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See detailLoss of type IV collagen alpha 5 and alpha 6 chains in human invasive prostate carcinomas
Dehan, Pierre ULg; Waltregny, David ULg; Beschin, Alain et al

in American Journal of Pathology (1997), 151(4), 1097-104

Type IV collagen, a major component of basement membranes, is organized in a network responsible for the mechanical resistance of the basement membranes. It also plays a key role in epithelial cell ... [more ▼]

Type IV collagen, a major component of basement membranes, is organized in a network responsible for the mechanical resistance of the basement membranes. It also plays a key role in epithelial cell adhesion to basement membranes. This study was designed to investigate the distribution of type IV collagen alpha-chains in normal, preneoplastic, and malignant prostate basement membranes. For this purpose, immunohistochemistry using specific antibodies raised against the different alpha-chains of type IV collagen was performed in eight normal samples, six prostatic intraepithelial neoplasia, and 20 malignant lesions of the prostate. Our results demonstrate the presence of the "novel" alpha 5 (IV) and alpha 6 (IV) chains along with the "classical" alpha 1 (IV)/alpha 2 (IV) chains in the basement membrane of the normal prostate gland. The alpha 3 (IV) chain was never detected in any prostate specimen. Prostatic intraepithelial neoplasia showed a similar immunostaining pattern to that found in normal glands. In cancer gland basement membranes, we demonstrate for the first time a specific loss of the alpha 5 (IV) and alpha 6 (IV) chains, whereas the classical alpha 1 (IV) and alpha 2 (IV) chains were consistently exhibited. Additionally, type VII collagen colocalized with alpha 5 (IV) collagen chain, and these two proteins, which were always observed in normal and prostatic intraepithelial neoplasia gland basement membranes, were lost in invasive carcinoma basement membranes. This observation raises questions about the possible association or cooperation between alpha 5 (IV)/alpha 6 (IV) chains and anchoring fibrils in prostate glands basement membrane. [less ▲]

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See detailLoss-of-function mutations in ATP6V0A2 impair vesicular trafficking, tropoelastin secretion and cell survival.
Hucthagowder, Vishwanathan; Morava, Eva; Kornak, Uwe et al

in Human Molecular Genetics (2009), 18(12), 2149-65

Autosomal recessive cutis laxa type 2 (ARCL2), a syndrome of growth and developmental delay and redundant, inelastic skin, is caused by mutations in the a2 subunit of the vesicular ATPase H+-pump ... [more ▼]

Autosomal recessive cutis laxa type 2 (ARCL2), a syndrome of growth and developmental delay and redundant, inelastic skin, is caused by mutations in the a2 subunit of the vesicular ATPase H+-pump (ATP6V0A2). The goal of this study was to define the disease mechanisms that lead to connective tissue lesions in ARCL2. In a new cohort of 17 patients, DNA sequencing of ATP6V0A2 detected either homozygous or compound heterozygous mutations. Considerable allelic and phenotypic heterogeneity was observed, with a missense mutation of a moderately conserved residue p.P87L leading to unusually mild disease. Abnormal N- and/or mucin type O-glycosylation was observed in all patients tested. Premature stop codon mutations led to decreased ATP6V0A2 mRNA levels by destabilizing the mutant mRNA via the nonsense-mediated decay pathway. Loss of ATP6V0A2 either by siRNA knockdown or in ARCL2 cells resulted in distended Golgi cisternae, accumulation of abnormal lysosomes and multivesicular bodies. Immunostaining of ARCL2 cells showed the accumulation of tropoelastin (TE) in the Golgi and in large, abnormal intracellular and extracellular aggregates. Pulse-chase studies confirmed impaired secretion and increased intracellular retention of TE, and insoluble elastin assays showed significantly reduced extracellular deposition of mature elastin. Fibrillin-1 microfibril assembly and secreted lysyl oxidase activity were normal in ARCL2 cells. TUNEL staining demonstrated increased rates of apoptosis in ARCL2 cell cultures. We conclude that loss-of-function mutations in ATP6V0A2 lead to TE aggregation in the Golgi, impaired clearance of TE aggregates and increased apoptosis of elastogenic cells. [less ▲]

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See detailLosses – Marks&Spencer
Richelle, Isabelle ULg

Conference (2014, January 23)

This conference will explore the history, impact, and potential for further development of the CJEU’s and the EFTA Court’s landmark decisions relating to direct taxation.

