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See detailPegase: a space-based nulling interferometer
Le Duigou, J. M.; Ollivier, M.; Léger, A. et al

in Mather, John C.; MacEwen, Howard A.; de Graauw, Mattheus W. M. (Eds.) Space Telescopes and Instrumentation I: Optical, Infrared, and Millimeter (2006, July 01)

The space based mission Pegase was proposed to CNES in the framework of its call for scientific proposals for formation flying missions. This paper presents a summary of the phase-0 performed in 2005. The ... [more ▼]

The space based mission Pegase was proposed to CNES in the framework of its call for scientific proposals for formation flying missions. This paper presents a summary of the phase-0 performed in 2005. The main scientific goal is the spectroscopy of hot Jupiters (Pegasides) and brown dwarfs from 2.5 to 5 mum. The mission can extend to other objectives such as the exploration of the inner part of protoplanetary disks, the study of dust clouds around AGN,... The instrument is basically a two-aperture (D=40 cm) interferometer composed of three satellites, two siderostats and one beam-combiner. The formation is linear and orbits around L2, pointing in the anti-solar direction within a +/-30° cone. The baseline is adjustable from 50 to 500 m in both nulling and visibility measurement modes. The angular resolution ranges from 1 to 20 mas and the spectral resolution is 60. In the nulling mode, a 2.5 nm rms stability of the optical path difference (OPD) and a pointing stability of 30 mas rms impose a two level control architecture. It combines control loops implemented at satellite level and control loops operating inside the payload using fine mechanisms. According to our preliminary study, this mission is feasible within an 8 to 9 years development plan using existing or slightly improved space components, but its cost requires international cooperation. Pegase could be a valuable Darwin/TPF-I pathfinder, with a less demanding, but still ambitious, technological challenge and a high associated scientific return. [less ▲]

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See detailPEGASE: UN MODÈLE INTÉGRÉ BASSIN HYDROGRAPHIQUE/ RIVIÈRES: PREMIÈRE APPLICATION TEST À LA COCAÏNE.
Deliège, Jean-François ULg; Everbecq, Etienne ULg; Magermans, Pol ULg et al

Conference (2009, October 15)

Le modèle PEGASE (Planification Et Gestion de l’ASsainissement des Eaux), développé à l’Aquapôle de l’Université de Liège a été utilisé pour réaliser une première simulation test de la cocaïne dans le ... [more ▼]

Le modèle PEGASE (Planification Et Gestion de l’ASsainissement des Eaux), développé à l’Aquapôle de l’Université de Liège a été utilisé pour réaliser une première simulation test de la cocaïne dans le réseau hydrographique belge. La principale conclusion de cette simulation test est qu’il est possible de simuler le devenir des dérivés de la cocaïne dans les eaux de surface ; cela démontre également la cohérence des mesures réalisées dans le cadre de l’étude COWAT. Des améliorations mineures au modèle PEGASE et aux données d’entrée seraient cependant souhaitables pour améliorer cette modélisation (possibilité de faire varier l’équivalent-habitant par zones). [less ▲]

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See detailPegfilgrastim compared with Filgrastim after autologous hematopoietic peripheral blood stem cell transplantation.
Vanstraelen, Gaetan; Frere, Pascale ULg; Ngirabacu, Marie-Christine et al

in Experimental hematology (2006), 34(3), 382-8

In order to assess the effect of Pegfilgrastim on the duration of neutropenia and clinical outcome of patients after autologous peripheral blood stem cell (PBSC) transplantation, we compared 20 ... [more ▼]

