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Peer Reviewed
See detailThe p27 ubiquitin ligase skp2 is overexpressed in breast cancer
Signoretti, Sabina; Monti, Francesca; Isaac, Beth et al

in Laboratory Investigation : Journal of Technical Methods & Pathology (2001), 81

Detailed reference viewed: 18 (0 ULg)
See detailp27(Kip1) as a master regulator of cortical neuron migration
Godin, Juliette ULg; Thomas, Noémie; Laguesse, Sophie ULg et al

Scientific conference (2011, June)

Detailed reference viewed: 16 (1 ULg)
See detailp27(Kip1) as a master regulator of cortical neuron migration.
Godin, Juliette ULg; Thomas, Noémie; Laguesse, Sophie ULg et al

Poster (2012)

Detailed reference viewed: 4 (0 ULg)
Peer Reviewed
See detailp27(Kip1) as a master regulator of cortical neuron migration.
Godin, Juliette ULg; Thomas, Noémie; Laguesse, Sophie ULg et al

Conference (2013, June)

Detailed reference viewed: 15 (5 ULg)
See detailp27(Kip1) as a master regulator of cortical neuron migration.
Godin, Juliette ULg; Thomas, Noémie; Laguesse, Sophie ULg et al

Poster (2013)

Detailed reference viewed: 4 (0 ULg)
See detailp27(Kip1) as a master regulator of cortical neuron migration.
Godin, Juliette ULg; Thomas, Noémie; Laguesse, Sophie ULg et al

Poster (2012)

Detailed reference viewed: 6 (0 ULg)
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See detailp27(Kip1) Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration.
Godin, Juliette ULg; Thomas, Noemie; Laguesse, Sophie ULg et al

in Developmental Cell (2012), 23(4), 729-44

The migration of cortical interneurons is characterized by extensive morphological changes that result from successive cycles of nucleokinesis and neurite branching. Their molecular bases remain elusive ... [more ▼]

The migration of cortical interneurons is characterized by extensive morphological changes that result from successive cycles of nucleokinesis and neurite branching. Their molecular bases remain elusive, and the present work describes how p27(Kip1) controls cell-cycle-unrelated signaling pathways to regulate these morphological remodelings. Live imaging reveals that interneurons lacking p27(Kip1) show delayed tangential migration resulting from defects in both nucleokinesis and dynamic branching of the leading process. At the molecular level, p27(Kip1) is a microtubule-associated protein that promotes polymerization of microtubules in extending neurites, thereby contributing to tangential migration. Furthermore, we show that p27(Kip1) controls actomyosin contractions that drive both forward translocation of the nucleus and growth cone splitting. Thus, p27(Kip1) cell-autonomously controls nucleokinesis and neurite branching by regulating both actin and microtubule cytoskeletons. [less ▲]

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See detailp27Kip1 independently promotes neuronal differentiation and migration in the cerebral cortex.
Nguyen, Laurent ULg; Besson, A.; Heng, J Ik-Tsen et al

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2007), 162(5-6), 310-4

The generation of glutamatergic neurons by stem and progenitor cells is a complex process involving the tight coordination of multiple cellular activities, including cell cycle exit, initiation of ... [more ▼]

The generation of glutamatergic neurons by stem and progenitor cells is a complex process involving the tight coordination of multiple cellular activities, including cell cycle exit, initiation of neuronal differentiation and cell migration. The mechanisms that integrate these different events into a coherent program are not well understood. Here we show that the cyclin-dependent kinase inhibitor p27Kip1 plays an important role in neurogenesis in the mouse cerebral cortex, by promoting the differentiation and radial migration of cortical projection neurons. Importantly, p27Kip1 promotes neuronal differentiation and neuronal migration via two distinct mechanisms, which are themselves independent of the cell cycle regulatory function of p27Kip1. p27Kip1 inactivation by gene targeting or RNA interference results in neuronal differentiation and radial migration defects, demonstrating that p27Kip1 regulates cell migration in vivo. The differentiation defect, but not the migration defect, is rescued by overexpression of the proneural gene Neurogenin 2. p27Kip1 acts by stabilizing Neurogenin 2 protein, an activity carried by the N-terminal half of the protein. The migration defect resulting from p27Kp1 inactivation is rescued by blocking RhoA signalling, an activity that resides in the c-terminal half of p27Kip1. Thus, p27Kip1 plays a key role in cortical development, acting as a modular protein that independently regulates and couples multiple cellular pathways contributing to neurogenesis. [less ▲]

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See detailp27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex.
Nguyen, Laurent ULg; Besson, Arnaud; Heng, Julian Ik-Tsen et al

in Genes & Development (2006), 20(11), 1511-24

The generation of neurons by progenitor cells involves the tight coordination of multiple cellular activities, including cell cycle exit, initiation of neuronal differentiation, and cell migration. The ... [more ▼]

The generation of neurons by progenitor cells involves the tight coordination of multiple cellular activities, including cell cycle exit, initiation of neuronal differentiation, and cell migration. The mechanisms that integrate these different events into a coherent developmental program are not well understood. Here we show that the cyclin-dependent kinase inhibitor p27(Kip1) plays an important role in neurogenesis in the mouse cerebral cortex by promoting the differentiation and radial migration of cortical projection neurons. Importantly, these two functions of p27(Kip1) involve distinct activities, which are independent of its role in cell cycle regulation. p27(Kip1) promotes neuronal differentiation by stabilizing Neurogenin2 protein, an activity carried by the N-terminal half of the protein. p27(Kip1) promotes neuronal migration by blocking RhoA signaling, an activity that resides in its C-terminal half. Thus, p27(Kip1) plays a key role in cortical development, acting as a modular protein that independently regulates and couples multiple cellular pathways contributing to neurogenesis. [less ▲]

