1->4)-[alpha- L-rhamnopyranosyl-(1->2)]-beta-D-glucopyranoside), as being the principal nematicidal agent. These data indicate that balanitin-7 has an appreciable nematocidal activity, which is not mediated by inducing an anti-acetylcholinesterase activity. [less ▲]

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See detailNematode Infection And Reproduction In Transgenic And Mutant Arabidopsis And Tobacco With An Altered Phenylpropanoid Metabolism
Wuyts, Nathalie; Lognay, Georges ULg; Swennen, R. et al

in Journal of Experimental Botany (2006), 57(11), 2825-2835

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See detailNEO 2003 EH_1, the Quadrantid Shower Parent
Jenniskens, P.; Lyytinen, E.; Jehin, Emmanuel ULg et al

in 35th COSPAR Scientific Assembly (2004)

Near Earth Object 2003 EH_1, first seen by LONEOS on 2003 March 6, was identified in early December as the parent of the Quadrantid shower based on the orbit calculated from 48 days of observations ... [more ▼]

Near Earth Object 2003 EH_1, first seen by LONEOS on 2003 March 6, was identified in early December as the parent of the Quadrantid shower based on the orbit calculated from 48 days of observations following its discovery [1]. The Quadrantids is our most intense annual shower and was until now the only major shower with no parent body. The orbit matches the inclination, semi-major axis, and argument of perihelion of the Quadrantid meteoroids, but has a perihelion distance outside of Earth orbit. It was shown that frequent close encounters with Jupiter result in a rapid dispersion of perihelion distances, accounting for the current orbit of the parent body. The dispersion of orbits in the meteor shower implies a young ˜ 500 year age and the large mass in the stream suggests formation during a comet breakup. This leaves open the possibility that comet C/1490 Y1 was a sighting of the object shortly after it broke up near aphelion, but to match the perihelion time with that of the backward integrated orbit of 2003 EH_1, a better orbit solution is needed. In December and January of 2003, we recovered the object with the ESO New Technology Telescope and computed a much improved orbit. We used that new orbit to study the formation of the Quadrantid stream for various epochs of ejection. In the context of evaluating the NEO impact hazard, those meteoroids trace the orbital evolution of other possible fragments from the breakup 500 years ago that may now be on a collision course with Earth. [1] P. Jenniskens, B.G. Marsden (2003) IAU Circular 8252 - December 08, 2003 (D.W.E. Green, ed.); P. Jenniskens (2004) 2003 EH_1 is the Quadrantid shower parent comet. Astronomical Journal (in press); http://leonid.arc.nasa.gov [less ▲]

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See detailLe néo-corporatisme réinterpellé : analyse comparée de deux politiques d'accès à l'emploi, l'apprentissage industriel en Belgique et le contrat de qualification "jeunes" en France
Levêque, Audrey ULg

Doctoral thesis (2006)

L'étude comparative de l'apprentissage industriel en Belgique francophone et du contrat de qualification "jeunes" en France permet de réinterpeller le modèle néo-corporatiste d'Etat social. L'analyse de l ... [more ▼]

L'étude comparative de l'apprentissage industriel en Belgique francophone et du contrat de qualification "jeunes" en France permet de réinterpeller le modèle néo-corporatiste d'Etat social. L'analyse de l'émergence et de la mise en oeuvre de ces deux politiques publiques d'accès à l'emploi pour les jeunes peu qualifiés permet de comprendre comment elles sont réappropriées par les acteurs de terrain et ce, plus particulièrement dans la branche de la métallurgie. Si ces politiques s'adressent théoriquement à ces jeunes peu qualifiés, la mise en oeuvre fait apparaître les employeurs au centre des deux dispositifs. Une logique de recrutement se substitue ainsi à une logique de formation. Si deux régulations particulières émergent, le rôle des partenaires sociaux, véritables activateurs de ces politiques, est primordial dans les deux cas. Acteurs clés du modèle néo corporatiste, ce dernier se voit réinterpellé à la lueur de cette recherche. [less ▲]

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See detailLe néo-japonisme. La contribution de la calligraphie japonaise à la peinture abstraite d’après-guerre
Bawin, Julie ULg

Master of advanced studies dissertation (2000)

