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See detailInnovative multilayered nanofibers for wound dressing application
Croisier, Florence ULiege; Detrembleur, Christophe ULiege; Jérôme, Christine ULiege

Poster (2012, April 18)

Chitosan is a natural polymer derived from the chitin of crustacean or mushroom shells, that intrinsically presents haemostatic, mucoadhesive, antimicrobial and immunostimulant properties. This ... [more ▼]

Chitosan is a natural polymer derived from the chitin of crustacean or mushroom shells, that intrinsically presents haemostatic, mucoadhesive, antimicrobial and immunostimulant properties. This polysaccharide has shown a great potential for biomedical and pharmaceutical applications, on account of its remarkable compatibility with physiological medium. Besides, it is degraded in a physiological environment into non-toxic products, which make chitosan an outstanding candidate for short- to medium-term applications. In this respect, nanometric fibers are highly interesting as their assembly mimics the skin extracellular matrix structure. Such nanofibrous materials can be prepared by electrospinning (ESP). This technique uses a high voltage to create an electrically charged jet of polymer solution or melt which leads to fibers formation. Depending on the polymer characteristics (a.o. molecular weight, solution viscosity and conductivity) and processing conditions (electric potential, distance between syringe-capillary and collection plate, concentration, flow rate), polymer fibers ranging from nanometers to a few microns in diameter can be obtained and subsequently used as potential scaffolds, a.o. to form a temporary, artificial extracellular matrix. In the present study, electrospinning technique was combined with layer-by-layer deposition method (LBL) - a well-known method for surface coating, based on electrostatic interactions - in order to prepare multilayered chitosan-based nanofibers. The antibacterial properties of the obtained material were then assessed, and the presence of a multilayered deposit was confirmed by several techniques. (Future) possibilities for valorization: These multilayered chitosan-based nanofibers present great prospects for the preparation of new biomedical scaffolds - such as wound dressings that could improve skin regeneration. [less ▲]

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See detailAn innovative non-animal chitosan hydrogel is able to restore the rheology of osteoarthritis synovial fluid ex vivo
Henrotin, Yves ULiege; Rocasalbas, Guillem; Chausson, Mickaël et al

Poster (2016, September)

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See detailAn innovative non-animal chitosan hydrogel is able to restore the rheology of osteoarthritis synovial fluid ex vivo
Henrotin, Yves ULiege; Rocasalbas, Guillem; Chausson, Mickaël et al

in Osteoarthritis and Cartilage (2017, April)

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See detailInnovative PCR without DNA extraction for African sickle cell disease diagnosis.
Detemmerman, L.; Olivier, S.; BOURS, Vincent ULiege et al

in Hematology (Amsterdam, Netherlands) (2017)

OBJECTIVES: Hemoglobin (Hb) disorders consist of thalassemia and Hb structural variants, of which the major forms are associated with severe anemia and/or vascular occlusion. Current diagnostic techniques ... [more ▼]

OBJECTIVES: Hemoglobin (Hb) disorders consist of thalassemia and Hb structural variants, of which the major forms are associated with severe anemia and/or vascular occlusion. Current diagnostic techniques are highly accurate and mostly based on isoelectric focusing, high-performance liquid chromatography or mass spectrometry, which often require advanced laboratory equipment. In sub-Saharan Africa, the Hb disorders are mainly associated to the pathological variants hemoglobin S (HbS) and HbC. Unfortunately, until now, it is not easy to get a diagnosis of these disorders in this area. In this study, we tested the performance of a new molecular diagnostic tests on qualified samples. METHODS: The Human Hb S/C Lamp assay is a new polymerase chain reaction test able to detect HbS, HbC and HbA alleles without DNA extraction, directly on fresh or frozen blood samples, or on dried blood spots (DBS). In this study, we compared the genotyping of 248 blood samples (56 whole blood and 192 DBS) with this LAMP assay to the routine diagnostic methods performed in the genetics lab at the university hospital of Liege. RESULTS: Our results show that the LAMP method can detect HbS and HbC with an accuracy of 100%. Moreover, this test can be used for the neonatal screening because we did not observe any interference with fetal Hb. DISCUSSION: To our knowledge, this method is the only molecular assay that can be performed directly on dried blood cards without DNA extraction, lowering handling, turnaround time and costs. [less ▲]

