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See detailOral glucose tolerance tests in schizophrenic patients treated with antipsychotics
De Hert, Marc; Van Eyck, Dominique; Hermans, Gilberte ULg et al

in International Journal of Neuropsychopharmacology (2004, June), 7(Suppl. 1), 424

Objective. –A recent consensus conference has proposed guidelines for the monitoring for diabetes in patients with schizophrenia and also identifies the need of long-term prospective studies. Method. – A ... [more ▼]

Objective. –A recent consensus conference has proposed guidelines for the monitoring for diabetes in patients with schizophrenia and also identifies the need of long-term prospective studies. Method. – A large scale prospective study on metabolic risks of antipsychotic medication is currently ongoing. At baseline, patients get a full laboratory screening, ECG and an oral glucose tolerance test (OGTT). Baseline data on 100 non-diabetic patients at study inclusion and stable on medication for at least 6 months are presented. Results. – Glucose abnormalities are found in 22% of patients at baseline.A monitoring protocol based only on fasting glucose would not have detected 63.6% of these patients with classifiable glucose abnormalities in our sample. Fasting insulin and measures for insulin resistance have a high predictive value for abnormalities late in the OGTT. Conclusion. – Already at baseline, metabolic problems are frequently present in patients with schizophrenia treated with antipsychotics. Adding assessment of fasting insulin in a monitoring protocol improves detection of glucose abnormalities late in an OGTT. [less ▲]

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See detailOral glucose tolerance tests in treated patients with schizophrenia. Data to support an adaptation of the proposed guidelines for monitoring of patients on second generation antipsychotics?
De Hert, Marc; Van Eyck, Dominique; Hanssens, Linda et al

in European Psychiatry (2006), 21(4), 224-226

Objective. - A recent consensus conference has proposed guidelines for the monitoring for diabetes in patients with schizophrenia and also identifies the need of long-term prospective studies. Method. - A ... [more ▼]

Objective. - A recent consensus conference has proposed guidelines for the monitoring for diabetes in patients with schizophrenia and also identifies the need of long-term prospective studies. Method. - A large scale prospective study on metabolic risks of antipsychotic medication is currently ongoing. At baseline, patients get a full laboratory screening, ECG and an oral glucose tolerance test (OGTT). Baseline data on 100 non-diabetic patients at study inclusion and stable on medication for at least 6 months are presented. Results. - Glucose abnormalities are found in 22% of patients at baseline, A monitoring protocol based only on fasting glucose would not have detected 63.6% of these patients with classifiable glucose abnormalities in our sample. Fasting insulin and measures for insulin resistance have a high predictive value for abnormalities late in the OGTT. Conclusion. - Already at baseline, metabolic problems are frequently present in patients with schizophrenia treated with antipsychotics. Adding assessment of fasting insulin in a monitoring protocol improves detection of glucose abnormalities late in an OGTT. (c) 2005 Elsevier SAS. All rights reserved. [less ▲]

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See detailOral ibandronate (150 mg) continues to be effective and well tolerated when administered monthly: the mobile study long-term extension
Stakkestad, J. A.; Lorenc, R.; Czerwinski, E. et al

in Osteoporosis International (2007, March), 18(Suppl.1), 135-136

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See detailOral ibandronate (150mg) administered monthly provides similar improvements in hip bone mineral density as oral alendronate (70mg) administered weekly in postmenopausal osteoporosis
Reginster, Jean-Yves ULg; Borges, Joao LC; Recknor, Chris et al

in Arthritis and Rheumatism (2007, September), 56(number 9 (suppl.)), 611

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See detailOral ibandronate: a less frequently administered therapeutic option for postmenopausal osteoporosis
Reginster, Jean-Yves ULg

in Expert Opinion on Pharmacotherapy (2005), 6(13), 2301-2313

Osteoporosis is a severe condition, associated with significant disability as a result of fragility fractures and increased mortality. Oral bisphosphonates effectively reduce the risk of osteoporotic ... [more ▼]

Osteoporosis is a severe condition, associated with significant disability as a result of fragility fractures and increased mortality. Oral bisphosphonates effectively reduce the risk of osteoporotic fracture and are generally well tolerated. Unfortunately, patient outcomes are often compromised by suboptimal therapeutic adherence. In other disease areas, reduced dosing frequency has been shown to improve therapeutic adherence. A positive impact for adherence has been observed with a reduction in the bisphosphonate dosing frequency from daily to weekly. However, overall adherence remains suboptimal. lbandronate is a potent nitrogen-containing bisphosphonate specifically designed for less frequent than weekly administration, without compromise for efficacy or tolerability. This article reviews the pharmacology, efficacy and tolerability of oral ibandronate when administered with extended dosing intervals in postmenopausal osteoporosis. [less ▲]

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See detailOral monthly ibandronate decrease bone turnover in postmenopausal women with low bone mass: results from the monthly oral pilot study (MOPS)
Reginster, Jean-Yves ULg; Wiese, C.; Wilson, K. et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 5

