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See detailLong-term effects of oral estradiol and dydrogesterone on carbohydrate metabolism in postmenopausal women.
Gaspard, Ulysse ULg; Wery, Olivier ULg; Scheen, André ULg et al

in Climacteric : The Journal of the International Menopause Society (1999), 2(2), 93-100

OBJECTIVE: To determine in postmenopausal women the long-term effects on carbohydrate metabolism of the administration of oral micronized 17 beta-estradiol (2 mg/day continuously) and cyclical ... [more ▼]

OBJECTIVE: To determine in postmenopausal women the long-term effects on carbohydrate metabolism of the administration of oral micronized 17 beta-estradiol (2 mg/day continuously) and cyclical dydrogesterone (10 mg/day for 14 days per 28-day cycle). METHODS: A 2-year open-label prospective, non-comparative study was carried out of 13 healthy postmenopausal women receiving cyclical estradiol and dydrogesterone and serving as their own controls. Concentrations of blood glucose, plasma insulin, C-peptide, glucagon and free fatty acids (FFAs) were determined before treatment (base-line) and at 6, 12 and 24 months of hormone replacement therapy under fasting conditions and during a standard 75-g, 3-h, oral glucose tolerance test (OGTT). RESULTS: Fasting blood glucose levels were unchanged throughout the study, and the mean areas under the curves (AUCs) for glucose response increased slightly but non-significantly versus baseline; fasting plasma insulin levels tended a decrease, and AUCs for insulin responses to the glucose load fell by 23% from baseline (not significant); fasting C-peptide levels and AUCs were unchanged; plasma glucagon fasting levels and responses were in the normal range and stable throughout the study; and plasma FFA fasting levels decreased significantly, as well as FFA AUCs during OGTTs, at the 12th and 24th months of the study. CONCLUSIONS: During a 2-year treatment with oral estradiol and cyclical dydrogesterone, a direct progesterone derivative, tolerance to glucose was unchanged, fasting plasma insulin and insulin response to repeated glucose loads were decreased, and C-peptide levels remained unchanged, indicating a potential improvement in insulin sensitivity and clearance, as in younger women; additionally, a slightly enhanced antilipolytic activity of insulin was observed. [less ▲]

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See detailLong-term efficacy and safety of Raltegravir combined with optimized background therapy in treatment-experienced patients with drug-resistant HIV infection: week 96 results of the BENCHMRK 1 and 2 phase iii trials.
Steigbigel, Roy T; Cooper, David A; Teppler, Hedy et al

in Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America (2010), 50(4), 605-12

BENCHMRK-1 and -2 are ongoing double-blind phase III studies of raltegravir in patients experiencing failure of antiretroviral therapy with triple-class drug-resistant human immunodeficiency virus ... [more ▼]

BENCHMRK-1 and -2 are ongoing double-blind phase III studies of raltegravir in patients experiencing failure of antiretroviral therapy with triple-class drug-resistant human immunodeficiency virus infection. At week 96 (combined data), raltegravir (400 mg twice daily) plus optimized background therapy was generally well tolerated, with superior and durable antiretroviral and immunological efficacy, compared with optimized background therapy alone. [less ▲]

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See detailLong-term efficacy and safety of strontium ranelate in postmenopausal osteoporotic women: results over 10 years
Reginster, Jean-Yves ULg; Kaufman, Jean-Marc; Devogelaer, Jean-Pierre et al

in Osteoporosis International (2011, March), 22(Suppl.1), 110-111

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See detailLong-term efficacy of infliximab and colectomy-free survival in outpatients with refractory ulcerative colitis.
Ferrante, M.; Vermeire, S.; Schnitzler, F. et al

in Journal of Crohn’s and Colitis [=JCC] (2008), 2(1), 3

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See detailLong-term efficacy of risedronate: a 5-year placebo-controlled clinical experience
Sorensen, O. H.; Crawford, G. M.; Mulder, H. et al

in BONE (2003), 32(2), 120-126

Limited placebo-controlled data are available to assess the long-term fracture efficacy of bisphosphonates. In order to determine the effects of 5 years of risedronate treatment, we extended a 3-year ... [more ▼]

