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See detailPollution chimique de l'environnement et risque toxique pour l'homme. Le rôle particulier des dérivés pesticides organochlorés
Charlier, Corinne ULg; Plomteux, Guy ULg

in Annales de Biologie Clinique (2002), 60(1, Jan-Feb), 37-46

There is an increasing concern about environmental exposure to multiple chemicals and adverse changes in reproductive development, function, or behaviour in wildlife. The major group of environmental ... [more ▼]

There is an increasing concern about environmental exposure to multiple chemicals and adverse changes in reproductive development, function, or behaviour in wildlife. The major group of environmental chemicals, such as organochlorine pesticides, polychlorinated biphenyls (PCBs) and other xenoestrogens are currently known to have estrogenic effects in vertebrates or fishes. Recent studies suggest that past exposure to such estrogenic compounds may affects the risk of developing breast cancer, precocious puberty, or impaired fertility in man. [less ▲]

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See detailLa pollution de la chaîne alimentaire par la dioxine
Maghuin-Rogister, Guy ULg; Delaunois, A.; De Pauwe, E. et al

in Annales de Médecine Vétérinaire (1999), 143

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See detailPollution des sols : interventions et responsabilités des pouvoirs publics
Delnoy, Michel ULg

in Sols contaminés, sols à décontaminer (1996)

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See detailPollution et contamination des sols due à l'industrie métallurgique à Lubumbashi (RDC): empreinte écologique, impact paysager, pistes de gestion
Vranken, Isabelle ULg

Master's dissertation (2010)

Depuis le début du siècle dernier à Lubumbashi (République démocratique du Congo), l’usine de traitement de minerai de cuivre de la société publique Gécamines, a longtemps pollué les sols avoisinants par ... [more ▼]

Depuis le début du siècle dernier à Lubumbashi (République démocratique du Congo), l’usine de traitement de minerai de cuivre de la société publique Gécamines, a longtemps pollué les sols avoisinants par ses fumées chargées en cuivre. Ces émissions ont un impact sanitaire et environnemental substantiel. Sous le vent de l’usine, la végétation est détruite, et l’érosion des sols nus en résultant disperse les polluants dans l’environnement. L’objet de ce mémoire est d’intégrer plusieurs recherches en cours sur cette pollution pour y formuler des pistes de gestion durable qui préservent l’environnement et la santé. Ce mémoire repose principalement sur deux travaux. Le premier est une analyse de la structure spatiale de la végétation, pour identifier l’empreinte écologique d’un cône de pollution issu de l’activité de l’usine Gécamines. Le second est une analyse de perception de l’impact paysager de l’activité minière et métallurgique par les habitants. Les pistes de gestion proposées préconisent le recours à la phytoremédiation, moins coûteuse que les techniques classiques de décontamination (enlèvement des terres, traitements chimiques). Cette technique consiste à revégétaliser les sols nus contaminés à l’aide de plantes tolérantes aux métaux lourds. Elle permet soit d’immobiliser les contaminants, soit de décontaminer les sols. L’applicabilité de cette technique à Lubumbashi est testée selon divers facteurs : relief, degré de contamination, proximité de la population. Ces recherches ont montré la nécessité de combiner les techniques où elles étaient les plus adaptées selon les critères précédemment mentionnés. Une typologie de zones à remédier a ainsi été élaborée, assortie d’un ensemble d’actions pour chaque zone, associant diverses formes de phytoremédiation à d’autres mesures décontaminatoires ou anti-érosives. Il a été tenté d’en maximiser la valorisabilité économique, par souci de viabilité : foresterie sur les zones les moins contaminées, vente de biomasse cupricole comme minerais, etc. En effet, la faisabilité technique de ces actions est conditionnée par la faisabilité économique et institutionnelle. Une prise en charge par l’Etat congolais d’un projet de gestion de l’ampleur attendue est peu probable, étant donné sa corruption et son manque de moyens. L’idée de valorisation pour les entreprises locales mais aussi les citoyens est alors avancée dans une optique de partenariat pour permettre l’application de la gestion. Beaucoup de données manquent pour concrétiser la gestion : pour caractériser la nature, l’intensité et la distribution spatiale de la pollution, ou évaluer le potentiel de remédiation des espèces métallicoles. Ce mémoire présente l’intérêt de cibler les données nécessaires, existantes ou non, à l’élaboration d’un plan de gestion, afin d’orienter les recherches ultérieures à Lubumbashi, pour pouvoir coordonner les recherches sur place. [less ▲]

