Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailMSH2 gene dosage mediates azathioprine-induced carcinogenesis in mice
Chalastanis, A.; Penard-Lacronique, V.; Svrcek, M. et al

in Journal of the National Cancer Institute (2010)

Detailed reference viewed: 64 (34 ULg)
Full Text
Peer Reviewed
See detailMT-ClustalW: Multithreading multiple sequence alignment
Chaichoompu, Kridsadakorn ULg; Kittitornkun, S.; Tongsima, S.

in the 20th International Parallel and Distributed Processing Symposium, 2006 (IPDPS 2006) (2006, April)

ClustalW is the most widely used tool for aligning multiple protein or nucleotide sequences. The alignment is achieved via three stages: pairwise alignment, guide tree generation and progressive alignment ... [more ▼]

ClustalW is the most widely used tool for aligning multiple protein or nucleotide sequences. The alignment is achieved via three stages: pairwise alignment, guide tree generation and progressive alignment. This paper analyzes and enhances a multithreaded implementation of ClustalW called ClustalW-SMP for higher throughput. Our goal is to maximize the degree of parallelism on multithreading ClustalW called MultiThreading-ClustalW (MT-ClustalW). As a result, bioinformatics laboratories are able to use this MT-ClustalW with much less energy consumption on multicore and SMP (Symmetric Multiprocessor) machines than that of PC clusters. The experiment results show that the MT-ClustalW framework can achieve a considerable speedup over the sequential ClustalW and original multithreaded ClustalW-SMP implementations. © 2006 IEEE. [less ▲]

Detailed reference viewed: 26 (3 ULg)
Peer Reviewed
See detailMT-MMP Expression and localisation in human lung and breast cancers
Polette, M.; Nawrocki-Raby, B.; Gilles, Christine ULg et al

in Virchows Archiv : An International Journal of Pathology (1996), 428(1), 29-35

Thirteen primary pulmonary squamous cell carcinomas, 4 specimens of normal lung from around tumours, 4 benign proliferations of the mammary gland and 16 breast carcinomas were analysed by in situ ... [more ▼]

Thirteen primary pulmonary squamous cell carcinomas, 4 specimens of normal lung from around tumours, 4 benign proliferations of the mammary gland and 16 breast carcinomas were analysed by in situ hybridisation. Northern blot and immunohistochemistry for the expression of a recently described metalloproteinase (MMP), the MT-MMP (membrane-type matrix metalloproteinase). This MT-MMP can activate gelatinase A, involved in the degradation of basement membranes. In situ hybridisation revealed MT-MMP transcripts distributed in both tumour and stromal cells in squamous cell lung cancers, whereas these mRNAs were principally detected in stromal cells in close contact to tumour clusters in breast carcinomas and in lung adenocarcinomas. Northern blot analysis showed a parallel expression of MT-MMP and gelatinase A transcripts in both lung and breast cancers. Immunohistochemistry displayed a more extensive distribution of MT-MMP in pulmonary and mammary carcinomas with numerous labelled preinvasive and infiltrating cancer cells and stromal cells near the tumour cells. The large degree of expression of MT-MMP in these cancers indicates a potential role of this enzyme in tumour progression. The finding of MT-MMP transcripts in stromal cells in the vicinity of lung and breast tumour cells emphasises the cooperation between these cells and cancer cells for the expression of MT-MMP and in tumour invasion in vivo. [less ▲]

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailMT-MMPs as regulators of vessel stability associated with angiogenesis
Sounni, Nor Eddine ULg; Paye, Alexandra ULg; Host, Lorin et al

in Frontiers in Pharmacology of Anti-Cancer Drugs (2011), 2:111

The development of vascular system depends on the coordinated activity of a number of distinct families of molecules including growth factors and their receptors, cell adhesion molecules, extracellular ... [more ▼]

