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See detailAssociation of the adaptor TANK with the IκB kinase (IKK) regulator NEMO connects IKK complexes with IKKε and TBK1 kinases
Chariot, Alain ULg; Leonardi, Antonio; Muller, Jean-Noel ULg et al

in Journal of Biological Chemistry (2002), 277(40), 37029-37036

Canonical activation of NF-kappaB is mediated via phosphorylation of the inhibitory IkappaB proteins by the IkappaB kinase complex (IKK). IKK is composed of a heterodimer of the catalytic IKKalpha and ... [more ▼]

Canonical activation of NF-kappaB is mediated via phosphorylation of the inhibitory IkappaB proteins by the IkappaB kinase complex (IKK). IKK is composed of a heterodimer of the catalytic IKKalpha and IKKbeta subunits and a presumed regulatory protein termed NEMO (NF-kappaB essential modulator) or IKKgamma. NEMO/IKKgamma is indispensable for activation of the IKKs in response to many signals, but its mechanism of action remains unclear. Here we identify TANK (TRAF family member-associated NF-kappaB activator) as a NEMO/IKKgamma-interacting protein via yeast two-hybrid analyses. This interaction is confirmed in mammalian cells, and the domains required are mapped. TANK was previously shown to assist NF-kappaB activation in a complex with TANK-binding kinase 1 (TBK1) or IKKepsilon, two kinases distantly related to IKKalpha/beta, but the underlying mechanisms remained unknown. Here we show that TBK1 and IKKepsilon synergize with TANK to promote interaction with the IKKs. The TANK binding domain within NEMO/IKKgamma is required for proper functioning of this IKK subunit. These results indicate that TANK can synergize with IKKepsilon or TBK1 to link them to IKK complexes, where the two kinases may modulate aspects of NF-kappaB activation. [less ▲]

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See detailAssociation of tibolone and fluoride displays a pronounced effect of bone mineral density in postmenopausal women
Reginster, Jean-Yves ULg; Agnusdei, D; Gennari, C et al

in Osteoporosis International (1996), 6(S1), 210

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See detailAssociation of Tibolone and Fluoride Displays a Pronounced Effect on Bone Mineral Density in Postmenopausal Osteoporotic Women
Reginster, Jean-Yves ULg; Agnusdei, D.; Gennari, C. et al

in Gynecological Endocrinology : The Official Journal of the International Society of Gynecological Endocrinology (1999), 13(5), 361-8

A double-blind, placebo-controlled, randomized, prospective two-center study was carried out to assess the effects of tibolone + fluoride versus placebo + fluoride therapy on trabecular and cortical bone ... [more ▼]

A double-blind, placebo-controlled, randomized, prospective two-center study was carried out to assess the effects of tibolone + fluoride versus placebo + fluoride therapy on trabecular and cortical bone in postmenopausal osteoporotic women. Ninety-four subjects (mean age 61.1 years, postmenopausal 13.5 years on average) with low bone mineral density (BMD) at baseline were randomized to 2.5 mg of tibolone (Org OD 14, Livial) plus 26.4 mg of fluoride (Fluocalcic) or placebo plus 26.4 mg of fluoride daily over 2 years; 55 (58.5%) subjects completed the study, the main reason for discontinuation being untoward gastrointestinal effects. BMD at the lumbar spine was measured by both dual photon absorptiometry (DPA) and dual-energy X-ray absorptiometry (DXA), and at the hip by DXA at 6-month intervals. Baseline values (DXA, g/cm2) for tibolone + fluoride and placebo + fluoride groups were 0.733 and 0.744 for the lumbar spine, and 0.761 and 0.788 for the hip. Change from baseline and percentage change from baseline were calculated for the intent-to-treat and completers groups. An analysis of variance (ANOVA) model or Wilcoxon test was used for statistical evaluation. There was a mean increase in BMD at the lumbar spine measured by DPA of 25.3% and 12.3% in tibolone + fluoride and placebo + fluoride groups, respectively (p = 0.01); with DXA, respective changes were 32.6% and 14.0% (p = 0.013). Data on BMD at the hip showed mean increases of 7.9% and 2.6% for the tibolone + fluoride and placebo + fluoride groups, respectively. We conclude that combined tibolone + fluoride treatment induces a highly significant increase in BMD at the lumbar spine without simultaneous loss of the cortical bone allowing for a meaningful reduction of the fluoride dose when given in combination with tibolone. [less ▲]