Detailed reference viewed: 87 (5 ULg)
See detailNéo-populismes, régionalismes radicaux et sous-nationalismes en Europe occidentale
Martiniello, Marco ULg

Scientific conference (2011, May 06)

Detailed reference viewed: 24 (3 ULg)
Peer Reviewed
See detailNeo-pouce par transplantation microchirurgicale du second orteil. A propos de deux observations.
Lejeune, G; Yoshimura, D; Alexandre, G et al

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1978), 133(11), 583-93

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See detailLe néo-régionalisme et l'UE dans le cadre de la globalisation
Santander, Sébastian ULg; Telò, Mario

in Magnette et Remacle, Paul et Eric (Ed.) Le nouveau modèle européen (2000)

L'article porte sur le nouveau régionalisme et l'Union européenne dans les relations internationales. Il vise à répondre aux questions suivantes: l'Union européenne exporte-t-elle son modèle d'intégration ... [more ▼]

L'article porte sur le nouveau régionalisme et l'Union européenne dans les relations internationales. Il vise à répondre aux questions suivantes: l'Union européenne exporte-t-elle son modèle d'intégration dans le monde? Comment? Avec quelles conséquences pour la gouvernance de la globalisation? Il est structuré en trois parties : dans la première partie, nous attirons l'attention sur l'importance du débat ouvert dans la littérature scientifique internationale concernant la nature du néo-régionalisme dans le monde, ses causes et ses implications dans le cadre des négociations multilatérales. Dans la deuxième partie, nous présentons une étude de cas, consacrée aux relations entre l'Union européenne et le MERCOSUR, organisation régionale la plus importante de l'Amérique Latine. Le papier se termine par des réflexions à propos de l'identité internationale de l'Union européenne. [less ▲]

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See detailNéo-rhétoriques made in Belgium : figures de style et argumentation
Leclercq, Bruno ULg

in Argumentum (2011), 9

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See detailNeoadjuvant chemotherapy in breast cancer induces miR-34a and miR-122 expression
FRERES, Pierre ULg; JOSSE, Claire ULg; Bovy, Nicolas ULg et al

in Journal of Cellular Physiology (2014)

Circulating microRNAs (miRNAs) have been extensively studied in cancer as biomarkers but little is known regarding the influence of anti-cancer drugs on their expression levels. In this article, we ... [more ▼]

Circulating microRNAs (miRNAs) have been extensively studied in cancer as biomarkers but little is known regarding the influence of anti-cancer drugs on their expression levels. In this article, we describe the modifications of circulating miRNAs profile after neoadjuvant chemotherapy (NAC) for breast cancer. The expression of 188 circulating miRNAs was assessed in the plasma of 25 patients before and after NAC by RT-qPCR. Two miRNAs, miR- 34a and miR-122, that were significantly increased after NAC, were measured in tumor tissue before and after chemotherapy in 7 patients with pathological partial response (pPR) to NAC. These 2 chemotherapy-induced miRNAs were further studied in the plasma of 22 patients with adjuvant chemotherapy (AC) as well as in 12 patients who did not receive any chemotherapy. Twenty-five plasma miRNAs were modified by NAC. Among these miRNAs, miR-34a and miR-122 were highly upregulated, notably in pPR patients with aggressive breast cancer. Furthermore, miR-34a level was elevated in the remaining tumor tissue after NAC treatment. Studying the kinetics of circulating miR-34a and miR-122 expression during NAC revealed that their levels were especially increased after anthracycline-based chemotherapy. Comparisons of the plasma miRNA profiles after NAC and AC suggested that chemotherapy-induced miRNAs originated from both tumoral and non-tumoral compartments. This study is the first to demonstrate that NAC specifically induces miRNA expression in plasma and tumor tissue, which might be involved in the anti-tumor effects of chemotherapy in breast cancer patients. [less ▲]

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See detailNeoadjuvant chemotherapy in breast cancer patients induces expression of tumor suppressor miR-34a
FRERES, Pierre ULg

Poster (2014, May 19)

Circulating microRNAs (miRNAs) are extensively studied in cancer as biomarkers but little is known about the influence of anti-cancer drugs on their expression. In this presentation, we describe the ... [more ▼]