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See detailPollution of P Cygni line profiles by Fe IV and Fe V photospheric absorption in the ultraviolet spectrum of O-type stars
Nemry, F.; Surdej, Jean ULg; Hernaiz, A.

in Astronomy and Astrophysics (1991), 247

It is reported that the main pollution in the spectral ranges 1270-1500 and 1500-1860 A is caused by photospheric absorption lines of FeV and FeIV, respectively. Making use of the first order moment W1 of ... [more ▼]

It is reported that the main pollution in the spectral ranges 1270-1500 and 1500-1860 A is caused by photospheric absorption lines of FeV and FeIV, respectively. Making use of the first order moment W1 of a P Cygni line profile, it is shown that the effect of this photospheric pollution may lead to systematic errors, exceeding typically 50 percent in the determination of mass loss rates. It is also emphasized that the importance to correct the observed P Cygni line profiles for this pollution when studying the dependence of the physical parameters, terminal velocity, etc. of the stellar winds upon the various classes and types of O stars. [less ▲]

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See detailLa pollution olfactive et ses caractéristiques
Romain, Anne-Claude ULg

Conference given outside the academic context (2006)

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See detailLes pollutions dans l'air intérieur des bâtiments - Diagnostic - Incidences sur la santé.
Kuske, Martyna; Nicolas, Jacques ULg

Book published by FUL et Observatoire de la santé (2000)

Ce n’est qu’au cours des années 70 que certains problèmes de santé ont pu être directement associés à l’environnement intérieur des maisons. Les crises pétrolières ont stimulé une réduction de la ... [more ▼]

Ce n’est qu’au cours des années 70 que certains problèmes de santé ont pu être directement associés à l’environnement intérieur des maisons. Les crises pétrolières ont stimulé une réduction de la consommation d’énergie, entraînant le renforcement de l'isolation thermique des maisons et une réduction de leur ventilation. Si l'objectif énergétique est atteint, il faut constater à présent que la plupart de ces actions ont provoqué l'augmentation des concentrations de certains polluants à l’intérieur des maisons. Cette problématique, généralement connue sous l'appellation "Indoor Pollution", a fait l'objet de nombreuses études et publications. Mais pour améliorer la situation, il ne suffit pas d'inventorier, voire d'étudier les effets possibles des polluants sur la santé, encore faut-il prendre les mesures nécessaires pour remédier au problème. Le présent ouvrage tente de couvrir l'ensemble de la question. Il constitue le résultat d'une recherche bibliographique de publications européennes et mondiales traitant du sujet, de travaux de chercheurs et d’étudiants de la F.U.L., de contacts avec les institutions et organisations s'occupant de la pollution intérieure ainsi que d’expériences personnelles dans ce domaine. Il est le fruit d'une réflexion commune entre la Province de Luxembourg et la F.U.L., dans l'esprit de la mise en place de services d'intervention en matière de pollution intérieure. Il s'adresse donc essentiellement à tous les professionnels qui, de près ou de loin, sont concernés par la question. En une bonne centaine de pages, le livre reprend synthétiquement chacun des principaux polluants communément rencontrés dans les maisons, et plus particulièrement en Belgique. Il en identifie les sources et les effets sur la santé, ainsi que la réglementation les concernant et un certain nombre de conseils pratiques. Par rapport à l'information généralement disponible dans d'autres ouvrages, celui-ci ajoute les méthodes d’analyses de référence ainsi que les techniques alternatives de détection de chaque polluant. Un accent tout particulier à été mis sur les méthodes optimales de terrain à mettre en place par un service de conseil d’analyse de l’air dans les bâtiments. Cette publication, originale par son caractère pratique et complet, doit intéresser un grand nombre de personnes concernées par la problématique de la pollution intérieure : les scientifiques, les médecins, les laboratoires, les pouvoirs publics, et en particulier les responsables et les travailleurs des services d’intervention en matière de pollutions intérieures, les services de sécurité et d’hygiène, etc. [less ▲]

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See detailPoly (D,L-lactic acid) macroporous guidance scaffolds seeded with Schwann cells genetically modified to secrete bi-functional neurotrophin implanted in the completely transected adult rat thoracic spinal cord
Hurtado, Andres; Moon, Lawrence D F; Maquet, Véronique et al

in Biomaterials (2006), 27(3), 430-442

Freeze-dried poly(D,L-lactic acid) macroporous scaffold filled with a fibrin solution containing Schwann cells (SCs) lentivirally transduced to produce and secrete D15A, a bi-functional neurotrophin with ... [more ▼]

