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See detailPaclitaxel-loaded PEGylated nanocarriers: Preparation, physicochemical characterization and in vitro anti-tumoral activity
Danhier, F.; Lecouturier, N.; Vroman, Benoit et al

in Acta Clinica Belgica (2008, February 16), 63(2), 124

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See detailPaclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation
Danhier, Fabienne; Lecouturier, Nathalie; Vroman, Benoît et al

in Journal of Controlled Release (2009), 133(1), 11-17

The incorporation efficiency of PTX was higher with the nanoprecipitation technique. The release behavior of PTX exhibited a biphasic pattern characterized by an initial burst release followed by a slower ... [more ▼]

The incorporation efficiency of PTX was higher with the nanoprecipitation technique. The release behavior of PTX exhibited a biphasic pattern characterized by an initial burst release followed by a slower and continuous release. The in vitro anti-tumoral activity was assessed using the Human Cervix Carcinoma cells (HeLa) by the MTT test and was compared to the commercial formulation Taxol® and to Cremophor® EL. When exposed to 25 µg/ml of PTX, the cell viability was lower for PTX-loaded nanoparticles than for Taxol® (IC50 5.5 vs 15.5 µg/ml). Flow cytometry studies showed that the cellular uptake of PTX-loaded nanoparticles was concentration and time dependent. Exposure of HeLa cells to Taxol® and PTX-loaded nanoparticles induced the same percentage of apoptotic cells. PTX-loaded nanoparticles showed greater tumor growth inhibition effect in vivo on TLT tumor, compared with Taxol®. Therefore, PTX-loaded nanoparticles may be considered as an effective anticancer drug delivery system for cancer chemotherapy. [less ▲]

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See detailPaclitaxel-Related Lymphedema and Scleroderma-Like Skin Changes
COLSON, Fany ULg; SIGHA, Berline; ARRESE ESTRADA, Jorge ULg et al

in Journal of Clinical Case Reports (2013), 3(11),

Paclitaxel is an antimucrotubule agent used for the treatment of metastatic breast cancer. The development of scleroderma-like skin changes is an exceptional adverse effect. We report two patients with ... [more ▼]

Paclitaxel is an antimucrotubule agent used for the treatment of metastatic breast cancer. The development of scleroderma-like skin changes is an exceptional adverse effect. We report two patients with metastatic breast cancer treated by paclitaxel who presented an enexplained unilateral lymphedema of the upper limb. Medical work-up did not demonstrate any mechanical or tumor obstruction of the lymphatic vessels. Dermatologic examination revealed cutaneous and bucutaneous indurations and hardening of certain areas of the involved arm. The clinical suspicion of scleroderma was confirmed by histology and immunohistology. Treatment was initiated with methotrexate and methylprednisolone, resulting in a clear reduction of the lymphedema and a regression of the scleroderma. These two cases suggest a pathogenic role of paclitaxel-induced scleroderma in the subsequent development of severe localized lymphedema. [less ▲]

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See detailUn Pacte pour la Wallonie
Delruelle, Edouard ULg

Conference given outside the academic context (2014)

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See detailUn Pacte pour la Wallonie. Le redressement socio-économique de la Wallonie : l'affaire des citoyens
Delruelle, Edouard ULg

Book published by Ministère wallon de l'économie (2014)

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See detailPADDY IRRIGATION SYSTEM USING SHALLOW RESERVOIR IN THE MEKONG RIVER FLOODPLAIN
Ly, Sarann ULg; Someth, Paradis; Men, Nareth

in The Proceeding of the 5th International Symposium on Earth Resources and Geological Engineering Education (2007)

The Tonle Sap Great Lake and the Mekong River in Cambodia have huge floodplain suitable for rice-based farming system and potential water resources for farming. Studies to exploit the flood and the water ... [more ▼]

