Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailThe OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p12-17p13 region of the human genome and reveals a MspI restriction fragment lenght polymorphism
Schurmans, Stéphane ULg; Muscatelli, F.; Miot, F. et al

in CytoGenetics & Cell Genetics (1993), 63

Olfactory receptors are believed to be encoded by an extremely large subfamily of G protein-coupled receptors. A human gene (OLFR1) encoding a member of this family was cloned from a genomic library by ... [more ▼]

Olfactory receptors are believed to be encoded by an extremely large subfamily of G protein-coupled receptors. A human gene (OLFR1) encoding a member of this family was cloned from a genomic library by cross-hybridization with a gene fragment obtained by the polymerase chain reaction. The nucleotide sequence of a 3.4-kb EcoRI fragment was determined, and the protein sequence was deduced from the single open reading frame. The gene was assigned by in situ hybridization of metaphase chromosomes to the 17p13-->p12 region of the human genome, in proximity to the tumor-suppressor gene encoding p53. When used as a probe on Southern blots under moderately stringent conditions, it hybridizes to at least three closely related genes. A restriction fragment length polymorphism was detected after MspI digestion. Mendelian segregation of the gene was assessed in three CEPH families, and linkage analysis confirmed the localization of the locus [less ▲]

Detailed reference viewed: 17 (5 ULg)
See detailOlgierd Kuty. Un parcours sociologique
Vrancken, Didier ULg

in Vrancken, Didier; Dubois, Christophe; Schoenaers, Frédéric (Eds.) Penser la négociation. Mélanges en hommage à Olgierd Kuty (2008)

Cet article retrace les principales étapes du parcours sociologique d'Olgierd Kuty. Depuis ses débuts, à une théorisation générale du droit, de l'organisation et de la société en passant par l'analyse des ... [more ▼]

Cet article retrace les principales étapes du parcours sociologique d'Olgierd Kuty. Depuis ses débuts, à une théorisation générale du droit, de l'organisation et de la société en passant par l'analyse des politiques sociales, les travaux d'Olgierd Kuty se sont déclinés autour d'une thématique transversale, celle de l'analyse de la négociation. [less ▲]

Detailed reference viewed: 54 (11 ULg)
Full Text
Peer Reviewed
See detailOligodendrocyte development and myelinogenesis are not impaired by high concentrations of phenylalanine or its metabolites.
Schoemans, Renaud; Aigrot, Marie-Stephane; Wu, Chaohong et al

in Journal of Inherited Metabolic Disease (2010), 33(2), 113-20

Phenylketonuria (PKU) is a metabolic genetic disease characterized by deficient phenylalanine hydroxylase (PAH) enzymatic activity. Brain hypomyelination has been reported in untreated patients, but its ... [more ▼]

Phenylketonuria (PKU) is a metabolic genetic disease characterized by deficient phenylalanine hydroxylase (PAH) enzymatic activity. Brain hypomyelination has been reported in untreated patients, but its mechanism remains unclear. We therefore investigated the influence of phenylalanine (Phe), phenylpyruvate (PP), and phenylacetate (PA) on oligodendrocytes. We first showed in a mouse model of PKU that the number of oligodendrocytes is not different in corpus callosum sections from adult mutants or from control brains. Then, using enriched oligodendroglial cultures, we detected no cytotoxic effect of high concentrations of Phe, PP, or PA. Finally, we analyzed the impact of Phe, PP, and PA on the myelination process in myelinating cocultures using both an in vitro index of myelination, based on activation of the myelin basic protein (MBP) promoter, and the direct quantification of myelin sheaths by both optical measurement and a bioinformatics method. None of these parameters was affected by the increased levels of Phe or its derivatives. Taken together, our data demonstrate that high levels of Phe, such as in PKU, are unlikely to directly induce brain hypomyelination, suggesting involvement of alternative mechanisms in this myelination defect. [less ▲]

Detailed reference viewed: 44 (8 ULg)
Peer Reviewed
See detailOligodendrocytes: From Development to Demyelinated Lesion Repair
Rogister, Bernard ULg; Belachew, Shibeshih ULg; Moonen, Gustave ULg

in Acta Neurologica Belgica (1999), 99(1), 32-9

Spontaneous but incomplete remyelination is observed after a demyelinating lesion. We know since ten years now that oligodendrocyte progenitors, (OP) and totipotent neural stem cells remain present in the ... [more ▼]

Spontaneous but incomplete remyelination is observed after a demyelinating lesion. We know since ten years now that oligodendrocyte progenitors, (OP) and totipotent neural stem cells remain present in the central nervous system of adult mammals. [less ▲]

