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See detailOver een toiletartikel: Hendrik van Veldekes 'Sente Servaes' en Camille Huysmans
Steyaert, Kris ULg

in Spiegel der Letteren (2013), 55(2), 189-200

In 1858 J.H. Bormans published the first edition of Hendrik van Veldeke’s legend of Saint Servatius which had only just come to light. Nearly forty years later, Camille Huysmans supplied additional ... [more ▼]

In 1858 J.H. Bormans published the first edition of Hendrik van Veldeke’s legend of Saint Servatius which had only just come to light. Nearly forty years later, Camille Huysmans supplied additional information about the work’s discovery. In a humorous letter printed in the Limburgsch jaarboek (1895-1896) he revealed how one of his former teachers, during a visit to a friend’s house, had stumbled upon the fifteenth-century manuscript in the toilet, ready to be used as toilet paper. Only recently have scholars begun to cast doubt on Huysmans’s story. A closer look at Huysmans’s student career in Liège and his involvement in the association Onze Taal (Our Language) may shed new light on the origins and veracity of his account. [less ▲]

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See detailOver het verschuiven van tafels en stoelen. Erik Spinoy en Anneleen De Coux spraken met de samenstellers van Hotel New Flandres
Spinoy, Erik ULg; De Coux, Anneleen

Article for general public (2009)

This is the text of an interview, taken by myself and by Anneleen de Coux, of the editors of Hotel New Flandres, an important new anthology of postwar Flemish poetry.

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See detailOver Kalligramme. Zur Medialität einer Schrift anhand von Paul van Ostaijens De feesten van angst en pijn
Spinoy, Erik ULg

in Spiegel der Letteren (2002), 44(3), 291-293

This is a review of a study by Sonja Neef on the work of Paul van Ostaijen

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See detailOver Kathrin Kötz, Die Prosa Paul van Ostaijens
Spinoy, Erik ULg

in Nachbarsprache Niederländisch (2002), 17(1-2), 122-125

This is a review of a study by Katrhin Kötz on Paul van Ostaijen's literary ('grotesque') prose and its German influences.

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See detailOver literaire prijzen
Spinoy, Erik ULg

in Freespace Nieuwzuid (2008), 8(32), 101

This issue reflects on the growing importance of literary prizes in literary life, and how this has changed literature in general.

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See detailOver literatuurgeschiedenis
Spinoy, Erik ULg

in Freespace Nieuwzuid (2006), 6(21), 126

The present issue is a collection of reflections on the way literary history is to be written at the beginning of the 21st century, primarily on the occasion of the publication of a new history of postwar ... [more ▼]

The present issue is a collection of reflections on the way literary history is to be written at the beginning of the 21st century, primarily on the occasion of the publication of a new history of postwar Dutch literature. [less ▲]

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See detailOver mimetismus
Fredericq, Léon ULg

in Vlaamse Gids (De) (1910), VI

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See detailOver stromen en watervallen : curricua die niet discrimineren
Demeuse, Marc; Friant, N.; Baye, Ariane ULg

in Nicaise, Julien; Desmedt, E. (Eds.) Gelijke kansen op school : het kan. Zestein sporen voor praktijk en beleid (2008)

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See detailAn Overall Magnetic $t$-$\omega$ Formulation without Cuts
Henrotte, F.; Dular, Patrick ULg; Geuzaine, Christophe ULg et al

in Proceedings of the 8th Conference on Electromagnetic Field Computation, CEFC 1998 (1998)

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See detailOverall properties of hot, massive stars in the X-ray domain
Nazé, Yaël ULg

(2011, July 01)

Despite the absence of large surveys, the recent X-ray observatories provide X-ray data for hundreds of massive stars (294 OB stars detected in the 2XMM catalog, 129 OB stars detected in the Chandra ... [more ▼]

Despite the absence of large surveys, the recent X-ray observatories provide X-ray data for hundreds of massive stars (294 OB stars detected in the 2XMM catalog, 129 OB stars detected in the Chandra Carina Complex Project). Analyzing medium-resolution spectra led to new results on the relationship between the X-ray luminosity and the bolometric luminosity, as well as on the typical properties (plasma temperature, variability) of these objects. [less ▲]

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See detailOvercoming problems with adherence to osteoporosis medication.
Rabenda, Véronique ULg; Reginster, Jean-Yves ULg

in Expert review of pharmacoeconomics & outcomes research (2010), 10(6), 677-89

Nonadherence to pharmacological treatment in osteoporosis is a well-recognized problem. As in other chronic diseases, adherence to osteoporosis treatment is poor, resulting in enormous burden on patients ... [more ▼]

