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See detailInterest of a prescreening questionnaire to reduce the cost of bone densitometry
Ben Sedrine, Wafa ULiege; Broers, P; Devogelaer, JP et al

in Clinical Rheumatology (2001), 20

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See detailInterest of a prescreening questionnaire to reduce the cost of bone densitometry
Ben Sedrine, Wafa ULiege; Broers, P.; Devogelaer, J. P. et al

in Osteoporosis International (2002), 13(5), 434-442

Bone mineral density (BMD) measurement is widely recognized as the best single tool to identify patients with a high lifetime risk of developing an osteoporosis-related fracture. However, the cost/benefit ... [more ▼]

Bone mineral density (BMD) measurement is widely recognized as the best single tool to identify patients with a high lifetime risk of developing an osteoporosis-related fracture. However, the cost/benefit value of screening the whole population has been repeatedly challenged and demonstrated to be rather poor. In many countries, BMD scan is not or no longer reimbursed because of lack of validated criteria to identify patients who should benefit from this procedure. Based on the proposals of a nationwide expert panel, a simple questionnaire identifying historical, clinical and behavioral risk factors for osteoporosis was developed. The aim of this study was to assess the diagnostic accuracy of the proposed criteria; to determine the extent to which this questionnaire could be useful for optimizing the use of densitometry tests; and, more specifically, to estimate the diagnostic costs per osteoporotic or osteopenic patient detected. For this purpose, we applied the questionnaire to 3998 consecutive individuals at least 20 years old, of both genders, either consulting spontaneously or referred for a BMD measurement to an outpatient osteoporosis center. BMD was measured by dual-energy X-ray absorptiometry (DXA) at the lumbar spine and at the hip (both total hip and femoral neck). Diagnostic accuracies were evaluated through measures of sensitivity, specificity, and positive and negative predictive values. After determining a benchmark value for age, different strategies were compared in order to identify the most cost-effective one in terms of cost per patient detected. According to the WHO operational definition of osteoporosis (T-score <-2.5), 31% of the subjects were classified as osteoporotic at one or more of the measured sites. If only patients with at least one of the proposed risk factors had been referred for scans, 33.3% of the BMD measurements would have been avoided. Among those, less than 5% were missclassified as they did have osteoporosis at the total hip and up to 23% at one or more of the considered sites. On the other hand, of the subjects who would be recommended for a densitometry test, only a small fraction were identified correctly (the positive predictive values varied from 11.3% at the total hip to 34.8% at any site). In this first setting, the suggested criteria seem useful chiefly for excluding subjects who do not need a DXA scan rather than selecting osteoporotic patients. When applied only to patients aged 61 years or more, the positive predictive values rose to 15.1% (total hip) and 42.9% (any site), whereas the corresponding negative predictive values were set at 93% and 68.6%. In comparison, with a mass screening scenario the estimated diagnostic costs (costs associated with the DXA procedure) per osteoporotic patient detected at any of the considered sites would be reduced by more than 9% (59.4 instead of 65.3 Euros) if the suggested indications are taken into account for prescreening patients. And when the questionnaire is applied only to women over the age of 60 years these costs would be further reduced to 50.6 Euros, representing a 23% decrease. Then, a prescreening strategy based on these indications concomitantly with an age-selective criterion could represent a promising way toward a more rational use of BMD measurement. [less ▲]

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See detailInterest of a simple pre-screening test for optimazing the cost/benefit value of bone densitometry
Ben Sedrine, Wafa ULiege; Broers, P; Brands, G et al

in Arthritis and Rheumatism (1999), 42(S1), 289

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See detailInterest of a simple pre-screening test for optimizing the cost/benefit value of bone densitometry
Ben Sedrine, Wafa ULiege; Broers, Ph; Brands, G et al

in Osteoporosis International (2000), SS(S5), 13

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See detailInterest of a specific training to reduce DOMS
Croisier, Jean-Louis ULiege; Camus, Gérard; Crielaard, Jean-Michel ULiege

in Isokinetics & Exercise Science (2000, March), 8

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See detailThe interest of associating Dopamine with Dobutamine in the treatment of cardiac failure secondary to acute myocardial infarction
EL ALLAF, D; CREMERS, S; D'Orio, Vincenzo ULiege et al

in Clinical Pharmacology & Therapeutics (1984), 35

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See detailInterest of biochemical markers of bone turnover for long-term prediction of new vertebral fracture in postmenopausal osteoporotic women
Bruyère, Olivier ULiege; Collette, Julien ULiege; Delmas, Pierre et al

in Maturitas (2003), 44(4), 259-265

Objective: To analyse the interest of baseline levels and short-term (3-months) changes in serum osteocalcin (BGP), serum bone-specific alkaline phosphatase (BALP) and urinary C-telopeptide of type I ... [more ▼]

