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See detailPaysages patrimoniaux en Wallonie (Belgique), analyse par approche des paysages témoins
Droeven, Emilie ULg; Dubois, Catherine; Feltz, Claude ULg

in Cahiers d'Economie et Sociologie Rurales (2007), 84-85

In 2000, the Walloon Region (Belgium) has initiated a research program at the Standing Conference on Territorial Development (CPDT) in order to address the European Landscape Convention requirements. The ... [more ▼]

In 2000, the Walloon Region (Belgium) has initiated a research program at the Standing Conference on Territorial Development (CPDT) in order to address the European Landscape Convention requirements. The research concentrated at first on the identification and the typology of Walloon macrolandscapes at a regional scale. Then the research focussed on the landscapes characterisation at a scale of 1/20 000 and their patrimonial qualification. The paper traces the research progress (definition of the concepts of landscape and patrimonial landscape, the adopted procedure) and presents the elaborated method to appreciate the landscapes scientific values, called the method of the “witness landscape”. It also presents the difficulties met during its application on the field. The method is iterative and combines the observation on the field, the review of both historic and present cartographies, the interpretation of aerial photographs and the mobilisation of the available bibliography. Reading, analysing, nderstanding and documenting the landscape in order to highlight the meaningful landscapes’ configurations and components, such was one of the research team contributions to the landscape management. [less ▲]

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See detailPaysages patrimoniaux en Wallonie (Belgique), analyse par approche des paysages temoins.
Droeven, Emilie ULg; Dubois, Catherine ULg; Feltz, Claude ULg

in Cahiers d'Economie et Sociologie Rurales (2007), 84-85

In 2000, the Walloon Region (Belgium) has initiated a research program at the Standing Conference on Territorial Development (CPDT) in order to address the European Landscape Convention requirements. The ... [more ▼]

In 2000, the Walloon Region (Belgium) has initiated a research program at the Standing Conference on Territorial Development (CPDT) in order to address the European Landscape Convention requirements. The research concentrated at first on the identification and the typology of Walloon macrolandscapes at a regional scale. Then the research focussed on the landscapes characterisation at a scale of 1/20 000 and their patrimonial qualification. The paper traces the research progress (definition of the concepts of landscape and patrimonial landscape, the adopted procedure) and presents the elaborated method to appreciate the landscapes scientific values, called the method of the “witness landscape”. It also presents the difficulties met during its application on the field. The method is iterative and combines the observation on the field, the review of both historic and present cartographies, the interpretation of aerial photographs and the mobilisation of the available bibliography. Reading, analysing, understanding and documenting the landscape in order to highlight the meaningful landscapes’ configurations and components, such was one of the research team contributions to the landscape management. [less ▲]

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See detailLes paysages
Melin, Eric ULg; Feltz, Claude ULg; Droeven, Emilie ULg et al

Report (2002)

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See detailLes paysans sans terre brésiliens en mouvement. Approche ethnographique.
Schoonbroodt, Bénédicte ULg

Master's dissertation (2003)

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See detailPazopanib (Votrient) dans le traitement du cancer du rein et des sarcomes des tissus mous.
GENNIGENS, Christine ULg; JERUSALEM, Guy ULg

in Revue Médicale de Liège (2012), 67(7-8), 437-42

Renal cell carcinoma accounts for 3% of all malignant tumors. Until a few years ago, immunotherapy (Interferon and/or Interleukin-2) was the only approved systemic treatment in the metastatic setting ... [more ▼]

Renal cell carcinoma accounts for 3% of all malignant tumors. Until a few years ago, immunotherapy (Interferon and/or Interleukin-2) was the only approved systemic treatment in the metastatic setting. Better knowledge of renal cell cancer biology drew attention on the fundamental role of angiogenesis. Several strategies targeting angiogenesis have been developed including VEGF and VEGFR inhibitors. They are now the standard treatment in first and second line. Pazopanib, a VEGFR tyrosine kinase inhibitor, is one of the treatment options recommended for patients with metastatic renal cell carcinoma, in first line and after cytokines failure. Since more recently, pazopanib is also approved in the treatment of metastatic soft tissue sarcoma, after failure of at least one line of chemoterapy. In this paper, we will review the mechanism of action and the clinical results of pazopanib in renal cell carcinoma and sarcoma. [less ▲]

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See detailPB15 polymorphic distinction in paint samples by combining micro- Raman spectroscopy and chemometrical analysis
Van Pevenage, Jolien; Defeyt, Catherine ULg; Moens, Luc et al

Poster (2013)

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See detailPB15’s discrimination in oil paintings by non-destructive methods
Defeyt, Catherine ULg; Vandenabeele, Peter; Van Pevenage, Jolien et al

Poster (2013, March 29)

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See detailPb3Fe3+2(PO4)4(H2O), a new octahedral-tetrahedral framework structure with double-strand chains
Mills, Stuart; Kolitsch, Uwe; Miyawaki, R. et al

in European Journal of Mineralogy (2010), 22

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See detailPBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies
Van Steen, Kristel ULg; Lange, C.

