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See detailPotential antimalarial activity of indole alkaloids
Angenot, Luc ULg

Conference (2006, July 06)

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See detailPotential Antioxidant properties of Aceclofenac and its Metabolites: Investigation on an in vitro model
Mouithys-Mickalad, Ange ULg; Mathy, Marianne ULg; Deby, Carol et al

Poster (2001, June 22)

Introduction: Recent studies have shown that some steroidal anti-inflammatory drugs (NSAIDs) could exert their actions by multifactorial processes. Among them, the potential antioxidant activity of ... [more ▼]

Introduction: Recent studies have shown that some steroidal anti-inflammatory drugs (NSAIDs) could exert their actions by multifactorial processes. Among them, the potential antioxidant activity of certain NSAIDs towards various reactive oxygen species (ROS) is often suggested and could have pharmacological relevance. Objective: This study was designed to assess the potential antioxidant properties (IC50 values) of aceclofenac and its metabolites (4’OH-aceclofenanc and diclofenac) on three different systems of ROS production, using chemiluminescence (CL) technique with luminal and electron spin resonance (ESR) spin trapping. Material and Methods: Isolated human PMNs (1x106 cells) were activated with 5x10-7 M PMA in the presence of luminal (CL assays) with or without drug addition. For spin trapping experiments, 100 mM DMPO, a radical trapping agent, was added to the reaction milieu containing 6x106 cells/ml. For free-cell experiments, the Fenton’s reagent was used for generation of ·OH and xanthine/xanthine-oxidase system for O2-radicals. The NaOCl-induced CL, amplified by luminal, was used to test the drug effects on HOCl. Results: On the model of PMA-activated PMNs, 4’OH-aceclofenac exhibited the best antioxidant profile (IC50 = 10 µM) while the effect of the parent drug was less pronounced (IC50 = 100 µM). Diclofenac did not inhibit CL response even at the high dose of 1 mM. Quite similar results were obtained on the NaOCl-induced chemiluminescence, where the efficacy of the drug was as follows: 4’HO-ACE (25 µM) > ACE (1 mM) > DICLO (no effect at 1 mM). By ESR technique, 4’HO-ACE also showed an inhibitory effect (501 µM) on the ROS production by PMA-activated PMN as well as on the ·OH production, while ACE (IC50 = 100 µM) was less efficient and DICLO (IC50 = 1 mM) without significant effect. These findings indicate that beside its anti-inflammatory effects, aceclofenac acts as an antioxidant, at least in part, by the way of its metabolite especially 4’HO-ACE. [less ▲]

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See detailPotential applications of PET imaging in developing novel cancer therapies.
Hustinx, Roland ULg; Eck, S. L.; Alavi, A.

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1999), 40(6), 995-1002

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See detailPotential benefits of laparoscopic aorto-bifemoral bypass surgery
Rouers, Anthony; MEURISSE, Nicolas; LAVIGNE, Jean-Paul ULg et al

in Acta Chirurgica Belgica (2005), 105(6), 610-615

Background: This series aims to prove the positive impact of laparoscopic approach in aortofemoral bypass grafting. Methods : It concerns a retrospective non randomized study comparing 58 consecutive ... [more ▼]

Background: This series aims to prove the positive impact of laparoscopic approach in aortofemoral bypass grafting. Methods : It concerns a retrospective non randomized study comparing 58 consecutive patients treated with laparoscopic procedure (n = 30) and with a standard open procedure (n = 28) in a single center. The different operating times, the complications and the follow-up of these two groups are compared Results : The demographics and angiographic data of the two groups were comparable. Operating time was longer in the laparoscopic group. However, we noticed a significant shorter hospitalisation stay (p < 0.0001) after the laparoscopic procedure with a mean 5.1 days. There was no significant difference of morbidity. Conclusion : We suggest that the trans-peritoneal approach is the best way in laparoscopic procedure in term of exposure and ergonomics. Laparoscopic aortofemoral bypass grafting is feasible, safe and effective. Shortening of operating time is observed as surgeon's experience grows. [less ▲]

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See detailPotential Clinical and Economic Impact of Nonadherence with Osteoporosis Medications.
Hiligsmann, Mickaël ULg; Rabenda, Véronique ULg; Gathon, Henry-Jean ULg et al

in Calcified Tissue International (2010), 86

This study aims to estimate the potential clinical and economic implications of therapeutic adherence to bisphosphonate therapy. A validated Markov microsimulation model was used to estimate the impact of ... [more ▼]