Detailed reference viewed: 21 (6 ULg)
Peer Reviewed
See detailOligodendrogliome de la fosse postérieure : à propos d'un cas
Martin, Didier ULg; Dooms, G.; Flandroy et al

Conference (1990, March)

Detailed reference viewed: 11 (0 ULg)
See detailLes Oligoéléments en céréales
Destain, Jean-Pierre ULg; Bodson, Bernard ULg; Falisse, André et al

in Fumure et protection phytosanitaire des céréales (1988, February 25)

Detailed reference viewed: 15 (3 ULg)
Full Text
Peer Reviewed
See detailOligomerization and copolymerization of γ-butyrolactone - a monomer known as unable to homopolymerize, 1. Copolymerization with epsilon-caprolactone
Duda, Andrzej; Penczek, Stanislaw; Dubois, Philippe ULg et al

in Macromolecular Chemistry and Physics (1996), 197(4), 1273-1283

Copolymerization of γ-butyrolactone (γBL) with ε-caprolactone (εCL) initiated with aluminium isopropoxide trimer ([Al(OiPr)3 ]3, (A3)) is described. Copolymers with molecular weights ( ) up to 3 ; 104 and ... [more ▼]

Copolymerization of γ-butyrolactone (γBL) with ε-caprolactone (εCL) initiated with aluminium isopropoxide trimer ([Al(OiPr)3 ]3, (A3)) is described. Copolymers with molecular weights ( ) up to 3 ; 104 and containing up to 43 mol-% repeating units derived from γBL are prepared. Their molecular weight is controlled by the concentrations of the consumed comonomers and the starting concentration of initiator { = (86.09 ; [γBL]c + 114.14 ; [εCL]0)/3[Al(OiPr)3] + 60.10}. 13C NMR and DSC data are indicative of a pseudoperiodic or random copolymer structure. [less ▲]

Detailed reference viewed: 39 (6 ULg)
Full Text
Peer Reviewed
See detailOligophrenin 1 (OPHN1) gene mutation causes syndromic X-linked mental retardation with epilepsy, rostral ventricular enlargement and cerebellar hypoplasia
Bergmann, C.; Zerres, K.; Senderek, J. et al

in Brain (2003), 126(7), 1537-1544

We identified an oligophrenin 1 (OPHN1) gene mutation in a family with five brothers affected by a recognizable pattern of clinical and neuroradiological hallmarks. The distinctive phenotype comprised ... [more ▼]

We identified an oligophrenin 1 (OPHN1) gene mutation in a family with five brothers affected by a recognizable pattern of clinical and neuroradiological hallmarks. The distinctive phenotype comprised moderate to severe mental retardation, myoclonic-astatic epilepsy, ataxia, strabismus and hypogenitalism. Neuroimaging displayed fronto-temporal atrophy with rostral enlargement of the lateral ventricles, lower vermian agenesis and asymmetric cerebellar hypoplasia. Mutation analysis of the OPHN1 gene on Xq12 disclosed a genomic deletion of exon 19 causing a frameshift. Notably, OPHN1 mutations have been previously reported as a rare cause of non-syndromic X-linked mental retardation. Our findings, however, indicate that OPHN1 mutations result in a recognizable syndrome. In addition, identification of OPHN1 as a further gene associated with epileptic seizures will help to unravel aetiologic factors of epilepsy. [less ▲]

Detailed reference viewed: 3 (0 ULg)
Full Text
See detailOligopoles, collusion tacite et droit communautaire de la concurrence
Petit, Nicolas ULg

Book published by Bruylant (2008)

Detailed reference viewed: 91 (14 ULg)
Full Text
See detailThe Oligopoly Problem in EU Competition Law
Petit, Nicolas ULg

in GERADIN, D.; LIANNOS, I. (Eds.) Research Handbook in European Competition Law (2013)

This paper offers a complete overview of the oligopoly problem in competition law and economics, with a specific focus on European Union (EU) law. A related purpose of the paper is to challenge the ... [more ▼]

This paper offers a complete overview of the oligopoly problem in competition law and economics, with a specific focus on European Union (EU) law. A related purpose of the paper is to challenge the dominant view that merger control is the ultimate preventive remedy against tacit collusion. On close analysis, the merger-only enforcement paradigm against tacit collusion generates a systemic risk of type II errors. Part of this enforcement gap may, however, be alleviated through a more muscular enforcement of the rules on coordinated conduct (i.e. Article 101 TFEU) and on unilateral conduct (i.e. Article 102 TFEU). In this later respect, the paper formulates a possible theory of harm that would entitle agencies and courts to apply Article 102 TFEU to specific types of conduct by oligopolists. The concept of abuse of collective dominance may in particular be applied to the artificial tactics which oligopolists adopt to protect an observed collusive equilibrium from the natural, disruptive effect caused by an external shock (entry, natural disaster, change in tax rate, etc.). In this sense, the paper is different from other scholarly proposals that recommend applying rules on unilateral conduct to excessive oligopoly prices and/or facilitating practices. [less ▲]