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See detailLost and found: Rediscovery of de Ryckholt's collection of Cretaceous Mollusca (Belgium and N. France)
Fischer, Valentin ULg; Denayer, Julien ULg; Mottequin, Bernard ULg

in 4th International Palaeontological Congress, Mendoza, Abstracts volume (2014)

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See detailLost Memories
Havelange, Carl ULg; DELRUE Rony

Book published by Hapax (2007)

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See detailLa loterie de l'Exposition (extrait d'une lettre adressée à M. Laisant)
Catalan, Eugène ULg

in Nouvelle Correspondance Mathématique (1879), 5

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See detailLoteries, combinatoire et heuristique
Breny, Henri; Esch, Louis ULg

in Mathématique et Pédagogie (1983), 40

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See detailLotissement périurbain et développement durable : les surcoûts collectifs
Halleux, Jean-Marie ULg

Conference given outside the academic context (2001)

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See detailA LOTOS Data Facility Compiler (DAFY)
Lallemand, Eric; Leduc, Guy ULg

in Parther, Ken; Rose, Gordon (Eds.) Formal Description Techniques IV (1991, November)

If we take a look at existing LOTOS specifications, we notice that the description of the needed data types is very often huge. This causes the lack of concision of most descriptions of complex systems ... [more ▼]

If we take a look at existing LOTOS specifications, we notice that the description of the needed data types is very often huge. This causes the lack of concision of most descriptions of complex systems. We propose to tackle this problem in two steps. First, we define extensions to the LOTOS language allowing short definitions of most of the data types used in practical LOTOS specifications. Second, we propose a tool called `'DAFY'' (Data Facility Compiler) which is able to translate these extensions into standard LOTOS. [less ▲]

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See detailLOTOS, un outil utile ou un autre langage académique ?
Leduc, Guy ULg

in Danthine, André (Ed.) Les réseaux de communication - nouveaux outils et tendances actuelles (1987, January)

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See detailLotze en Amérique. Le renouveau réaliste en philosophie chez Santayana
Boccaccini, Federico ULg

in Boccaccini, Federico (Ed.) Lotze et son héritage. Son influence et son impact sur la philosophie du XXème siècle (2015)

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See detailLotze en Amérique. Le renouveau réaliste en philosophie chez Santayana
Boccaccini, Federico ULg

Conference (2011, December)

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See detailLotze et la psychologie physiologique
Seron, Denis ULg

in Boccaccini, Federico (Ed.) Lotze et son héritage: Son influence et son impact sur la philosophie du XXe siècle (2015)

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See detailLotze et son héritage. Son influence et son impact sur la philosophie du XXème siècle
Boccaccini, Federico ULg

Book published by Peter Lang (2014)

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See detailLoud & Bright Purple Birds & Blue Eyed Bitches Dancing. A Task for Poetry # 2
Spinoy, Erik ULg

Book published by Onomatopee (2009)

The present volume is an introduction to the work of the young Belgian artist Tamara Van San. It contains two articles, an interview and a portfolio.

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See detailLouis Althusser. Politique et subjectivité. Editorial
Bruschi, Fabio; Mancuso, Eva ULg

in Cahiers du GRM (2015), VII

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See detailLouis Couperus: Eline Vere (study pack)
Steyaert, Kris ULg; Eagar, Erna

Learning material (2002)

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See detailLouis Paul Boon in de Engelse neerlandistiek
Steyaert, Kris ULg

in Boelvaar Poef. Tijdschrift van het Louis Paul Boongenootschap (2002), 2(2), 69-77

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See detailLouis Paul Boon: 'Het eerste uur' (study pack)
Steyaert, Kris ULg; Fenoulhet, Jane

Learning material (2001)

Detailed reference viewed: 31 (0 ULg)
See detailLouis Pirard (1927-1937)
Brüll, Christoph ULg

in Raxhon, Philippe (Ed.) Les Gouverneurs de la Province de Liège. Histoire d'une fonction, mémoire d'une action (2015)

Detailed reference viewed: 24 (0 ULg)