Objective: To analyse the interest of baseline levels and short-term (3-months) changes in serum osteocalcin (BGP), serum bone-specific alkaline phosphatase (BALP) and urinary C-telopeptide of type I collagen/creatinine ratio (U-TX) to predict 3-years changes in bone mineral density (BMD) and spinal deformity index (SDI) in postmenopausal osteoporotic women. Methods: Data were derived from a cohort of 603 osteoporotic women corresponding to the placebo arm of a 3-years prospective, double-blind study. Results: Baseline values of BALP, BGP and U-CTX were negatively and significantly correlated with baseline spinal BMD. Significant correlations were also observed between the changes in BMD observed after 36 months at the spine and baseline BALP (r = 0.20, P = 0.0001), BGP (r = 0.09, P = 0.05) and U-CTX (r = -0.11, P = 0.02). At 3 years, 71 women (15.9%) showed an increase in their SDI, corresponding to the occurrence of at least one new vertebral deformity. Baseline values of the four bone turnover markers (BTM) were not significantly related to the occurrence of new vertebral deformities. However, when considering the changes in the BTM observed after 3-months of follow-up, BGP (P = 0.003) and U-CTX (P = 0.047) were identified as significant predictors of an increase of SDI. The associated odds ratios (95% confidence interval (CI)) were 10.922 (2.218-53.78) for unit changes of log BGP and 1.369 (1.003-1.867) for unit changes of log U-CTX. The relative risk (RR) (IC 95%) of having a new vertebral fracture over 36 months was 0.31 (0.15-0.65) when being in the lowest quartile of 3-months changes in BGP as compared with the highest. Conclusion: We conclude that two sequential measurements of BGP and U-CTX performed at 3-months intervals could be of interest to identify postmenopausal osteoporotic women with the highest risk to present new vertebral deformities. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailInterest of cerebral Doppler in neonates
Battisti, Oreste ULiege

Conference (1993)

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See detailInterest of creatine supplementation insoccer
Miny, Kevin ULiege; Burrowes, J; Jidovtseff, Boris ULiege

in Science & Sports (2017), 32(2), 61-72

Objectives This review article aimed to summarize the current state of understanding on creatine supplementation for soccer players. In other words, it investigated the beneficial (and potentially ... [more ▼]

Objectives This review article aimed to summarize the current state of understanding on creatine supplementation for soccer players. In other words, it investigated the beneficial (and potentially negative) effects of this supplementation on sport-specific skills and performance in soccer players. Furthermore, this article accordingly discussed the safest and most recommended protocols for the consumption of creatine by these athletes. News Studies have shown that creatine supplementation can have positive effects on sprint and vertical jump performances in soccer players. This supplementation may also enhance soccer players’ muscle strength and adaptation to a high-intensity training regimen. Besides, creatine may be able to enhance muscle glycogen (as well as phosphocreatine) storage, reduce oxidative stress, and improve muscular repair and hypertrophy. Interestingly, creatine supplementation does not seem to affect aerobic performance. Prospects and projects Soccer players could take creatine during pre-season training (3 to 5g/day) in order to help them endure a high-intensity training regimen and enhance their muscular strength and adaptation resulting from strength and/or resistance training. A lower dosage (less than 3g/day) might also be sufficient and beneficial during the season in case of fatigue, in order to sustain adequate levels of phosphocreatine and glycogen in the muscles. Occasional intakes (about 3g) before games and/or extenuating practices could also give a physical and mental boost to the players. Conclusion Most of the studies measured the effects of creatine on skills or physical performances in isolation from the true athletic demands of soccer match play. In conclusion, there is still a need for more research in order to determine whether creatine supplementation is ergogenic regarding the (aerobic) capacity to repeat (very) high-intensity actions, more particularly during competitive soccer. [less ▲]

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See detailInterest of cyclodextrins in spray-dried microparticles formulation for sustained pulmonary delivery of budesonide
Dufour, Gilles ULiege; Bigazzi, William ULiege; Wong, Nelson et al

in International Journal of Pharmaceutics (2015), 495(2), 869-878

Detailed reference viewed: 61 (28 ULiège)
See detailInterest of DOC in the study of consciousness
Vanhaudenhuyse, Audrey ULiege