In order to assess the effect of Pegfilgrastim on the duration of neutropenia and clinical outcome of patients after autologous peripheral blood stem cell (PBSC) transplantation, we compared 20 consecutive patients with lymphoma or multiple myeloma receiving a single 6-mg dose of Pegfilgrastim on day 1 posttransplant to an historical control group of 60 patients receiving daily Filgrastim 5 microg/kg starting on day 1 posttransplant. The duration of neutropenia was similar in the Pegfilgrastim group compared with the control group. There were no differences in time to neutrophil, erythroid, or platelet engraftment nor in the incidence of fever and infections. The duration of antibiotic therapy, transfusion support, and time to hospital discharge were similar in the two groups. However, after initial hematopoietic reconstitution, we observed significantly higher values of lymphocytes (e.g., 1,660+/-1,000 versus 970+/-460 on day 80, p=0.0002), neutrophils (e.g., 3,880+/-2,030 versus 2,420+/-1,500 on day 25, p=0.0004), reticulocytes (e.g., 148,160+/-90,590 versus 87,140+/-65,920 on day 25, p<0.0001), and platelets (e.g., 210,700+/-116,090 versus 150,240+/-58,230 on day 55, p=0.0052) up to day 100 in the Pegfilgrastim group compared with the Filgrastim group. These observations had no impact on clinical outcome of the patients after day 30 due to the low incidence of infectious events after engraftment in autologous PBSC transplantation. We conclude that the effect of Pegfilgrastim administrated on day 1 posttransplant is comparable to that of daily Filgrastim on initial hematopoietic reconstitution. The possibly superior effect of Pegfilgrastim on cell counts we observed after initial engraftment should be further tested in a prospective randomized trial. [less ▲]

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See detailPeginterferon alpha-2b is safe and effective in HBeAg-positive chronic hepatitis B patients with advanced fibrosis.
Buster, Erik H C J; Hansen, Bettina E; Buti, Maria et al

in Hepatology (Baltimore, Md.) (2007), 46(2), 388-94

Chronic hepatitis B (CHB) patients with advanced fibrosis are often not considered for treatment with peginterferon (PEG-IFN) because IFN therapy may precipitate immunological flares, potentially inducing ... [more ▼]

Chronic hepatitis B (CHB) patients with advanced fibrosis are often not considered for treatment with peginterferon (PEG-IFN) because IFN therapy may precipitate immunological flares, potentially inducing hepatic decompensation. We investigated the efficacy and safety of treating hepatitis B e antigen (HBeAg)-positive CHB patients with 52 weeks of PEG-IFN-alpha-2b (100 microg weekly) alone or in combination with lamivudine (100 mg daily). Seventy patients with advanced fibrosis (Ishak fibrosis score 4-6) and 169 patients without advanced fibrosis, all with compensated liver disease, participated in the study. Virologic response, defined as HBeAg seroconversion and hepatitis B virus (HBV) DNA < 10,000 copies/ml at week 78, occurred significantly more often in patients with advanced fibrosis than in those without (25% versus 12%, respectively; P = 0.02). Also patients with cirrhosis (n = 24) exhibited a virologic response more frequently than did patients without cirrhosis (30% versus 14%, respectively; P = 0.02). Improvement in liver fibrosis occurred more frequently in patients with advanced fibrosis (66% versus 26%, P < 0.001). HBV genotype A was more prevalent among patients with advanced fibrosis than among those without (57% versus 24%, P < 0.001). Most adverse events, including serious adverse events, were observed equally as frequently in patients with advanced fibrosis and those without. Fatigue, anorexia, and thrombocytopenia occurred more often in patients with advanced fibrosis than in those without (P < 0.01). Necessary dose reduction or discontinuation of therapy was comparable for both patient groups (P = 0.92 and P = 0.47, respectively). CONCLUSION: PEG-IFN is effective and safe for HBeAg-positive patients with advanced fibrosis. Because PEG-IFN therapy results in a high rate of sustained off-therapy response, patients with advanced fibrosis or cirrhosis but compensated liver disease should not be excluded from PEG-IFN treatment. [less ▲]

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See detailPEGylated PLGA-based nanoparticles targeting M cells for oral vaccination
Garinot, Marie; Fievez, Virginie; Pourcelle, Vincent et al

in Journal of Controlled Release (2007), 120(3), 195-204

To improve the efficiency of orally delivered vaccines, PEGylated PLGA-based nanoparticles displaying RGD molecules at their surface were designed to target human M cells. RGD grafting was performed by an ... [more ▼]