Freeze-dried poly(D,L-lactic acid) macroporous scaffold filled with a fibrin solution containing Schwann cells (SCs) lentivirally transduced to produce and secrete D15A, a bi-functional neurotrophin with brain-derived neurotrophic factor and neurotrophin-3 activity, and to express green fluorescent protein (GFP) were implanted in the completely transected adult rat thoracic spinal cord. Control rats were similarly injured and then implanted with scaffolds containing the fibrin solution with SCs lentivirally transduced to produce express GFP only or with the fibrin solution only. Transgene production and biological activity in vitro, SC survival within the scaffold in vitro and in vivo, scaffold integration, axonal regeneration and myelination, and hind limb motor function were analyzed at 1, 2, and 6 weeks after implantation. In vitro, lentivirally transduced SCs produced 87.5 ng/24 h/10(6) Cells of D15A as measured by neurotrophin-3 activity in ELISA. The secreted D15A was biologically active as evidenced by its promotion of neurite outgrowth of dorsal root ganglion neurons in culture. In vitro, SCs expressing GFP were present in the scaffolds for up to 6 It, the end of a typical surgery session. Implantation of SC-seeded scaffolds caused modest loss of spinal nervous tissue. Reactive astrocytes and chondroitin sulfate glycosaminoglycans were present in spinal tissue adjacent to the scaffold. Vascularization of the scaffold was ongoing at I week post-implantation. There were no apparent differences in scaffold integration and blood vessel formation between groups. A decreasing number of implanted (GFP-positive) SCs were found within the scaffold during the first 3 days after implantation. Apoptosis was identified as one of the mechanisms of cell death. At 1 week and later time points after implantation, few of the implanted SCs were present in the scaffold. Neurofilament-positive axons were found in the scaffold. At 6 weeks post-grafting, myelinated axons were observed within and at the external surface of the scaffold. Axons did not grow from the scaffold into the caudal cord. All groups demonstrated a similar improvement of hind limb motor function. Our findings demonstrated that few seeded SCs survived in vivo, which could account for the modest axonal regeneration response into and across the scaffold. For the development of SC-seeded macroporous scaffolds that effectively promote axonal regeneration in the injured spinal cord, the survival and/or total number of SCs in the scaffold needs to be improved. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

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See detailPoly (ε-caprolactone-b-glycolide) and Poly(D,L-lactide-b-glycolide) diblock copolyesters: controlled synthesis, characterization, and colloidal dispersions
Barakat, Ibrahim; Dubois, Philippe ULg; Grandfils, Christian ULg et al

in Journal of Polymer Science. Part A, Polymer Chemistry (2001), 39(2), 294-306

Living -aluminum alkoxide poly--caprolactone and poly-D,L-lactide chains were synthesized by the ring-opening polymerization of -caprolactone (-CL) and D,L-lactide (D,L-LA), respectively, and were used as ... [more ▼]

Living -aluminum alkoxide poly--caprolactone and poly-D,L-lactide chains were synthesized by the ring-opening polymerization of -caprolactone (-CL) and D,L-lactide (D,L-LA), respectively, and were used as macroinitiators for glycolide (GA) polymerization in tetrahydrofuran at 40 °C. The P(CL-b-GA) and P(LA-b-GA) diblock copolymers that formed were fractionated by the use of a selective solvent for each block and were characterized by 1H NMR spectroscopy and differential scanning calorimetry analysis. The livingness of the operative coordination-insertion mechanism is responsible for the control of the copolyester composition, the length of the blocks, and, ultimately, the thermal behavior. Because of the inherent insolubility of the polyglycolide blocks, microphase separation occurs during the course of the sequential polymerization, resulting in a stable, colloidal, nonaqueous copolymer dispersion, as confirmed by photon correlation spectroscopy. [less ▲]

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See detailPoly [glycidyl methacrylate (GMA) / methylmethacrylate (MMA)-b-butadiene (B)-b-GMA/MMA] reactive thermoplastic elastomers: synthesis and characterization
Yu, Jian Ming; Dubois, Philippe ULg; Jérôme, Robert ULg

in Journal of Polymer Science. Part A, Polymer Chemistry (1997), 35(16), 3507-3515