Conference (2007)

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See detailInterest of Face Mask--Cpap in One Case of Severe Accidental Hypothermia
Canivet, Jean-Luc ULiege; Larbuisson, Robert ULiege; Lamy, Maurice ULiege

in Acta Anaesthesiologica Belgica (1989), 40(4), 281-3

one case of severe accidental hypothermia; rectal temperature was 25 degrees C. Hypoxemia unmodified by 100 O2 inhalation in an ordinary face-mask was easily corrected using a face-mask CPAP; a ... [more ▼]

one case of severe accidental hypothermia; rectal temperature was 25 degrees C. Hypoxemia unmodified by 100 O2 inhalation in an ordinary face-mask was easily corrected using a face-mask CPAP; a ventilation-perfusion mismatching could be implicated in the cold induced hypoxemia. Active rewarming (1.5 degrees C/h) was pursued from 25 to 37 degrees C, using non aggressive methods: warming blankets and a Bennett heated humidifier inserted in the CPAP system. Even in severe hypothermia successful results may be obtained without resort to sophisticated methods. [less ▲]

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See detailInterest of Health Economic Analyses
Hiligsmann, Mickaël ULiege

Conference given outside the academic context (2011)

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See detailInterest of lasofoxifene in the treatment of osteoporosis. Evaluation of "Lasofoxifene in postmenopausal women with osteoporosis". N Engl J Med 2010;362:686-96.
Reginster, Jean-Yves ULiege

in Expert Opinion on Pharmacotherapy (2010), 11(10), 1773-5

Lasofoxifene, a new selective estrogen receptor modulator (SERM), was investigated to assess its efficacy and safety in the management of postmenopausal osteoporosis. A dose of 0.5 mg/day of lasofoxifene ... [more ▼]

Lasofoxifene, a new selective estrogen receptor modulator (SERM), was investigated to assess its efficacy and safety in the management of postmenopausal osteoporosis. A dose of 0.5 mg/day of lasofoxifene, given to postmenopausal women with osteoporosis, induced a reduction in vertebral fracture rates after 3 years and a reduction, after 5 years, of nonvertebral fractures, estrogen receptor-positive and invasive breast cancers, major coronary heart diseases and strokes. However, this dose was associated with significant side effects including venous thromboembolisms, pulmonary embolisms, leg cramps, hot flushes, uterine polyps, endometrial hypertrophy, arthralgia and vaginal candidiasis. Since no effect was evidenced on hip fractures, the risk-benefit ratio of this new medication, compared with previously marketed SERMs is, at best, uncertain. [less ▲]

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See detailInterest of Locometrix compared with others clinical tests to assess gait’s profile in some specific old populations
Gillain, Sophie ULiege; Warzee, Emmanuelle ULiege; Maquet, Didier ULiege et al

in Journal of Nutrition, Health & Aging (The) (2009), 13(Supp 1),

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See detailInterest of Locometrix to assess gait’s profile in specific old populations
Gillain, Sophie ULiege; Warzee, Emmanuelle ULiege; Lekeu, Françoise ULiege et al

in Journal of Nutrition, Health & Aging (The) (2009, June), 13(Supp 1),

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See detailInterest of multisite bacterial screening for the diagnosis of congenital listerisosis with negative blood culture: a case report
Snyers, Diane ULiege; Thirion, Sophie ULiege; Kalenga, Masendu ULiege et al

Scientific conference (2017, March 23)

Listeria monocytogenes (LM) is known to cause severe invasive disease in pregnant women and in newborns. Fortunately, despite the wide natural distribution of this pathogen, clinically overt neonatal ... [more ▼]

Listeria monocytogenes (LM) is known to cause severe invasive disease in pregnant women and in newborns. Fortunately, despite the wide natural distribution of this pathogen, clinically overt neonatal infections occurs rarely. As a consequence, listeriosis is not always considered for early onset neonatal infection, especially when blood culture is negative. Indeed, identification of listeria in the blood stream by conventional bacteriological methods remains the reference method for diagnosing listeriosis. We report a case of congenital listeriosis with negative blood culture despite typical chorioamnionitis, where the pathogen was cultured in gastric aspirate.Although the disease is rare, congenital listeriosis still remain a possible challenging condition in neonatal practice as revealed by this case report. This also shows the importance of multisite bacterial culture beside conventional blood and CSF culture, in combination with histological examination of the placenta for the diagnosis of congenital listeriosis. [less ▲]

Detailed reference viewed: 33 (4 ULiège)