Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailOrganization of a quality-assurance project in all Belgian multidisciplinary diabetes centres treating insulin-treated diabetes patients: 5 years' experience.
Debacker, Nathalie ULg; Nobels, F.; Vandenberghe, H. et al

in Diabetic Medicine : A Journal of the British Diabetic Association (2008), 25(2), 179-85

AIMS: To describe the IQED, a quality-assurance system started in 2001 in Belgian hospital-based multidisciplinary diabetes centres, and its effects on the quality of care. METHODS: The study was ... [more ▼]

AIMS: To describe the IQED, a quality-assurance system started in 2001 in Belgian hospital-based multidisciplinary diabetes centres, and its effects on the quality of care. METHODS: The study was conducted through four data collections (in 2001, 2002, 2004 and 2006). Approximately 120 diabetes centres provided data on a systematic random sample of 10% of their adult diabetic patients on at least two daily insulin injections. Data on patient characteristics, glycaemic control, cardiovascular risk, diabetes complications, follow-up procedures and treatment were obtained. Local quality promotion was encouraged by returning comprehensive feedback (benchmarks) and during information meetings. RESULTS: Nearly all diabetes centres (98-100%) participated. The pooled sample consisted of 9194 (32%) Type 1 and 19 828 (68%) Type 2 diabetes patients, with mean diabetes duration of 17 years and 14 years, prevalence of microvascular complications of 23% and 38% and prevalence of macrovascular complications of 9% and 26%, respectively. At the start, the quality of care was good in terms of risk-factor testing rates and moderate in terms of patients meeting goals for risk-factor management. At least 50% of the centres initiated quality-promoting initiatives. After 5 years, significant improvements were seen in risk-factor testing rates, apart from renal screening. Improvements in intermediate outcomes were less obvious, apart from an increase in patients reaching the targets for blood pressure and LDL cholesterol. CONCLUSIONS: It is feasible to implement a continuous quality-improvement project on a nationwide scale, with improvements particularly in process indicators. [less ▲]

Detailed reference viewed: 36 (1 ULg)
Full Text
Peer Reviewed
See detailOrganization of microbeads in Leidenfrost droplet
Maquet, Laurent ULg; Colinet, Pierre; Dorbolo, Stéphane ULg

in Soft Matter (2014), 10

Detailed reference viewed: 29 (14 ULg)
See detailOrganization of myxoviruses: structural basis of several biological properties of Newcastle Disease Virus
Rentier, Bernard ULg; Calberg-Bacq, C. M.; Reginster, Monique

in Proceedings (1973)

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detailOrganization of networks with tagged nodes and biased links: A priori distinct communities The case of intelligent design proponents and Darwinian evolution defenders
Rotundo, G.; Ausloos, Marcel ULg

in Physica A: Statistical Mechanics and its Applications (2010), 389(23), 5479-5494

Among the topics of opinion formation it is of interest to observe the characteristics of networks with a priori distinct communities. The citation network(s) between selected members of the ... [more ▼]

Among the topics of opinion formation it is of interest to observe the characteristics of networks with a priori distinct communities. The citation network(s) between selected members of the Neocreationist and Intelligent Design and the Darwinian Evolution communities are unfolded through the available internet citations. The resulting adjacency matrix is not symmetric. A generalization of considerations pertaining to the case of networks with tagged nodes and biased links, directed or undirected, is presented. The main characteristic coefficients describing the structure of such networks are outlined. The structural features are discussed searching for statistical aspects of the communities. The degree distributions, each network's assortativity, specific global and local clustering coefficients and the Average Overlap Indices are especially calculated since the distribution of elements in the rectangular submatrices represent inter-community connections. The various closed and open triangles made from nodes, distinguishing the community, are listed. The z-scores of patterns are calculated. One can distinguish between opinion leaders, followers and main rivals and briefly interpret their relationships through intuitively expected behavior in defence of an opinion. Suggestions for more elaborate models describing such communities and their subsequent structures are found in conclusions. (C) 2010 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 5 (0 ULg)
Peer Reviewed
See detailOrganization of partner preference and sexual behavior and its nocturnal rhythmicity in male rats.
Bakker, Julie ULg; van Ophemert, J.; Slob, A. K.

in Behavioral Neuroscience (1993), 107(6), 1049-58

Male rats were neonatally treated with 1,4,6-androstatriene-3,17-dione (ATD), which blocks aromatization of testosterone (T) to estradiol (E2), from Days 0, 2, or 5 through 14. Adult partner preference ... [more ▼]