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See detailInnovative polyelectrolytes/poly(ionic liquid)s for energy and environment
Ajjan, Fátima N.; Ambrogi, Martina; Tiruye, Girum Ayalneh et al

in Polymer International (2017), 66(8), 1119-1126

This manuscript presents the work carried out within the European Project RENAISSANCE-ITN, which was dedicated to the development of innovative polyelectrolytes for energy and environmental applications ... [more ▼]

This manuscript presents the work carried out within the European Project RENAISSANCE-ITN, which was dedicated to the development of innovative polyelectrolytes for energy and environmental applications. Within the project different types of innovative polyelectrolytes were synthesized such as poly(ionic liquid)s coming from renewable or natural ions, thiazolium cations, cathechol functionalities or from a new generation of cheap deep-eutectic monomers. Further, macromolecular architectures such as new poly(ionic liquid) block copolymers and new (semi)conducting polymer/polyelectrolyte complexes were also developed. As the final goal, the application of these innovative polymers in energy and environment was investigated. Important advances in energy storage technologies included the development of new carbonaceous materials, new lignin/conducting polymer biopolymer electrodes, new iongels and single-ion conducting polymer electrolytes for supercapacitors and batteries and new poly(ionic liquid) binders for batteries. On the other hand, the use of the innovative polyelectrolytes into sustainable environmental technologies led to the development of new liquid and dry water, new materials for water cleaning technologies such as floculants, oil absorbers, new recyclable organocatalysts platform and multifunctional polymer coatings with antifouling and antimicrobial properties. All in all this article demonstrates the potential of the poly(ionic liquid)s for high-value applications in Energy & Enviromental areas. [less ▲]

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See detailAn innovative procedure for smoothing parameter selection
Frasso, Gianluca ULiege; Eilers, Paul H.C.

in Proceedings of 46th scientific meeting of the Italian Statistical Society (2012, June)

Smoothing with penalized splines calls for an automatic method to select the size of the penalty parameter λ. We propose a not well known smoothing parameter selection procedure: the L-curve method. AIC ... [more ▼]

Smoothing with penalized splines calls for an automatic method to select the size of the penalty parameter λ. We propose a not well known smoothing parameter selection procedure: the L-curve method. AIC and (generalized) cross validation represent the most common choices in this kind of problems even if they indicate light smoothing when the data represent a smooth trend plus correlated noise. In those cases the L-curve is a computationally efficient alternative and robust alternative. [less ▲]

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See detailInnovative Proteomics for the Discovery of Systemically Accessible Cancer Biomarkers Suitable for Imaging and Targeted Therapies
Turtoi, Andrei ULiege; De Pauw, Edwin ULiege; Castronovo, Vincenzo ULiege

in American Journal of Pathology (2011), 178(1), 12-18

The discovery of biomarkers that are readily accessible through the circulating blood and are selectively overexpressed in pathological tissues has become a major research objective, particularly in the ... [more ▼]

The discovery of biomarkers that are readily accessible through the circulating blood and are selectively overexpressed in pathological tissues has become a major research objective, particularly in the field of oncology. Indisputably, this group of molecules has a high potential to serve as an innovative tool for effective imaging and targeted cancer therapy approaches. In this attractive therapeutic concept, specific cancer proteins are reached by intravenously administered ligands that are coupled to cytotoxic drugs. Such compounds are able to induce cancer destruction while sparing normal tissues. Owing to the performance of mass spectrometry technology, current high-throughput proteomic analysis allows for the identification of a high number of proteins that are differentially expressed in the cancerous tissues. However, such approaches provide no information regarding the effective accessibility of the biomarkers and, therefore, the possibility for these discovered proteins to be targeted. To bypass this major limitation, which clearly slows the discovery of such biomarkers, innovative methodological strategies have been developed to enrich the clinical specimens before the mass spectrometry analysis. The focus is laid on the group of proteins that are necessarily located either at the exterior face of the plasma membrane or in the extracellular matrix. The present review addresses the current technologies meant for the discovery and analysis of accessible antigens from clinically relevant samples. [less ▲]

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See detailInnovative semiconducting oxide materials reducing the energy footprint of buildings
Dewalque, Jennifer ULiege; Maho, Anthony ULiege; Spronck, Gilles ULiege et al

Conference (2015, October 26)

In the current energy context, many efforts are devoted to the reduction of the energy footprint of buildings. To meet this challenge, the LCIS-GREENMAT laboratory developes a front edge research in the ... [more ▼]

