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See detailThe Pbx Interaction Motif of Hoxa1 Is Essential for Its Oncogenic Activity
Delval, Stéphanie; Taminiau, Arnaud; Lamy, Juliette et al

in PLoS ONE (2011), 6(9), 2547

Hoxa1 belongs to the Hox family of homeodomain transcription factors involved in patterning embryonic territories and governing organogenetic processes. In addition to its developmental functions, Hoxa1 ... [more ▼]

Hoxa1 belongs to the Hox family of homeodomain transcription factors involved in patterning embryonic territories and governing organogenetic processes. In addition to its developmental functions, Hoxa1 has been shown to be an oncogene and to be overexpressed in the mammary gland in response to a deregulation of the autocrine growth hormone. It has therefore been suggested that Hoxa1 plays a pivotal role in the process linking autocrine growth hormone misregulation and mammary carcinogenesis. Like most Hox proteins, Hoxa1 can interact with Pbx proteins. This interaction relies on a Hox hexapeptidic sequence centred on conserved Tryptophan and Methionine residues. To address the importance of the Hox-Pbx interaction for the oncogenic activity of Hoxa1, we characterized here the properties of a Hoxa1 variant with substituted residues in the hexapeptide and demonstrate that the Hoxa1 mutant lost its ability to stimulate cell proliferation, anchorage-independent cell growth, and loss of contact inhibition. Therefore, the hexapeptide motif of Hoxa1 is required to confer its oncogenic activity, supporting the view that this activity relies on the ability of Hoxa1 to interact with Pbx. [less ▲]

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See detailA PC Based Remote Sensing System
Donnay, Jean-Paul ULg

in Proceedings of the Second ACIS European Studies Conference (1987)

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See detailPCAM: a multi-user facility-based protein crystallization apparatus for microgravity
Carter, Daniel; Wright, Brenda; Miller, Teresa et al

in Journal of Crystal Growth (1999), 196

A facility-based protein crystallization apparatus for microgravity (PCAM) has been constructed and flown on a series of Space Shuttle Missions. The hardware development was undertaken largely because of ... [more ▼]

A facility-based protein crystallization apparatus for microgravity (PCAM) has been constructed and flown on a series of Space Shuttle Missions. The hardware development was undertaken largely because of the many important examples of quality improvements gained from crystal growth in the diffusion-limited environment in space. The concept was based on the adaptation for microgravity of a commonly available crystallization tray to increase sample density, to facilitate co-investigator participation and to improve flight logistics and handling. A co-investigator group representing scientists from industry, academia, and government laboratories has been established. Microgravity applications of the hardware have produced improvements in a number of structure-based crystallographic studies and include examples of enabling research. Additionally, the facility has been used to support fundamental research in protein crystal growth which has delineated factors contributing to the effect of microgravity on the growth and quality of protein crystals. [less ▲]

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See detailLes PCB non apparentés aux dioxines (non dioxin-like PCB) dans les denrées alimentaires et les aliments pour animaux: mise en place d'une législation européenne
Eppe, Gauthier ULg

Article for general public (2012)

La famille des PolyChloroBiphényles ou PCB regroupe un ensemble de 209 composés différents (dénommés usuellement congénères) se différenciant par le nombre (1 à 10 atomes) et la position des atomes de ... [more ▼]

La famille des PolyChloroBiphényles ou PCB regroupe un ensemble de 209 composés différents (dénommés usuellement congénères) se différenciant par le nombre (1 à 10 atomes) et la position des atomes de chlore sur la molécule biphényle. Cette famille de composés peut être divisée en deux catégories selon leurs propriétés toxicologiques, et plus particulièrement les effets tératogènes des PCB. Le premier groupe, composé de 12 congénères, se caractérise par des propriétés toxicologiques similaires aux dioxines, et il est par conséquent désigné par le terme ‘PCB de type dioxine’ (dioxin-like PCB, DL-PCB). L’autre groupe de PCB non apparenté aux dioxines (non dioxin-like PCB, NDL-PCB), présente d’autres mécanismes de toxicité pris en compte dans la gestion du risque PCB. Parmi ces 197 NDL-PCB, une sous-catégorie de six congénères relativement abondants dans l’environnement et dans les chaînes alimentaires (PCB 28, 52, 101, 138, 153 et 180), représente ce que nous appelons communément les PCB indicateurs. De par leurs propriétés de persistance, de bioaccumulation et de biomagnification, l’ensemble des PCB (DL-PCB et NDL-PCB) se retrouve fréquemment dans l’alimentation humaine et dans les aliments pour animaux. La fixation de teneurs maximales en NDL-PCB dans divers aliments fait l’objet d’une nouvelle réglementation européenne qui entrera en vigueur dès 2012. Cet article fait le point sur l’impact de ces nouvelles propositions par rapport au niveau de bruit de fond des principales classes d’aliments mais également sur l’évolution des méthodes d’analyse nécessaires pour atteindre les performances requises. [less ▲]

