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See detailNo-carrier-added asymmetric synthesis of alpha-methyl-alpha-amino acids labelled with fluorine-18
Damhaut, Philippe; Lemaire, Christian ULg; Plenevaux, Alain ULg et al

in Tetrahedron (1997), 53(16), 5785-5796

Various [18F]fluoro aromatic α-methyl-L-amino acids 11 have been synthesized with high enantiomeric purity (ee > 97%). These new radiopharmaceuticals for Positron Emission Tomography (PET), potential ... [more ▼]

Various [18F]fluoro aromatic α-methyl-L-amino acids 11 have been synthesized with high enantiomeric purity (ee > 97%). These new radiopharmaceuticals for Positron Emission Tomography (PET), potential inhibitors of enzymatic functions, were regiospecifically labelled by nucleophilic substitution on trimethylammoniumbenzaldehyde triflate precursors 9. The [18F]fluoro aromatic aldehydes 12 obtained were easily converted to the corresponding [18F]fluorobenzyl halides [13 (X = 1)]. After alkylation of the lithium enolate of (2S,5S)-l-tert-Boc-2-tert-butyl-3,5-dimethyl-imidazolidin-4-one 2, the adducts were cleaved to give, after HPLC purification, various [18F]fluoro-α-methyl amino acid analogs with radiochemical yields of 10% (End of Bombardment, EOB) after a synthesis time of 120 min. The corresponding [19F]fluorinated amino acids 4 and [19F]fluoro intermediates were also prepared. [less ▲]

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See detailNo-carrier-added regioselective preparation of 6-[18F]fluoro-L-dopa
Lemaire, Christian ULg; Guillaume, Marcel ULg; Cantineau, Robert et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1990), 31(7), 1247-1251

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See detailNo-Carrier-Added Regioselective Preparation of 6-[18f]Fluoro-L-Dopa
Bozet, Claire ULg; Guillaume, Marcel; Cantineau, R. et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1990), 31(7), 1247-51

This paper describes the preparation of 6-[18F]fluoro-L-dopa by a no-carrier-added method based on the nucleophilic displacement of nitro groups of two commercially available substrates, 3,4-dimethoxy-2 ... [more ▼]

This paper describes the preparation of 6-[18F]fluoro-L-dopa by a no-carrier-added method based on the nucleophilic displacement of nitro groups of two commercially available substrates, 3,4-dimethoxy-2-nitrobenzaldehyde (nitroveratraldehyde) and 6-nitropiperonal. Fluorination was conducted in DMSO with fluorine-18 (18F) in the presence of the aminopolyether Kryptofix 222 and potassium carbonate. The condensation of the fluorinated aldehydes with phenyloxazolone and the subsequent hydrolysis with HI/P yield, after purification by HPLC, only the 6-(D, L) isomers. The racemic mixture (50/50) was resolved on an analytical scale chiral column. The method, which requires 100 min (EOB) to complete, produces 6-[18F]fluoro-L-dopa with a decay-corrected radiochemical yield of 10%, an enantiomeric purity greater than 99%, and a specific activity of 1.2 Ci/mumole. [less ▲]

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See detailNO2 and CO interaction with plasma treated Au-decorated MWCNTs: Detection pathways
Leghrib, R.; Llobet, E.; Felten, A. et al

in Procedia Chemistry (2009), 1(1), 931-934

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See detailNO3- Reduction is Fe-Dependent in a Ferruginous Chemocline
Michiels, C.; Darchambeau, François ULg; Roland, Fleur ULg et al

Conference (2014)

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See detailNoam Chomsky, De quoi les médias dominants tirent-ils leur domination ?
Durand, Pascal ULg

in Durand, Pascal (Ed.) Médias et Censure. Figures de l'orthodoxie (2004)

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See detailNoble, chevalier, pénitent, martyr : l'idéal de sainteté d'après une Vita mosane du XIIe siècle
George, Philippe ULg

in Moyen Age (Le) (1983), LXXXIX

Un nouvel idéal, l'idéal du chevalier chrétien, est mis en exergue dans une Vie latine mosane du XIIe siècle

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See detailNoblesse éclairée, bourgeoisie tendre dans la principauté de Liège au XVIIIe siècle
Droixhe, Daniel ULg

in Etudes sur le XVIIIe siècle (1982), 9

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See detailLa noblesse en milieu urbain dans l’espace mosan (XIIIe-XVe siècles)
Marchandisse, Alain ULg

in Dutour, Thierry (Ed.) Les Nobles et la ville dans l’espace francophone (XIIe-XVIe siècles) (2010)

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See detailNoblesse féodale et pouvoir épiscopal dans la principauté de Liège des XIIIe-XVe siècles
Marchandisse, Alain ULg

in Gentile, Marco; Savy, Pierre (Eds.) Noblesse et États princiers en Italie et en France au XVe siècle (2009)

