Resveratrol and curcumin reduce the respiratory burst of Chlamydia-primed THP-1 cells

in Biochemical and Biophysical Research Communications (2005), 333(1), 21-27

The intracellular bacterium Chlamydia pneumoniae is involved in the inflammation process of atherosclerosis. We previously demonstrated that C. pneumonia infected monocytes (THP-1 cells) responded to ... [more ▼]

The intracellular bacterium Chlamydia pneumoniae is involved in the inflammation process of atherosclerosis. We previously demonstrated that C. pneumonia infected monocytes (THP-1 cells) responded to stimulation by an increased respiratory burst linked to an increased NADPH oxidase (NOX) activity. We now tested agents acting on the assembly of the NOX subunits or on protein kinase C, a trigger of NOX activity. Apocynin, resveratrol, rutin, quercetin, curcumin, and tocopherols were tested. The cells were pre-incubated with Chlamydia and the agent for 19 h, and then stimulated with phorbol myristate acetate. The NOX activity was monitored by measuring the hydrogen peroxide production. Resveratrol and curcumin (10(-4)-10(-6) M) were better inhibitors than apocynin. alpha-Tocopherol was inactive, and gamma-tocopherol inhibitor at 10(-4) M only. Quercetin was inactive, and rutin a moderate but significant inhibitor. The inhibition by resveratrol was increased by 10(-6) M rutin or quercetin. Resveratrol and curcumin thus appeared to be interesting for atherosclerosis treatment. [less ▲]

Le retable de l'église Saint-Denis. Les panneaux peints de la prédelle: analyse technologique

in Denhaene, Godelieve (Ed.) Lambert Lombard, Peintre de la Renaissance. Liège 1505/06-1566 :Essais interdiscipinaires et catalogue de l'exposition (2006)

Retail planning policy in Belgium

in Davies, R. L. (Ed.) Retail Planning Policies in Western Europe (1995)

Chapter on Belgium in a book that seeks to demonstrate through the analysis of trade policies of different countries of Western Europe divergences and convergences in the distribution

Retard neuromoteur et neuropsychologique: critères de recours à une prise en charge spécialisée

in Percentile (1996), .(3), 103-107

Retards de Sartre

in Etudes Sartriennes (2005), (10), 189-209

Rétention et transfert des pollutions chimiques solubles : mécanismes fondamentaux et modélisation numérique

in Delage, Pierre; Schrefler, Bernard (Eds.) Géomécanique Environnementale – sols pollués et déchets (2005)

Rétention gazeuse dans une colonne à bulles contenant un liquide visqueux non-newtonien

in Tribune de l'Eau (La) (2003), 56(622), 15-20

Retention of immune complexes by murine lymph node or spleen follicular dendritic cells. Role of antibody isotype.

in Scandinavian Journal of Immunology (1986), 24(3), 327-34

Using monoclonal anti-trinitrophenyl (TNP) antibodies complexed to TNP-myoglobin-coated gold particles, we analysed at the ultrastructural level the retention by follicular dendritic cells (FDC) of immune ... [more ▼]

Using monoclonal anti-trinitrophenyl (TNP) antibodies complexed to TNP-myoglobin-coated gold particles, we analysed at the ultrastructural level the retention by follicular dendritic cells (FDC) of immune complexes containing various antibody isotypes. Gold-labelled immune complexes were injected subcutaneously or intravenously into naive mice and, after 24 h, germinal centres of draining lymph nodes or spleen were examined by electron microscopy. FDC generally retained complexes containing IgG2a and IgG2b better than those formed with IgG1 or IgG3. IgM was rarely retained. FDC isolated from lymph nodes or spleens were incubated in vitro with gold-labelled complexes in a serum-free medium. IgG2a and IgG2b complexes were also retained in vitro in large quantities by FDC; IgG1 and IgG3 complexes were retained in smaller quantities or in highly variable quantities compared with IgG2; IgM complexes were rarely seen on FDC. There was no difference between FDC isolated from lymph nodes or from spleen with respect to the Ig isotypes required for Fc-mediated retention of immune complexes. [less ▲]

Rethinking Flexicurity at the Level of Work Situations

in Madsen, P. K.; Jorgensen, H. (Eds.) Flexicurity and Beyond. Finding a New Agenda for the European Social Model (2007)

Proposes new landmarks for balancing flexibility and security requirements in a context of interorganizational parnerships

Rethinking Regulatory Capture

in Harrington, Joseph; Katsoulacos, Yannis (Eds.) Recent Advances in the Analysis of Competition Policy and Regulation (2012)

Conventional capture models rely on the idea that regulator is induced to lenient behavior by the regulated firm through offers of monetary transfers, the bribery model, or future employment, the ... [more ▼]

Conventional capture models rely on the idea that regulator is induced to lenient behavior by the regulated firm through offers of monetary transfers, the bribery model, or future employment, the revolving doors model. To avoid socially costly capture, the political principal should then either implement collusion-proof mechanisms through the delegation of welfare gains, or severely restrict the career paths of regulatory staff. The paradox of capture is that neither the two modes of capture, nor the remedy are commonly found in practice. This paper proposes to rethink capture based on the widespread use of industry-commissioned consultants, experts and lobbyists that produce information for regulatory and policy use. A small model (Agrell and Gautier, 2010) introduces a 'soft capture' concept based on a self-enforced collusion between the firm and regulator, linked to the role of the regulator as information-processing intermediate for the political principal. The firm puts processed but biased information at the free disposal of the regulator, 'no strings attached', who can then either use the submitted information or produce a more accurate information by a costly process. Under a set of mild conditions, the equilibrium involves soft capture and the regulator uses the submitted information, leading to some distortions in welfare. A case study of the Occupational Safety and Health Administration (OSHA) in USA serves to motivate and illustrate the model. As shown by the case, the soft capture model may have a stronger positive potential than the conventional models, also implying that policy advice based on it may be valuable. [less ▲]