Limited placebo-controlled data are available to assess the long-term fracture efficacy of bisphosphonates. In order to determine the effects of 5 years of risedronate treatment, we extended a 3-year, placebo-controlled vertebral fracture study in osteoporotic women for an additional 2 years; women who entered the extension study continued to receive 5 mg risedronate or placebo according to the original randomization, with maintenance of blinding. End points included vertebral and nonvertebral fracture assessments, bone mineral density measurements, and changes in biochemical markers of bone turnover. A total of 265 women (placebo, 130; 5 mg risedronate, 135) entered the study extension and 220 (83%) completed the additional 2 years. Fracture results observed in the study extension were consistent with those observed in the first 3 years. The risk of new vertebral fractures was significantly reduced with risedronate treatment in years 4 and 5 by 59% (95% confidence interval, 19 to 79%, P = 0.01) compared with a 49% reduction in the first 3 years. Rapid and significant decreases in markers of bone turnover observed in the first 3 years were similarly maintained in the next 2 years of treatment. Increases in spine and hip bone mineral density that occurred in the risedronate group during the first 3 years were maintained or increased with a further 2 years of treatment. The mean increase from baseline in lumbar spine BMD over 5 years was 9.3% (P < 0.001). This study demonstrates that the effects of risedronate over 3 years on vertebral fracture and BMD are maintained with a further 2 years of treatment. (C) 2003 Elsevier Science (USA). All rights reserved. [less ▲]

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See detailLong-term elasticity in the continental lithosphere; Modelling the Aden Ridge Propagation and the Anatolian Extrusion Process
King, J; Hubert, Aurelia ULg

in Geophysical Research Abstracts (2002, April), 4

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See detailLong-term Elasticity in the Continental Lithosphere; Modelling the Aden Ridge Propagation and the Anatolian Extrusion Process
King, G; Hubert, Aurelia ULg

in EOS : Transactions, American Geophysical Union (2002, December), 83

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Peer Reviewed
See detailLong-term evaluation of spinal cord stimulation for neuropathic/vascular pain
WANET, Thomas; Kaschten, Bruno ULg; DUBUISSON, Annie ULg et al

Conference (2012, March 10)

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See detailLong-term evolution and seasonal modulation of methanol above Jungfraujoch (46.5°N, 8.0°E): Optimisation of the retrieval strategy, comparison with model and independant observations
Bader, Whitney ULg; Stavrakou, T; Muller, J-F et al

in Atmospheric Measurement Techniques (2014), 7

Methanol (CH3OH) is the second most abundant organic compound in the Earth's atmosphere after methane. In this work, we present the first long-term time series of methanol total, lower tropospheric and ... [more ▼]

Methanol (CH3OH) is the second most abundant organic compound in the Earth's atmosphere after methane. In this work, we present the first long-term time series of methanol total, lower tropospheric and upper tropospheric-lower stratospheric partial columns derived from the analysis of high resolution Fourier transform infrared solar spectra recorded at the Jungfraujoch station (46.5° N, 3580 m a.s.l.). The retrieval of methanol is very challenging due to strong absorptions of ozone in the region of the selected υ8 band of CH3OH. Two wide spectral intervals have been defined and adjusted in order to maximize the information content. Methanol does not exhibit a significant trend over the 1995–2012 time period, but a strong seasonal modulation characterized by maximum values and variability in June–July, minimum columns in winter and a peak-to-peak amplitude of 130%. In situ measurements performed at the Jungfraujoch and ACE-FTS occultations give similar results for the methanol seasonal variation. The total and lower tropospheric columns are also compared with IMAGESv2 model simulations. There is no systematic bias between the observations and IMAGESv2 but the model underestimates the peak-to-peak amplitude of the seasonal modulations. [less ▲]

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See detailLong-term evolution and seasonal modulation of methanol above Jungfraujoch (46.5°N, 8.0°E): Optimisation of the retrieval strategy, comparison with model and independent observations
Bader, Whitney ULg; Stavrakou, J; Muller, J-F et al

Poster (2014, May)

Methanol (CH3OH) is the second most abundant organic compound in the Earth’s atmosphere after methane. In this work, we present the first long-term time series of methanol total, lower tropospheric and ... [more ▼]