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See detailPCB residues in a breast cancer patient population
Charlier, Corinne ULg; Pitance, François ULg; Plomteux, Guy ULg

in Bulletin of Environmental Contamination & Toxicology (2003), 71(5), 887-891

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See detailPCB trends and patterns in the plankton of the river Meuse (Belgium).
Joaquim-Justo, Célia ULg; Schockert, Vincianne ULg; Deguée, N et al

Poster (2002, May 12)

PCB concentrations were monitored in the river Meuse (Belgium) from 1993 to 1998; compartments sampled were water, suspended matter (mainly phytoplankton), zooplankton and sediment. The PCB patterns were ... [more ▼]

PCB concentrations were monitored in the river Meuse (Belgium) from 1993 to 1998; compartments sampled were water, suspended matter (mainly phytoplankton), zooplankton and sediment. The PCB patterns were compared to those of Aroclors and found to best match a mixture of 30 to 40% of Aroclor 1254 and 60 to 70% of Aroclor 1260 for all compartments with the exception of suspended matter where the proportions were of 50% of both Aroclor 1254 and 1260. These patterns together with the average total concentrations did not show any trends throughout the monitoring period nor did they show any particular seasonal pattern variations. Mean total PCBs concentrations were of 0.029 ng/g in the water, 3408 ng/g D.W. in suspended matter, 862 ng/g D.W. in zooplankton and 387 ng/g D.W. in the sediment. Bioconcentration factors for phytoplankton (suspended matter) and zooplankton were respectively of 118 000 and 30 000 indicating there is no biomagnification between these two trophic levels. These results will be commented on the basis of in vitro contamination experiments with planktonic organisms. [less ▲]

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See detailDe PCB/dioxine vergiftiging in België (1999): analyse van de gezondheidsrisico’s
Bernard, A.; Broekaert, F.; De Poorter, G. et al

in Vlaams Diergeneeskundig Tijdschrift (2001), 70

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See detailPCBs versus PBDEs: how similar compounds can behave differently in harbour porpoises
Weijs, Liesbeth; Yang, R. S. H.; Das, Krishna ULg et al

in Organohalogen Compounds (2011)

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See detailPCBs, PBDEs AND THEIR HYDROXYLATED METABOLITES IN SERUM OF FREE-RANGING HARBOUR SEALS (PHOCA VITULINA): LEVELS AND PROFILES
Weijs, Liesbeth; Das, Krishna ULg; Siebert, Ursula et al

in Organohalogen Compounds (2008), 70

The objective of the present study was to investigate the levels and profiles of PCBs, PBDEs and their hydroxylated metabolites in blood of free-ranging harbour seals in order to elucidate the metabolism ... [more ▼]

The objective of the present study was to investigate the levels and profiles of PCBs, PBDEs and their hydroxylated metabolites in blood of free-ranging harbour seals in order to elucidate the metabolism of PCBs and PBDEs. [less ▲]

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See detailPCDD, PCDF AND PCB DETERMINATION IN DOLPHINS REVEALS A WORLD HOTSPOT FOR PCBS IN GUANABARA BAY, BRAZIL
Dorneles, Paulo; Lailson-Brito, José; Eppe, Gauthier ULg et al

in Organohalogen Compounds (2008), 70

The main objective of the present study was to determine the current concentrations of PCDDs, PCDFs and PCBs in dolphins from a region of high industrialization and urbanization in the Southern Hemisphere ... [more ▼]