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See detailAssociation of two single-isomer anionic CD in NACE for the chiral and achiral separation of fenbendazole, its sulphoxide and sulphone metabolites: Application to their determination after in vitro metabolism
Rousseau, Anne ULg; Gillotin, Florian; Chiap, Patrice ULg et al

in Electrophoresis (2010), 31

A NACE method was developed for the separation of fenbendazole (FBZ), a prochiral drug giving rise to chiral (oxfendazole or OFZ) and nonchiral (FBZ sulphone or FBZSO2) metabolites. First, the effect of ... [more ▼]

A NACE method was developed for the separation of fenbendazole (FBZ), a prochiral drug giving rise to chiral (oxfendazole or OFZ) and nonchiral (FBZ sulphone or FBZSO2) metabolites. First, the effect of the nature and the concentration of CD as well as that of the acidic BGE on the enantiomeric separation of OFZ were studied. OFZ enantiomers were completely resolved using a BGE made up of 10 mM ammonium formate and 0.5 M TFA in methanol containing 10 mM heptakis(2,3-di-O-acetyl-6-O-sulfo)-beta-CD and 10 mM heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-CD. Moreover, the NACE method was found to be particularly well suited to the simultaneous determination of FBZ, OFZ enantiomers, and FBZSO2. Thiabendazole was selected as an internal standard. The CD-NACE potential was then evaluated for in vitro metabolism studies using FBZ as a model case. The OFZ enantiomers and FBZSO2 could be detected after incubation of FBZ in the phenobarbital-induced male rat liver microsomes systems. [less ▲]

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See detailL'Association. Une utopie éditoriale et esthétique
Groupe ACME; Dejasse, Erwin ULg; Habrand, Tanguy ULg et al

Book published by Les Impressions nouvelles (2011)

L’Association, Une utopie éditoriale et esthétique est le premier volume d’histoire et d’analyse consacré à ce projet à tous égards exceptionnel. Richement illustré, interrogeant l’économie globale du ... [more ▼]

L’Association, Une utopie éditoriale et esthétique est le premier volume d’histoire et d’analyse consacré à ce projet à tous égards exceptionnel. Richement illustré, interrogeant l’économie globale du collectif, ses auteurs et ses réalisations, mais aussi ses crises de croissance, L’Association, Une utopie éditoriale et esthétique est aussi l’œuvre de passionnés de bande dessinée. Passant d’un chapitre chronologique à une étude sémiotique, d’un article critique à une analyse esthétique, l’ouvrage forme un ensemble généreux et passionnant. Il offre plus de deux cents pages d’images célèbres et de documents rares qui nous donnent envie de (re)découvrir les auteurs et les albums de L’Association. Bel hommage éditorial, ce superbe album donne à voir et à comprendre vingt ans d’édition et de croisades esthétiques. [less ▲]

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See detailL’associationnisme ethnique à l’épreuve du temps : étude de cas. Le Movimiento Asociativo de Emigrantes Españoles en Bélgica
Molina Marmol, Maïté ULg

in Actes des journée d’étude du 10 novembre 2011 « Immigration et troisième âge. Vieillir en migration, constats et solutions pour des populations silencieuses » (2014, January)

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See detailL'associationnisme régional italien en Belgique : point final de l'immigritude ?
Martiniello, Marco ULg

Scientific conference (1989, November 21)

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See detailL'associationnisme régional italien en Belgique : point final de l'immigritude?
Martiniello, Marco ULg

in Van Der Wee, H.; Dumoulin, M. (Eds.) Hommes, cultures et capitaux dans les relations italo-belges aux XIXe et XXe siècles (1993)

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See detailAssociations among BCS, milk production and days-open in Walloon primiparous dairy cows
Laloux, Laurent; Bastin, Catherine ULg; Gillon, Alain ULg et al

in Book of abstracts of the 60th annual meeting of the European Association for Animal Production (2009, August)

