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See detailMrs Gandhi's Final Term and the Remaking of the Congress (I)'s Social Base
Maiorano, Diego ULg

in India Review (2012), 11(1),

This article examines the impact that national economic policies adopted during Indira Gandhi's final term in office (1980–84) had on four “national” social groups, namely the big industrialists, the ... [more ▼]

This article examines the impact that national economic policies adopted during Indira Gandhi's final term in office (1980–84) had on four “national” social groups, namely the big industrialists, the middle class, the rich peasantry, and the poor. The study argues that the Congress (I) chose the former two as its major allies, while the rich peasantry and the poor were relegated to a secondary position. In the process, the focus of India's strategy of development shifted from the agrarian to the industrial sector, and from the rural to the urban world. [less ▲]

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See detailLes MRSA et la peau. Nouveaux visages des HAMRSA, des CAMRSA et des PAMRSA.
Devillers, Céline; Pierard-Franchimont, Claudine ULg; Henry, Frédérique ULg et al

in Skin (2008), 11

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See detailMRSA, une menace réelle, un défit persistant !
MELIN, Pierrette ULg

Scientific conference (1994, April)

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See detailMRSA: le point de vue du bactériologiste
Bardiau, Marjorie ULg

Conference (2013, January)

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See detailMSC in clinics: Liver Transplantation
DETRY, Olivier ULg

Conference (2014, March 21)

For several years, mesenchymal stem cells (MSC) have been evaluated in vivo and in vitro for their immunomodulatory, anti-inflammatory, anti- ischemia-reperfusion injury and “tissue repair” properties ... [more ▼]

For several years, mesenchymal stem cells (MSC) have been evaluated in vivo and in vitro for their immunomodulatory, anti-inflammatory, anti- ischemia-reperfusion injury and “tissue repair” properties. These characteristics could make them interesting in various clinical applications, and particularly in organ transplantation. Taking advantage of our centre expertise and experience concerning MSC use in graft-versus-host disease after bone marrow transplantation and using already functioning GMP-compliant laboratory able to produce clinical-grade MSC, we initiated in 2011 a first trial exploring safety and tolerability of third party MSC infusions after kidney or liver transplantation in a prospective phase I-II study. In this study, after successful transplantation, 10 liver and 10 kidney transplant recipients under standard immunosuppressive treatment (tacrolimus, mycophenolate, steroids) receive an intravenous infusion of 1.5 - 3x106/kg of third-party MSC, on post-operative day 3+/-2. These patients are prospectively compared to the same number of liver and kidney transplant recipients who meet inclusion criteria but do not receive MSC infusion. Safety is assessed by recording side effects, including opportunistic infections and cancers. Immunosuppressive potential is evaluated by rejection episode rates, graft/patient survivals, immunohistology of 3-month (kidney) and 6-month (liver) graft biopsies, and in vitro evaluation of recipient immunity profile. In a second step, reduction (kidney) and progressive weaning (liver) of immunosuppression is attempted in recipients who received MSC. Inclusion of liver patients is now complete, and to date 3 kidney patients received MSC. Primary results will be presented, and complete 6-month liver results are expected for the end of 2014. The next step will be to assert the immunosuppressive potential of MSC after organ transplantation, and the opportunity to develop larger randomised, controlled, phase III trials. [less ▲]

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See detailMSH2 gene dosage mediates azathioprine-induced carcinogenesis in mice
Chalastanis, A.; Penard-Lacronique, V.; Svrcek, M. et al

in Journal of the National Cancer Institute (2010)

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See detailMT-ClustalW: Multithreading multiple sequence alignment
Chaichoompu, Kridsadakorn ULg; Kittitornkun, S.; Tongsima, S.

in the 20th International Parallel and Distributed Processing Symposium, 2006 (IPDPS 2006) (2006, April)

ClustalW is the most widely used tool for aligning multiple protein or nucleotide sequences. The alignment is achieved via three stages: pairwise alignment, guide tree generation and progressive alignment ... [more ▼]

ClustalW is the most widely used tool for aligning multiple protein or nucleotide sequences. The alignment is achieved via three stages: pairwise alignment, guide tree generation and progressive alignment. This paper analyzes and enhances a multithreaded implementation of ClustalW called ClustalW-SMP for higher throughput. Our goal is to maximize the degree of parallelism on multithreading ClustalW called MultiThreading-ClustalW (MT-ClustalW). As a result, bioinformatics laboratories are able to use this MT-ClustalW with much less energy consumption on multicore and SMP (Symmetric Multiprocessor) machines than that of PC clusters. The experiment results show that the MT-ClustalW framework can achieve a considerable speedup over the sequential ClustalW and original multithreaded ClustalW-SMP implementations. © 2006 IEEE. [less ▲]

