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See detailOral contraception and cardiovascular risk factors during adolescence
Paulus, Dominique; Saint-Remy, Annie ULg; JeanJean, Michel

in Contraception (2000)

The objective of the present study was to analyze the pattern of oral contraceptive (OC) use in teenagers and to examine the relationship between OC use and other cardiovascular risk factors. The study ... [more ▼]

The objective of the present study was to analyze the pattern of oral contraceptive (OC) use in teenagers and to examine the relationship between OC use and other cardiovascular risk factors. The study was conducted in 24 Belgian secondary schools. Most students (1526 adolecents aged 12-17 years) agreed to participate (participation rate: 83.6%). Smoking, physical activity habits, menarche, and OC use were assessed by a self-administered questionnaire. Total cholesterol level, blood pressure and anthropometric measurements were also measured. Fourteen per cent of mature girls (14%, n=92) were OC users. Two-thirds of them (66.3%, n=61) were taking OC which contained either gestodene or desogestrel. Blood pressure and BMI were similar for OC users and non-users. Total cholesterol level was significantly higher in OC users than in non-users (191 mg/dL versus 172 mg/dL). Logistic regression model confirmed the significant influence of OC use on total cholesterol level (OR=3.08). OC users were also often smokers (39% versus 20% for non-users). In conclusion, the present study has found significant relationship between OC use and cardiovascular risk factors i.e., high total cholesterol and smoking. The first implication is a need for further research on lipoprotein profile in young OC users. Secondly, the combined use of OC and smoking in teenagers calls for preventive actions. [less ▲]

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See detailOral contraception and lipid peroxidation
De Groote, D.; Pincemail, Joël ULg; Defraigne, Jean-Olivier ULg et al

in Clinical Chemistry (2007, June), 53(6, Suppl. S), 30-30

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See detailOral exposure to culture material extract containing fumonisins predisposes swine to the development of pneumonitis caused by Pasteurella multocida.
Halloy, David J; Gustin, Pascal ULg; Bouhet, Sandrine et al

in Toxicology (2005), 213(1-2), 34-44

Fumonisin B(1) (FB(1)) is a mycotoxin produced by Fusarium verticillioides and F. proliferatum that commonly occurs in maize. In swine, consumption of contaminated feed induces liver damage and pulmonary ... [more ▼]

Fumonisin B(1) (FB(1)) is a mycotoxin produced by Fusarium verticillioides and F. proliferatum that commonly occurs in maize. In swine, consumption of contaminated feed induces liver damage and pulmonary edema. Pasteurella multocida is a secondary pathogen, which can generate a respiratory disorder in predisposed pigs. In this study, we examined the effect of oral exposure to fumonisin-containing culture material on lung inflammation caused by P. multocida. Piglets received by gavage a crude extract of fumonisin, 0.5mg FB(1)/kg body weight/day, for 7 days. One day later, the animals were instilled intratracheally with a non toxin producing type A strain of P. multocida and followed up for 13 additional days. Pig weight and cough frequency were measured throughout the experiment. Lung lesions, bronchoalveolar lavage fluid (BALF) cell composition and the expression of inflammatory cytokines were evaluated at the autopsy. Ingestion of fumonisin culture material or infection with P. multocida did not affect weight gain, induced no clinical sign or lung lesion, and only had minimal effect on BALF cell composition. Ingestion of mycotoxin extract increased the expression of IL-8, IL-18 and IFN-gamma mRNA compared with P. multocida infection that increased the expression of TNF-alpha. The combined treatment with fumonisin culture material and P. multocida delayed growth, induced cough, and increased BALF total cells, macrophages and lymphocytes. Lung lesions were significantly enhanced in these animals and consisted of subacute interstitial pneumonia. TNF-alpha, IFN-gamma and IL-18 mRNA expression was also increased. Taken together, our data showed that fumonisin culture material is a predisposing factor to lung inflammation. These results may have implications for humans and animals consuming FB(1) contaminated food or feed. [less ▲]

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See detailOral glucose tolerance tests in schizophrenic patients treated with antipsychotics
De Hert, Marc; Van Eyck, Dominique; Hermans, Gilberte ULg et al

in International Journal of Neuropsychopharmacology (2004, June), 7(Suppl. 1), 424