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See detailA noção de texto em Hjelmslev
Badir, Sémir ULg

in CASA : Cadernos de Semiótica Aplicada (2005), 3(2),

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See detailNociception coma scale-revised scores correlate with metabolism in the anterior cingulate cortex.
Chatelle, Camille ULg; Thibaut, Aurore ULg; Bruno, Marie-Aurelie et al

in Neurorehabilitation and neural repair (2014), 28(2), 149-52

BACKGROUND: . The Nociception Coma Scale-Revised (NCS-R) was recently validated to assess possible pain perception in patients with disorders of consciousness. OBJECTIVE: . To identify correlations ... [more ▼]

BACKGROUND: . The Nociception Coma Scale-Revised (NCS-R) was recently validated to assess possible pain perception in patients with disorders of consciousness. OBJECTIVE: . To identify correlations between cerebral glucose metabolism and NCS-R total scores. METHODS: . [18F]-fluorodeoxyglucose positron emission tomography, NCS-R, and Coma Recovery Scale-Revised assessments were performed in 49 patients with disorders of consciousness. RESULTS: . We identified a significant positive correlation between NCS-R total scores and metabolism in the posterior part of the anterior cingulate cortex, known to be involved in pain processing. No other cluster reached significance. No significant effect of clinical diagnosis (vegetative/unresponsive vs minimally conscious states), etiology or interval since insult was observed. CONCLUSIONS: . Our data support the hypothesis that the NCS-R total scores are related to cortical processing of nociception and may constitute an appropriate behavioral tool to assess, monitor, and treat possible pain in brain-damaged noncommunicative patients with disorders of consciousness. Future studies using event-related functional magnetic resonance imaging should investigate the correlation between NCS-R scores and brain activation in response to noxious stimulation at the single-subject level. [less ▲]

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See detailThe nociception coma scale: A new tool to assess nociception in disorders of consciousness.
Schnakers, Caroline ULg; Chatelle, Camille ULg; Vanhaudenhuyse, Audrey ULg et al

in Pain (2010), 148

Assessing behavioral responses to nociception is difficult in severely brain-injured patients recovering from coma. We here propose a new scale developed for assessing nociception in vegetative (VS) and ... [more ▼]

Assessing behavioral responses to nociception is difficult in severely brain-injured patients recovering from coma. We here propose a new scale developed for assessing nociception in vegetative (VS) and minimally conscious (MCS) coma survivors, the Nociception Coma Scale (NCS), and explore its concurrent validity, inter-rater agreement and sensitivity. Concurrent validity was assessed by analyzing behavioral responses of 48 post-comatose patients to a noxious stimulation (pressure applied to the fingernail) (28 VS and 20 MCS; age range 20-82years; 17 of traumatic etiology). Patients' were assessed using the NCS and four other scales employed in non-communicative patients: the 'Neonatal Infant Pain Scale' (NIPS) and the 'Faces, Legs, Activity, Cry, Consolability' (FLACC) used in newborns; and the 'Pain Assessment In Advanced Dementia Scale' (PAINAD) and the 'Checklist of Non-verbal Pain Indicators' (CNPI) used in dementia. For the establishment of inter-rater agreement, fifteen patients were concurrently assessed by two examiners. Concurrent validity, assessed by Spearman rank order correlations between the NCS and the four other validated scales, was good. Cohen's kappa analyses revealed a good to excellent inter-rater agreement for the NCS total and subscore measures, indicating that the scale yields reproducible findings across examiners. Finally, a significant difference between NCS total scores was observed as a function of diagnosis (i.e., VS or MCS). The NCS constitutes a sensitive clinical tool for assessing nociception in severely brain-injured patients. This scale constitutes the first step to a better management of patients recovering from coma. [less ▲]

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See detailNociceptive blink reflex and visual evoked potential habituations are correlated in migraine
Di Clemente, Laura; Coppola, Gianluca; Magis, Delphine ULg et al

in Headache (2005), 45(10, Nov-Dec), 1388-1393

BACKGROUND: Lack of habituation, as reported in migraine patients between attacks for evoked cortical responses, was also recently found for the nociceptive blink reflex (nBR) mediated by brainstem ... [more ▼]