Nonadherence to pharmacological treatment in osteoporosis is a well-recognized problem. As in other chronic diseases, adherence to osteoporosis treatment is poor, resulting in enormous burden on patients and healthcare resources. Most importantly, low adherence rates consistently result in increased rates of fractures. However, it seems that efforts to evaluate and improve rates of both compliance and persistence are increasing. The extension of dosing intervals may be an element, among others, allowing improvements in therapeutic adherence. Improved patient education, enhancing healthcare provider-patients interaction, taking into account patient's preferences and involving them in treatment decisions may improve adherence. [less ▲]

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See detailOverestimation of the 25OHD serum concentration with the automated IDS EIA kit.
Cavalier, Etienne ULg; Huberty, V.; Cormier, C. et al

in Journal of Bone and Mineral Research (2011), 26(2), 434-6

We have recently observed an increasing number of patients presenting very high serum levels of 25-hydroxyvitamin D [25(OH)D] (> 150 ng/mL), which, in all cases, had been measured with the IDS EIA kit ... [more ▼]

We have recently observed an increasing number of patients presenting very high serum levels of 25-hydroxyvitamin D [25(OH)D] (> 150 ng/mL), which, in all cases, had been measured with the IDS EIA kit adapted on different "open" automated platforms. We performed a comparison between the IDS EIA kit adapted on two different "open"automated platforms and the DiaSorin RIA. We found a systematic bias (higher levels with the IDS EIA kit) for concentrations more than 50-60 ng/mL that was less obvious when the IDS EIA was used in its manual procedure. We thus suggest to use the IDS EIA kit in its manual procedure rather than to adapt it on an automated platform, and to interpret cautiously a 25(OH)D greater than 100 ng/mL with this kit. [less ▲]

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See detailOverexpression and function of the CIPAR1 gene in a rat prostatic cell line.
Cornet, Anne ULg

Scientific conference (1997, November 29)

In prostate cancer therapy, as the components of the cell death pathway play an important role, it is conceivable that targeted transfer of apoptosis inducer genes into prostatic cells could be useful. A ... [more ▼]

In prostate cancer therapy, as the components of the cell death pathway play an important role, it is conceivable that targeted transfer of apoptosis inducer genes into prostatic cells could be useful. A new gene, CIPAR1 (Castration Induced Prostatic Apoptosis Related gene 1) was identified by differential screening for genes that were upregulated when rat prostates were induced to undergo apoptosis. To define the role of CIPAR1 in the apoptosis pathway, we have therefore investigated its ability to induce apoptosis in the Mat LyLu cells. The CIPAR1 gene was transiently overexpressed in these cells. The rate of apoptosis in the transfected cells was estimated with the help of the following tests: qualitative methods (DNA ladder, TUNEL on slide) and also quantitative methods using flow cytolmetric analysis. Induction of apoptosis was higher in the pcDNA3-CIPAR1 transfected cells than in controls. The establishment of a stable cell line that contains the gene CIPAR1 under the control of an inducible promoter would be an useful model to study the role of CIPAR1 in prostatic cell death. [less ▲]

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See detailOverexpression of a novel member of the mitochondrial carrier family rescues defects in both DNA and RNA metabolism in yeast mitochondria.
Van Dyck, E.; Jank, B.; Ragnini, A. et al

in Molecular & General Genetics [=MGG] (1995), 246

The PIF1 and MRS2 gene products have previously been shown to be essential for mitochondrial DNA maintenance at elevated temperatures and mitochondrial group II intron splicing, respectively, in the yeast ... [more ▼]

The PIF1 and MRS2 gene products have previously been shown to be essential for mitochondrial DNA maintenance at elevated temperatures and mitochondrial group II intron splicing, respectively, in the yeast Saccharomyces cerevisiae. A multicopy suppressor capable of rescuing the respiratory deficient phenotype associated with null alleles of either gene has been isolated. This suppressor is a nuclear gene that was called RIM2/MRS12. The RIM2/MRS12 gene encodes a predicted protein of 377 amino acids that is essential for mitochondrial DNA metabolism and proper cell growth. Inactivation of this gene causes the total loss of mitochondrial DNA and, compared to wild-type rhoo controls, a slow-growth phenotype on media containing glucose. Analysis of the RIM2/MRS12 protein sequence suggests that RIM2/MRS12 encodes a novel member of the mitochondrial carrier family. In particular, a typical triplicate structure, where each repeat consists of two putative transmembrane segments separated by a hydrophilic loop, can be deduced from amino acid sequence comparisons and the hydropathy profile of RIM2/MRS12. Antibodies directed against the aminoterminus of RIM2/MRS12 detect this protein in mitochondria. The function of the RIM2/MRS12 protein and the substrates it might transport are discussed. [less ▲]

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See detailOverexpression of CD39 in mouse airways promotes bacteria induced inflammation
Theatre, Emilie ULg; Frederix, Kim; Guilmain, William et al

in Journal of Immunology (2012), 189(4), 1966-1974

In airways, the ecto-nucleoside triphosphate diphosphohydrolase CD39 plays a central role in the regulation of physiological mucosal nucleotide concentrations and likely contributes to the control of ... [more ▼]