Methanol (CH3OH) is the second most abundant organic compound in the Earth’s atmosphere after methane. In this work, we present the first long-term time series of methanol total, lower tropospheric and upper tropospheric-lower stratospheric partial columns derived from the analysis of high resolution Fourier transform infrared solar spectra recorded at the Jungfraujoch station (46.5°N, 3580 m a.s.l.). The retrieval of methanol is very challenging due to strong absorptions of ozone in the region of the selected 8 band of CH3OH. Two wide spectral intervals have been defined and adjusted in order to maximize the information content. Methanol does not exhibit a significant trend over the 1995-2012 time period, but a strong seasonal modulation characterized by maximum values and variability in June-July, minimum columns in winter and a peak-to-peak amplitude of 130 %. In situ measurements performed at the Jungfraujoch and ACE-FTS occultations give similar results for the methanol seasonal variation. The total and lower tropospheric columns are also compared with IMAGESv2 model simulations. There is no systematic bias between the observations and IMAGESv2 but the model underestimates the peak-to-peak amplitude of the seasonal modulations. [less ▲]

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See detailLong-term evolution in the tropospheric concentration of chlorofluorocarbon 12 (CCl2F2) derived from high-spectral resolution infrared solar absorption spectra: retrieval and comparison with in situ surface measurements
Rinsland, Curtis P.; Goldman, Aaron; Mahieu, Emmanuel ULg et al

in Journal of Quantitative Spectroscopy & Radiative Transfer (2005), 92(2), 201-209

The average tropospheric volume mixing ratios of chlorofluorocarbon 12 (CCl2F2) have been retrieved from high-spectral resolution ground-based infrared solar-absorption spectra recorded from March 1982 to ... [more ▼]

The average tropospheric volume mixing ratios of chlorofluorocarbon 12 (CCl2F2) have been retrieved from high-spectral resolution ground-based infrared solar-absorption spectra recorded from March 1982 to October 2003 with the McMath Fourier transform spectrometer at the US National Solar Observatory facility on Kitt Peak in southern Arizona (31.9degreesN, 111.6degreesW, 2.09 km altitude). The retrievals are based on fits to the unresolved v(8) band Q-branches near 922 cm(-1) using the SFIT2 retrieval algorithm. The annual increase rate was equal to (16.88 +/- 1.37) parts per trillion (10(-12)) by volume at the beginning of the time series, March 1982, or (4.77 +/- 0.04)%, 1 sigma, declining progressively to (2.49 +/- 1.24) parts per trillion, by volume at the end, October 2003, or (0.46 +/- 0.24)%, 1 sigma. Average tropospheric mixing ratios from the solar spectra have been compared with average surface flask and in situ sampling measurements from the Climate Monitoring and Diagnostics Laboratory (CMDL) station at Niwot Ridge, CO, (USA) (40.0degreesN, 105.5degreesW, 3013 m altitude). The average ratio and standard deviation of the monthly means of the retrieved tropospheric mixing ratios relative to the CMDL surface mixing ratios is (1.01 +/- 0.03) for the overlapping time period. Both datasets demonstrate the progressive impact of the Montreal protocol and its strengthening amendments on the trend of CCl2F2, though a tropospheric decrease has yet to be observed. (C) 2004 Elsevier Ltd. All rights reserved. [less ▲]

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See detailLong-term evolution of the loading of CH4, N2O, CO, CCl2F2, CHClF2 and SF6 above Central Europe during the last 15 years
Zander, Rodolphe ULg; Mahieu, Emmanuel ULg; Demoulin, Philippe ULg et al

in J. van Ham (Ed.) Non-CO2 greenhouse gases: scientific understanding, control and implementation (2000)

Long-term monitoring activities of some 20 atmospheric constituents are continuing at the International Scientific Station of the Jungfraujoch, Switzerland, based on remote infra-red solar observations ... [more ▼]

Long-term monitoring activities of some 20 atmospheric constituents are continuing at the International Scientific Station of the Jungfraujoch, Switzerland, based on remote infra-red solar observations with high spectral resolution Fourier transform spectrometers. As a contribution to non-CO2 greenhouse gas investigations, we report the trends observed in the vertical column abundances measured regularly since the mid-1980s for CH4, N2O, CO, CCl2F2, CHClF2 and SF6. With the exception of CO, all species show positive rates of change in their near past atmospheric loading, those of CH4, N2O and CCl2F2 having slowed significantly during the more recent years. The derived rates of change will be compared to findings resulting from ground-level in situ investigations at latitudes similar to that of the Jungfraujoch, and be interpreted in terms of resulting global loading changes. [less ▲]