New block copolymers of the ABA type, where B stands for polybutadiene (PBD) and A for polyglycidylmethacrylate(PGMA), poly(methylmethacrylate(MMA)-co-GMA) and PMMA-b-PGMA, respectively, have been ... [more ▼]

New block copolymers of the ABA type, where B stands for polybutadiene (PBD) and A for polyglycidylmethacrylate(PGMA), poly(methylmethacrylate(MMA)-co-GMA) and PMMA-b-PGMA, respectively, have been successfully synthesized by using the diadduct of tert-butyllithium (tert-BuLi) to meta-diisopropenylbenzene (m-DIB) as a difunctional initiator. The PBD midblock has been synthesized in a cyclohexane/diethylether (100/6, v/v) mixture at room temperature, whereas the methacrylate outer blocks have been synthesized in a cyclohexane/diethylether/THF (100/6/150, v/v/v) mixture at -78°C. Block copolymers of a very narrow molecular weight distribution (1.10) have been analyzed by differential scanning calorimetry (DSC), transmission electron microscopy (TEM), and tensile testing. These materials are phase separated and can exhibit tensile strength up to 22 MPa together with very high elongation at break (1500%). [less ▲]

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See detailPoly(2-dimethylamino ethylmethacrylate)-Based Polymers To Camouflage Red Blood Cell Antigens
Cerda Cristerna, Bernardino Isaac ULg; COTTIN, Sophie ULg; Flebus, Luca ULg et al

in Biomacromolecules (2012), 13(4), 1172-1180

Poly(2-dimethylamino-ethylmethacrylate) (PDMAEMA) is a cationic polymer when dissolved in a 7.4 pH fluid. Owing to its ionic nature, this polycation interacts with the negatively charged cell membrane ... [more ▼]

Poly(2-dimethylamino-ethylmethacrylate) (PDMAEMA) is a cationic polymer when dissolved in a 7.4 pH fluid. Owing to its ionic nature, this polycation interacts with the negatively charged cell membrane surface of red blood cells (RBCs). The electrostatic self-assembly of PDMAEMA on RBCs membrane can be employed for inducing the formation of a polymeric shield camouflaging blood group antigens on RBCs as a valuable strategy for developing “universal RBCs” for blood transfusion. The purpose of this research was to evaluate the camouflaging ability of PDMAEMA homopolymers and PDMAEMA-copoly(nethylene glycol) copolymers differing in molecular weight and architecture. Surprisingly, the PDMAEMAs caused a partially masking, no masking, and sensitization of the same RBCs population. The MW and architecture of the polymers as well as temperature of PDMAEMA-RBCs treatment influenced the results observed. Herein, the very particular reactivity of PDMAEMAs and RBCs is analyzed and discussed. [less ▲]

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See detailPoly(2-oxepane-1,5-dione) : a highly crystalline modified poly (epsilon-caprolactone) of a high melting temperature
Tian, Dong; Halleux, Olivier; Dubois, Philippe ULg et al

in Macromolecules (1998), 31(3), 924-927

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See detailPoly(3-hydroxybutyrate) production by Cupriavidus necator using waste glycerol
Cavalheiro, Joao M.B.T.; de Almeida, M. Catarina M.D.; Grandfils, Christian ULg et al

in Process Biochemistry (2009), 44

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See detailPoly(A) RNA is reduced by half during bovine oocyte maturation but increases when meiotic arrest is maintained with CDK inhibitors.
Lequarré, Anne-Sophie ULg; Traverso, Juan M; Marchandise, Joelle et al

in Biology of Reproduction (2004), 71(2), 425-31

Variations in the amount of different RNA species were investigated during in vitro maturation of bovine oocytes. Total RNA content was estimated to be 2 ng before meiosis, and after meiosis resumption ... [more ▼]