The main objective of the present study was to determine the current concentrations of PCDDs, PCDFs and PCBs in dolphins from a region of high industrialization and urbanization in the Southern Hemisphere. Since most of these compounds biomagnify in food chains and changes in ratios of stable isotopes of nitrogen (15N/14N) have been used to elucidate trophic relationships 7, measurements of these isotopes have been carried out in marine tucuxi dolphins and their prey in Guanabara Bay. Stable isotopes were measured, firstly, to quantitatively assess the trophic level of the dolphin, and, secondly, to provide information for future human risk assessment investigations related to fish consumption [less ▲]

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See detailPCDD/F and non-ortho PCB body burden of the general population in Wallonia, Belgium: impact of different sources of environmental pollution
Fierens, S.; Mairesse, Hélène; Focant, Jean-François ULg et al

in Organohalogen Compounds (2002), 55

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See detailPCDD/Fs and dioxin-like PCBs in home-produced eggs from Belgium: levels, contamination sources and health risks.
Van Overmeire, I.; Waegeneers, N.; Sioen, I. et al

in Science of the Total Environment (2009), 407(15), 4419-29

This paper discusses the dioxin TEQ levels as determined by the chemically activated luciferase gene expression assay (CALUX) and by HRGC-HRMS in eggs, soils, faeces and kitchen waste samples obtained in ... [more ▼]

This paper discusses the dioxin TEQ levels as determined by the chemically activated luciferase gene expression assay (CALUX) and by HRGC-HRMS in eggs, soils, faeces and kitchen waste samples obtained in the CONTEGG study. The samples were collected in each Belgian province at private homes and in small gardens where chickens are held. The CALUX levels for eggs sampled in autumn were higher than the levels in eggs obtained at the same locations in spring (median values of 5.86 and 4.08 pg CALUX TEQ/g fat, respectively). The total WHO-TEQ levels in eggs, determined by HRGC-HRMS, ranged from 3.29 to 95.35 pg TEQ/g fat in autumn and from 1.50 to 64.79 pg TEQ/g fat in spring. In the soils on which the chickens forage, levels of 2.51-11.35 pg I-TEQ/g in autumn and 2.00-7.86 pg I-TEQ/g in spring were found. The congener pattern of PCDD/Fs in the eggs, soils and faeces was dominated by OCDD, in addition to 1,2,3,4,6,7,8-HeptaCDD, OCDF and 1,2,3,4,6,7,8-HeptaCDF. The predominant dioxin-like PCBs were PCB118, PCB 105 and PCB 156. The dioxin-like PCBs contributed on average 47%, 14% and 20% to the total WHO-TEQ in eggs, soils and faeces, respectively. Kitchen waste samples were very low-contaminated with dioxin-like compounds. The present results showed a good agreement between egg and soil TEQ levels for PCDD/Fs but not for dioxin-like PCBs. This study showed that current soil levels found in some private gardens do not lead to egg levels below the current EU maximal level of 6 pg total TEQ/g fat for dioxins and dioxin-like PCBs. The consumers of the analysed eggs attained 5-79% of the tolerable weekly intake (TWI) of 14 pg TEQ/kg bw for dioxins and dioxin-like PCBs by exposure to their home-produced eggs only. [less ▲]

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See detailpCO2 - del 13C POC relationships in surface waters of the Gulf of Biscay.
Dauby, Patrick ULg; Frankignoulle, Michel

Poster (1997, September)

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See detailpCO2 - del13CPOC relationships in srface waters of the Gulf of Biscay.
Dauby, Patrick ULg; Frankignoulle, Michel

Poster (2000, February)

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See detailpCO2 distribution of surface water in the English Channel
Frankignoulle, Michel; Bourge, Isabelle; Dauby, Patrick ULg et al

Poster (1994, October)

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See detailpCO2 distribution of surface water in the English Channel
Frankignoulle, Michel; Bourge, Isabelle; Canon, Christine et al

Conference (1994, May)

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See detailpCO2 dynamics and related airice CO2 fluxes during sea-ice growth and decay in an ice-tank experiment
Delille, Bruno ULg; Thomas, D. N.; Dieckmann, Gerhard et al

Poster (2010, June)

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See detailpCO2 dynamics in the subantarctic coastal waters off the Kerguelen archipelago
Delille, Bruno ULg; Delille, D.; Frankignoulle, M.

Poster (2000, May)

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See detailpCO2 in sea ice and CO2 fluxes estimates: where do we stand today?
Tison, J.; Delille, Bruno ULg; Papakyriakou, T. N. et al

Conference (2009, December)

Detailed reference viewed: 3 (0 ULg)