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See detailP2P File Sharing for P2P Computing
Briquet, Cyril ULg; Dalem, Xavier ULg; Jodogne, Sébastien ULg et al

in Multiagent and Grid Systems (2009), 2009/5(2), 137-164

The transfer of large input data files in P2P computing Grids often leads to delays in Task completion times. Existing research related to this topic has been focused on the spatial grouping of Tasks, i.e ... [more ▼]

The transfer of large input data files in P2P computing Grids often leads to delays in Task completion times. Existing research related to this topic has been focused on the spatial grouping of Tasks, i.e. reuse of available data through data caching and data-aware scheduling. However, it tends to decrease the level of parallelism of Task execution. In this paper, this issue is addressed by integrating the BitTorrent P2P file sharing protocol, a novel Task selection scheduling algorithm, an existing online, data-aware Resource selection algorithm (similar to Storage Affinity), and caching support. These algorithms have been implemented in the Lightweight Bartering Grid middleware. The Java implementation relies exclusively on Free and Open Source data transfer software (Azureus, Apache FTP server, edtFTPj). The proposed data transfer architecture does not need Predictive Communications Ordering or an explicit deployment of an overlay network. It is also easily deployable. Our main contribution is the joint use of P2P computing and P2P file sharing technologies, enabling a highly scalable and adaptive data transfer architecture to support P2P computing. [less ▲]

Detailed reference viewed: 434 (30 ULg)
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See detailP2P Implications on Web Surfing
Merciadri, Luca ULg

E-print/Working paper (2009)

P2P (Peer-to-Peer) technology comprises various ways to exchange information rapidly, each participant sharing a portion of his own resources. Anyway, despite of the numerous advantages of using P2P, a ... [more ▼]

P2P (Peer-to-Peer) technology comprises various ways to exchange information rapidly, each participant sharing a portion of his own resources. Anyway, despite of the numerous advantages of using P2P, a real problem is often encountered when using cheap internet connections: web surfing becomes so slow that it seems impossible to reach a web page, for the P2P’s user. It is especially the case when using connections with a low upload speed. The problem has also an importance, even if it is minor, when using high-speed connections (VDSL, ... ), as it is also a waste of capacity. [less ▲]

Detailed reference viewed: 90 (27 ULg)
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See detailA P2X Ion Channel-triggered NF-{kappa}B Pathway Enhances TNF-{alpha}-induced IL-8 Expression in Airway Epithelial Cells.
Theatre, Emilie ULg; Bours, Vincent ULg; Oury, Cécile ULg

in American Journal of Respiratory Cell and Molecular Biology (2009)

Extracellular ATP, acting at P2Y and P2X receptors, has recently been shown to contribute to airway inflammation. Using different epithelial cell models, this study shows that ATP promotes TNF-alpha ... [more ▼]

Extracellular ATP, acting at P2Y and P2X receptors, has recently been shown to contribute to airway inflammation. Using different epithelial cell models, this study shows that ATP promotes TNF-alpha-elicited IL-8 expression through P2X ion channel-triggered Ca(2+) entry, leading to CaMK-dependent IKK activation and binding of active p65 to IL-8 gene promoter. [less ▲]

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See detailP2X(1)-mediated activation of extracellular signal-regulated kinase 2 contributes to platelet secretion and aggregation induced by collagen.
Oury, Cécile ULg; Toth-Zsamboki, Emese; Vermylen, Jos et al

in Blood (2002)

This study shows that mild platelet stimulation with collagen rapidly releases ATP, which activates the P2X(1)-PKC-ERK2 pathway. This process enhances further degranulation of the collagen-primed granules ... [more ▼]

This study shows that mild platelet stimulation with collagen rapidly releases ATP, which activates the P2X(1)-PKC-ERK2 pathway. This process enhances further degranulation of the collagen-primed granules allowing platelet aggregation to be completed. [less ▲]

Detailed reference viewed: 7 (2 ULg)
Peer Reviewed
See detailThe P2X1 ion channel in platelets acts as a functional receptor for ATP and is weakly antagonized by ADP.
Oury, Cécile ULg; Toth-Zsamboki, Emese; Thys, Chantal et al

in Thrombosis and Haemostasis (2001)

Detailed reference viewed: 8 (1 ULg)
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See detailP2X1 Ion Channels Promote Neutrophil Chemotaxis through Rho Kinase Activation
Lecut, Christelle ULg; Frederix, Kim ULg; Johnson, Daniel M et al

in Journal of Immunology (2009)

This study shows that activation of P2X1 ion channels by ATP promotes neutrophil chemotaxis, a process involving Rho kinase-dependent actomyosin-mediated contraction at the cell rear. These ion channels ... [more ▼]

This study shows that activation of P2X1 ion channels by ATP promotes neutrophil chemotaxis, a process involving Rho kinase-dependent actomyosin-mediated contraction at the cell rear. These ion channels may therefore play a significant role in host defense and inflammation. [less ▲]

Detailed reference viewed: 58 (20 ULg)
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See detailP2X1 receptors as new regulators of neutrophil life span
Faccinetto, Céline ULg; Lecut, Christelle ULg; Jacobs, Nathalie ULg et al

in Journal of Thrombosis and Haemostasis [=JTH] (2007)

Detailed reference viewed: 27 (4 ULg)
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See detailP2X1-induced activation of Ca2+ calmodulin leads to myosin light chain and ERK2 phosphorylation in human platelets.
Toth-Zsamboki, Emese; Oury, Cécile ULg; De Vos, Rita et al

in Journal of Thrombosis and Haemostasis [=JTH] (2003)

Detailed reference viewed: 7 (1 ULg)