The Tonle Sap Great Lake and the Mekong River in Cambodia have huge floodplain suitable for rice-based farming system and potential water resources for farming. Studies to exploit the flood and the water resources of the lake and the river have not been well conducted yet. Batheay irrigation system is located in the floodplain of the Tonle Sap River and the Mekong River. In this research, the irrigation system is studied as a model site for future development of the floodplain of the Tonle Sap Great Lake and the Mekong River. Batheay reservoir directly receives floodwater from the Mekong. It functions as both a reservoir and a paddy field. In wet season, dike around the Batheay reservoir prevents floodwater from entering the reservoir. Rainy season rice is grown inside the reservoir. After harvesting, gates around the reservoir are opened to receive floodwater. The water is stored for cultivating dry season rice outside the reservoir. In this work, we attempt to study water management of the Batheay irrigation system by analyzing water use pattern in the irrigation system and uncover effectiveness of the system. A development scenario for the floodplain of the Mekong River is then proposed. [less ▲]

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See detailPadvinder voor het leven
Meesters, Gert ULg

Article for general public (2009)

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See detailPaedomorphosis in the Alpine newt (Triturus alpestris): decoupling behavioural and morphological change
Denoël, Mathieu ULg

in Behavioral Ecology and Sociobiology (2002), 52(5), 394-399

Paedomorphosis is a heterochronic pattern leading to morphological change, i.e. retention of larval characters in the adult phenotype. The aim of this study was to find out whether behaviour and ... [more ▼]

Paedomorphosis is a heterochronic pattern leading to morphological change, i.e. retention of larval characters in the adult phenotype. The aim of this study was to find out whether behaviour and morphology are decoupled in heterochronic phenotypes. To this end, I compared qualitative and quantitative aspects of courtship behaviour in syntopic metamorphic and paedomorphic Alpine newts, Triturus alpestris. Morphologically, the two morphs differ considerably (e.g. by the presence of gills only in paedomorphs), but their patterns of sexual behaviours are exhibited at similar frequencies and males use the same alternative reproductive tactics to attract unresponsive females. These results show that morphology and behaviour follow different ontogenetic pathways and are thus decoupled. Decoupling of the two traits offers the possibility of morphological evolution without alteration of sexual patterns. [less ▲]

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See detailPAF receptor and cache-oreilles effect. Simple PAF antagonists
Lamotte-Brasseur, Josette; Heymans, Françoise; Dive, Georges ULg et al

in Lipids (1991), 26(12), 1167-1171

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See detailPAF receptor structure: a hypothesis
Godfroid, Jean-Jacques; Dive, Georges ULg; Lamotte-Brasseur, Josette et al

in Lipids (1991), 26(12), 1162-1166

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See detailPaf-Receptor. 1. 'Cache-Oreilles' Effect of Selected High-Potency Platelet-Activating Factor (Paf) Antagonists
Dive, Georges ULg; Godfroid, Jean-Jacques; Lamotte-Brasseur, Josette et al

in Journal of Lipid Mediators (1989), 1(4, Jul-Aug), 201-15

Three-dimensional electrostatic maps were calculated for six potent antagonists of platelet-activating factor (PAF), the antagonists being selected for their apparent structural heterogeneity. The ... [more ▼]

Three-dimensional electrostatic maps were calculated for six potent antagonists of platelet-activating factor (PAF), the antagonists being selected for their apparent structural heterogeneity. The molecules examined were the compact Ginkgolides BN 52020, BN 52021 and BN 52022 (1, 2 and 3), the semi-rigid kadsurenone (4), a flexible synthetic dinor type C furanoid lignan L-652,731 (5a) and the triazolothienobenzodiazepine WEB 2086 (7). Calculation of the electrostatic potential generated around all the above molecules showed the existence of two wells of negative potential or 'cache-oreilles' (ear-muffs), i.e., the isocontours drawn at -10 kcal/mol, located at 180 degrees from each other and separated by a maximum distance of 22-27 A. Except for the synthetic dinor type C furanoid lignan (5a), the molecules also presented a moderate hydrophobic fragment, which constitutes a third point of interaction with the high-affinity binding site in rabbit and human platelets. The findings of the present study allow speculation that this high-affinity acceptor site may be a 'polarized cylinder' with a diameter of 10-12 A. [less ▲]