Objective. –A recent consensus conference has proposed guidelines for the monitoring for diabetes in patients with schizophrenia and also identifies the need of long-term prospective studies. Method. – A ... [more ▼]

Objective. –A recent consensus conference has proposed guidelines for the monitoring for diabetes in patients with schizophrenia and also identifies the need of long-term prospective studies. Method. – A large scale prospective study on metabolic risks of antipsychotic medication is currently ongoing. At baseline, patients get a full laboratory screening, ECG and an oral glucose tolerance test (OGTT). Baseline data on 100 non-diabetic patients at study inclusion and stable on medication for at least 6 months are presented. Results. – Glucose abnormalities are found in 22% of patients at baseline.A monitoring protocol based only on fasting glucose would not have detected 63.6% of these patients with classifiable glucose abnormalities in our sample. Fasting insulin and measures for insulin resistance have a high predictive value for abnormalities late in the OGTT. Conclusion. – Already at baseline, metabolic problems are frequently present in patients with schizophrenia treated with antipsychotics. Adding assessment of fasting insulin in a monitoring protocol improves detection of glucose abnormalities late in an OGTT. [less ▲]

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See detailOral glucose tolerance tests in treated patients with schizophrenia. Data to support an adaptation of the proposed guidelines for monitoring of patients on second generation antipsychotics?
De Hert, Marc; Van Eyck, Dominique; Hanssens, Linda et al

in European Psychiatry (2006), 21(4), 224-226

Objective. - A recent consensus conference has proposed guidelines for the monitoring for diabetes in patients with schizophrenia and also identifies the need of long-term prospective studies. Method. - A ... [more ▼]

Objective. - A recent consensus conference has proposed guidelines for the monitoring for diabetes in patients with schizophrenia and also identifies the need of long-term prospective studies. Method. - A large scale prospective study on metabolic risks of antipsychotic medication is currently ongoing. At baseline, patients get a full laboratory screening, ECG and an oral glucose tolerance test (OGTT). Baseline data on 100 non-diabetic patients at study inclusion and stable on medication for at least 6 months are presented. Results. - Glucose abnormalities are found in 22% of patients at baseline, A monitoring protocol based only on fasting glucose would not have detected 63.6% of these patients with classifiable glucose abnormalities in our sample. Fasting insulin and measures for insulin resistance have a high predictive value for abnormalities late in the OGTT. Conclusion. - Already at baseline, metabolic problems are frequently present in patients with schizophrenia treated with antipsychotics. Adding assessment of fasting insulin in a monitoring protocol improves detection of glucose abnormalities late in an OGTT. (c) 2005 Elsevier SAS. All rights reserved. [less ▲]

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See detailOral ibandronate (150 mg) continues to be effective and well tolerated when administered monthly: the mobile study long-term extension
Stakkestad, J. A.; Lorenc, R.; Czerwinski, E. et al

in Osteoporosis International (2007, March), 18(Suppl.1), 135-136

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See detailOral ibandronate (150mg) administered monthly provides similar improvements in hip bone mineral density as oral alendronate (70mg) administered weekly in postmenopausal osteoporosis
Reginster, Jean-Yves ULg; Borges, Joao LC; Recknor, Chris et al

in Arthritis and Rheumatism (2007, September), 56(number 9 (suppl.)), 611

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See detailOral ibandronate: a less frequently administered therapeutic option for postmenopausal osteoporosis
Reginster, Jean-Yves ULg

in Expert Opinion on Pharmacotherapy (2005), 6(13), 2301-2313

Osteoporosis is a severe condition, associated with significant disability as a result of fragility fractures and increased mortality. Oral bisphosphonates effectively reduce the risk of osteoporotic ... [more ▼]

