Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailP2X1 receptors as new regulators of neutrophil life span
Faccinetto, Céline ULg; Lecut, Christelle ULg; Jacobs, Nathalie ULg et al

in Journal of Thrombosis and Haemostasis [=JTH] (2007)

Detailed reference viewed: 28 (4 ULg)
Full Text
Peer Reviewed
See detailP2X1-induced activation of Ca2+ calmodulin leads to myosin light chain and ERK2 phosphorylation in human platelets.
Toth-Zsamboki, Emese; Oury, Cécile ULg; De Vos, Rita et al

in Journal of Thrombosis and Haemostasis [=JTH] (2003)

Detailed reference viewed: 7 (1 ULg)
Full Text
Peer Reviewed
See detailP2X1-mediated activation of Ca2+-calmodulin leads to myosin light chain and ERK2 phosphorylation in human platelets.
Toth-Zsamboki, Emese; Oury, Cécile ULg; De Vos, Rita et al

in Haematologica (2002), 87

Detailed reference viewed: 10 (2 ULg)
Full Text
Peer Reviewed
See detailP2X1-mediated ERK2 activation amplifies the collagen-induced platelet secretion by enhancing myosin light chain kinase activation.
Oury, Cécile ULg; Toth-Zsamboki, Emese; Cornelissen, Heidi et al

in Journal of Biological Chemistry (2003)

This study shows that, at low doses of collagen, glycoprotein VI activation leads to early protein kinase C- and MLC kinase-dependent platelet degranulation. Rapidly released ATP triggers P2X1 -mediated ... [more ▼]

This study shows that, at low doses of collagen, glycoprotein VI activation leads to early protein kinase C- and MLC kinase-dependent platelet degranulation. Rapidly released ATP triggers P2X1 -mediated Ca2+ influx, activating ERK2, in turn amplifying platelet secretion by reinforcing the early MLC kinase phosphorylation. Hence, the P2X1-ERK2-MLC axis contributes to collagen-induced platelet activation by enhancing platelet degranulation. [less ▲]

Detailed reference viewed: 22 (5 ULg)
Full Text
Peer Reviewed
See detailThe P2Y1 receptor antagonist adenosine-2',5'-diphosphate non-selectively antagonizes the platelet P2X1 ion channel.
Oury, Cécile ULg; Toth-Zsamboki, Emese; Tytgat, Jan et al

in Thrombosis and Haemostasis (2001)

This letter indicates a lack of specificity of a platelet P2Y1 receptor antagonist.

Detailed reference viewed: 14 (1 ULg)
Full Text
See detailP3 panel summary: exozodiacal dust disks
Absil, Olivier ULg

Scientific conference (2009, September 18)

When observing an extrasolar planetary system, the most luminous component after the star itself is generally the light scattered and/or thermally emitted by a population of micron-sized dust grains ... [more ▼]

When observing an extrasolar planetary system, the most luminous component after the star itself is generally the light scattered and/or thermally emitted by a population of micron-sized dust grains. These grains are expected to be continuously replenished by the collisions and evaporation of larger bodies just as in our solar zodiacal cloud. Exozodiacal clouds (\exozodis") must therefore be seriously taken into account when attempting to directly image faint Earth-like planets (exoEarths, for short). This paper summarizes the oral contributions and discussions that took place during the Satellite Meeting on exozodiacal dust disks, in an attempt to address the following two questions: Do we need to solve the exozodi question? If yes, how to best solve it? [less ▲]

Detailed reference viewed: 7 (0 ULg)
Peer Reviewed
See detailP300 and personality: an investigation with the Cloninger's model.
Hansenne, Michel ULg

in Biological Psychology (1999), 50(2), 143-55

The relationships between P300 and personality have been explored mainly in reference to the model of personality described by Eysenck because of its biological bases. Recently, Cloninger and his ... [more ▼]

The relationships between P300 and personality have been explored mainly in reference to the model of personality described by Eysenck because of its biological bases. Recently, Cloninger and his colleagues have proposed a model of personality based on four temperaments and three characters. The Temperament and Character Inventory (TCI) is a 226-item self-questionnaire developed to assess these seven dimensions of personality. In the present study, the relationships between these dimensions of personality and P300 have been investigated in 43 normal subjects. The results show that P300 amplitude is positively correlated with the novelty seeking dimension and negatively correlated with the harm avoidance dimension. In contrast, the other dimensions of the TCI were not related to P300 amplitude. Moreover, P300 latency and reaction time were not associated with the TCI dimensions of personality. This study confirms that personality is related to P300. [less ▲]

Detailed reference viewed: 24 (0 ULg)
Peer Reviewed
See detailP300 event-related brain potential and personality in depression.
Hansenne, Michel ULg; Pitchot, William ULg; Pinto, Emmanuel ULg et al

in European Psychiatry (2000), 15(6), 370-7

P300 is an event-related brain potential (ERP) particularly interesting to the study of cognitive processes in normal subjects and in psychopathology. P300 has been applied in depression with ... [more ▼]