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See detailPaf-Receptor. iii. Conformational and Electronic Properties of Paf-Like Agonists and Antagonists
Lamotte-Brasseur, Josette; Dive, Georges ULg; Lamouri, Aazdine et al

in Biochimica et Biophysica Acta (1991), 1085(1), 91-105

In order to compare electronic and conformational properties of PAF-agonists and PAF-antagonists, 14 analogues structurally related to PAF were studied. A common conformation of the glycerol backbone was ... [more ▼]

In order to compare electronic and conformational properties of PAF-agonists and PAF-antagonists, 14 analogues structurally related to PAF were studied. A common conformation of the glycerol backbone was present in all agonists and all constrained or flexible antagonists. The distinction between agonists and antagonists appears to be casted on position-2 where the folded conformation of the substituent for agonists should be the most probable. In position-3 the gauche conformation can be adopted by all the analysed compounds. The electrostatic potential well at -30 kcal/mol stretches to the carbonyl group in position-2 in the folded conformation of the agonists. On the contrary, in constrained antagonists, a second negative zone appears around the carbamate group. Given the modelling results, the triethylammonium PAF analogue considered in literature as a weak agonist, was resynthesized and proved to be more potent than previously reported. These experimental results confirm our hypothesis in terms of a common conformation of agonist and antagonist PAF-like molecules. [less ▲]

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See detailPAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I.
Seither, P.; Iben, S.; Thiry, Marc ULg et al

in Biological Chemistry (2001), 382(8), 1163-70

Mammalian RNA polymerase I (Pol I) is a multisubunit enzyme that is decorated with accessory proteins, termed PAFs (polymerase-associated factors). The presence or absence of distinct PAFs may account for ... [more ▼]

Mammalian RNA polymerase I (Pol I) is a multisubunit enzyme that is decorated with accessory proteins, termed PAFs (polymerase-associated factors). The presence or absence of distinct PAFs may account for the functional differences of distinct fractions of cellular Pol I, and suggests that PAFs could be targets of regulatory pathways. Here we describe and functionally characterize PAF67, a novel 67 kDa protein that is tightly associated with a subpopulation of cellular Pol I. Both PAF67-containing and -deficient Pol I transcribe non-specific templates with similar efficiency, however, only the enzyme that contains PAF67 is capable of specifically transcribing rDNA templates. PAF67 co-localizes with Pol I in the nucleolus at sites of active rDNA transcription, indicating that PAF67 serves a role in rDNA transcription initiation. The results suggest that association of PAF67 with the 'core' enzyme endows Pol I with the capability to assemble into a productive transcription initiation complex at the rDNA promoter. [less ▲]

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See detailPAG és progeszteron profilok alalkulás in vitro embrióbeültetést követõ vemhességnel hormanális stimuláció és petesejt kinyerés után tehenekben
Tomašković, A.; Prvanović, N.; Beckers, Jean-François ULg et al

in Proceedings: The 5th Middle-European Buiatrics Congress (2004)

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See detailPAG profiles in postpartum dairy cows and newborn calves
Ropstad, E; Kalberg, K; Dahl, E et al

in Reproduction in Domestic Animals (2002), 37(4), 249

In ruminants, pregnancy associated glycoproteins (PAG), synthesized in the outer layers of the trophoblast, enter the maternal bloodstream. In this study, blood samples from cows in the postpartum period ... [more ▼]