Circulating microRNAs (miRNAs) are extensively studied in cancer as biomarkers but little is known about the influence of anti-cancer drugs on their expression. In this presentation, we describe the modifications of circulating miRNAs profile under neoadjuvant chemotherapy (NAC) for breast cancer. [less ▲]

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See detailNeoadjuvant Radiochemotherapy of Locally/Regionally Advanced Rectal Cancer is a standard treatment option
Farkas, Róbert; Al-Farhat, Yousuf; GULYBAN, Akos ULg et al

in Radiotherapy & Oncology (2006), 81(suppl1), 237

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See detailNeoadjuvant treatment with docetaxel plus lapatinib, trastuzumab, or both followed by an anthracycline based chemotherapy in HER2-positive breast cancer: results of the randomised phase II EORTC 10054 study.
Bonnefoi, H.; Jacot, W.; Saghatchian, M. et al

in Annals of oncology : official journal of the European Society for Medical Oncology / ESMO (2014)

BACKGROUND: Neoadjuvant trials conducted using a double HER2-blockade with lapatinib and trastuzumab, combined with different paclitaxel-containing chemotherapy regimens, have shown high pathological ... [more ▼]

BACKGROUND: Neoadjuvant trials conducted using a double HER2-blockade with lapatinib and trastuzumab, combined with different paclitaxel-containing chemotherapy regimens, have shown high pathological complete response (pCR) rates, but at the cost of important toxicity. We hypothesised that this toxicity might be due to a specific interaction between paclitaxel and lapatinib. This trial assesses the toxicity and activity of the combination of docetaxel with lapatinib and trastuzumab. PATIENTS AND METHODS: Patients with stage IIA to IIIC HER2-positive breast cancer received six cycles of chemotherapy (three cycles of docetaxel followed by three cycles of fluorouracil, epirubicin, cyclophosphamide). They were randomised 1:1:1 to receive during the first three cycles either lapatinib (1000 mg orally daily), trastuzumab (4 mg/kg loading dose followed by 2 mg/kg weekly), or trastuzumab+lapatinib at the same dose. The primary endpoint was pCR rate defined as ypT0/is. Secondary endpoints included safety and toxicity. pCR rate defined as ypT0/is ypN0 was assessed as an exploratory analysis. In June 2012, arm A was closed for futility based on the results from other studies. RESULTS: From October 2010 to January 2013, 128 patients were included in 14 centres. The percentage of the 122 evaluable patients with pCR in the breast, and pCR in the breast and nodes, was numerically highest in the lapatinib+trastuzumab group (60% and 56%, respectively), intermediate in the trastuzumab group (52% and 52%), and lowest in the lapatinib group (46% and 36%). Frequency (%) of the most common grade 3-4 toxicities in the lapatinib /trastuzumab/lapatinib+trastuzumab arms were: febrile neutropenia 23/15/10, diarrhea 9/2/18, infection (other) 9/4/8, and hepatic toxicity 0/2/8. CONCLUSIONS: This study demonstrates a numerically modest pCR rate increase with double anti-HER2 blockade plus chemotherapy, but suggests that the use of docetaxel rather than paclitaxel may not reduce toxicity. This study is registered with ClinicalTrials.gov, number NCT00450892. [less ▲]

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See detailNeodymium: YAG laser hysteroscopy in large submucous fibroids.
Donnez, Jacques; Gillerot, Stéphane; Bourgonjon, Damien et al

in Fertility and Sterility (1990), 54(6), 999-1003

The preoperative use of a potent, subcutaneously injected gonadotropin-releasing hormone agonist (GnRH-a) was evaluated in a series of 60 women with large submucosal fibroids. Myomectomy by hysteroscopy ... [more ▼]

The preoperative use of a potent, subcutaneously injected gonadotropin-releasing hormone agonist (GnRH-a) was evaluated in a series of 60 women with large submucosal fibroids. Myomectomy by hysteroscopy and Nd:YAG laser was easily performed. In 12 cases, the largest portion of the myoma was not inside the uterine cavity and myomectomy was carried by a two-step hysteroscopy. In women who wished to become pregnant, a pregnancy rate of 66% was achieved. Advantages of preoperative use of a GnRH-a are (1) the significant decrease of the fibroid size, (2) a lower fluid absorption, and (3) the restoration of a normal hemoglobin concentration. [less ▲]

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