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See detailAssociations among BCS, milk production and days-open in Walloon primiparous dairy cows
Massart, Xavier; Laloux, Laurent; Bastin, Catherine ULg et al

Conference (2009, August 27)

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See detailAssociations between casein haplotypes and first lactation milk production traits in Finnish Ayrshire cows
Ikonen, T.; Bovenhuis, H.; Ojala, M. et al

in Journal of Dairy Science (2001), 84(2), 507-514

The objective of this study was to estimate the effects of ß--casein (CN) haplotypes on first-lactation milk production traits. The ß--CN haplotypes were deduced using information on ß- and -CN genotypes ... [more ▼]

The objective of this study was to estimate the effects of ß--casein (CN) haplotypes on first-lactation milk production traits. The ß--CN haplotypes were deduced using information on ß- and -CN genotypes of cows and their sires for 16,973 Finnish Ayrshire cows that had at least nine paternal half sibs. Effects of CN haplotypes on milk production traits were estimated for one haplotype at a time using an animal model, which included the fixed effects for calving year and month, age at calving, days open, ß-lactoglobulin, and a ß--CN haplotype. Differences in milk production traits were also estimated between haplotype combinations A1A+A2B and A1B+A2A within ß--CN genotype A1A2AB and between combinations A1E+A2A and A1A+A2E within genotype A1A2AE. The ß--CN haplotypes A2A and A2B were associated with high milk and protein yields and low fat content, and those that included the ß-CN A1 allele were associated with low yields and high fat content. Protein content was affected by the -CN locus; haplotype A1B was associated with high protein content and A1E was with low protein content. The haplotype combination A1A+A2B was associated with 140 kg more milk yield (P = 0.045) and 0.03 percentage units less protein content (P = 0.055) than combination A1B+A2A, and combination A1A+A2E showed 0.02 percentage units greater protein content (P = 0.098) than A1E+A2A. These results indicate that genes linked to the CN loci contribute to the variation in milk yield and protein content. [less ▲]

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See detailAssociations Between Dimensions of Alexithymia and Psychometric Schizotypy in Nonclinical Participants
Laroi, Frank ULg; Van der Linden, Martial ULg; Aleman, A.

in Journal of Nervous & Mental Disease (2008), 196(12), 927-930

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See detailAssociations between hallucinations and personality structure in a non-clinical sample : comparison between young and elderly samples
Laroi, Frank ULg; DeFruyt, F.; van Os, J. et al

in Personality and Individual Differences (2005), 39(1), 189-200

Few studies have explored the prevalence of hallucinations in the non-clinical, elderly population. Also, the association between personality structure and hallucinations remains poorly investigated. The ... [more ▼]

Few studies have explored the prevalence of hallucinations in the non-clinical, elderly population. Also, the association between personality structure and hallucinations remains poorly investigated. The aims of the present study were twofold. First, to explore the influence of age on the prevalence of hallucination-proneness, and second, to examine the association between personality and hallucination-proneness in young and elderly subjects. A sample of young (n = 230) and elderly adults (n = 183) completed an elaborated and validated version of the Launay-Slade Hallucinations Scale (LSHS; Laroi, Marczewski, & Van der Linden, 2004) and the Five Factor Inventory version of the NEO Personality Inventory (NEO-FFI; Costa, [less ▲]

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See detailAssociations between health representation and BMI in a pediatric population
Guillaume, Michèle ULg; Burnotte, C.

in International Journal of Obesity (1998, August)

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See detailAssociations between increase in bone mineral density and decrease in clinical vertebral fracture incidence during a treatment with strontium ranelate
Bruyère, Olivier ULg; Roux, Christian; Cannata, J. B. et al

in Osteoporosis International (2006, March), 17(Suppl.1), 8

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See detailAssociations between properties linked with persistence in a collection of Staphylococcus aureus isolates from bovine mastitis
Bardiau, Marjorie ULg; Detilleux, Johann; Farnir, Frédéric et al

in Veterinary Microbiology (2013)

Detailed reference viewed: 15 (6 ULg)