Male rats were neonatally treated with 1,4,6-androstatriene-3,17-dione (ATD), which blocks aromatization of testosterone (T) to estradiol (E2), from Days 0, 2, or 5 through 14. Adult partner preference behavior (PPB; choice between estrous female rat [F] and active male rat [M]) was studied in the early part of the dark phase of the light-dark (LD) cycle. ATD Day 0 Ms showed a preference for the stimulus M or showed no preference for either of the stimulus Ss. Controls preferred the estrous F. ATD Days 2 and 5 Ms showed PPB intermediate between ATD Day 0 Ms and controls. Thus the neonatally sensitive period for organization of adult PPB extends beyond Day 5. Furthermore, PPB showed a nocturnal rhythmicity in ATD Ms but not in controls. In the late part of the dark phase, all Ms showed a preference for the stimulus F. ATD Days 2 and 5 Ms and control Ms were no longer different in PPB, but ATD Day 0 Ms still showed significantly lower preference scores for F than all other Ms. Thus the E2 metabolite of T suppresses organization of an adult nocturnal rhythm in PPB. [less ▲]

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailOrganizational and dynamical aspects of a small network with two distinct communities: Neo-creationists vs. Evolution Defenders
Cantu, A. G.; Ausloos, Marcel ULg

in Scientometrics (2009), 80(2), 457-472

Social impacts and degrees of organization inherent to opinion formation for interacting agents on networks present interesting questions of general interest from physics to sociology. We present a ... [more ▼]

Social impacts and degrees of organization inherent to opinion formation for interacting agents on networks present interesting questions of general interest from physics to sociology. We present a quantitative analysis of a case implying an evolving small size network, i.e. that inherent to the ongoing debate between modern creationists (most are Intelligent Design (ID) proponents (IDP) and Darwin's theory of Evolution Defenders (DED)). This study is carried out by analyzing the structural properties of the citation network unfolded in the recent decades by publishing works belonging to members of the two communities. With the aim of capturing the dynamical aspects of the interaction between the IDP and DED groups, we focus on two key quantities, namely, the degree of activity of each group and the corresponding degree of impact on the intellectual community at large. A representative measure of the former is provided by the rate of production of publications (RPP), whilst the latter can be assimilated to the rate of increase in citations (RIC). These quantities are determined, respectively, by the slope of the time series obtained for the number of publications accumulated per year and by the slope of a similar time series obtained for the corresponding citations. The results indicate that in this case, the dynamics can be seen as geared by triggered or damped competition. The network is a specific example of marked heterogeneity in exchange of information activity in and between the communities, particularly demonstrated through the nodes having a high connectivity degree, i.e. opinion leaders. [less ▲]

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailOrganizational and Institutional Arrangements for e-Government: A Preliminary Report on Contemporary IT Management Approaches in US State Governments
Markus, M. Lynne; Jacobson, Dax D.; Bui, Quang Neo et al

E-print/Working paper (2012)

The success of e-government is believed to depend in part on the organizational and institutional arrangements that governments enact for the management of their IT resources. This paper develops the ... [more ▼]

The success of e-government is believed to depend in part on the organizational and institutional arrangements that governments enact for the management of their IT resources. This paper develops the conceptualization of IT management arrangements by considering possible interactions between two dimensions — 1) the organization of IT activities and 2) control over decisions about IT activities (also known as governance) — for each of two categories of IT activities — 1) IT projects (such as website development) and 2) IT services (such as the operation of networks). In addition, the paper provides preliminary empirical evidence obtained from applying this expanded conceptualization in the context of American state governments. Many states appear to employ centralization of IT activities to offset decentralization of IT control and vice versa. Consequently, neither dimension alone provides a good characterization of governmental IT management arrangements. These findings have the potential to enhance our understanding of the barriers to, and enablers of, e-government success. [less ▲]

Detailed reference viewed: 68 (29 ULg)
Full Text
Peer Reviewed
See detailOrganizational and Institutional Arrangements for e-Government: A Preliminary Report on Contemporary IT Management Approaches in US State Governments
Markus, M. Lynne; Jacobson, Dax D.; Bui, Quang Neo et al

Conference (2013, January)

The success of e-government is believed to depend in part on the organizational and institutional arrangements that governments enact for the management of their IT resources. This paper develops the ... [more ▼]

The success of e-government is believed to depend in part on the organizational and institutional arrangements that governments enact for the management of their IT resources. This paper develops the conceptualization of IT management arrangements by considering possible interactions between two dimensions—1) the organization of IT activities and 2) control over decisions about IT activities (also known as governance)—for each of two categories of IT activities—1) IT projects (such as website development) and 2) IT services (such as the operation of networks). In addition, the paper provides preliminary empirical evidence obtained from applying this expanded conceptualization in the context of American state governments. Many states appear to employ centralization of IT activities to offset decentralization of IT control and vice versa. Consequently, neither dimension alone provides a good characterization of governmental IT management arrangements. These findings have the potential to enhance our understanding of the barriers to, and enablers of, e-government success. [less ▲]

Detailed reference viewed: 67 (10 ULg)
Peer Reviewed
See detailOrganizational identification and affective commitment: An integrative approach.
Marique, Géraldine; Stinglhamber, Florence; Hansez, Isabelle ULg et al

Conference (2011, May 25)