Variations in the amount of different RNA species were investigated during in vitro maturation of bovine oocytes. Total RNA content was estimated to be 2 ng before meiosis, and after meiosis resumption, no decrease was observed. Ribosomal RNA did not appear to be degraded either, whereas poly(A) RNA was reduced by half after meiosis resumption, from 53 pg to 25 pg per oocyte. Real-time polymerase chain reaction was performed on growth and differentiation factor-9 (GDF-9), on cyclin B1, and on two genes implicated in the resistance to oxidative stress, glucose-6-phosphate-dehydrogenase (G6PD) and peroxiredoxin-6 (PRDX6). When these transcripts were reverse-transcribed with hexamers, the amplification results were not different before or after in vitro maturation. But when reverse transcription was performed with oligo(dT), amplification was dramatically reduced after maturation, except for cyclin B1 mRNA, implying deadenylation without degradation of three transcripts. Although calf oocytes have a lower developmental competence, their poly(A) RNA contents were not different from that of cow oocytes, nor were they differently affected during maturation. When bovine oocytes were maintained in vitro under meiotic arrest with CDK inhibitors, their poly(A) RNA amount increased, but this rise did not change the poly(A) RNA level once maturation was achieved. The increase could not be observed under transcription inhibition and, when impeding transcription and adenylation, the poly(A) RNA decreased to a level normally observed after maturation, in spite of the maintenance of meiotic arrest. These results demonstrate the importance of adenylation and deadenylation processes during in vitro maturation of bovine oocytes. [less ▲]

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See detailPoly(acrylic acid) with disulfide bond for the elaboration of pH-responsive brush surfaces
Van Camp, Wim; Du Prez, Filip E; Alem, Halima et al

in European Polymer Journal (2010), 46(2), 195-201

We report on a new route for the facile prepn. of pH-responsive tethered brushes on metallic surfaces, starting from poly(acrylic acid) (PAA) contg. a disulfide (S-S) bond (PAA-S-S-PAA). First, atom ... [more ▼]

We report on a new route for the facile prepn. of pH-responsive tethered brushes on metallic surfaces, starting from poly(acrylic acid) (PAA) contg. a disulfide (S-S) bond (PAA-S-S-PAA). First, atom transfer radical polymn. (ATRP) of 1-ethoxyethyl acrylate (EEA) with a disulfide-contg. initiator was performed to obtain the poly(EEA) precursor polymer (PEEA-S-S-PEEA). Deprotection of PEEA by a heating step resulted in the desired PAA chains without any further purifn. The brushes, obtained by the grafting to' of PAA-S-S-PAA onto gold, were then characterized by at. force microscopy in water at various pH values. The results evidence a large collapsing/swelling capacity. [less ▲]

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See detailPoly(acrylic acid)-block-poly(vinyl alcohol) anchored maghemite nanoparticles designed for multi-stimuli triggered drug release
Liu, Ji ULg; Detrembleur, Christophe ULg; Debuigne, Antoine ULg et al

in Nanoscale (2013), 5(23), 11464-11477

Original core/corona nanoparticles composed of amaghemite core and a stimuli-responsive polymer coating made of poly(acrylic acid)-block-poly(vinyl alcohol) macromolecules were fabricated for drug ... [more ▼]

Original core/corona nanoparticles composed of amaghemite core and a stimuli-responsive polymer coating made of poly(acrylic acid)-block-poly(vinyl alcohol) macromolecules were fabricated for drug delivery system (DDS) application. This kind of DDS aims to combine the advantage of stimuli-responsive polymer coating, in order to regulate the drug release behaviours under different conditions and furthermore, improve the biocompatibility and in vivo circulation half-time of the maghemite nanoparticles. Drug loading capacity was evaluated with methylene blue (MB), a cationic model drug. The triggered release of MB was studied under various stimuli such as pH, ionic strength and temperature. Local heating generated under alternating magnetic field (AMF) application was studied, and remotely AMF-triggered release was also confirmed, while a mild heating-up of the release medium was observed. Furthermore, their potential application as magnetic resonance imaging (MRI) contrast agents was explored via relaxivity measurements and acquisition of T2-weighted images. Preliminary studies on the cytotoxicity against mouse fibroblast-like L929 cell line and also their cellular uptake within human melanoma MEL-5 cell line were carried out. In conclusion, this kind of stimuli-responsive nanoparticles appears to be promising carriers for delivering drugs to some tumour sites or into cellular compartments with an acidic environment. [less ▲]

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See detailPoly(caprolactone)/clay masterbatches prepared in supercritical CO2 as efficient clay delamination promoters in poly(styrene-co-acrylonitrile)
Urbanczyk, Laetitia ULg; Calberg, Cédric ULg; Benali, Samira et al

in Journal of Materials Chemistry (2008), 18(39), 4623-4630

Poly(styrene-co-acrylonitrile) (SAN)/clay nanocomposites with a high degree of clay exfoliation were prepared upon melt blending of pre-exfoliated poly(-caprolactone) (PCL)/organoclay masterbatches in a ... [more ▼]