Osteoporosis is a severe condition, associated with significant disability as a result of fragility fractures and increased mortality. Oral bisphosphonates effectively reduce the risk of osteoporotic fracture and are generally well tolerated. Unfortunately, patient outcomes are often compromised by suboptimal therapeutic adherence. In other disease areas, reduced dosing frequency has been shown to improve therapeutic adherence. A positive impact for adherence has been observed with a reduction in the bisphosphonate dosing frequency from daily to weekly. However, overall adherence remains suboptimal. lbandronate is a potent nitrogen-containing bisphosphonate specifically designed for less frequent than weekly administration, without compromise for efficacy or tolerability. This article reviews the pharmacology, efficacy and tolerability of oral ibandronate when administered with extended dosing intervals in postmenopausal osteoporosis. [less ▲]

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See detailOral monthly ibandronate decrease bone turnover in postmenopausal women with low bone mass: results from the monthly oral pilot study (MOPS)
Reginster, Jean-Yves ULg; Wiese, C.; Wilson, K. et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 5

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See detailOral monthly ibandronate is well tolerated and efficacious in postmenopausal women: results from the monthly oral pilot study (MOPS)
Reginster, Jean-Yves ULg; Dumont, E.; Wiese, C. et al

in Osteoporosis International (2004, May), 15(Suppl.1), 105-106

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See detailOral monthly ibandronate: rationale and clinical potential in postmenopausal osteoporosis
Reginster, Jean-Yves ULg; McClung, M.; Coutant, K. et al

in Annals of the Rheumatic Diseases (2003, June)

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See detailOral Photography
LAMBERT, France ULg

Conference (2009, October 17)

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See detailOral salt supplementation and long-distance exercise
Lehance, Cédric ULg; Rodriguez de la Cruz, Carlos ULg; Counet, Laurence ULg et al

in British Journal of Sports Medicine (2011), 45

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See detailOral scrapie infection modifies the homeostasis of Peyer's patches' dendritic cells
Dorban, Gauthier ULg; Defaweux, Valérie ULg; Levavasseur, Etienne et al

in Histochemistry & Cell Biology (2007), 128(3), 243-251

In transmitted prion diseases the immune system supports the replication and the propagation of the pathogenic agent (PrPSc). DCs, which are mobile cells present in large numbers within lymph organs, are ... [more ▼]

In transmitted prion diseases the immune system supports the replication and the propagation of the pathogenic agent (PrPSc). DCs, which are mobile cells present in large numbers within lymph organs, are suspected to carry prions through the lymphoid system and to transfer them towards the peripheral nervous system. In this study, C57Bl/6 mice were orally inoculated with PrPSc (scrapie strain 139A) and sacrificed at the preclinical stages of the disease. Immunolabelled cryosections of Peyer's patches were analysed by confocal microscopy. Membrane prion protein expression was studied by flow cytometry. In Peyer's patches (PP), dissected at day one and day 105 after oral exposure to scrapie, we observed an increased population of DCs localised in the follicular-associated epithelium. On day 105, PrPSc was found in the follicles inside the PP of prion-infected mice. A subset of Peyer's patches DCs, which did not express cellular prion protein on their surface in non-infected mice conditions, was prion-positive in scrapie conditions. Within Peyer's patches oral scrapie exposure thus induced modifications of the homeostasis of DCs at the preclinical stages of the disease. These results give new arguments in favour of the implication of DCs in prion diseases. [less ▲]

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See detailOral status and nutrition in the institutionalized elderly.
Lamy, Marc ULg; Mojon, P.; Kalykakis, G. et al

in Journal of Dentistry (1999), 27(6), 443-8

OBJECTIVES: To evaluate, in an elderly population, whether poor oral status might be a contributing factor to the development of undernutrition and might be associated with less eating pleasure, more ... [more ▼]