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See detailMT-MMP Expression and localisation in human lung and breast cancers
Polette, M.; Nawrocki-Raby, B.; Gilles, Christine ULg et al

in Virchows Archiv : An International Journal of Pathology (1996), 428(1), 29-35

Thirteen primary pulmonary squamous cell carcinomas, 4 specimens of normal lung from around tumours, 4 benign proliferations of the mammary gland and 16 breast carcinomas were analysed by in situ ... [more ▼]

Thirteen primary pulmonary squamous cell carcinomas, 4 specimens of normal lung from around tumours, 4 benign proliferations of the mammary gland and 16 breast carcinomas were analysed by in situ hybridisation. Northern blot and immunohistochemistry for the expression of a recently described metalloproteinase (MMP), the MT-MMP (membrane-type matrix metalloproteinase). This MT-MMP can activate gelatinase A, involved in the degradation of basement membranes. In situ hybridisation revealed MT-MMP transcripts distributed in both tumour and stromal cells in squamous cell lung cancers, whereas these mRNAs were principally detected in stromal cells in close contact to tumour clusters in breast carcinomas and in lung adenocarcinomas. Northern blot analysis showed a parallel expression of MT-MMP and gelatinase A transcripts in both lung and breast cancers. Immunohistochemistry displayed a more extensive distribution of MT-MMP in pulmonary and mammary carcinomas with numerous labelled preinvasive and infiltrating cancer cells and stromal cells near the tumour cells. The large degree of expression of MT-MMP in these cancers indicates a potential role of this enzyme in tumour progression. The finding of MT-MMP transcripts in stromal cells in the vicinity of lung and breast tumour cells emphasises the cooperation between these cells and cancer cells for the expression of MT-MMP and in tumour invasion in vivo. [less ▲]

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See detailMT-MMPs as regulators of vessel stability associated with angiogenesis
Sounni, Nor Eddine ULg; Paye, Alexandra ULg; Host, Lorin et al

in Frontiers in Pharmacology of Anti-Cancer Drugs (2011), 2:111

The development of vascular system depends on the coordinated activity of a number of distinct families of molecules including growth factors and their receptors, cell adhesion molecules, extracellular ... [more ▼]

The development of vascular system depends on the coordinated activity of a number of distinct families of molecules including growth factors and their receptors, cell adhesion molecules, extracellular matrix (ECM) molecules, and proteolytic enzymes. Matrix metalloproteases (MMPs) are a family of ECM degrading enzymes required for both physiological and pathological angiogenesis. Increasing evidence, point to a direct role of membrane type-MMPs (MT-MMPs) in vascular system stabilization, maturation, and leakage. Our understanding of the nature of MT-MMP interaction with extracellular and cell surface molecules and their multiple roles in vessel walls and perivascular stroma may provide new insights into mechanisms underlying vascular cell-ECM interactions and cell fate decisions in pathological conditions. Regulation of vascular leakage by MT-MMP interactions with the ECM could also lead to novel targeting opportunities for drug delivery in tumor. This review will shed lights on the emerging roles of MT1-MMP and MT4-MMP in vascular system alterations associated with cancer progression. [less ▲]

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See detailMT1-MMP expression promotes tumor growth and angiogenesis
Sounni, Nor Eddine ULg

Conference (2001, April 19)

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See detailMT1-MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expression
Sounni, Nor Eddine ULg; Devy, L.; Hajitou, A. et al

in FASEB Journal (2002), 16(6), 555-564

Membrane type 1 metalloprotease (MT1-MMP) is a transmembrane metalloprotease that plays a major role in the extracellular matrix remodeling, directly by degrading several of its components and indirectly ... [more ▼]

Membrane type 1 metalloprotease (MT1-MMP) is a transmembrane metalloprotease that plays a major role in the extracellular matrix remodeling, directly by degrading several of its components and indirectly by activating pro-MMP2. We investigated the effects of MT1-MMP overexpression on in vitro and in vivo properties of human breast adenocarcinoma MCF7 cells, which do not express MT1-MMP or MMP-2. MT1-MMP and MMP-2 cDNAs were either transfected alone or cotransfected. All clones overexpressing MT1-MMP 1) were able to activate endogenous or exogenous pro-MMP-2, 2) displayed an enhanced in vitro invasiveness through matrigel-coated filters independent of MMP-2 transfection, 3) induced the rapid development of highly vascularized tumors when injected subcutaneously in nude mice, and 4) promoted blood vessels sprouting in the rat aortic ring assay. These effects were observed in all clones overexpressing MT1-MMP regardless of MMP-2 expression levels, suggesting that the production of MMP-2 by tumor cells themselves does not play a critical role in these events. The angiogenic phenotype of MT1-MMP-producing cells was associated with an up-regulation of VEGF expression. These results emphasize the importance of MT1-MMP during tumor angiogenesis and open new opportunities for the development of anti-angiogenic strategies combining inhibitors of MT1-MMP and VEGF antagonists. [less ▲]

