Report from Belgium

in Doomernik, Jeroen; Jandl, Michael (Eds.) Modes of Migration Regulation and Control in Europe. (2008)

Report of a joint research project between Interbull and Copa/Cogeca of the feasability of a simultaneous genetics evaluation of Black and White dairy bulls across European Community Countries

(1993)

Report of geophysical investigations on the contaminated site of Maldegem

Report (2010)

Report of the activities of the European Science Foundation (ESF) Network Neuroimmunomodualtion

Report (1992)

Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: definitions, frequency and pharmacological aspects.

in Journal of Crohn’s and Colitis [=JCC] (2010), 4(4), 355-66

The first ECCO pathogenesis workshop focused on anti-TNF therapy failures in inflammatory bowel diseases (IBDs). The overall objective was to better understand and explore primary non response and loss of ... [more ▼]

The first ECCO pathogenesis workshop focused on anti-TNF therapy failures in inflammatory bowel diseases (IBDs). The overall objective was to better understand and explore primary non response and loss of response to anti-TNF agents in IBD. The outcome of this workshop is presented into two parts. This first section addresses definitions, frequency and pharmacological aspects of anti-TNF therapy failure, including pharmacokinetics of anti-TNF monoclonal antibodies and immune and non-immune mediated clearance of anti-TNF mAbs. The second section concerns the biological roles of TNF and TNF antagonists, including mechanisms of action of anti-TNF agents, and discuss hypothesis regarding their failures and phenomenon of paradoxical inflammation, including the potential role of TNF independent inflammatory pathways. [less ▲]

Report of the OECD Workshop on Statitsical Analysis of Aquatic Toxicity Data

Report (1998)

Following a decision taken by the National Co-ordinators of the OECD Test Guideline Programme and the OECD Risk Assessment Advisory Body (RAAB) at their joint session in December 1995, an OECD Workshop on ... [more ▼]

Following a decision taken by the National Co-ordinators of the OECD Test Guideline Programme and the OECD Risk Assessment Advisory Body (RAAB) at their joint session in December 1995, an OECD Workshop on Statistical Analysis of Aquatic Ecotoxicity Data was held in Braunschweig, Germany on 15-17 October 1996. The workshop was hosted by the Biologische Bundesanstalt für Land-und Forstwirtschaft (BBA) in Braunschweig and was chaired by Dr Arno Lange of the German Umweltbundesamt (UBA). The objectives of the workshop were: • to review the options available for the analysis of data from ecotoxicity tests; • to compare their advantages and disadvantages; • to recommend (a) the most appropriate approach for deriving a summary parameter(s) which has (have) scientific validity, and (b) further work to be undertaken by the OECD and/or others, as appropriate. In plenary and working group sessions participants discussed statistical data analysis appropriate for single-species chronic/subchronic studies using a number of test concentrations, i.e. dose-response tests. Aquatic tests served as a basis for these discussions, however the issues addressed may be similar for toxicity tests in general. Background documents had been prepared on the following main existing data analysis approaches for such tests: analysis of variance/hypothesis testing (“ANOVA/NOEC approach”); regression analysis (based on empirical models); and mechanistic modelling (theory-based). It was concluded that the NOEC, as the main summary parameter of aquatic ecotoxicity tests, is inappropriate for a number of reasons (see detailed discussion in the report) and should therefore be phased out. It was recommended that the OECD should move towards a regression-based estimation procedure. The time course of effects should be incorporated in the analytical procedures, and the OECD should initiate a study of the available time-dependent regression models (both mechanistic and empirical) in order to select those which best meet its needs. The study should also address the issue of appropriate values of x for ECx and the optimal experimental designs. A steering group should be set up to direct the mathematical, statistical and biological work required to take the workshop recommendations forward. This group should include representatives from the appropriate scientific and regulatory communities. [less ▲]

Report of the task force on designing clinical trials in early (predementia) AD

in Neurology (2011), 76

BACKGROUND: A large number of promising candidate disease-modifying treatments for Alzheimer disease (AD) continue to advance into phase II and phase III testing. However, most completed trials have ... [more ▼]

BACKGROUND: A large number of promising candidate disease-modifying treatments for Alzheimer disease (AD) continue to advance into phase II and phase III testing. However, most completed trials have failed to demonstrate efficacy, and there is growing concern that methodologic difficulties may contribute to these clinical trial failures. The optimal time to intervene with such treatments is probably in the years prior to the onset of dementia, before the neuropathology has progressed to the advanced stage corresponding to clinical dementia. METHOD: An international task force of individuals from academia, industry, nonprofit foundations, and regulatory agencies was convened to discuss optimal trial design in early (predementia) AD. RESULTS: General consensus was reached on key principles involving the scope of the AD diagnosis, the selection of subjects for trials, outcome measures, and analytical methods. CONCLUSION: A consensus has been achieved in support of the testing of candidate treatments in the early (predementia) AD population. [less ▲]

Report of two cases of gastric cancer after bariatric surgery: Lymphoma of the bypassed stomach after Roux-en-Y gastric bypass and gastrointestinal stromal tumor (GIST) after vertical banded gastroplasty

in Obesity Surgery (2006), 16(7), 928-931

We report two new cases of gastric cancer diagnosed after a bariatric operation. The first case is a 66-year-old male who 3 years after gastric bypass suffered from a perforation of the fundus that was ... [more ▼]

We report two new cases of gastric cancer diagnosed after a bariatric operation. The first case is a 66-year-old male who 3 years after gastric bypass suffered from a perforation of the fundus that was found to be secondary to a diffuse large B-cell lymphoma of the distal stomach. The second case is a 47-year-old woman who presented 12 years after a vertical banded gastroplasty with a gastric pouch outlet obstruction caused by a gastrointestinal stromal tumor (GIST). Based on the few reports of cancer in the literature, analysis of these cases suggests that the main risk of gastric cancer after bariatric surgery comes from the delayed diagnosis of malignancy. [less ▲]

The report of Wenamun. A journey in the Egyptian Literature

Scientific conference (2010, December 10)

The report of Wenamun.

Scientific conference (2006, November 01)