OBJECTIVES: To evaluate, in an elderly population, whether poor oral status might be a contributing factor to the development of undernutrition and might be associated with less eating pleasure, more subjective eating difficulty and increased mashed food consumption. METHODS: An oral examination and an evaluation of masticatory capacity were performed on 120 institutionalized elderly subjects. The nutritional assessment included serum albumin concentration, the Mini Nutritional Assessment and a questionnaire on eating habits. RESULTS: Edentulous subjects without dentures or with only one complete denture had significantly lower MNA scores than edentulous subjects with two complete dentures (p < 0.05). Edentulous subjects with two complete dentures more frequently reported taking pleasure from eating (p = 0.05), and had less frequent difficulties with hard foods (p = 0.01) than edentulous subjects without dentures or with only one complete denture. Mashed food consumption (p < 0.01) was also reported more frequently in edentulous subjects without dentures or with only one complete denture. Subjects with two complete dentures had similar or better MNA scores as dentate subjects with relatively few remaining teeth (10.4 +/- 7.8 teeth). About half of the subjects (53%) could not perform the masticatory test. These subjects had lower MNA scores (p = 0.001) and a larger proportion ate mashed food (p < 0.001) compared to those who were able to perform the test. CONCLUSIONS: Poor oral status (edentulous without dentures or with only one complete denture) increased difficulty in eating hard foods, increased mashed food consumption and decreased eating pleasure. It seemed also to put institutionalized subjects at higher risk of undernutrition. [less ▲]

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See detailOral taurine supplementation modulates ethanol-conditioned stimulus preference
Quertemont, Etienne ULg; Goffaux, Valérie; Vlaminck, Anne-Michèle et al

in Alcohol (1998), 16(3), 201-206

The present study investigated the possible modulatory action of oral taurine supplementation on the rewarding and aversive properties of low and high ethanol doses in male Wistar rats. A vinegar odor ... [more ▼]

The present study investigated the possible modulatory action of oral taurine supplementation on the rewarding and aversive properties of low and high ethanol doses in male Wistar rats. A vinegar odor stimulus was daily paired with either ethanol (0.3 or 2.0 g/kg) or saline. In addition, half of the rats were supplemented orally with taurine (0.5 g/kg/day). After eight conditioning sessions, all rats were tested for their vinegar stimulus preference or aversion. In nontaurine-treated rats, 2.0 g/kg ethanol conditioning induced a significant aversion for the vinegar stimulus, while there was no preference after 0.3 g/kg ethanol conditioning. However, in taurine-supplemented rats, the 2.0 g/kg ethanol-induced aversion for the stimulus was decreased significantly, while the rats administered the lower ethanol doses, 0.3 g/kg, in combination with taurine supplementation, demonstrated a significant stimulus preference. Such results suggest that taurine modulates some of the aversive or rewarding effects of ethanol. [less ▲]

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See detailOral temperature as an index of core temperature during heat transients
Mairiaux, Philippe ULg; Sagot, J. C.; Candas, V.

in European Journal of Applied Physiology and Occupational Physiology (1983), 50(3), 331-41

Rectal (Tre), oral (Tor) and oesophageal (Tes) temperatures were measured in five exercising subjects exposed for two hours to five conditions (1) a steady condition (WR) involving a constant work load ... [more ▼]

Rectal (Tre), oral (Tor) and oesophageal (Tes) temperatures were measured in five exercising subjects exposed for two hours to five conditions (1) a steady condition (WR) involving a constant work load (50 W) at a constant air temperature (Ta = 36.5 degrees C); (2) air temperature variations (delta Ta) between 28 degrees C and 45 degrees C and (3) between 23 degrees C and 50 degrees C at constant work load (50 W); (4) and (5) to work load variations (delta W) between 25 W and 75 W at a constant Ta (= 36.5 degrees C). Oral temperature recordings were taken sublingually and were either continuous or discontinuous. When discontinuous, the time needed for Tor to stabilize after the mouth opening was taken into account. The respective reliability of Tor and Tre as estimates of Tes were compared in each condition. Results showed that the resting (Tor - Tes) difference (+ 0.12 degrees C) was barely modified after two hours of exposure, whereas Tre overestimated Tes by 0.2 degrees C to 0.4 degrees C depending on the condition. The Tor variations were highly correlated with Tes variations under steady condition and under air temperature variations. In these conditions, Tor represented the best estimate of Tes. Under work-load variations, Tor was less closely related to Tes than was Tre. It is suggested that the relative inertia of Tor to step changes in exercise intensity could be ascribed to work induced variations in mouth blood flow. [less ▲]

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See detailOral Tiludronate: a new perspective for prevention and treatment of postmenopausal osteoporosis
Reginster, Jean-Yves ULg; Ethgen, D; Barbier, A et al

in Calcified Tissue International (1993), 52(S2), 30

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