Detailed reference viewed: 38 (2 ULg)
Full Text
Peer Reviewed
See detailOrganizational identification and commitment: The impact of POS and prestige
Marique, Géraldine; Stinglhamber, Florence; Desmette, Donatienne et al

Poster (2012, April)

Detailed reference viewed: 23 (1 ULg)
Full Text
See detailOrganizations, Autonomy and Leadership: the importance of the context
Robert, Jocelyne ULg

in Autio, Veli Matti; Akihiro, Ishikawa; Juuti, Pauli (Eds.) Contempory Corporate culture under globalization (2012)

We want to present the place of autonomy and freedom ro take initiatives in the organizations. The response is one balance between control and autonomy. Corporate culture, leadership and corporate social ... [more ▼]

We want to present the place of autonomy and freedom ro take initiatives in the organizations. The response is one balance between control and autonomy. Corporate culture, leadership and corporate social responsibility play one essentiel role in contextual situations. [less ▲]

Detailed reference viewed: 94 (41 ULg)
Full Text
Peer Reviewed
See detailOrganized Proteomic Heterogeneity in Colorectal Cancer Liver Metastases and Implications for Therapies
Turtoi, Andrei ULg; Blomme, Arnaud; Debois, Delphine et al

in Hepatology (Baltimore, Md.) (2013)

Tumor heterogeneity is a major obstacle for developing effective anticancer treatments. Recent studies have pointed to large stochastic genetic heterogeneity within cancer lesions, where no pattern seems ... [more ▼]

Tumor heterogeneity is a major obstacle for developing effective anticancer treatments. Recent studies have pointed to large stochastic genetic heterogeneity within cancer lesions, where no pattern seems to exist that would enable a more structured targeted therapy approach. Because to date no similar information is available at the protein (phenotype) level, we employed matrix assisted laser desorption ionization (MALDI) image-guided proteomics and explored the heterogeneity of extracellular and membrane subproteome in a unique collection of eight fresh human colorectal carcinoma (CRC) liver metastases. Monitoring the spatial distribution of over 1,000 proteins, we found unexpectedly that all liver metastasis lesions displayed a reproducible, zonally delineated pattern of functional and therapeutic biomarker heterogeneity. The peritumoral region featured elevated lipid metabolism and protein synthesis, the rim of the metastasis dis- played increased cellular growth, movement, and drug metabolism, whereas the center of the lesion was characterized by elevated carbohydrate metabolism and DNA-repair activity. From the aspect of therapeutic targeting, zonal expression of known and novel biomarkers was evident, reinforcing the need to select several targets in order to achieve optimal coverage of the lesion. Finally, we highlight two novel antigens, LTBP2 and TGFBI, whose expression is a consistent feature of CRC liver metastasis. We demon- strate their in vivo antibody-based targeting and highlight their potential usefulness for clinical applications. Conclusion: The proteome heterogeneity of human CRC liver metastases has a distinct, organized pattern. This particular hallmark can now be used as part of the strategy for developing rational therapies based on multiple sets of target- able antigens. [less ▲]

Detailed reference viewed: 26 (11 ULg)
Full Text
Peer Reviewed
See detailOrganized proteomic heterogeneity in colorectal liver metastases and implications for therapies
Turtoi, Andrei ULg; Blomme, Arnaud ULg; Debois, Delphine ULg et al

in Acta Gastro-Enterologica Belgica (2014, March), 77(1), 07

Introduction : Tumor heterogeneity is a major obstacle for developing effective anti-cancer treatments. Recent studies have pointed at large stochastic genetic heterogeneity within cancer lesions, where ... [more ▼]

Introduction : Tumor heterogeneity is a major obstacle for developing effective anti-cancer treatments. Recent studies have pointed at large stochastic genetic heterogeneity within cancer lesions, where no pattern seems to exist that would enable a more structured targeted therapy approach. Aim : Because to date no similar information is available at the protein (phenotype) level, we aimed at characterising the proteomic heterogeneity in human colorectal carcinoma (CRC) liver metastases. Methods & Results : We employed MALDI imaging-guided proteomics and explored the heterogeneity of extracellular distribution of over 1000 proteins we found unexpectedly that all liver metastasis lesions displayed a reproducible, zon- ally delineated, pattern of functional and therapeutic biomarker heterogeneity. Peritumoral region featured elevated lipid metabolism and protein synthesis, the rim of the metastasis displayed increased cellular growth, movement and drug metabolism whereas the center of the lesion was characterized by elevated carbohydrate metabolism and DNA- repair activity. From the aspect of therapeutic targeting zonal expression of known and novel biomarkers was evident, reinforcing the need to select several targets in order to achieve optimal coverage of the lesion. Finally we highlight two novel antigens, LTBP2 and TGFBI, whose expression is a consistent feature of CRC liver metastasis. Conclusions : proteome heterogeneity has a distinct, organized, pattern. This particular hallmark can now be used as a part of the strategy for developing rational therapies based on multiple sets of targetable antigens. [less ▲]

Detailed reference viewed: 17 (1 ULg)