In the current energy context, many efforts are devoted to the reduction of the energy footprint of buildings. To meet this challenge, the LCIS-GREENMAT laboratory developes a front edge research in the field of advanced materials associated to energy and environment, including structured materials for dye-sensitized solar cells (DSSCs) and electrochromic coatings. DSSCs have been reported by O’Regan and Grätzel in the early nineties as a very promising alternative to conventional photovoltaic silicon devices. Main benefits of these cells are their low cost as well as their mild manufacturing process. In most of the specific literature, DSSCs are made of TiO2 films prepared by doctor-blade or screen-printing of anatase nanoparticles paste. However, due to the random organization of the nanoparticles, pore accessibility by the dye and electrolyte could be incomplete. Moreover, some anatase crystallites could suffer from a lack of connectivity, leading to electron transfer issues. The strategy adopted by our group to improve photovoltaic efficiencies involves a templating-assisted process to prepare highly porous layers with well-ordered and accessible pores as well as improved crystallites connectivity. This talk especially focuses on the templating-assisted synthesis of TiO2 and ZnO semiconducting layers used as photoelectrode in DSSCs. Due to the surface area improvement as well as the perfect control of the pore organization and the pore size, the templating strategy is an effective solution to maximize the adsorption of active dye and the electrolyte infiltration inside the porous network. Besides, in the last few years, there has been increasing interest in electrochromic glazing due to its potential use as an energy-efficient component for buildings, as it could reduce considerably their CO2 emission by decreasing their energy consumption up to 30%. The crucial issues of such devices are the durability, the coloration efficiency and the reversibility upon coloration and bleaching of the electrochromic layers. In order to improve the performances of those electrochromic films, we have investigated a surfactant-assisted deposition process for WO3 layer and the insertion of lithium in the NiO layer. All films have been deposited on FTO glass substrates by ultrasonic spray pyrolysis (USP), which is a low-cost alternative to industrial vacuum processes for manufacturing high quality thin films. The presence of lithium ions in nickel oxide films has shown improved coloration efficiency compared to the undoped films. The higher active surface of surfactant-assisted tungsten oxide films has led to higher reversibility and coloration contrast. [less ▲]

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See detailInnovative silage additives to reduce proteolysis in the silo
Herremans, Sophie ULiege; Decruyenaere, Virginie; Beckers, Yves ULiege et al

Poster (2017, May 10)

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See detailInnovative smart sensors to enhance eco-efficiency of a continuous (steel) production line
Saint-Mard, Michel; Stoukatch, Serguei ULiege; Schischke, Karsten et al

in Proc. Conf. of the AMA Association for Sensor Technology (2013, May 15)

The paper aims to demonstrate the benefits for a global approach that allows to define new research directions, new potential industrial markets, and increasing interest from potential users. Combining ... [more ▼]

The paper aims to demonstrate the benefits for a global approach that allows to define new research directions, new potential industrial markets, and increasing interest from potential users. Combining performance, economic and environmental criteria in a joint assessment approach for the target applications of sensor systems, facilitates significantly the communication between service provider and user. The environmental assessment approach for sensor systems will be available as a beta-version online tool tentatively from July 2013 onwards. Interested SMEs are invited to get involved as the LCA to go consortium will provide also a comprehensive mentoring for SMEs [less ▲]

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See detailAn innovative solution to improve the seismic robustness of reinforced concrete frames
Degée, Hervé ULiege; Plumier, André ULiege

in Proceedings of the 14ECEE Conference (2010)

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See detailInnovative strategies for the control of apple scab (Venturia inaequalis [Cke.] Wint.) in organic apple production
Jamar, Laurent ULiege

Doctoral thesis (2011)

The aim of this thesis, conducted over six growing seasons (2003-2008), is to define new measures for reducing the use of fungicides and in particular, copper fungicides, for the control of apple scab (V ... [more ▼]