Detailed reference viewed: 95 (9 ULg)
Full Text
Peer Reviewed
See detailOligosaccharide binding in family 8 glycosidases: Crystal structures of active-site mutants of the beta-1,4-xylanase pXyl from Pseudoaltermonas haloplanktis TAH3a in complex with substrate and product
De Vos, D.; Collins, T.; Nerinckx, W. et al

in Biochemistry (2006), 45(15), 4797-4807

The structures of inactive mutants D144A and E78Q of the glycoside hydrolase family 8 (GH-8) endo-beta-1,4-D-Xylanase (pXyl) from the Antarctic bacterium Pseudoalteromonas haloplanktis TAH3a in complex ... [more ▼]

The structures of inactive mutants D144A and E78Q of the glycoside hydrolase family 8 (GH-8) endo-beta-1,4-D-Xylanase (pXyl) from the Antarctic bacterium Pseudoalteromonas haloplanktis TAH3a in complex with its substrate xylopentaose (at 1.95 angstrom resolution) and product xylotriose (at 1.9 angstrom resolution) have been determined by X-ray crystallography. A detailed comparative analysis of these with the apoenzyme and with other GH-8 structures indicates an induced fit mechanism upon ligand binding whereby a number of conformational changes and, in particular, a repositioning of the proton donor into a more catalytically competent position Occurs. This has also allowed for the description of protein-ligand interactions in this enzyme and for the demarcation of subsites -3 to +3. An in-depth analysis of each of these subsites gives an insight into the structure-function relationship of this enzyme and the basis of xylose/glucose discrimination in family 8 glycoside hydrolases. Furthermore, the structure of the -1/+1 subsite spanning complex reveals that the substrate is distorted from its ground state conformation. Indeed, structural analysis and in silico docking Studies indicate that substrate hydrolysis in GH-8 members is preceded by a conformational change, away from the substrate ground-state chair conformation, to a pretransition state local minimum S-2(O) conformation. [less ▲]

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailLes oligosaccharides pectiques: production et applications possibles
Combo, Agnan Marie Michel ULg; Mario, Aguedo ULg; Paquot, Michel ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2011), 15(1), 153-164

Les oligosaccharides pectiques ou POS sont des fragments de composition complexe issus de la dégradation chimique, physique ou enzymatique de la pectine. Du fait de l’intérêt de leurs propriétés ... [more ▼]

Les oligosaccharides pectiques ou POS sont des fragments de composition complexe issus de la dégradation chimique, physique ou enzymatique de la pectine. Du fait de l’intérêt de leurs propriétés biologiques, les oligosaccharides pectiques font l’objet de nombreuses études et trouvent aujourd’hui des applications dans des domaines aussi différents que la médecine, l’agriculture et l’industrie agro-alimentaire. Cet écrit présente la structure des pectines ainsi que les différents modes de production des POS en insistant particulièrement sur les différentes enzymes microbiennes permettant de les obtenir et sur les applications possibles de ces POS. [less ▲]

Detailed reference viewed: 29 (8 ULg)
Full Text
Peer Reviewed
See detailOlive mill wastewater valorization : use by non-conventional yeasts.
Gonçalves, C.; Lopes, M.; Aguedo, Mario ULg et al

in Nzihou, Ange; Lyberatos, Gerasimos (Eds.) Proceedings of the 2nd International Conference on Engineering for Waste Valorisation (2008)

The ability of the strains Yarrowia lipolytica and Candida rugosa to grow on Olive Mill Wastewater (OMW) based medium and to produce high-value compounds from OMW (such as enzymes), while degrading this ... [more ▼]

The ability of the strains Yarrowia lipolytica and Candida rugosa to grow on Olive Mill Wastewater (OMW) based medium and to produce high-value compounds from OMW (such as enzymes), while degrading this waste, was tested. Factors affecting cellular growth and OMW degradation were also studied, such as OMW composition, dilution and supplementation. OMW collected from 3-phase olive mill of the north region of Portugal were used and characterized chemical and biochemically. OMW with COD ranging from 100 g·L-1 to 200 g·L-1 were supplemented with yeast extract and ammonium chloride proportionally to its organic composition. Preliminary studies of OMW consumption were carried out in batch cultures of Y. lipolytica W29 and C. rugosa PYCC 3238. The strains were able to grow in the OMW used without dilution, to consume almost all of the sugars present in the media and to significantly reduce COD. Y. lipolytica W29 was less affected by operating conditions changes such as, stirring rate variation and OMW medium supplementation. [less ▲]