To improve the efficiency of orally delivered vaccines, PEGylated PLGA-based nanoparticles displaying RGD molecules at their surface were designed to target human M cells. RGD grafting was performed by an original method called "photografting" which covalently linked RGD peptides mainly on the PEG moiety of the PCL-PEG, included in the formulation. First, three non-targeted formulations with size and zeta potential adapted to M cell uptake and stable in gastro-intestinal fluids, were developed. Their transport by an in vitro model of the human Follicle associated epithelium (co-cultures) was largely increased as compared to mono-cultures (Caco-2 cells). RGD-labelling of nanoparticles significantly increased their transport by co-cultures. due to interactions between the RGD ligand and the I intregrins detected at the apical surface of co-cultures. In vivo studies demonstrated that RGD-labelled nanoparticles particularly concentrated in M cells. Finally, ovalbumin-loaded nanoparticles were orally administrated to mice and induced an IgG response, attesting antigen ability to elicit an immune response after oral delivery. [less ▲]

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See detailPEGylated quaternized copolymer/DNA complexes for gene delivery
Vroman, Benoît; Ferreira, Isabel; Jérôme, Christine ULg et al

in International Journal of Pharmaceutics (2007), 344(1-2), 88-95

The aim of this study was to improve the colloidal stability, decrease unspecific interactions with cells and blood components of a novel gene delivery system composed of epsilon-caprolactone and ... [more ▼]

The aim of this study was to improve the colloidal stability, decrease unspecific interactions with cells and blood components of a novel gene delivery system composed of epsilon-caprolactone and quaternized epsilon-caprolactone. For this purpose, diblock 50/50 copolymer was used to generate complexes-with DNA by either the solvent evaporation technique and by dialysis. The size, surface charge and degree of interaction of the plasmid-loaded formulations were measured. Then, polyplexes were combined with a poly(CL)-b-PEG copolymer to create a hydrophilic corona on the surface of the complexes. The cytotoxicity, transfection efficiency and cellular uptake of polyplexes and their association with PEG were evaluated on HeLa cells. The dialysis method did not allow to reduce the size of complexes as compared to the solvent evaporation method. The zeta potential of polyplexes became positive from a charge ratio of 4. The degree of interaction of copolymer with plasmid DNA was very high. Cytotoxicity and transfection efficiency were found to be comparable to polyethylenimine 50 kDa. Association of polyplexes with poly(CL)-b-PEG copolymer led to a small increase in particle size and a sharp decrease of charge surface. Cytotoxicity, transfection efficiency and cellular uptake were significantly reduced relative to unshielded copolymer/DNA complexes. The PEGylated formulations may be an attractive approach for an in vivo application. [less ▲]

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See detailPegylated thermally responsive block copolymer micelles and nanogels via in situ RAFT aqueous dispersion polymerization
Rieger, Jutta ULg; Grazon, Chloé; Charleux, Bernadette et al

in Journal of Polymer Science. Part A, Polymer Chemistry (2009), 47(9), 2373-2390

A very straightforward approach was developed to synthesize pegylated thermoresponsive core-shell nanoparticles in a minimum of steps, directly in water. It is based on RAFT-controlled radical ... [more ▼]

A very straightforward approach was developed to synthesize pegylated thermoresponsive core-shell nanoparticles in a minimum of steps, directly in water. It is based on RAFT-controlled radical crosslinking copolymerization of N,N-diethylacrylamide (DEAAm) and N,N-methylene bisacrylamide (MBA) in aqueous dispersion polymerization. Because DEAAm is water-soluble and poly(N,N-diethylacrylamide) (PDEAAm) exhibits a lower critical solution temperature at 32 °C, the initial medium was homogeneous, whereas the polymer formed a separate phase at the reaction temperature. The first macroRAFT agent was a surface-active trithiocarbonate based on a hydrophilic poly(ethylene oxide) block and a hydrophobic dodecyl chain. It was further extented with N,N-dimethylacrylamide (DMAAm) to target macroRAFT agents with increasing chain length. All macroRAFT agents provided excellent control over the aqueous dispersion homopolymerization of DEAAm. When they were used in the radical crosslinking copolymerization of DEAAm and MBA, the stability and size of the resulting gel particles were found to depend strongly on the chain length of the macroRAFT agent, on the concentrations of both the monomer and the crosslinker, and on the process (one step or two steps). The best-suited experimental conditions to reach thermosensitive hydrogels with nanometric size and well-defined surface properties were determined. [less ▲]

