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See detailIon channel modulators: more diversity than previously thought
Dilly, Sébastien ULg; Lamy, Cédric; Marrion, Neil et al

in Chembiochem : A European Journal of Chemical Biology (2011), 12(12), 1808-1812

Ion channel function can be modified in various ways. For example, numerous studies have shown that currents through voltage-gated ion channels are affected by pore block or modification of voltage ... [more ▼]

Ion channel function can be modified in various ways. For example, numerous studies have shown that currents through voltage-gated ion channels are affected by pore block or modification of voltage-dependence of activation/inactivation. Recent experiments performed on various ion channels show that allosteric modulation is an important mechanism to affect channel function. For instance, in KCa2 (formerly SK) channels, the prototypic “blocker” apamin prevents conduction by an allosteric mechanism, while TRPV1 channels are prevented from closing by a tarantula toxin, DkTx, through an interaction with residues located away from the selectivity filter. The recent evidence therefore suggests that, in several ion channels, the region around the outer mouth of the pore is rich in binding sites which may be exploited therapeutically. These discoveries also suggest that the pharmacological vocabulary should be adapted to define these various actions. [less ▲]

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See detailIon Dissociation Kinetics in Mass Spectrometry
Leyh, Bernard ULg

in Reedijk, J. (Ed.) Reference Module in Chemistry, Molecular Sciences and Chemical Engineering (2013)

The variation of fragmentation rate constants as a function of the parent ion internal energy, or, alternatively, as a function of temperature, is crucial information to unravel the dissociation ... [more ▼]

The variation of fragmentation rate constants as a function of the parent ion internal energy, or, alternatively, as a function of temperature, is crucial information to unravel the dissociation mechanisms of molecular ions. This contribution provides the reader first with basic information on the statistical theories used to model unimolecular rate constants. Various experimental methods to measure such rate constants in the 102 to 1010 s^(-1) range are then discussed. Kinetic isotope effects are also briefly dealt with. How reaction mechanisms can be inferred from kinetic data is handled in an extensive section where selected examples from the recent literature are discussed. [less ▲]

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See detailIon homeostasis in the chloroplast
Hanikenne, Marc ULg; Bernal, Maria; Urzica, Eugen

in Wollman, Francis-Andre; Theg, Steve M. (Eds.) Plastid Biology (2014)

The chloroplast is an organelle of high demand for macro- and micro-nutrient ions, which are required for the maintenance of the photosynthetic process. To avoid deficiency while preventing excess ... [more ▼]

The chloroplast is an organelle of high demand for macro- and micro-nutrient ions, which are required for the maintenance of the photosynthetic process. To avoid deficiency while preventing excess, homeostasis mechanisms must be tightly regulated. Here, we describe the needs for nutrient ions in the chloroplast and briefly highlight their functions in the chloroplastidial metabolism. We further discuss the impact of nutrient deficiency on chloroplasts and the acclimation mechanisms that evolved to preserve the photosynthetic apparatus. We finally present what is known about import and export mechanisms for these ions. Whenever possible, a comparison between cyanobacteria, algae and plants is provided to add an evolutionary perspective to the description of ion homeostasis mechanisms in photosynthesis. [less ▲]

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See detailIon Mobility - Mass Spectrometry as a new approach for the screening of pesticide residues in food
Joly, Laure; Goscinny, Séverine ULg; Touilloux, Romain et al

Conference (2011, September)

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See detailIon Mobility Spectrometry Reveals Duplex DNA Dissociation Intermediates
Burmistrova, Anastasia; Gabelica, Valérie; Duwez, Anne-Sophie ULg et al

in Journal of the American Society for Mass Spectrometry (2013), 24

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See detailION MOBILITY – MASS SPECTROMETRY AS A NEW APPROACH FOR THE SCREENING OF PESTICIDE RESIDUES IN FOOD
Goscinny, Séverine ULg; Touilloux, Romain; Joly, Laure et al

in Organohalogen Compounds (2011)