Detailed reference viewed: 9 (0 ULg)
Full Text
See detailOliver PRIMAVESI et Katharina LUCHNER (Éd.), "The Presocratics from the Latin Middle Ages to Hermann Diels"
Gavray, Marc-Antoine ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (2013), 82

Detailed reference viewed: 29 (0 ULg)
Full Text
Peer Reviewed
See detailOlmesartan for the delay or prevention of microalbuminuria in type 2 diabetes
Haller H; Ito S; Izzo JL Jr, et al

in New England Journal of Medicine [=NEJM] (2011), 364

BACKGROUND: Microalbuminuria is an early predictor of diabetic nephropathy and premature cardiovascular disease. We investigated whether treatment with an angiotensin-receptor blocker (ARB) would delay or ... [more ▼]

BACKGROUND: Microalbuminuria is an early predictor of diabetic nephropathy and premature cardiovascular disease. We investigated whether treatment with an angiotensin-receptor blocker (ARB) would delay or prevent the occurrence of microalbuminuria in patients with type 2 diabetes and normoalbuminuria. METHODS: In a randomized, double-blind, multicenter, controlled trial, we assigned 4447 patients with type 2 diabetes to receive olmesartan (at a dose of 40 mg once daily) or placebo for a median of 3.2 years. Additional antihypertensive drugs (except angiotensin-converting-enzyme inhibitors or ARBs) were used as needed to lower blood pressure to less than 130/80 mm Hg. The primary outcome was the time to the first onset of microalbuminuria. The times to the onset of renal and cardiovascular events were analyzed as secondary end points. RESULTS: The target blood pressure (<130/80 mm Hg) was achieved in nearly 80% of the patients taking olmesartan and 71% taking placebo; blood pressure measured in the clinic was lower by 3.1/1.9 mm Hg in the olmesartan group than in the placebo group. Microalbuminuria developed in 8.2% of the patients in the olmesartan group (178 of 2160 patients who could be evaluated) and 9.8% in the placebo group (210 of 2139); the time to the onset of microalbuminuria was increased by 23% with olmesartan (hazard ratio for onset of microalbuminuria, 0.77; 95% confidence interval, 0.63 to 0.94; P=0.01). The serum creatinine level doubled in 1% of the patients in each group. Slightly fewer patients in the olmesartan group than in the placebo group had nonfatal cardiovascular events--81 of 2232 patients (3.6%) as compared with 91 of 2215 patients (4.1%) (P=0.37)--but a greater number had fatal cardiovascular events--15 patients (0.7%) as compared with 3 patients (0.1%) (P=0.01), a difference that was attributable in part to a higher rate of death from cardiovascular causes in the olmesartan group than in the placebo group among patients with preexisting coronary heart disease (11 of 564 patients [2.0%] vs. 1 of 540 [0.2%], P=0.02). CONCLUSIONS: Olmesartan was associated with a delayed onset of microalbuminuria, even though blood-pressure control in both groups was excellent according to current standards. The higher rate of fatal cardiovascular events with olmesartan among patients with preexisting coronary heart disease is of concern. (Funded by Daiichi Sankyo; ClinicalTrials.gov number, NCT00185159.). [less ▲]

Detailed reference viewed: 34 (5 ULg)
Full Text
See detailOltre Piaget e Skinner
Richelle, Marc ULg

in Rivista di applicazioni psicologiche (1979), 1(3), 425-439

Dopo aver indicato alcuni elementi di convergenza fra Piaget e Skinner, l'autore esamina criticamente il concetto piagetiano di "stadio" alla luce della teoria dell'apprendimento. Vengono esaminate ... [more ▼]

Dopo aver indicato alcuni elementi di convergenza fra Piaget e Skinner, l'autore esamina criticamente il concetto piagetiano di "stadio" alla luce della teoria dell'apprendimento. Vengono esaminate situazioni di seriazione e classificazione. Procedure d'addestramento e d'esme differenti da quelle tradizionali portano a concludere che talune abilità compaiono prima di quanto è ipotizzato da Piaget, mentre altre apparirebbero molto piú tardi o sarebbero lacunose nello stresso adulto. [less ▲]

Detailed reference viewed: 20 (0 ULg)
See detailOlympiades mathématiques belges - Recueil de questions - Tome 5 (1999-2002)
Dupont, Pascal ULg; Villers, Claude

Book published by Société belge des professeurs de mathématique d'expression française (2002)

Detailed reference viewed: 68 (0 ULg)