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See detailOral monthly ibandronate is well tolerated and efficacious in postmenopausal women: results from the monthly oral pilot study (MOPS)
Reginster, Jean-Yves ULg; Dumont, E.; Wiese, C. et al

in Osteoporosis International (2004, May), 15(Suppl.1), 105-106

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See detailOral monthly ibandronate: rationale and clinical potential in postmenopausal osteoporosis
Reginster, Jean-Yves ULg; McClung, M.; Coutant, K. et al

in Annals of the Rheumatic Diseases (2003, June)

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See detailOral Photography
LAMBERT, France ULg

Conference (2009, October 17)

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See detailOral salt supplementation and long-distance exercise
Lehance, Cédric ULg; Rodriguez de la Cruz, Carlos ULg; Counet, Laurence ULg et al

in British Journal of Sports Medicine (2011), 45

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See detailOral scrapie infection modifies the homeostasis of Peyer's patches' dendritic cells
Dorban, Gauthier ULg; Defaweux, Valérie ULg; Levavasseur, Etienne et al

in Histochemistry & Cell Biology (2007), 128(3), 243-251

In transmitted prion diseases the immune system supports the replication and the propagation of the pathogenic agent (PrPSc). DCs, which are mobile cells present in large numbers within lymph organs, are ... [more ▼]

In transmitted prion diseases the immune system supports the replication and the propagation of the pathogenic agent (PrPSc). DCs, which are mobile cells present in large numbers within lymph organs, are suspected to carry prions through the lymphoid system and to transfer them towards the peripheral nervous system. In this study, C57Bl/6 mice were orally inoculated with PrPSc (scrapie strain 139A) and sacrificed at the preclinical stages of the disease. Immunolabelled cryosections of Peyer's patches were analysed by confocal microscopy. Membrane prion protein expression was studied by flow cytometry. In Peyer's patches (PP), dissected at day one and day 105 after oral exposure to scrapie, we observed an increased population of DCs localised in the follicular-associated epithelium. On day 105, PrPSc was found in the follicles inside the PP of prion-infected mice. A subset of Peyer's patches DCs, which did not express cellular prion protein on their surface in non-infected mice conditions, was prion-positive in scrapie conditions. Within Peyer's patches oral scrapie exposure thus induced modifications of the homeostasis of DCs at the preclinical stages of the disease. These results give new arguments in favour of the implication of DCs in prion diseases. [less ▲]

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See detailOral status and nutrition in the institutionalized elderly.
Lamy, Marc ULg; Mojon, P.; Kalykakis, G. et al

in Journal of Dentistry (1999), 27(6), 443-8

OBJECTIVES: To evaluate, in an elderly population, whether poor oral status might be a contributing factor to the development of undernutrition and might be associated with less eating pleasure, more ... [more ▼]

OBJECTIVES: To evaluate, in an elderly population, whether poor oral status might be a contributing factor to the development of undernutrition and might be associated with less eating pleasure, more subjective eating difficulty and increased mashed food consumption. METHODS: An oral examination and an evaluation of masticatory capacity were performed on 120 institutionalized elderly subjects. The nutritional assessment included serum albumin concentration, the Mini Nutritional Assessment and a questionnaire on eating habits. RESULTS: Edentulous subjects without dentures or with only one complete denture had significantly lower MNA scores than edentulous subjects with two complete dentures (p < 0.05). Edentulous subjects with two complete dentures more frequently reported taking pleasure from eating (p = 0.05), and had less frequent difficulties with hard foods (p = 0.01) than edentulous subjects without dentures or with only one complete denture. Mashed food consumption (p < 0.01) was also reported more frequently in edentulous subjects without dentures or with only one complete denture. Subjects with two complete dentures had similar or better MNA scores as dentate subjects with relatively few remaining teeth (10.4 +/- 7.8 teeth). About half of the subjects (53%) could not perform the masticatory test. These subjects had lower MNA scores (p = 0.001) and a larger proportion ate mashed food (p < 0.001) compared to those who were able to perform the test. CONCLUSIONS: Poor oral status (edentulous without dentures or with only one complete denture) increased difficulty in eating hard foods, increased mashed food consumption and decreased eating pleasure. It seemed also to put institutionalized subjects at higher risk of undernutrition. [less ▲]

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See detailOral taurine supplementation modulates ethanol-conditioned stimulus preference
Quertemont, Etienne ULg; Goffaux, Valérie; Vlaminck, Anne-Michèle et al

in Alcohol (1998), 16(3), 201-206

The present study investigated the possible modulatory action of oral taurine supplementation on the rewarding and aversive properties of low and high ethanol doses in male Wistar rats. A vinegar odor ... [more ▼]

