Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailMannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study.
Mandal, Jyotshna; Malla, Bijaya; Steffensen, Rudi et al

in Respiratory research (2015), 16

BACKGROUND: Functional deficiency of mannose-binding lectin (MBL) may contribute to the pathogenesis of chronic obstructive pulmonary disease. We hypothesized that specific MBL2 gene polymorphisms and ... [more ▼]

BACKGROUND: Functional deficiency of mannose-binding lectin (MBL) may contribute to the pathogenesis of chronic obstructive pulmonary disease. We hypothesized that specific MBL2 gene polymorphisms and circulating MBL protein levels are associated with clinically relevant outcomes in the Predicting Outcome using systemic Markers In Severe Exacerbations of COPD PROMISE-COPD cohort. METHODS: We followed 277 patients with stable COPD GOLD stage II-IV COPD over a median period of 733 days (IQR 641-767) taking survival as the primary outcome parameter. Patients were dichotomized as frequent (>/= 2 AECOPD/year) or infrequent exacerbators. Serum MBL levels and single nucleotide polymorphisms of the MBL2 gene were assessed at baseline. RESULTS: The MBL2-HYPD haplotype was significantly more prevalent in frequent exacerbators (OR: 3.33; 95% CI, 1.24-7.14, p = 0.01). The median serum MBL concentration was similar in frequent (607 ng/ml, [IQR; 363.0-896.0 ng/ml]) and infrequent exacerbators (615 ng/ml, [IQR; 371.0-942.0 ng/ml]). Serum MBL was not associated with lung function characteristics or bacterial colonization in sputum. However, high serum MBL at stable state was associated with better survival compared to low MBL (p = 0.046, log rank test). CONCLUSIONS: In COPD, the HYPD haplotype of MBL2 gene is associated with frequent exacerbations and high serum MBL is linked to increased survival. The PROMISE-COPD study was registered at www.controlled-trials.com under the identifier ISRCTN99586989. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Full Text
See detailMannosylated amphiphilic and degradable PEO-b-PCL copolymers for drug delivery systems: preparation and sugar availability characterizations
Freichels, Hélène ULg; Imberty, Anne; Auezély-Velty, Rachel et al

Poster (2009, May 14)

Over the last decade, polymer micelles and nanoparticles attracted an increasing interest in pharmaceutical research because they can be used as efficient drug delivery systems. In this field, amphiphilic ... [more ▼]

Over the last decade, polymer micelles and nanoparticles attracted an increasing interest in pharmaceutical research because they can be used as efficient drug delivery systems. In this field, amphiphilic copolymers combining poly(ethylene oxide) and aliphatic polyester (such as poly(ε-caprolactone) (PCL) or polylactide (PLA)) are particularly of interest because (i) PEO has unique protein- repellent properties and thus provides a stealth behaviour to the drug carriers and (ii) aliphatic polyesters are biocompatible and biodegradable hydrophobic matrices well-suited for the incorporation of an hydrophobic drug. By end-capping the hydrophilic segment by a targeting moiety so that they may interact with membrane receptors, the biodistribution of polymeric micelles and nanoparticles stabilized with this copolymer can be modulated and can induce specific cellular uptake by receptor-mediated endocytosis. One class of interesting targeting agent is the saccharides, in particular the mannose, because of its specific interaction with mannose receptor, which are found on peripheral and bone marrow macrophages, dendritic cells and sinusoidal liver cells. In this study, the reductive amination reaction is use to attach this targeting agent. After optimisation of the reaction with amino fluorescein, a model amine, mannosylated copolymer of PEO and PCL has been prepared. The surface availability of the saccharide upon the micelles in aqueous phosphate buffer was then assessed by DLS through binding with the protein Concanavalin A (ConA), a known mannose receptor. The interactions between the Bcla lectin and the mannosylated micelles have then been studied by Isothermal Titration Calorimetry (ITC) and the thermodynamic parameters have been obtained. This polymer is particularly useful for the stabilization of PLGA nanoparticles with the goal to target M cells for oral vaccination. [less ▲]

Detailed reference viewed: 96 (10 ULg)
Full Text
Peer Reviewed
See detailMannosylated poly(ethylene oxide)-b-Poly(epsilon-caprolactone) diblock copolymers: Synthesis, characterization, and interaction with a bacterial lectin
Rieger, Jutta ULg; Stoffelbach, François; Cui, Di et al

in Biomacromolecules (2007), 8(9), 2717-2725

A novel bioeliminable amphiphilic poly(ethylene oxide)-b-poly(epsilon-caprolactone) (PEO-b-PCL) diblock copolymer end-capped by a mannose residue was synthesized by sequential controlled polymerization of ... [more ▼]

A novel bioeliminable amphiphilic poly(ethylene oxide)-b-poly(epsilon-caprolactone) (PEO-b-PCL) diblock copolymer end-capped by a mannose residue was synthesized by sequential controlled polymerization of ethylene oxide and epsilon-caprolactone, followed by the coupling of a reactive mannose derivative to the PEO chain end. The anionic polymerization of ethylene oxide was first initiated by potassium 2-dimethylaminoethanolate. The ring-opening polymerization of epsilon-caprolactone was then initiated by the omega-hydroxy end-group of PEO previously converted into an Al alkoxide. Finally, the saccharidic end-group was attached by quaternization of the tertiary amine (alpha-end-group of the PEO-b-PCL with a brominated mannose derivative. The copolymer was fully characterized in terms of chemical composition and purity by high-resolution NMR spectroscopy and size exclusion chromatography. Furthermore, measurements with a pendant drop tensiometer showed that both the mannosylated copolymer and the non-mannosylated counterpart significantly decreased the dichloromethane/water interfacial tension. Moreover, these amphiphilic copolymers formed monodisperse spherical micelles in water with an average diameter of similar to 11 nin as measured by dynamic light scattering and cryo-transmission electron microscopy. The availability of mannose as a specific recognition site at the surface of the micelles was proved by isothermal titration microcalorimetry (ITC), using the BclA lectin (from Burkholderia cenocepacia), which interacts selectively with a-D-mannopyranoside derivatives. The thermodynamic parameters of the lectin/mannose interaction were extracted from the ITC data. These colloidal systems have great potential for drug targeting and vaccine delivery systems. [less ▲]