P300 is an event-related brain potential (ERP) particularly interesting to the study of cognitive processes in normal subjects and in psychopathology. P300 has been applied in depression with controversial results. A major source for these controversial results could result from the diversity of depressed patients included in the different studies. Supporting this assumption, impulsivity, blunted affect, suicidal behavior and psychotic features significantly influence P300 amplitude. However, no data are available on the possible influences of the personality of depressed patients on P300. Since personality is related to P300 in normal subjects, the aim of the present study is to investigate the relationship between ERPs (P200, N200, and P300) and the Temperament and Character Inventory (TCI) in 54 depressed patients. The main results of the study concern the absence of major correlations between personality dimensions as assessed by the TCI and ERP parameters among depressed patients. Only weak partial positive correlations relate N200 latency with harm avoidance, and P300 amplitude (Pz) with the self-directedness dimension. N200 amplitude is also negatively correlated to persistence. However, the preliminary nature of the presented results with respect to the weak statistical significance should be underlined. [less ▲]

Detailed reference viewed: 40 (0 ULg)
Peer Reviewed
See detailP300 event-related potential and serotonin-1A activity in depression.
Hansenne, Michel ULg; Ansseau, Marc ULg

in European Psychiatry (1999), 14(3), 143-7

The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of P300 could lead to important clinical implications. Since serotonin disturbances seem ... [more ▼]

The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of P300 could lead to important clinical implications. Since serotonin disturbances seem to play a critical role in depression, the aim of the study was to assess the possible relationships between the P300 event-related brain potential and serotonergic activity in depression. The study was conducted among 45 major depressive inpatients, and serotonergic activity was assessed by prolactin (PRL) response to flesinoxan (a 5-HT1A agonist). Results showed a significant negative correlation between P300 amplitude and PRL response to flesinoxan (r = -0.40, P = 0.007 at Cz; r = -0.47, P = 0.001 at Pz). In contrast, both P300 latency and reaction time were not related to endocrine response. This study supports a role for serotonin-1A in the neurobiological modulation of P300 amplitude. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Peer Reviewed
See detailP300 in posttraumatic stress disorder.
Charles, G.; Hansenne, Michel ULg; Ansseau, Marc ULg et al

in Neuropsychobiology (1995), 32(2), 72-4

In the present study, P300 has been recorded in 26 subjects (15 women) 1 month after an aggression without organic complications. Among our sample, 16 subjects fulfilled DSM-III-R criteria for ... [more ▼]

In the present study, P300 has been recorded in 26 subjects (15 women) 1 month after an aggression without organic complications. Among our sample, 16 subjects fulfilled DSM-III-R criteria for posttraumatic stress disorder (PTSD) and 10 did not. P300 amplitude was significantly lower in the 16 PTSD subjects as compared to the 10 subjects without PTSD. This study supports information processing disturbances in PTSD. [less ▲]

Detailed reference viewed: 27 (6 ULg)
Full Text
Peer Reviewed
See detailThe p40* adhesin pseudogene of Mycoplasma bovis
Thomas, Anne; Linden, Annick ULg; Mainil, Jacques ULg et al

in Veterinary Microbiology (2004), 104(3-4), 213-217

An analogue of the adhesin gene p40 of Mycoplasma agalactiae was found in Mycoplasma bovis. Nucleotide sequence analysis of the p40* gene in M. bovis revealed the presence of a large deletion involving a ... [more ▼]

An analogue of the adhesin gene p40 of Mycoplasma agalactiae was found in Mycoplasma bovis. Nucleotide sequence analysis of the p40* gene in M. bovis revealed the presence of a large deletion involving a frameshift that causes premature truncation of the translated protein, indicating that p40* exists as a pseudogene in M. bovis. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 24 (1 ULg)
Peer Reviewed
See detailP53, Bax and Bcl-2 in Vivo Expression in the Murine Thymus after Apoptogenic Treatments
Denis, Ghislaine; Humblet, Chantal ULg; Verlaet, Myriam ULg et al

in Anticancer Research (1998), 18(5, Sep-Oct), 3315-21

BACKGROUND: Neoplasia can results from a lack of cell elimination by apoptosis. In order to determine if mechanisms controlling apoptosis are disturbed during neoplastic transformation in a model of ... [more ▼]

BACKGROUND: Neoplasia can results from a lack of cell elimination by apoptosis. In order to determine if mechanisms controlling apoptosis are disturbed during neoplastic transformation in a model of murine radio-induced thymic lymphomas, we have assessed the kinetics of p53, Bax and Bcl-2 in situ expression after induction of thymic apoptosis by irradiation or glucocorticoids at first in normal mice. MATERIALS AND METHODS: TUNEL method was used for in situ detection of apoptosis and protein expression was determined by indirect immunohistochemistry. RESULTS: After hydrocortisone injection, levels of p53 and Bax, but not Bcl-2, expression were raised. A whole body sublethal irradiation led to an increase of p53 and Bcl-2, but not Bax, expression. CONCLUSIONS: This is the first in vivo report of in situ protein expression in the thymus after apoptogenic treatments of mice. The results suggest that Bax could be involved in glucocorticoid-mediated apoptosis. The increased levels of Bcl-2 expression are discussed. [less ▲]