in Human Genomics (2005), 2(1), 67-9

The PBAT software package (v2.5) provides a unique set of tools for complex family-based association analysis at a genome-wide level. PBAT can handle nuclear families with missing parental genotypes ... [more ▼]

The PBAT software package (v2.5) provides a unique set of tools for complex family-based association analysis at a genome-wide level. PBAT can handle nuclear families with missing parental genotypes, extended pedigrees with missing genotypic information, analysis of single nucleotide polymorphisms (SNPs), haplotype analysis, quantitative traits, multivariate/longitudinal data and time to onset phenotypes. The data analysis can be adjusted for covariates and gene/environment interactions. Haplotype-based features include sliding windows and the reconstruction of the haplotypes of the probands. PBAT's screening tools allow the user successfully to handle the multiple comparisons problem at a genome-wide level, even for 100,000 SNPs and more. Moreover, PBAT is computationally fast. A genome scan of 300,000 SNPs in 2,000 trios takes 4 central processing unit (CPU)-days. PBAT is available for Linux, Sun Solaris and Windows XP. [less ▲]

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See detailPBingen 1 (= PTebt 897)
Marganne, Marie-Hélène ULg

in Corpus dei Papiri Filosofici Greci e Latini (CPF), I 2* (2008)

Edition, translation and commentary of the Greek papyrus PBingen 1 (= PTebt 897), Tebtynis, IIIex. B.C., which contains another version or comment of Hippocrates med., De diaeta II 49

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See detailPBP5 complementation of a PBP3 deficiency in Enterococcus hirae
Leimanis, S.; Hoyez, N.; Hubert, S et al

in Journal of Bacteriology (2006), 188(17), 6298-6307

The low susceptibility of enterococci to beta-lactams is due to the activity of the low-affinity penicillin-binding protein 5 (PBP5). One important feature of PBP5 is its ability to substitute for most ... [more ▼]

The low susceptibility of enterococci to beta-lactams is due to the activity of the low-affinity penicillin-binding protein 5 (PBP5). One important feature of PBP5 is its ability to substitute for most, if not all, penicillin-binding proteins when they are inhibited. That substitution activity was analyzed in Enterococcus hirae SL2, a mutant whose pbp5 gene was interrupted by the nisRK genes and whose PBP3 synthesis was submitted to nisin induction. Noninduced SL2 cells were unable to divide except when plasmid-borne pbp5 genes were present, provided that the PBP5 active site was functional. Potential protein-protein interaction sites of the PBP5 N-terminal module were mutagenized by site-directed mutagenesis. The T-167-L-184 region (designated site D) appeared to be an essential intramolecular site needed for the stability of the protein. Mutations made in the two globular domains present in the N-terminal module indicated that they were needed for the suppletive activity. The P-197-N-209 segment (site E) in one of these domains seemed to be particularly important, as single and double mutations reduced or almost completely abolished, respectively, the action of PBP5. [less ▲]

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See detailThe Pbx Interaction Motif of Hoxa1 Is Essential for Its Oncogenic Activity
Delval, Stéphanie; Taminiau, Arnaud; Lamy, Juliette et al

in PLoS ONE (2011), 6(9), 2547

Hoxa1 belongs to the Hox family of homeodomain transcription factors involved in patterning embryonic territories and governing organogenetic processes. In addition to its developmental functions, Hoxa1 ... [more ▼]

Hoxa1 belongs to the Hox family of homeodomain transcription factors involved in patterning embryonic territories and governing organogenetic processes. In addition to its developmental functions, Hoxa1 has been shown to be an oncogene and to be overexpressed in the mammary gland in response to a deregulation of the autocrine growth hormone. It has therefore been suggested that Hoxa1 plays a pivotal role in the process linking autocrine growth hormone misregulation and mammary carcinogenesis. Like most Hox proteins, Hoxa1 can interact with Pbx proteins. This interaction relies on a Hox hexapeptidic sequence centred on conserved Tryptophan and Methionine residues. To address the importance of the Hox-Pbx interaction for the oncogenic activity of Hoxa1, we characterized here the properties of a Hoxa1 variant with substituted residues in the hexapeptide and demonstrate that the Hoxa1 mutant lost its ability to stimulate cell proliferation, anchorage-independent cell growth, and loss of contact inhibition. Therefore, the hexapeptide motif of Hoxa1 is required to confer its oncogenic activity, supporting the view that this activity relies on the ability of Hoxa1 to interact with Pbx. [less ▲]

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See detailA PC Based Remote Sensing System
Donnay, Jean-Paul ULg

in Proceedings of the Second ACIS European Studies Conference (1987)

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See detailPCAM: a multi-user facility-based protein crystallization apparatus for microgravity
Carter, Daniel; Wright, Brenda; Miller, Teresa et al

in Journal of Crystal Growth (1999), 196

A facility-based protein crystallization apparatus for microgravity (PCAM) has been constructed and flown on a series of Space Shuttle Missions. The hardware development was undertaken largely because of ... [more ▼]