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See detailLong-term evolution of the North Anatolian Fault
Hubert, Aurelia ULg; Van Der Woerd, Jerome; King, G. et al

in Abstracts with Programs - Geological Society of America (2010, October)

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See detailLong-term evolution of the North Anatolian fault (Turkey)
Hubert, Aurelia ULg; Van Der Woerd, J.; King, G. et al

in Geological Society of London (Special publication : Geodynamics of Collision and Collapse at the Africa-Arabia-Eurasia Subduction Zone, Editor R. Govers) (2008)

The deformation and 40Ar-39Ar dating of recent volcanism that remarkably sits across the North Anatolian Fault eastern termination in Turkey, together with previous studies, put strong constraints on the ... [more ▼]

The deformation and 40Ar-39Ar dating of recent volcanism that remarkably sits across the North Anatolian Fault eastern termination in Turkey, together with previous studies, put strong constraints on the long- term evolution of the fault. We argue that after a first phase of 10 Ma, characterized by a slip rate of about 3 mm/yr, and during which most of the trace was established, the slip rate jumped to about 20 mm/yr on average over the last 2.5 Ma, without substantial increase of the fault length. The transition correlates with a change in the geometry at the junction with the East Anatolian Fault that makes the extrusion process more efficient. [less ▲]

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See detailLong-term fate of exogenous metals in a sandy Luvisol subjected to intensive irrigation with raw wastewater
Dere, Christelle ULg; Lamy, Isabelle; Jaulin, Anne et al

in Environmental Pollution (2007), 145

From 1899 to 2002, sandy Luvisol in the Paris region has been intensively irrigated with raw wastewater, resulting in major soil pollution by metallic trace elements (MTE). To identify the soil phases ... [more ▼]

From 1899 to 2002, sandy Luvisol in the Paris region has been intensively irrigated with raw wastewater, resulting in major soil pollution by metallic trace elements (MTE). To identify the soil phases implicated in retaining these metals, sequential extractions were performed on a solum irrigated with untreated wastewater and another reference solum. The endogenous and exogenous fractions of MTE in the contaminated soil were discriminated using correlations between MTE and major elements defined from unpolluted soils of the area. In the contaminated soil no exogenous lead and chromium are present below the surface horizon, whereas exogenous zinc and copper are found down to the base of the solum. The endogenous MTE are mainly found in the residual fraction. Exogenous MTE appear to be associated with organic matter in the surface horizon, and exogenous zinc seems to be readsorbed on iron and manganese oxyhydroxides in the underlying horizons. [less ▲]

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See detailLong-Term Feeding Ecology and Habitat Use in Harbour Porpoises Phocoena Phocoena from Scandinavian Waters Inferred from Trace Elements and Stable Isotopes
Fontaine, Michael ULg; Tolley, K. A.; Siebert, U. et al

in BMC Ecology (2007), 7

BACKGROUND: We investigated the feeding ecology and habitat use of 32 harbour porpoises by-caught in 4 localities along the Scandinavian coast from the North Sea to the Barents Sea using time-integrative ... [more ▼]

BACKGROUND: We investigated the feeding ecology and habitat use of 32 harbour porpoises by-caught in 4 localities along the Scandinavian coast from the North Sea to the Barents Sea using time-integrative markers: stable isotopes (delta13C, delta15N) and trace elements (Zn, Cu, Fe, Se, total Hg and Cd), in relation to habitat characteristics (bathymetry) and geographic position (latitude). RESULTS: Among the trace elements analysed, only Cd, with an oceanic specific food origin, was found to be useful as an ecological tracer. All other trace elements studied were not useful, most likely because of physiological regulation and/or few specific sources in the food web. The delta13C, delta15N signatures and Cd levels were highly correlated with each other, as well as with local bathymetry and geographic position (latitude). Variation in the isotopic ratios indicated a shift in harbour porpoise's feeding habits from pelagic prey species in deep northern waters to more coastal and/or demersal prey in the relatively shallow North Sea and Skagerrak waters. This result is consistent with stomach content analyses found in the literature. This shift was associated with a northward Cd-enrichment which provides further support to the Cd 'anomaly' previously reported in polar waters and suggests that porpoises in deep northern waters include Cd-contaminated prey in their diet, such as oceanic cephalopods. CONCLUSION: As stable isotopes and Cd provide information in the medium and the long term respectively, the spatial variation found, shows that harbour porpoises experience different ecological regimes during the year along the Scandinavian coasts, adapting their feeding habits to local oceanographic conditions, without performing extensive migration. [less ▲]