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailp53-dependent downregulation of metastasis-associated laminin receptor
Modugno, Michele; Tagliabue, Elda; Ardini, Elena et al

in Oncogene (2002), 21(49), 7478-7487

Based on observations suggesting a role for the tumor suppressor protein p53 in regulating expression of the 67-kDa laminin receptor precursor, 37LRP, we analysed the 37LRP promoter activity in a wild ... [more ▼]

Based on observations suggesting a role for the tumor suppressor protein p53 in regulating expression of the 67-kDa laminin receptor precursor, 37LRP, we analysed the 37LRP promoter activity in a wild-type p53 (wt p53) ovarian carcinoma cell line and in a cisplatin-resistant subline with mutated p53. We observed an increased promoter activity in wt p53 cells as compared to the mutated-p53 line when the first intron of the 37LRP gene was present in the reporter construct. Cotransfection experiments showed that the promoter is downregulated by both wt and mutated p53. Deletion analysis of the first intron localized an enhancer activity in the first 5' 214 bp that upregulates both 37LRP and SV40 promoter activity and is repressed by both wt and mutant p53. Cotransfection, mutagenesis and gel-shift experiments identified a functional AP-2 cis-acting element in this intron region that is repressed by increased levels of both wt and mutated p53. Coimmunoprecipitation studies revealed AP-2 in physical association in vivo with both wt and mutated p53, indicating for the first time that interaction of p53 with AP-2 is involved in the repression mechanism and in the regulation of genes involved in cancer growth and progression. [less ▲]

Detailed reference viewed: 18 (0 ULg)
Full Text
Peer Reviewed
See detailp63 is a prostate basal cell marker and is required for prostate development.
Signoretti, Sabina; Waltregny, David ULg; Dilks, James et al

in American Journal of Pathology (2000), 157(6), 1769-75

The p53 homologue p63 encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives (DeltaNp63). p63 is expressed in the basal cells of many ... [more ▼]

The p53 homologue p63 encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives (DeltaNp63). p63 is expressed in the basal cells of many epithelial organs and its germline inactivation in the mouse results in agenesis of organs such as skin appendages and the breast. Here, we show that prostate basal cells, but not secretory or neuroendocrine cells, express p63. In addition, prostate basal cells in culture predominantly express the DeltaNp63alpha isotype. In contrast, p63 protein is not detected in human prostate adenocarcinomas. Finally, and most importantly, p63(-/-) mice do not develop the prostate. These results indicate that p63 is required for prostate development and support the hypothesis that basal cells represent and/or include prostate stem cells. Furthermore, our results show that p63 immunohistochemistry may be a valuable tool in the differential diagnosis of benign versus malignant prostatic lesions. [less ▲]

Detailed reference viewed: 39 (4 ULg)
Peer Reviewed
See detailp65 homodimer activity in BAL cells is correlated to lung dysfunction in equine heaves
Sandersen, Charlotte ULg; Bureau, Fabrice ULg; Turlej, R. et al

in Proceedings: 2001 World Equine Airways Symposium (2001)

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailP65 Homodimer Activity in Distal Airway Cells Determines Lung Dysfunction in Equine Heaves
Sandersen, Charlotte ULg; Bureau, Fabrice ULg; Turlej, R. et al

in Veterinary Immunology and Immunopathology (2001), 80(3-4), 315-26

Nuclear factor-kappaB (NF-kappaB) activity, which is a key regulator of inflammatory gene expression, is increased in bronchial epithelial cells from horses suffering from heaves (a hypersensitivity ... [more ▼]

Nuclear factor-kappaB (NF-kappaB) activity, which is a key regulator of inflammatory gene expression, is increased in bronchial epithelial cells from horses suffering from heaves (a hypersensitivity-associated inflammatory condition of the lung). To determine whether this increased activity extends to distal airways and to other pulmonary cells, cells recovered by broncho-alveolar lavage (BAL) in healthy and heaves-affected horses were assessed for NF-kappaB activity. NF-kappaB activity was much higher in BAL cells from heaves-affected horses, especially during crisis (disease exacerbation), than in cells from healthy horses. Moreover, the level of NF-kappaB activity found in BAL cells was positively correlated to total lung resistance and to the proportion of neutrophils present in BAL fluid. Finally, prototypical p65-p50 NF-kappaB heterodimers were absent from BAL cells, which mostly contained p65 homodimers. These results (1) show that increased NF-kappaB activity is a general feature of heaves lung; (2) demonstrate the importance of p65 homodimers in neutrophilic inflammation; and (3) suggest that the use of specific NF-kappaB inhibitors could improve lung function in heaves-affected horses. [less ▲]

Detailed reference viewed: 24 (9 ULg)
Full Text
See detailDe paardenstalfetisjist
Meesters, Gert ULg

in Over Taal (1998), 37(1), 16-18

Detailed reference viewed: 11 (0 ULg)
Full Text
See detailLa PAC ? Marché conclu ?
Terrones Gavira, François ULg; Burny, Philippe ULg

Article for general public (2013)

Detailed reference viewed: 30 (13 ULg)