A facility-based protein crystallization apparatus for microgravity (PCAM) has been constructed and flown on a series of Space Shuttle Missions. The hardware development was undertaken largely because of the many important examples of quality improvements gained from crystal growth in the diffusion-limited environment in space. The concept was based on the adaptation for microgravity of a commonly available crystallization tray to increase sample density, to facilitate co-investigator participation and to improve flight logistics and handling. A co-investigator group representing scientists from industry, academia, and government laboratories has been established. Microgravity applications of the hardware have produced improvements in a number of structure-based crystallographic studies and include examples of enabling research. Additionally, the facility has been used to support fundamental research in protein crystal growth which has delineated factors contributing to the effect of microgravity on the growth and quality of protein crystals. [less ▲]

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See detailLes PCB non apparentés aux dioxines (non dioxin-like PCB) dans les denrées alimentaires et les aliments pour animaux: mise en place d'une législation européenne
Eppe, Gauthier ULg

Article for general public (2012)

La famille des PolyChloroBiphényles ou PCB regroupe un ensemble de 209 composés différents (dénommés usuellement congénères) se différenciant par le nombre (1 à 10 atomes) et la position des atomes de ... [more ▼]

La famille des PolyChloroBiphényles ou PCB regroupe un ensemble de 209 composés différents (dénommés usuellement congénères) se différenciant par le nombre (1 à 10 atomes) et la position des atomes de chlore sur la molécule biphényle. Cette famille de composés peut être divisée en deux catégories selon leurs propriétés toxicologiques, et plus particulièrement les effets tératogènes des PCB. Le premier groupe, composé de 12 congénères, se caractérise par des propriétés toxicologiques similaires aux dioxines, et il est par conséquent désigné par le terme ‘PCB de type dioxine’ (dioxin-like PCB, DL-PCB). L’autre groupe de PCB non apparenté aux dioxines (non dioxin-like PCB, NDL-PCB), présente d’autres mécanismes de toxicité pris en compte dans la gestion du risque PCB. Parmi ces 197 NDL-PCB, une sous-catégorie de six congénères relativement abondants dans l’environnement et dans les chaînes alimentaires (PCB 28, 52, 101, 138, 153 et 180), représente ce que nous appelons communément les PCB indicateurs. De par leurs propriétés de persistance, de bioaccumulation et de biomagnification, l’ensemble des PCB (DL-PCB et NDL-PCB) se retrouve fréquemment dans l’alimentation humaine et dans les aliments pour animaux. La fixation de teneurs maximales en NDL-PCB dans divers aliments fait l’objet d’une nouvelle réglementation européenne qui entrera en vigueur dès 2012. Cet article fait le point sur l’impact de ces nouvelles propositions par rapport au niveau de bruit de fond des principales classes d’aliments mais également sur l’évolution des méthodes d’analyse nécessaires pour atteindre les performances requises. [less ▲]

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See detailPCB residues in a breast cancer patient population
Charlier, Corinne ULg; Pitance, François ULg; Plomteux, Guy ULg

in Bulletin of Environmental Contamination & Toxicology (2003), 71(5), 887-891

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See detailPCB trends and patterns in the plankton of the river Meuse (Belgium).
Joaquim-Justo, Célia ULg; Schockert, Vincianne ULg; Deguée, N et al

Poster (2002, May 12)

PCB concentrations were monitored in the river Meuse (Belgium) from 1993 to 1998; compartments sampled were water, suspended matter (mainly phytoplankton), zooplankton and sediment. The PCB patterns were ... [more ▼]

PCB concentrations were monitored in the river Meuse (Belgium) from 1993 to 1998; compartments sampled were water, suspended matter (mainly phytoplankton), zooplankton and sediment. The PCB patterns were compared to those of Aroclors and found to best match a mixture of 30 to 40% of Aroclor 1254 and 60 to 70% of Aroclor 1260 for all compartments with the exception of suspended matter where the proportions were of 50% of both Aroclor 1254 and 1260. These patterns together with the average total concentrations did not show any trends throughout the monitoring period nor did they show any particular seasonal pattern variations. Mean total PCBs concentrations were of 0.029 ng/g in the water, 3408 ng/g D.W. in suspended matter, 862 ng/g D.W. in zooplankton and 387 ng/g D.W. in the sediment. Bioconcentration factors for phytoplankton (suspended matter) and zooplankton were respectively of 118 000 and 30 000 indicating there is no biomagnification between these two trophic levels. These results will be commented on the basis of in vitro contamination experiments with planktonic organisms. [less ▲]

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See detailDe PCB/dioxine vergiftiging in België (1999): analyse van de gezondheidsrisico’s
Bernard, A.; Broekaert, F.; De Poorter, G. et al

in Vlaams Diergeneeskundig Tijdschrift (2001), 70

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See detailPCBs versus PBDEs: how similar compounds can behave differently in harbour porpoises
Weijs, Liesbeth; Yang, R. S. H.; Das, Krishna ULg et al

in Organohalogen Compounds (2011)

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