Pesticide residue analysis requires methods that can determine hundreds of compounds at low levels in complex food matrices. This challenge has given rise to multi residue methods, the only efficient ... [more ▼]

Pesticide residue analysis requires methods that can determine hundreds of compounds at low levels in complex food matrices. This challenge has given rise to multi residue methods, the only efficient analytical approach. This type of analytical method entails a “generic” extraction followed by a soft or no purification step to avoid any analytes looses. With over a 1000 active compounds with different physical chemical properties, gas and liquid chromatography are used as complementary separative techniques. In the past decade, the determination has been performed on tandem mass analyzers, a powerful tool to overcome co-eluting compounds with excellent sensitivity. Nevertheless, these instruments can guarantee these results per acquisition cycles for more or less 150 compounds. This represents a serious limitation when the number of pesticides to be sought for monitoring and MRL enforcement is growing each year. As multiple injections from the same sample are not viable for laboratories, alternative options have to be explored. We propose the investigation of ion mobility (IM) coupled with mass spectrometry as a new approach for pesticide residue analysis in food. [less ▲]

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See detailIon Mobility-Mass Spectrometry as a Tool for the Structural Characterization of Peptides Bearing Intramolecular Disulfide Bond(s)
Massonnet, Philippe ULg; Haler, Jean ULg; Upert, Gregory et al

in Journal of the American Society for Mass Spectrometry (2016)

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See detailIon mobility-mass spectrometry to perform structural classifications of disulfide-bridged-peptides
Massonnet, Philippe ULg; Upert, Gregory; Morsa, Denis ULg et al

Poster (2014, November)

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See detailIon mobility-mass spectrometry to perform structural classifications of disulfide-bridged-peptides
Massonnet, Philippe ULg; Upert, Gregory; Morsa, Denis ULg et al

Poster (2014, November)

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See detailIon Mobility-Mass Spectrometry: Going beyond the numbers
Haler, Jean ULg; Far, Johann ULg; Béchet, Eric ULg et al

Scientific conference (2017, July 03)

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See detailIon outflow observed by IMAGE: Implications for source regions and heating mechanisms
Fuselier, S. A.; Ghielmetti, A. G.; Moore, T. E. et al

in Geophysical Research Letters (2001), 28

Images of the Earth's proton aurora from the IMAGE spacecraft on 8 June 2000 indicate a temporally and spatially isolated ionospheric response to a shock that impinged on the Earth's magnetopause ... [more ▼]

Images of the Earth's proton aurora from the IMAGE spacecraft on 8 June 2000 indicate a temporally and spatially isolated ionospheric response to a shock that impinged on the Earth's magnetopause. Sometime after this ionospheric response, the Low Energy Neutral Atom imager on IMAGE detected enhanced ionospheric outflow. The time delay between the ionospheric response and the enhanced outflow is consistent with the travel time of ~30 eV neutral Oxygen (created by charge exchange of outflowing O[SUP]+[/SUP] with the exosphere) from the low altitude ionosphere to the spacecraft. The prompt ionospheric outflow implies that the shock deposited sufficient energy in the topside ionosphere near or above the O[SUP]+[/SUP] exobase to initiate the outflow. [less ▲]

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See detailAn Ion Retarding Potential Difference Method applied to Dissociative Photoionization Mass Spectrometry.
Locht, Robert ULg; Rühl, E.; Hagenow, G. et al

in Dalgarno, A.; Freund, R. S.; Lubell, M. S. (Eds.) et al 16th International Conference on the Physics of Electronic and Atomic Collisions: Abstract of Contributed Papers. (1989)

Dissociative photoionization of O2 has been investigated by using the ion retarding potential for the translational energy analysis of the O+ fragment. Synchrotron radiation is used as a light source ... [more ▼]

Dissociative photoionization of O2 has been investigated by using the ion retarding potential for the translational energy analysis of the O+ fragment. Synchrotron radiation is used as a light source. Ionization efficiency curves have been recorded at several retarding potential settings. [less ▲]

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