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See detailMT1-MMP protects breast carcinoma cells against type I collagen-induced apoptosis
Maquoi, Erik ULg; Assent, Delphine; Detilleux, Julien et al

in Oncogene (2012), 31(4), 480-93

As invading breast carcinoma cells breach their underlying basement membrane, they become confronted with a dense three-dimensional reactive stroma dominated by type I collagen. To develop metastatic ... [more ▼]

As invading breast carcinoma cells breach their underlying basement membrane, they become confronted with a dense three-dimensional reactive stroma dominated by type I collagen. To develop metastatic capabilities, invading tumor cells must acquire the capacity to negotiate this novel microenvironment. Collagen influences the fate of epithelial cells by inducing apoptosis. However, the mechanisms used by invading tumor cells to evade collagen-induced apoptosis remain to be defined. We demonstrate that membrane type-1 matrix metalloproteinase (MT1-MMP/MMP-14) confers breast cancer cells with the ability to escape apoptosis when embedded in a collagen gel and after orthotopic implantation in vivo. In the absence of MMP-14-dependent proteolysis, type I collagen triggers apoptosis by inducing the expression of the pro-apoptotic Bcl-2-interacting killer in luminal-like breast cancer cells. These findings reveal a new mechanism whereby MMP-14 activity promotes tumor progression by circumventing apoptosis. [less ▲]

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See detailMtDNA haplogroups define two phenotypes of osteoarthritis
Rego-Perez, I; Fernandez-Moreno, M; DEBERG, Michelle ULg et al

in Arthritis and Rheumatism (2010), 62

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See detailMTHFR C677T polymorphism and susceptibility to migraine with aura
Magis, Delphine ULg; Coppola, Gianluca; Allena, Marta et al

in Cephalalgia : An International Journal of Headache (2005, October), 25(10), 863-864

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See detailmTOR inhibitors in advanced breast cancer: ready for prime time?
Martin, Lesley-Ann; Andre, Fabrice; Campone, Mario et al

in Cancer Treatment Reviews (2013), 39(7), 742-52

Current therapeutic approaches for advanced breast cancer frequently target receptors mediating cell survival and proliferation, such as the estrogen receptor and/or progesterone receptor and human ... [more ▼]

Current therapeutic approaches for advanced breast cancer frequently target receptors mediating cell survival and proliferation, such as the estrogen receptor and/or progesterone receptor and human epidermal growth factor receptor-2. Although these approaches are effective for many patients, treatment resistance is common. Therefore, new treatment approaches are needed for patients with advanced breast cancer. Mammalian target of rapamycin is a highly conserved serine-threonine kinase that acts as a major signaling hub that integrates and synergizes with cellular proliferation, survival, and/or motility signals mediated by estrogen receptor, human epidermal growth factor receptor-2, and other receptor tyrosine kinases. Dysregulation of mammalian target of rapamycin signaling occurs in various tumor types, including breast cancer, and has been associated with cancer pathogenesis, disease progression, and treatment resistance. Recent clinical trials show that combined inhibition of mammalian target of rapamycin and estrogen receptor represents an effective strategy for treating hormone receptor-positive advanced breast cancer progressing on nonsteroidal aromatase inhibitor therapy, and data from ongoing trials combining mammalian target of rapamycin inhibition with human epidermal growth factor receptor-2-targeted therapy are awaited. This review focuses on the molecular rationale underlying strategies to enhance sensitivity to treatment in hormone receptor-positive and human epidermal growth factor receptor-2-positive advanced breast cancer, the clinical efficacy of such approaches, and future perspectives. [less ▲]

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See detailA much lower density for the transiting extrasolar planet WASP-7 (Research Note)
Southworth, J.; Dominik, M.; Jorgensen, U~G et al

in Astronomy and Astrophysics (2011), 527

We present the first high-precision photometry of the transiting extrasolar planetary system WASP-7, obtained using telescope defocussing techniques and reaching a scatter of 0.68 mmag per point. We find ... [more ▼]

We present the first high-precision photometry of the transiting extrasolar planetary system WASP-7, obtained using telescope defocussing techniques and reaching a scatter of 0.68 mmag per point. We find that the transit depth is greater and that the host star is more evolved than previously thought. The planet has a significantly larger radius (1.330 +/- 0.093 Rjup versus 0.915 +0.046 -0.040 Rjup) and much lower density (0.41 +/- 0.10 rhojup versus 1.26 +0.25 -0.21 rhojup) and surface gravity (13.4 +/- 2.6 m/s2 versus 26.4 +4.4 -4.0 m/s2) than previous measurements showed. Based on the revised properties it is no longer an outlier in planetary mass--radius and period--gravity diagrams. We also obtain a more precise transit ephemeris for the WASP-7 system. [less ▲]

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See detailA much lower density for the transiting extrasolar planet WASP-7.
Southworth, J.; Dominik, M.; Jorgensen, U~G et al

Textual, factual or bibliographical database (2011)

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