This study aims to estimate the potential clinical and economic implications of therapeutic adherence to bisphosphonate therapy. A validated Markov microsimulation model was used to estimate the impact of varying adherence to bisphosphonate therapy on outcomes (the number of fractures and the quality-adjusted life-years [QALYs]), health-care costs, and the cost-effectiveness of therapy compared with no treatment. Adherence was divided into persistence and compliance, and multiple scenarios were considered for both concepts. Analyses were performed for women aged 65 years with a bone mineral density T-score of -2.5. Health outcomes and the cost-effectiveness of therapy improved significantly with increasing compliance and/or persistence. In the case of real-world persistence and with a medical possession ratio (MPR; i.e., the number of doses taken divided by the number of doses prescribed) of 100%, the QALY gain and the number of fractures prevented represented only 48 and 42% of the values estimated assuming full persistence, respectively. These proportions fell to 27 and 23% with an MPR value of 80%. The costs per QALY gained, for branded bisphosphonates (and generic alendronate), were estimated at <euro>19,069 (<euro>4,871), <euro>32,278 (<euro>11,985), and <euro>64,052 (<euro>30,181) for MPR values of 100, 80, and 60%, respectively, assuming real-world persistence. These values were <euro>16,997 (<euro>2,215), <euro>24,401 (<euro>6,179), and <euro>51,750 (<euro>20,569), respectively, assuming full persistence. In conclusion, poor compliance and failure to persist with osteoporosis medications results not only in deteriorating health outcomes, but also in a decreased cost-effectiveness of drug therapy. Adherence therefore remains an important challenge for health-care professionals treating osteoporosis. [less ▲]

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See detailPotential contribution of prenatal estrogens to the sexual differentiation of mate preferences in mice.
Brock, Olivier; Bakker, Julie ULg

in Hormones and Behavior (2011), 59(1), 83-9

The neural mechanisms controlling sexual behavior are sexually differentiated by perinatal actions of gonadal hormones. We recently observed using female mice deficient in alpha-fetoprotein (AFP-KO) and ... [more ▼]

The neural mechanisms controlling sexual behavior are sexually differentiated by perinatal actions of gonadal hormones. We recently observed using female mice deficient in alpha-fetoprotein (AFP-KO) and which lack the protective actions of AFP against maternal estrogens, that exposure to prenatal estrogens completely defeminized their potential to show lordosis behavior in adulthood. Therefore, we determined here whether mate preferences were also affected in female AFP-KO mice. We observed a robust preference for an estrous female over an intact male in female AFP-KO mice, which were ovariectomized in adulthood and subsequently treated with estradiol and progesterone, whereas similarly treated WT females preferred the intact male over the estrous female. Gonadally intact WT males preferred the estrous female over the male, but only when visual cues were blocked by placing stimulus animals behind opaque partitions. Furthermore, when given the choice between an intact male and a castrated male, WT females preferred the intact male, whereas AFP-KO females showed no preference. Finally when given the choice between an estrous female and an ovariectomized female, WT males preferred the estrous female whereas AFP-KO females preferred the ovariectomized female or showed no preference depending on whether they could see the stimulus animals or not. Taken together, when AFP-KO females are tested under estrous conditions, they do not show any male-directed preferences, indicating a reduced sexual motivation to seek out the male in these females. However, they do not completely resemble males in their mate preferences suggesting that the male-typical pattern of mate preferences is not solely organized by prenatal estrogens. [less ▲]

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See detailPotential cost-effectiveness of denosumab for the treatment of postmenopausal osteoporotic women.
Hiligsmann, Mickaël ULg; Reginster, Jean-Yves ULg

in BONE (2010), 47

Denosumab has recently been shown to be safe and to significantly reduce the risk of vertebral, hip and non-vertebral fractures in the "Fracture REduction Evaluation of Denosumab in Osteoporosis every ... [more ▼]