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See detailPEGylation of antibody fragments greatly increases their local residence time following delivery to the respiratory tract.
Koussoroplis, Salome Juliette; Paulissen, Geneviève ULg; Tyteca, Donatienne et al

in Journal of Controlled Release (2014), sous presse

Inhalation aerosols offer a targeted therapy for respiratory diseases. However, the therapeutic efficacy of inhaled biopharmaceuticals is limited by the rapid clearance of macromolecules in the lungs. The ... [more ▼]

Inhalation aerosols offer a targeted therapy for respiratory diseases. However, the therapeutic efficacy of inhaled biopharmaceuticals is limited by the rapid clearance of macromolecules in the lungs. The aim of this research was to study the effects of the PEGylation of antibody fragments on their local residence time after administration to the respiratory tract. We demonstrate that the conjugation of a two-armed 40-kDa polyethylene glycol (PEG) chain to anti-interleukin-17A (IL-17A) F(ab')2 and anti-IL-13 Fab' greatly prolonged the presence of these fragments within the lungs of mice. The content of PEGylated antibody fragments within the lungs plateaued up to 4hours post-delivery, whereas clearance of unconjugated proteins started immediately after administration. Forty-eight hours post-delivery, F(ab')2 and Fab' content in the lungs had decreased to 10 and 14 % of the dose initially deposited, respectively. However, this value was 40 % for both PEG40-F(ab')2 and PEG40-Fab'. The prolonged pulmonary residency of the anti-IL-17A PEG40-F(ab')2 translated into an improved efficacy in reducing lung inflammation in a murine model of house dust mite-induced lung inflammation. We demonstrate that PEGylated proteins were principally retained within the lung lumen rather than the nasal cavities or lung parenchyma. In addition, we report that PEG increased pulmonary retention of antibody fragments through mucoadhesion and escape from alveolar macrophages rather than increased hydrodynamic size or improved enzymatic stability. The PEGylation of proteins might find broad application in the local delivery of therapeutic proteins to diseased airways. [less ▲]

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See detailLa peine de travail - Quelques observations pratiques
Jacobs, Ann ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

Detailed reference viewed: 35 (3 ULg)
See detailPeine de travail et vécu du condamné. De beleving van de veroordeelde tot een werkstraf.
Duchêne, Judith ULg; Vlaemynck, Marieke; Aertsen, Ivo et al

Report (2009)

Detailed reference viewed: 235 (17 ULg)
See detailLa peine de travail
Jacobs, Ann ULg

in Memorialis Postal (2004)

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See detailLa peine subsidiaire à une peine de travail
Jacobs, Ann ULg

in Revue de Droit Pénal et de Criminologie (2004)

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See detailLa peine vue par les policiers. Essai à travers l'étude de l'opinion d'un échantillon de policiers locaux liégeois
Dantinne, Michaël ULg; Canossi, Vincent

in Revue de Droit Pénal et de Criminologie (2007), (6), 591-601

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See detailLes peines privées - Rapport belge
Biquet, Christine ULg

in L'indemnisation (2007)

Detailed reference viewed: 33 (3 ULg)
See detailPeinlichkeit kennt kein Pardon – Peinlichkeit.
Pontzen, Alexandra ULg

in Korte; Kiesow (Eds.) EGB. Emotionales Gesetzbuch. Dekalog der Gefühle (2005)

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See detailPeinlichkeit und Imagination
Pontzen, Alexandra ULg

in Ziemer, Gesa; Zumsteg, Simon; Huber, Jörg (Eds.) Archipele des Imaginären (2008)

Detailed reference viewed: 29 (2 ULg)
See detailLe peintre et le mathématicien. À propos de l'idée-tableau chez Descartes
Bouquiaux, Laurence ULg

in La raison par quatre chemins. En hommage à Claude Troisfontaines (2007)

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See detailLe peintre Jean
Kurth, Godefroid ULg

in Bulletin de l'Institut Archéologique Liégeois (1903), XXXIII

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See detailLa peinture de 1520 à 1580
Allart, Dominique ULg

in DaKosta-Kaufmann, Thomas (Ed.) L'art flamand et hollandais: Belgique et Pays-Bas 1520-1914 (2002)

Detailed reference viewed: 24 (1 ULg)