Detailed reference viewed: 85 (4 ULg)
Peer Reviewed
See detailManoeuvrability of ships in shallow and restricted waters
Marchal, Jean ULg

Conference (1993, September)

Detailed reference viewed: 22 (4 ULg)
See detailManoscritti teatrali della Biblioteca Riccardiana di Firenze.
Moreno, Paola ULg

in Scriptorium (1999)

Detailed reference viewed: 17 (0 ULg)
See detailIl manoscritto di Santa Caterina
Deweert, Willy; Ricciardi, Stefania ULg

Book published by Rizzoli (2011)

Detailed reference viewed: 17 (0 ULg)
Full Text
Peer Reviewed
See detailLe manque de généralisation chez les enfants dysphasiques : une étude longitudinale
Leroy, Sandrine ULg; Parisse, Christophe; Maillart, Christelle ULg

in ANAE : Approche Neuropsychologique des Apprentissages chez l'Enfant (2014), 26(131), 357-365

Usage-based theories postulate that development of linguistic system depends on a gradual generalization mechanism during which use of lexicalized language forms are little-by-little replaced by use of ... [more ▼]

Usage-based theories postulate that development of linguistic system depends on a gradual generalization mechanism during which use of lexicalized language forms are little-by-little replaced by use of abstract construction schemas. Several studies have shown limited morphosyntactic productivity in children with specific language impairment (SLI). In this longitudinal study, we have tested hypothesis according to which generalization would be hindered in children with SLI. [less ▲]

Detailed reference viewed: 169 (19 ULg)
Full Text
Peer Reviewed
See detailLe manque de variabilité des schémas de construction comme facteur explicatif des difficultés morphosyntaxiques chez les enfants dysphasiques
Leroy, Sandrine ULg; Moulin, Mélissa; Parisse, Christophe et al

Conference (2010, July 06)

Detailed reference viewed: 93 (6 ULg)
Peer Reviewed
See detailA mantle-derived parent massif anorthosites
Longhi, John; Vander Auwera, Jacqueline ULg

Conference (1994)

Detailed reference viewed: 3 (0 ULg)
See detailA manual of advanced celestial photography -- Brad D. Wallis et Robert W. Provin
Manfroid, Jean ULg

in Ciel et Terre (1989), 105

Detailed reference viewed: 36 (0 ULg)
Full Text
See detailLe manuel : pourquoi ? comment ?
Pochet, Bernard ULg

Conference (2016, March 01)

The aim of this communication is to present the objective the tools used to perform, meet objectives and overcome technical constraints

Detailed reference viewed: 28 (3 ULg)
Full Text
See detailManuel d'analyse qualitative. Analyser sans compter ni classer
Lejeune, Christophe ULg

Book published by De Boeck (2014)

La méthode qualitative s'est dotée d'outils et de techniques : journal de bord, propriété, dimension, catégorie, échantillonnage, saturation, scénario, mémo et compte rendu, codage (ouvert, axial et ... [more ▼]

La méthode qualitative s'est dotée d'outils et de techniques : journal de bord, propriété, dimension, catégorie, échantillonnage, saturation, scénario, mémo et compte rendu, codage (ouvert, axial et sélectif). Cet ouvrage présente le rôle respectif de chacun de ces éléments et permet à tous de s'approprier la logique qui les sous-tend. S'appuyant sur des exemples issus de recherches réelles, il expose avec clarté comment conduire sa propre recherche. Il fournit des astuces développées par les praticiens les plus aguerris et permet ainsi au lecteur d'évaluer sa propre avancée dans le monde passionnant de la recherche qualitative. [less ▲]

Detailed reference viewed: 858 (176 ULg)
Full Text
See detailManuel d’auto-diagnostic de gestion des âges
Dieu, Anne-Marie ULg; Randaxhe, David ULg; Cornet, Annie ULg et al

Learning material (2010)

Detailed reference viewed: 155 (18 ULg)
See detailManuel d'autoformation accompagnée d'anglais pour la FAPSE
Bouvy, Christine ULg; Carl, Françoise ULg; Leclercq, Dieudonné ULg et al

Book published by Université de Liège, Faculté de Psychologie et des Sciences de l'Education, Belgique (1996)

Detailed reference viewed: 132 (25 ULg)
See detailManuel d'enseignement de la LPC chez des enfants sourds en début de scolarité primaire
Lejeune, Brigitte ULg; Miesse, Gabrielle

Book published by Elsevier Masson (2012)

Cet ouvrage présente des exercices ludiques en vue d'enseigner à l'enfant sourd le décodage de la LPC (Langue française Parlée Complétée). Les exercices sont adaptés aux enfants de 5-9 ans. CD-rom inclus ... [more ▼]

Cet ouvrage présente des exercices ludiques en vue d'enseigner à l'enfant sourd le décodage de la LPC (Langue française Parlée Complétée). Les exercices sont adaptés aux enfants de 5-9 ans. CD-rom inclus. Exercies et planches de jeu du livre imprimables en couleurs. [less ▲]

Detailed reference viewed: 167 (12 ULg)
See detailManuel d'histoire universelle à l'usage de l'enseignement moyen
Kurth, Godefroid ULg

Book published by L.De Roisin (1912)

Detailed reference viewed: 34 (2 ULg)