Denosumab has recently been shown to be safe and to significantly reduce the risk of vertebral, hip and non-vertebral fractures in the "Fracture REduction Evaluation of Denosumab in Osteoporosis every 6Months" (FREEDOM) Trial. Besides the clinical profile of a new drug, it becomes increasingly important to assess whether the drug represents good value for money. This study aims to examine the potential cost-effectiveness of denosumab in the treatment of postmenopausal osteoporotic women. An updated version of a validated Markov microsimulation model was used to estimate the cost (euro2009) per quality-adjusted life-year (QALY) gained of a 3-year denosumab treatment compared with no treatment. The model was populated with cost and epidemiological data for Belgium from a health-care perspective and the base-case population was defined from the FREEDOM Trial. The effect of denosumab after treatment cessation was conservatively assumed to decline linearly over 1year. Uncertainty was investigated using one-way and probabilistic sensitivity analyses. In particular, additional analyses were performed in populations (over 60years) where osteoporosis medications are currently reimbursed in many European countries, i.e. with bone mineral density (BMD) T-score</=-2.5 or prevalent vertebral fracture. In the base-case analysis, the cost per QALY gained of denosumab compared with no treatment was estimated at euro28,441. This value decreased to euro15,532 and to euro11,603 for women with a BMD T-score of -2.5 or prevalent vertebral fracture, respectively. Additional analyses showed that the cost-effectiveness of denosumab fall below commonly accepted threshold of euro30,000per QALY gained for women with a BMD T-score </=-2.5 or prevalent vertebral fracture, over the entire age range examined (60-80years). The results were robust under a wide range of plausible assumptions. In conclusion, this study suggests, on the basis of currently available data, that denosumab is cost-effective compared with no treatment for postmenopausal Belgian women with low bone mass and who are similar to patients included in the FREEDOM Trial. In addition, denosumab was found to be cost-effective in population currently reimbursed in Europe with T-score</=-2.5 or prevalent vertebral fracture, aged 60years and above. Additional data are needed on the relative cost-effectiveness compared with other anti-osteoporotic agents and on the long-term safety of denosumab. [less ▲]

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See detailPotential doubling time determination in a multicentre clinical study.
COUCKE, Philippe ULg

in Abstract book (1996)

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See detailPotential early indicators of anthropogenically derived nutrients : a multiscale stable isotope analysis
Vermeulen, Simon ULg; Sturaro, Nicolas ULg; Gobert, Sylvie ULg et al

in Marine Ecology. Progress Series (2011), 422

Increasing human pressure along Mediterranean coastlines raises the need to define sensitive bioindicators that provide an early response to nutrient enrichment. We performed multiscale carbon and ... [more ▼]

Increasing human pressure along Mediterranean coastlines raises the need to define sensitive bioindicators that provide an early response to nutrient enrichment. We performed multiscale carbon and nitrogen stable isotope analyses on the limpet Patella caerulea, the snail Monodonta turbinata, epilithic biofilms, and the macroalga Rissoella verruculosa inhabiting the rocky midlittoral zone. Samples were seasonally collected in 2006 from 5 sites exposed to a range of anthropogenic discharges in the Revellata Bay area and in Marseille harbour (France). All bioindicators exhibited strongly elevated δ15N values at impacted sites compared to pristine ones, which revealed the biological availability of anthropogenically derived nutrients. Only epilithic biofilms tended to show both the occurrence of nutrient pulses during the tourist season and a δ13C response at impacted sites. In contrast to macroalgae, which exhibited a somewhat equivocal signal, gastropods and especially M. turbinata provided the best time-integrated picture of the graduated exposure of the 5 sites to anthropogenic impact. Results also showed first evidence of large isotopic variability at a scale of tens of metres, close to that found at the kilometre scale. The intra- and interspecific isotopic variability in gastropods may be explained by the patchiness of resources and specific morphological and behavioural features, but these factors do not greatly hamper their potential as early bioindicators of wastewater disturbances. [less ▲]

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See detailPOTENTIAL EFFECTS OF BLOOD CONTAMINANTS ON IMMUNE RESPONSES IN HARBOUR SEALS (PHOCA VITULINA)
Dupont, Aurélie ULg; Weijs, Liesbeth; Siebert, Ursula et al

in Organohalogen Compounds (2011), 73

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See detailPotential effects of blood contaminants on immune responses in harbour seals (Phoca vitulina)
Dupont, Aurélie ULg; Weijs, Liesbeth; Siebert, Ursula et al

Poster (2011, August 23)

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See detailPotential effects of NSAID on myocellular enzyme leakage and delayed onset muscle soreness induced by isokinetic eccentric exercise
Croisier, Jean-Louis ULg; Camus, Gérard; Crielaard, Jean-Michel ULg

in Actes du XIXe Congrès National de la Société Française de Médecine du Sport (1999, October)