In airways, the ecto-nucleoside triphosphate diphosphohydrolase CD39 plays a central role in the regulation of physiological mucosal nucleotide concentrations and likely contributes to the control of inflammation because accelerated ATP metabolism occurs in chronic inflammatory lung diseases.We sought to determine whether constant elevated CD39 activity in lung epithelia is sufficient to cause inflammation and whether this affects the response to acute LPS or Pseudomonas aeruginosa exposure. We generated transgenic mice overexpressing human CD39 under the control of the airway-specific Clara cell 10-kDa protein gene promoter. Transgenic mice did not develop any spontaneous lung inflammation. However, intratracheal instillation of LPS resulted in accelerated recruitment of neutrophils to the airways of transgenic mice. Macrophage clearance was delayed, and the amounts of CD8+ T and B cells were augmented. Increased levels of keratinocyte chemoattractant, IL-6, and RANTES were produced in transgenic lungs. Similarly, higher numbers of neutrophils and macrophages were found in the lungs of transgenic mice infected with P. aeruginosa, which correlated with improved bacteria clearance. The transgenic phenotype was partially and differentially restored by coinstillation of P2X1 or P2X7 receptor antagonists or of caffeine with LPS. Thus, a chronic increase of epithelial CD39 expression and activity promotes airway inflammation in response to bacterial challenge by enhancing P1 and P2 receptor activation. [less ▲]

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See detailOverexpression of CD9 in human breast cancer cells promotes the development of bone metastases.
Kischel, Philippe; Bellahcene, Akeila ULg; Deux, Blandine et al

in Anticancer Research (2012), 32(12), 5211-20

BACKGROUND: Bone is a preferred target for circulating metastatic breast cancer cells. We found that the CD9 protein was up-regulated in the B02 osteotropic cell line, derived from the aggressive parental ... [more ▼]

BACKGROUND: Bone is a preferred target for circulating metastatic breast cancer cells. We found that the CD9 protein was up-regulated in the B02 osteotropic cell line, derived from the aggressive parental MDA-MB-231 breast cancer cell line. Here, we investigated the putative relationship between CD9 expression and the osteotropic phenotype. MATERIALS AND METHODS: Overexpression of CD9 was analyzed by immunoblotting in different cell lines. Immunohistochemistry was used to assess CD9 expression in primary tumors and metastatic lesions. In vivo experiments were conducted in mice using a monoclonal antibody against CD9. RESULTS: CD9 overexpression was confirmed in osteotropic cells. CD9 was significantly overexpressed in bone metastases versus primary tumors and visceral metastatic lesions. Finally, in vivo experiments showed that an antibody against CD9 delays homing of B02 cells in bone marrow, slowing down bone destruction. CONCLUSION: Our study reveals a potential implication of CD9 in the formation of bony metastases from breast cancer cells. [less ▲]

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See detailOverexpression of GRP94 in breast cancer cells resistant to oxidative stress promotes high levels of cancer cell proliferation and migration: implications for tumor recurrence.
Dejeans, Nicolas; Glorieux, Christophe; Guénin, Samuel ULg et al

in Free Radical Biology & Medicine (2012), 52(6), 993-1002

Targeting the altered redox status of cancer cells is emerging as an interesting approach to potentiate chemotherapy. However, to maximize the effectiveness of this strategy and define the correct ... [more ▼]

Targeting the altered redox status of cancer cells is emerging as an interesting approach to potentiate chemotherapy. However, to maximize the effectiveness of this strategy and define the correct chemotherapeutic associations, it is important to understand the biological consequences of chronically exposing cancer cells to reactive oxygen species (ROS). Using an H(2)O(2)-generating system, we selected a ROS-resistant MCF-7 breast cancer cell line, namely Resox cells. By exploring different survival pathways that are usually induced during oxidative stress, we identified a constitutive overexpression of the endoplasmic reticulum chaperone, GRP94, in these cells, whereas levels of its cytoplasmic homolog HSP90, or GRP78, were not modified. This overexpression was not mediated by constitutive unfolded protein response (UPR) activation. The increase in GRP94 is tightly linked to an increase in cell proliferation and migration capacities, as shown by GRP94-silencing experiments. Interestingly, we also observed that GRP94 silencing inhibits migration and proliferation of the highly aggressive MDA-MB-231 cells. By immunohistochemistry, we showed that GRP94 expression was higher in recurrent human breast cancers than in their paired primary neoplasias. Similar to the situation in the Resox cells, this increase was not associated with an increase in UPR activation in recurrent tumors. In conclusion, this study suggests that GRP94 overexpression may be a hallmark of aggressiveness and recurrence in breast cancers. [less ▲]

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