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See detailLong-term fluctuations (1979 – 2008) of the phytoplankton dynamics in the Bay of Calvi (Corsica, NW Mediterranean): relations with wind stress variability and NAO index
Goffart, Anne ULg; Hecq, Jean-Henri ULg

Conference (2008)

The development of the winter-spring phytoplankton bloom is investigated in the oligotrophic Bay of Calvi (Corsica, Ligurian Sea, Northwestern Mediterranean) since 1979. Time-series results enlighten that ... [more ▼]

The development of the winter-spring phytoplankton bloom is investigated in the oligotrophic Bay of Calvi (Corsica, Ligurian Sea, Northwestern Mediterranean) since 1979. Time-series results enlighten that changes in environmental conditions in the Corsican sector have altered the coastal phytoplankton dynamics and induced a drastic reduction of the winter-spring phytoplankton biomass over the last three decades. At the local scale, variations in winter wind stress control the development of the winter-spring phytoplankton bloom and the structure of the phytoplankton assemblages. Results emphasize that the total phytoplankton biomass (chl a) is higher during high winter wind stress years. From a specific point of view, flagellates are always the dominant component of the phytoplankton bloom communities. However, diatoms tend to be more abundant during high winter wind stress years. At a wider scale, a link between the intensity of the phytoplankton bloom and the winter NAO index is established. Lastly, the decrease in phytoplankton abundance coincides with changes in zooplankton populations. As a consequence, the entire pelagic food web dynamics is affected by climate variations and the ecosystem resilience is threatened. [less ▲]

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See detailLong-term fluvastatin reduces the hazardous effect of renal impairment on four-year atherosclerotic outcomes (a LIPS substudy)
Lemos, P. A.; Serruys, P. W.; de Feyter, P. et al

in American Journal of Cardiology (2005), 95(4), 445-451

Mild renal impairment is an important risk factor for late cardiovascular complications. This substudy of the Lescol Intervention Prevention Study (LIPS) assessed the effect of fluvastatin on outcome of ... [more ▼]

Mild renal impairment is an important risk factor for late cardiovascular complications. This substudy of the Lescol Intervention Prevention Study (LIPS) assessed the effect of fluvastatin on outcome of patients who had renal dysfunction and those who did not. Complete data for creatinine clearance calculation. (Cockcroft=Gault formula) were available for 1,558 patients (92.9% of the LIPS population). Patients were randomized to fluvastatin or placebo after successful completion of a first percutaneous coronary intervention. Follow-up time was, 3 to 4 years. The effect of baseline creatinine clearance on coronary atherosclerotic events (cardiac death, non-fatal myocardial infarction, and coronary reinterventions not related to restenosis) was evaluated. Baseline creatinine clearance (logarithmic transformation) was inversely associated with an incidence of adverse events among patients who received, placebo. (hazard ratio 0.99, 95% confidence interval 0.982 to 0.998, p = 0.01). However, no association was noted between creatinine clearance and the incidence of adverse events among patients who received fluvastatin (hazard ratio 1.0, 95% confidence interval 0.99 to 1.0, p = 0.63). No further deterioration in creatinine clearance was observed during follow-up; regardless of baseline renal function or allocated treatment. Occurrence of adverse events was not related to changes in renal function during follow-up. Fluvastatin therapy markedly decreased the risk of coronary atherosclerotic events after percutaneous intervention in: patients who had lower values of creatinine clearance at baseline: The benefit of fluvastatin was unrelated to any effect on renal function. (C) 2005 by Excerpta Medica Inc. [less ▲]

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See detailLong-term follow-up from the STRIDE (anti-restenosis with the biodivysio dexamethasone-eluting stent) clinical study
Liu, X.; Hanet, C.; Legrand, Victor ULg et al

in European Heart Journal (2003), 24(Suppl. S), 268

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