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See detailPotential energy surfaces and dissociation mechanisms of molecular ions
Lorquet, Jean-Claude ULg; Dehareng, Dominique ULg; Sannen, Christian et al

in Journal de Chimie Physique (1980), 77

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See detailPotential Energy Surfaces and Theory of Unimolecular Dissociation.
Lorquet, Jean-Claude ULg; Leyh, Bernard ULg

in Almoster Ferreira, M. A. (Ed.) Ionic Processes in the Gas Phase. (1984)

Reaction mechanisms can be determined from ab initio calculations of potential energy surfaces. Their complicated nature explains the frequent success of statistical theories, but non-statistical ... [more ▼]

Reaction mechanisms can be determined from ab initio calculations of potential energy surfaces. Their complicated nature explains the frequent success of statistical theories, but non-statistical behaviour is also accounted for. A certain correlation between structure and reactivity can be established, subject to many qualifications. Information on the nuclear motion on the potential energy surfaces of an ionized molecule can be extracted from a photoelectron spectrum by a Fourier transform operation. [less ▲]

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See detailPotential Estimation of Fatty Acid Content in Cow Milk by Mid-Infrared Spectrometry
Soyeurt, Hélène ULg; Dardenne, Pierre; Lognay, Georges ULg et al

in Prooceedings of the 35th ICAR session (2006)

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See detailPotential estimation of fatty acid content in cow milk by mid-infrared spectrometry
Soyeurt, Hélène ULg; Dardenne, Pierre; Lognay, Georges ULg et al

Conference (2006, June)

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See detailPotential estimation of major mineral contents in cow milk using mid-infrared spectrometry.
Soyeurt, Hélène ULg; Bruwier, Damien; Romnee, Jean-Michel et al

in Journal of Dairy Science (2009), 92(6), 2444-2454

Milk and dairy products are a major source of minerals, particularly calcium, involved in several metabolic functions in humans. Currently, several dairy products are enriched with calcium to prevent ... [more ▼]

Milk and dairy products are a major source of minerals, particularly calcium, involved in several metabolic functions in humans. Currently, several dairy products are enriched with calcium to prevent osteoporosis. The development of an inexpensive and fast quantitative analysis for minerals is required to offer dairy farmers an opportunity to improve the added value of the produced milk. The aim of this study was to develop 5 equations to measure Ca, K, Mg, Na, and P contents directly in bovine milk using mid-infrared (MIR) spectrometry. A total of 1,543 milk samples were collected between March 2005 and May 2006 from 478 cows during the Walloon milk recording and analyzed by MIR spectrometry. Using a principal component approach, 62 milk samples were selected by their spectral variability and separated in 2 calibration sets. Five outliers were detected and deleted. The mineral contents of the selected samples were measured by inductively coupled plasma atomic emission spectrometry. Using partial least squares combined with a repeatability file, 5 calibration equations were built to estimate the contents of Ca, K, Mg, Na, and P in milk. To assess the accuracy of the developed equations, a full cross-validation and an external validation were performed. The cross-validation coefficients of determination (R(2)cv) were 0.80, 0.70, and 0.79 for Ca, Na, and P, respectively (n = 57), and 0.23 and 0.50 for K and Mg, respectively (n = 31). Only Ca, Na, and P equations showed sufficient R(2)cv for a potential application. These equations were validated using 30 new milk samples. The validation coefficients of determination were 0.97, 0.14, and 0.88 for Ca, Na, and P, respectively, suggesting the potential to use the Ca and P calibration equations. The last 30 samples were added to the initial milk samples and the calibration equations were rebuilt. The R(2)cv for Ca, K, Mg, Na, and P were 0.87, 0.36, 0.65, 0.65, and 0.85, respectively, confirming the potential utilization of the Ca and P equations. Even if new samples should be added in the calibration set, the first results of this study showed the feasibility to quantify the calcium and phosphorus directly in bovine milk using MIR spectrometry. [less ▲]

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See detailPotential Estimation of Minerals Content in Cow Milk Using Mid-Infrared Spectrometry
Soyeurt, Hélène ULg; Bruwier, Damien; Gengler, Nicolas ULg et al

in ICAR Proceedings of the Biennial Sessions (2008, June 16)

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