The aim of this thesis, conducted over six growing seasons (2003-2008), is to define new measures for reducing the use of fungicides and in particular, copper fungicides, for the control of apple scab (V. inaequalis) in organic apple production. Special emphasis is put on primary scab infection control during spring season. An original approach is proposed for defining a specific spray timing involving spraying during the infection processes, especially before fungal penetration, determined by the RIMpro software warning system. This ‘during-infection’ spray strategy allows reducing from 30 to 50% the amount of fungicide usually used for effective apple scab control, on high scab-susceptible cultivars. The field study shows that six alternative products (e.g., potassium bicarbonate and lime sulphur), among 60 products tested, have the potential to reduce copper use. However, copper use, even with low doses, seems to be still necessary in presence of scab-susceptible cultivars. The results obtained in these experiments could not be attributed to the specific technical performances of the tunnel sprayer used, which however, offer valuable environmental benefits. On the basis of the present study, the organic management system seems a good farming approach for maintaining soil quality with regard to biological indicators. This work shows and draws attention to the fact that (i) planting cultivars with polygenic scab-resistance traits, (ii) increasing emphasis on sanitation practices aimed at reducing initial inoculum in autumn, and (iii) applying an accurate spray strategy in spring, as defined in the present study, are the three most promising approaches for substantial further reductions in protection products fully compliant with international organic crop production standards. [less ▲]

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See detailInnovative Surface Plasmon Resonance biosensing architectures
Desfours, Caroline; Piron, Pierre ULiege; Habraken, Serge ULiege et al

Conference (2012, December 11)

Surface Plasmons Resonance (SPR) architectures involving multi-wavelength interrogation are an attractive alternative for droplet biosensing. We present our results for in situ measurements of biological ... [more ▼]

Surface Plasmons Resonance (SPR) architectures involving multi-wavelength interrogation are an attractive alternative for droplet biosensing. We present our results for in situ measurements of biological molecules with a two-wavelength sensor and a SPR Coupler-Disperser spectroscopic sensor. [less ▲]

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See detailInnovative Surface Plasmon Resonance biosensing architectures
desfours, Caroline; Hastanin, Juriy ULiege; Drucbert, Anne-Sophie et al

in International Conference on Fibre Optics and Photonics (2012, December)

Surface Plasmons Resonance (SPR) architectures involving multi-wavelength interrogation are an attractive alternative for droplet biosensing. We present our results for in situ measurements of biological ... [more ▼]

Surface Plasmons Resonance (SPR) architectures involving multi-wavelength interrogation are an attractive alternative for droplet biosensing. We present our results for in situ measurements of biological molecules with a two-wavelength sensor and a SPR Coupler- Disperser spectroscopic sensor. [less ▲]

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See detailInnovative utilization of the Lactoperoxidase System against apple’s postharvest diseases
Bafort, Françoise ULiege; Jijakli, Haissam ULiege; Perraudin, Jean-Paul

Conference (2012, September 21)

Detailed reference viewed: 43 (5 ULiège)
See detailInnovatives techniques in implant dentistry
LAMBERT, France ULiege

Scientific conference (2008)

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See detailInnovativité et Modes de Coopération des Projets Inter-organisationnels Développés dans le Cadre d'une Politique Publique
Antoine, Mélanie ULiege

in Bo, D.; Huron, D.; Spindler, J. (Eds.) Les pôles de compétitivité se décrètent-ils? Une comparaison européenne (2011)

Nous nous intéressons à la nature de l’innovation poursuivie par les projets inter-organisationnels initiés dans le cadre d'une politique publique, plus précisément à leur innovativité, ainsi qu'aux modes ... [more ▼]

Nous nous intéressons à la nature de l’innovation poursuivie par les projets inter-organisationnels initiés dans le cadre d'une politique publique, plus précisément à leur innovativité, ainsi qu'aux modes de coopération qui s’y développent. Une littérature émergente présente l'adéquation entre ces variables comme un facteur clé de succès des projets d'innovation multi-partenaires. Chaque type de projet appellerait un mode de pilotage approprié, les activités radicalement innovantes ne pouvant être gérées comme le développement d'innovations incrémentales. Dans cette étude, nous nous interrogeons sur la marge de manœuvre dont disposent les acteurs pour innover et organiser leurs actions lorsqu'ils répondent à l'initiative des autorités politiques. La recherche s'appuie sur deux études de cas de projets financés dans le cadre des Pôles de Compétitivité wallons. Alors qu'ils font face à des contraintes similaires, ces cas illustrent des configurations variées, tant en ce qui concerne la nature de l'innovation que les modes de coopération. L'analyse révèle en outre que les critères utilisés pour appréhender l'innovativité des projets, plutôt que de former un ensemble homogène, prennent des orientations différentes. Nous tentons alors d'identifier les principaux enjeux du pilotage des projets étudiés. [less ▲]

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