In ruminants, pregnancy associated glycoproteins (PAG), synthesized in the outer layers of the trophoblast, enter the maternal bloodstream. In this study, blood samples from cows in the postpartum period, pregnant cows and calves were collected to determine 1) the clearance rate of PAG, 2) the accuracy of PAG measurements used for pregnancy diagnosis and 3) PAG concentrations and clearance rate in newborn calves. A curvilinear decline in PAG was found with increasing days from calving. Between day 70–80 pp 3 out of 11 samples (27%) had PAG concentrations > 4 ng/ml plasma. A cut-off value of 4 ng/ml was found to give the best accuracy for pregnancy diagnosis 28–36 days after service (n ¼58: sensitivity¼0.97; specificity ¼1.0). PAG concentrations in newborn calves (n¼10) varied between 78–880 ng/ml, declining with increasing age in a curvilinear pattern to < 1 ng/ml between 20–40 days pp. In two male twin calves PAG concentrations were 880 and 101 ng/ml, respectively, at one day of age. We conclude: 1) 4 ng PAG /ml provides the best cut-off value for pregnancy diagnosis. 2) Cows serviced before 60 days pp can produce false positive pregnancy diagnoses due to PAG originating from the previous pregnancy. 3) High PAG concentrations can be found in newborn calves. [less ▲]

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See detailPage de Beckett et Beckett de Page
Demoulin, Laurent ULg

E-print/Working paper (2013)

Compte rendu du livre de Martin Page L'Apiculture selon Samuel Beckett.

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See detailPaget’s disease of bone : diagnosis and management
Hosking, D; Meunier, PJ; Ringe, JD et al

in British Medical Journal (1996), 312

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See detailPaget's Disease of Bone Treated with a Five Day Course of Oral Tiludronate
Reginster, Jean-Yves ULg; Lecart, Marie-Paule ULg; Deroisy, Rita ULg et al

in Annals of the Rheumatic Diseases (1993), 52(1), 54-7

Chloro-4-phenyl thiomethylene bisphosphonate (tiludronate) is a new drug which can be used as an inhibitor of bone resorption. As it remains in bone for a long time, and as mineralisation defects have ... [more ▼]

Chloro-4-phenyl thiomethylene bisphosphonate (tiludronate) is a new drug which can be used as an inhibitor of bone resorption. As it remains in bone for a long time, and as mineralisation defects have only been seen at doses much higher than those required to decrease osteoclastic activity, it could be given at high doses over a short period of time. Eighteen patients with Paget's disease of bone were randomly allocated to three therapeutic groups receiving respectively 600, 800, and 1200 mg/day tiludronate for five days. Serum alkaline phosphatase activity and the urinary hydroxyproline/creatinine ratio were quickly and drastically reduced in all three groups. A significant reduction of serum alkaline phosphatases and the hydroxyproline/creatinine ratio was still present six months after the five day therapeutic course, reflecting a sustained activity of tiludronate even after stopping treatment. Dose dependent short and long term reductions of bone turnover rate were observed. Biochemical assessment of haematological, renal, or hepatic tolerance did not show any toxicity of tiludronate. Fifty per cent of patients treated by a dose of 1200 mg/day reported gastrointestinal disturbances, however, making this dosage unsuitable for clinical practice. [less ▲]

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See detailPágina impar: el lugar del traductor en el auge de la industria editorial
Willson, Patricia ULg

in Saítta, Sylvia (Ed.) Historia crítica de la literatura argentina. Volumen 9: El oficio se afirma (2004)

This chapter examines the place occupied by the translator during the period in which Buenos Aires was the publishing Mecca of Latin America. Starting in the 1930s and during the forties and fifties ... [more ▼]

This chapter examines the place occupied by the translator during the period in which Buenos Aires was the publishing Mecca of Latin America. Starting in the 1930s and during the forties and fifties, translating activity was particularly intense in Argentina and incorporated a profusion of what was being written in other literatures. Two realities converged in this boom: a favourable context of the book market and a tradition of handling «the new» set forth by the porteño avant-gardes of the 1920s. [less ▲]

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