The development of vascular system depends on the coordinated activity of a number of distinct families of molecules including growth factors and their receptors, cell adhesion molecules, extracellular matrix (ECM) molecules, and proteolytic enzymes. Matrix metalloproteases (MMPs) are a family of ECM degrading enzymes required for both physiological and pathological angiogenesis. Increasing evidence, point to a direct role of membrane type-MMPs (MT-MMPs) in vascular system stabilization, maturation, and leakage. Our understanding of the nature of MT-MMP interaction with extracellular and cell surface molecules and their multiple roles in vessel walls and perivascular stroma may provide new insights into mechanisms underlying vascular cell-ECM interactions and cell fate decisions in pathological conditions. Regulation of vascular leakage by MT-MMP interactions with the ECM could also lead to novel targeting opportunities for drug delivery in tumor. This review will shed lights on the emerging roles of MT1-MMP and MT4-MMP in vascular system alterations associated with cancer progression. [less ▲]

Detailed reference viewed: 81 (9 ULg)
See detailMT1-MMP expression promotes tumor growth and angiogenesis
Sounni, Nor Eddine ULg

Conference (2001, April 19)

Detailed reference viewed: 3 (0 ULg)
Full Text
Peer Reviewed
See detailMT1-MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expression
Sounni, Nor Eddine ULg; Devy, L.; Hajitou, A. et al

in FASEB Journal (2002), 16(6), 555-564

Membrane type 1 metalloprotease (MT1-MMP) is a transmembrane metalloprotease that plays a major role in the extracellular matrix remodeling, directly by degrading several of its components and indirectly ... [more ▼]

Membrane type 1 metalloprotease (MT1-MMP) is a transmembrane metalloprotease that plays a major role in the extracellular matrix remodeling, directly by degrading several of its components and indirectly by activating pro-MMP2. We investigated the effects of MT1-MMP overexpression on in vitro and in vivo properties of human breast adenocarcinoma MCF7 cells, which do not express MT1-MMP or MMP-2. MT1-MMP and MMP-2 cDNAs were either transfected alone or cotransfected. All clones overexpressing MT1-MMP 1) were able to activate endogenous or exogenous pro-MMP-2, 2) displayed an enhanced in vitro invasiveness through matrigel-coated filters independent of MMP-2 transfection, 3) induced the rapid development of highly vascularized tumors when injected subcutaneously in nude mice, and 4) promoted blood vessels sprouting in the rat aortic ring assay. These effects were observed in all clones overexpressing MT1-MMP regardless of MMP-2 expression levels, suggesting that the production of MMP-2 by tumor cells themselves does not play a critical role in these events. The angiogenic phenotype of MT1-MMP-producing cells was associated with an up-regulation of VEGF expression. These results emphasize the importance of MT1-MMP during tumor angiogenesis and open new opportunities for the development of anti-angiogenic strategies combining inhibitors of MT1-MMP and VEGF antagonists. [less ▲]

Detailed reference viewed: 81 (10 ULg)
Full Text
Peer Reviewed
See detailMT1-MMP protects breast carcinoma cells against type I collagen-induced apoptosis
Maquoi, Erik ULg; Assent, Delphine; Detilleux, Julien et al

in Oncogene (2012), 31(4), 480-93

As invading breast carcinoma cells breach their underlying basement membrane, they become confronted with a dense three-dimensional reactive stroma dominated by type I collagen. To develop metastatic ... [more ▼]

As invading breast carcinoma cells breach their underlying basement membrane, they become confronted with a dense three-dimensional reactive stroma dominated by type I collagen. To develop metastatic capabilities, invading tumor cells must acquire the capacity to negotiate this novel microenvironment. Collagen influences the fate of epithelial cells by inducing apoptosis. However, the mechanisms used by invading tumor cells to evade collagen-induced apoptosis remain to be defined. We demonstrate that membrane type-1 matrix metalloproteinase (MT1-MMP/MMP-14) confers breast cancer cells with the ability to escape apoptosis when embedded in a collagen gel and after orthotopic implantation in vivo. In the absence of MMP-14-dependent proteolysis, type I collagen triggers apoptosis by inducing the expression of the pro-apoptotic Bcl-2-interacting killer in luminal-like breast cancer cells. These findings reveal a new mechanism whereby MMP-14 activity promotes tumor progression by circumventing apoptosis. [less ▲]