Poly(styrene-co-acrylonitrile) (SAN)/clay nanocomposites with a high degree of clay exfoliation were prepared upon melt blending of pre-exfoliated poly(-caprolactone) (PCL)/organoclay masterbatches in a Brabender-type internal mixer. These highly filled masterbatches were synthesized by a one-pot process using supercritical carbon dioxide as a polymerization medium. During their dispersion into SAN, PCL is expected to act as a compatibilizer at the polymer–clay interface as it is miscible with the host matrix under these conditions. Reference nanocomposites based on direct melt mixing of the commercial organoclay were also prepared for the sake of comparison. The superiority of the masterbatch route in term of clay delamination efficiency has been evidenced by XRD analysis, visual and TEM observations. The effect of the nanocomposite morphology on the polymer properties was then investigated. A substantial improvement of the fire behaviour and a decrease in gas permeability have been observed for the nanocomposite containing the highest level of clay exfoliation, accompanied with a higher brittleness as evidenced by traction and impact tests. [less ▲]

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See detailPoly(D,L-lactide) (PDLLA) foams with TiO2 nanoparticles and PDLLA/TiO2-Bioglass (R) foam composites for tissue engineering scaffolds
Boccaccini, Aldo R.; Blaker, Jonny J.; Maquet, Véronique et al

in Journal of Materials Science (2006), 41(13), 3999-4008

Porous poly(D,L-lactide) PDLLA foams containing 0, 5 and 20 wt% of TiO2 nanoparticles were fabricated and characterised. The addition of Bioglassg particles was also studied in a composite containing 5 wt ... [more ▼]

Porous poly(D,L-lactide) PDLLA foams containing 0, 5 and 20 wt% of TiO2 nanoparticles were fabricated and characterised. The addition of Bioglassg particles was also studied in a composite containing 5 wt% of Bioglass(R) particles and 20 wt% of TiO2 nanoparticles. The microstructure of the four different foam types was characterised using scanning electron microscopy (SEM) and their mechanical properties assessed by quasi-static compression testing. The in vitro behaviour of the foams was studied in simulated body fluid (SBF) at three different time points: 3, 21 and 28 days. The degradation of the samples was characterised quantitatively by measuring the water absorption and weight loss as a function of immersion time in SBE The bioactivity of the foams was characterised by observing hydroxyapatite (HA) formation after 21 days of immersion in SBF using SEM and confirmed with X-ray diffraction (XRD) analysis. It was found that the amount of HA was dependent on the distribution of TiO2 nanoparticles and on the presence of Bioglassg in the foam samples. (c) 2006 Springer Science + Business Media, Inc. [less ▲]

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See detailPoly(D,L-lactide) foams modified by poly(ethylene oxide)-block-poly(D,L-lactide) copolymers and a-FGF: in vitro and in vivo evaluation for spinal cord regeneration
Maquet, Véronique; Martin, Didier ULg; Scholtes, Félix ULg et al

in Biomaterials (2001), 22(10), 1137-1146

The first goal of this study was to examine the influence that poly(ethylene oxide)-block-poly(D,L-lactide) (PELA) copolymer can have on the wettability, the in vitro controlled delivery capability, and ... [more ▼]

The first goal of this study was to examine the influence that poly(ethylene oxide)-block-poly(D,L-lactide) (PELA) copolymer can have on the wettability, the in vitro controlled delivery capability, and the degradation of poly(D,L-lactide) (PDLLA) foams. These foams were prepared by freeze-drying and contain micropores (10 μm) in addition of macropores (100 μm) organized longitudinally. Weight loss, water absorption, changes in molecular weight, polymolecularity (Mw/Mn) and glass transition temperature ( Tg) of PDLLA foams mixed with various amounts of PELA were followed with time. It was found that 10 wt% of PELA increased the wettability and the degradation rate of the polymer foams. The release of sulforhodamine (SR) was compared for PDLLA and PDLLA-PELA foams in relation with the foam porosity. An initial burst release was observed only in the case of the 90:10 PDLLA/PELA foam. The ability of the foam of this composition to be integrated and to promote tissue repair and axonal regeneration in the transected rat spinal cord was investigated. After implantation of ca. 20 polymer rods assembled with fibrin-glue, the polymer construct was able to bridge the cord stumps by forming a permissive support for cellular migration, angiogenesis and axonal regrowth. [less ▲]

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