BACKGROUND: Lack of habituation, as reported in migraine patients between attacks for evoked cortical responses, was also recently found for the nociceptive blink reflex (nBR) mediated by brainstem neurons. It is not known if both brain stem and cortical habituation deficits are correlated in the same patient, which would favor a common underlying mechanism. OBJECTIVE: To search for intraindividual correlations between habituation of pattern reversal-visual evoked potentials and that of the nociception-specific blink reflex in migraineurs and in healthy volunteers (HV). METHODS: We recorded 15 HV and 15 migraine without aura patients between attacks. Habituation for visual evoked potentials was measured by comparing the N1-P1 amplitude change (%) between the first and sixth block of 100 sequential averaged responses. Habituation for the nBR was defined as the percentage change of the R2 response area between the 1st and 10th block of five averaged EMG responses, elicited by stimulating the right side every 2 minutes for 32 minutes. We also calculated the slope of N1-P1 amplitude and R2 response area changes from the first to the last response and the correlation with attack frequency. RESULTS: A significant habituation deficit in both cortical and brain stem evoked activity characterized on average the group of migraineurs compared to controls. In migraine patients, but not in HV, we found a significant positive correlation between habituation of pattern reversal-visual evoked potentials and that of the nociception-specific blink reflex both for the degree of habituation between first and last blocks of averagings (r = 0.703; P = .003) and for the habituation slope (r = 0.751; P = .001). Moreover, nBR habituation was positively correlated with attack frequency (r = 0.548; P = .034). CONCLUSION: The positive correlation between visual evoked potential and nBR habituations is consistent with the idea that in migraine the same neurobiological dysfunction might be responsible for the habituation deficit both in cortex and brain stem. As nBR habituation increases with attack frequency, its interictal deficit is unlikely to be due to trigeminal sensitization. [less ▲]

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See detailNocturnal moth inventory in Malagasy tapia woods, with focus on silk-producing species
Barsics, Fanny ULg; Razafimanantsoa, Tsiresy Maminiaina; Minet, Joël et al

in Verheggen, François; Bogaert, Jan; Haubruge, Eric (Eds.) Les vers à soie malgaches. Enjeux écologiques et socio-économiques (2013)

In Madagascar, the tapia woods (Uapaca bojeri) shelter a wide diversity of moth species, among which the landibe, a silk moth of the genus Borocera. Threatened by diverse pressures – anthropogenic and ... [more ▼]

In Madagascar, the tapia woods (Uapaca bojeri) shelter a wide diversity of moth species, among which the landibe, a silk moth of the genus Borocera. Threatened by diverse pressures – anthropogenic and environmental – its populations have drastically decreased during the last twenty years. We report on night inventories by means of light traps, performed in the tapia woods. We observed at least 68 species, notably another silk producing moth, Europtera punctillata, whose caterpillars are called landifotsy by villagers. We unveiled specific behavioural traits of species sampled during four successive night periods, between 8:00 pm and 4:00 am. sixty-eight moth species were observed, some of them are silk producing species, including landifotsy (E. punctillata). [less ▲]

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See detailNocturnal vertical migrations by amphipods of the Posidonia oceanica (L.) Delile foliar stratum : Importance of the litter cover
Michel, Loïc ULg; Sturaro, Nicolas ULg; Lepoint, Gilles ULg et al

Poster (2007, November)

In seagrass meadows, several groups of vagile invertebrates are well known to perform a nocturnal rise from the lower layers of the meadow to the foliar stratum. This vertical migration is generally ... [more ▼]

In seagrass meadows, several groups of vagile invertebrates are well known to perform a nocturnal rise from the lower layers of the meadow to the foliar stratum. This vertical migration is generally regarded as a defense mechanism against predation by diurnal fishes, as well as a mean to maximize the exploitation of trophic resources offered by the meadow. Here, we focused on the amphipods from a Mediterranean Posidonia oceanica meadow. We sampled the community present in the meadows of Calvi Bay (NW Corsica) using two different techniques (hand-towed net and litter collecting). Samples were taken at two seasons, during both night and daytime. Our results confirm the nocturnal rise to the foliar stratum. Combined to an analysis of the recent literature, they also tend to show that amphipods spend the daytime not in the matte itself, as it has been proposed in the past, but in the thin layer of Posidonia litter present at the interface between the foliar stratum and the root/rhizome system. This would emphasize the role of the litter cover in the complexity of the habitat within the meadow, and therefore in the vagile invertebrate community structure and the functioning of the whole meadow as an ecosystem. [less ▲]

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See detailNOD2 interactome
Lecat, Aurore ULg; Di Valentin, Emmanuel ULg; Fillet, Marianne ULg et al

Poster (2010, January 28)

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See detailNOD2/CARD15 does not influence response to infliximab in Crohn's disease
Vermeire, S.; Louis, Edouard ULg; Rutgeerts, P. et al

in Gastroenterology (2002), 123(1), 106-111

Background

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See detailNodal staging of head and neck squamous cell carcinomas : impact of a dedicated PET/CT protocol.
MINON, AL.; CABAY, Jean-Evrard ULg; DEMEZ, Pierre ULg et al

in Journal of Nuclear Medicine (The) (2012), 53(SUPPL), 1354

Detailed reference viewed: 6 (1 ULg)