Detailed reference viewed: 88 (21 ULg)
Full Text
Peer Reviewed
See detailMtDNA haplogroups define two phenotypes of osteoarthritis
Rego-Perez, I; Fernandez-Moreno, M; DEBERG, Michelle ULg et al

in Arthritis and Rheumatism (2010), 62

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailMTHFR C677T polymorphism and susceptibility to migraine with aura
Magis, Delphine ULg; Coppola, Gianluca; Allena, Marta et al

in Cephalalgia : An International Journal of Headache (2005, October), 25(10), 863-864

Detailed reference viewed: 18 (2 ULg)
Full Text
Peer Reviewed
See detailmTOR inhibitors in advanced breast cancer: ready for prime time?
Martin, Lesley-Ann; Andre, Fabrice; Campone, Mario et al

in Cancer Treatment Reviews (2013), 39(7), 742-52

Current therapeutic approaches for advanced breast cancer frequently target receptors mediating cell survival and proliferation, such as the estrogen receptor and/or progesterone receptor and human ... [more ▼]

Current therapeutic approaches for advanced breast cancer frequently target receptors mediating cell survival and proliferation, such as the estrogen receptor and/or progesterone receptor and human epidermal growth factor receptor-2. Although these approaches are effective for many patients, treatment resistance is common. Therefore, new treatment approaches are needed for patients with advanced breast cancer. Mammalian target of rapamycin is a highly conserved serine-threonine kinase that acts as a major signaling hub that integrates and synergizes with cellular proliferation, survival, and/or motility signals mediated by estrogen receptor, human epidermal growth factor receptor-2, and other receptor tyrosine kinases. Dysregulation of mammalian target of rapamycin signaling occurs in various tumor types, including breast cancer, and has been associated with cancer pathogenesis, disease progression, and treatment resistance. Recent clinical trials show that combined inhibition of mammalian target of rapamycin and estrogen receptor represents an effective strategy for treating hormone receptor-positive advanced breast cancer progressing on nonsteroidal aromatase inhibitor therapy, and data from ongoing trials combining mammalian target of rapamycin inhibition with human epidermal growth factor receptor-2-targeted therapy are awaited. This review focuses on the molecular rationale underlying strategies to enhance sensitivity to treatment in hormone receptor-positive and human epidermal growth factor receptor-2-positive advanced breast cancer, the clinical efficacy of such approaches, and future perspectives. [less ▲]

Detailed reference viewed: 40 (2 ULg)
Full Text
Peer Reviewed
See detailA much lower density for the transiting extrasolar planet WASP-7 (Research Note)
Southworth, J.; Dominik, M.; Jorgensen, U~G et al

in Astronomy and Astrophysics (2011), 527

We present the first high-precision photometry of the transiting extrasolar planetary system WASP-7, obtained using telescope defocussing techniques and reaching a scatter of 0.68 mmag per point. We find ... [more ▼]

We present the first high-precision photometry of the transiting extrasolar planetary system WASP-7, obtained using telescope defocussing techniques and reaching a scatter of 0.68 mmag per point. We find that the transit depth is greater and that the host star is more evolved than previously thought. The planet has a significantly larger radius (1.330 +/- 0.093 Rjup versus 0.915 +0.046 -0.040 Rjup) and much lower density (0.41 +/- 0.10 rhojup versus 1.26 +0.25 -0.21 rhojup) and surface gravity (13.4 +/- 2.6 m/s2 versus 26.4 +4.4 -4.0 m/s2) than previous measurements showed. Based on the revised properties it is no longer an outlier in planetary mass--radius and period--gravity diagrams. We also obtain a more precise transit ephemeris for the WASP-7 system. [less ▲]

Detailed reference viewed: 24 (11 ULg)
See detailA much lower density for the transiting extrasolar planet WASP-7.
Southworth, J.; Dominik, M.; Jorgensen, U~G et al

Textual, factual or bibliographical database (2011)

Detailed reference viewed: 21 (7 ULg)
Full Text
Peer Reviewed
See detailMucilage and polysaccharides in the halophyte plant species Kosteletzkya virginica : Localozation and composition in relation to salt stress
Ghanem, Michel Edmond; Han, Rui-Ming; Classen, Birgit et al

in Journal of Plant Physiology (2010), 167

Detailed reference viewed: 44 (2 ULg)
See detailA mucin-enriched fermentation model to assess prebiotic potential of new indigestible carbohydrates
Boudry, Christelle ULg; Tran, Thi Hanh Tham ULg; Blaise, Yannick ULg et al

in 64th Annual Meeting of the European Federation of Animal Science (2013, August 29)

Screening the prebiotic potential of novel indigestible carbohydrates (ICH) is a challenge for feed and food industry and in vitro models are increasingly used for such purposes. Recently extracellular ... [more ▼]

Screening the prebiotic potential of novel indigestible carbohydrates (ICH) is a challenge for feed and food industry and in vitro models are increasingly used for such purposes. Recently extracellular binding proteins responsible for the adherence to intestinal mucus were described for several Lactobacillus species. As this genus is known for its beneficial effect on gut health, we enriched the in vitro gas fermentation model with mucin in order to evaluate the prebiotic potential of 5 ICH. Mucin-coated microcosms (MCM) were prepared as described by Van den Abbeele et al. (2012, Microbial Biotechnology, 5, 106-115) and introduced in the fermentation bottles with an inoculum prepared from fresh faeces of 3 sows mixed with a nutritive buffer solution. Fermentation was performed at 39°C, using 200 mg of substrate, 30 ml of inoculum and 6 MCM, yielding approx. 20 mg mucin each, in 140 ml glass bottles. A first study was performed with inulin and cellulose as substrates, with and without mucus in the bottles. A second study was performed with 5 substrates (inulin, IMO, beet pulp POS, cellobiose and gluconate) in presence of mucus. After 8 and 72h, SCFA and the microflora of fermentation broth was analysed as well as the microflora on the MCM. The comparison of the microflora evolution with and without mucus showed a better development of the Lactobacillus in the fermentation broth, mainly in presence of inulin. The development of the Lactobacillus genus allowed the classification of the 5 substrates tested in the second study (Inulin > IMO > Gluconate > Cellobiose > POS)(P < 0.05) which was not possible without mucus (P > 0.05). Inulin and IMO showed also the highest development of Bifidobacteria (P < 0.05) and the highest levels of butyrate production (P < 0.05) compared to the three other substrates, indicating a high prebiotic potential. [less ▲]

Detailed reference viewed: 132 (23 ULg)
Full Text
Peer Reviewed
See detailMucoadhesive cellulosic derivative sponges as drug delivery system for vaginal application
Furst, Tania ULg; Piette, Marie ULg; Lechanteur, Anna ULg et al

in European Journal of Pharmaceutics & Biopharmaceutics (2015)

Vaginal delivery of active drugs has been largely studied for local and systemic applications. It is well known that vagina is a complex route, due to physiological and non-physiological changes ... [more ▼]

Vaginal delivery of active drugs has been largely studied for local and systemic applications. It is well known that vagina is a complex route, due to physiological and non-physiological changes. Therefore, in order to achieve a prolonged local effect, these variations have to be considered. The aim of this study was to formulate and to characterize a solid system, called sponges, obtained by lyophilization of cellulosic derivative (HEC 250M) hydrogels. These sponges have to meet particular criteria to be adapted for vaginal application: they have to adhere to the vaginal cavity and to be rehydrated by the small amount of vaginal fluids. Moreover, they have to be easily manipulated and to be stable. Three freezing temperatures have been tested to prepare sponges ( 15 C, 25 C, 35 C). By SE analyzes, it was observed that the pores into the sponges were smaller and numerous as the freezing temperature decreases. However, this temperature did not have any influence on the rehydration speed that was rather influenced by the HEC concentration. Viscosity and mucoadhesive strength of hydrogels and corresponding sponges were also measured. It appeared that these parameters are mainly dépendent on the HEC concentration. These mucoadhesive sponges can be considered as potential drug delivery systems intended for vaginal application. [less ▲]

Detailed reference viewed: 30 (11 ULg)