The present study investigated the possible modulatory action of oral taurine supplementation on the rewarding and aversive properties of low and high ethanol doses in male Wistar rats. A vinegar odor stimulus was daily paired with either ethanol (0.3 or 2.0 g/kg) or saline. In addition, half of the rats were supplemented orally with taurine (0.5 g/kg/day). After eight conditioning sessions, all rats were tested for their vinegar stimulus preference or aversion. In nontaurine-treated rats, 2.0 g/kg ethanol conditioning induced a significant aversion for the vinegar stimulus, while there was no preference after 0.3 g/kg ethanol conditioning. However, in taurine-supplemented rats, the 2.0 g/kg ethanol-induced aversion for the stimulus was decreased significantly, while the rats administered the lower ethanol doses, 0.3 g/kg, in combination with taurine supplementation, demonstrated a significant stimulus preference. Such results suggest that taurine modulates some of the aversive or rewarding effects of ethanol. [less ▲]

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See detailOral temperature as an index of core temperature during heat transients
Mairiaux, Philippe ULg; Sagot, J. C.; Candas, V.

in European Journal of Applied Physiology and Occupational Physiology (1983), 50(3), 331-41

Rectal (Tre), oral (Tor) and oesophageal (Tes) temperatures were measured in five exercising subjects exposed for two hours to five conditions (1) a steady condition (WR) involving a constant work load ... [more ▼]

Rectal (Tre), oral (Tor) and oesophageal (Tes) temperatures were measured in five exercising subjects exposed for two hours to five conditions (1) a steady condition (WR) involving a constant work load (50 W) at a constant air temperature (Ta = 36.5 degrees C); (2) air temperature variations (delta Ta) between 28 degrees C and 45 degrees C and (3) between 23 degrees C and 50 degrees C at constant work load (50 W); (4) and (5) to work load variations (delta W) between 25 W and 75 W at a constant Ta (= 36.5 degrees C). Oral temperature recordings were taken sublingually and were either continuous or discontinuous. When discontinuous, the time needed for Tor to stabilize after the mouth opening was taken into account. The respective reliability of Tor and Tre as estimates of Tes were compared in each condition. Results showed that the resting (Tor - Tes) difference (+ 0.12 degrees C) was barely modified after two hours of exposure, whereas Tre overestimated Tes by 0.2 degrees C to 0.4 degrees C depending on the condition. The Tor variations were highly correlated with Tes variations under steady condition and under air temperature variations. In these conditions, Tor represented the best estimate of Tes. Under work-load variations, Tor was less closely related to Tes than was Tre. It is suggested that the relative inertia of Tor to step changes in exercise intensity could be ascribed to work induced variations in mouth blood flow. [less ▲]

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See detailOral Tiludronate: a new perspective for prevention and treatment of postmenopausal osteoporosis
Reginster, Jean-Yves ULg; Ethgen, D; Barbier, A et al

in Calcified Tissue International (1993), 52(S2), 30

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See detailOral vitamin C attenuates acute ischaemia-reperfusion injury in skeletal muscle.
Kearns, S. R.; Moneley, D.; Murray, P. et al

in Journal of Bone & Joint Surgery, British Volume (2001), 83(8), 1202-6

Ischaemia-reperfusion injury (IRI) is caused by endothelial and subendothelial damage by neutrophil-derived oxidants. Vitamin C is an antioxidant which attenuates endothelial injury after IRI. Our aim was ... [more ▼]

Ischaemia-reperfusion injury (IRI) is caused by endothelial and subendothelial damage by neutrophil-derived oxidants. Vitamin C is an antioxidant which attenuates endothelial injury after IRI. Our aim was to evaluate the effect of oral vitamin C in the prevention of IRI in skeletal muscle. We used a model of cross-clamping (3 hours) and reperfusion (1 hour) of the cremaster muscle in rats. Muscle function was assessed electrophysiologically by electrical field stimulation. Infiltration by neutrophils was determined by the activity of tissue myeloperoxidase (MPO) and tissue oedema by the wet-to-dry ratio. Neutrophil respiratory burst activity was measured in control animals and groups pretreated with vitamin C. IRI significantly decreased muscle function and increased muscle neutrophil MPO activity and muscle oedema. Pretreatment with vitamin C preserved muscle function and reduced tissue oedema and neutrophil infiltration. Neutrophil respiratory burst activity was reduced in the group treated with vitamin C compared with the control group. We conclude that pretreatment with oral vitamin C protects against acute muscle IRI, possibly by attenuating neutrophil respiratory burst activity. [less ▲]

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See detailOral vitamin C reduces the injury to skeletal muscle caused by compartment syndrome.
Kearns, S. R.; Daly, Adrian ULg; Sheehan, K. et al

in Journal of Bone & Joint Surgery, British Volume (2004), 86(6), 906-11

Compartment syndrome is a unique form of ischaemia of skeletal muscle which occurs despite patency of the large vessels. Decompression allows the influx of activated leucocytes which cause further injury ... [more ▼]

Compartment syndrome is a unique form of ischaemia of skeletal muscle which occurs despite patency of the large vessels. Decompression allows the influx of activated leucocytes which cause further injury. Vitamin C is a powerful antioxidant which concentrates preferentially in leucocytes and attenuates reperfusion-induced muscle injury. We have evaluated the use of pretreatment with oral vitamin C in the prevention of injury caused by compartment syndrome in a rat cremasteric muscle model. Acute and delayed effects of pretreatment with vitamin C were assessed at one and 24 hours after decompression of compartment syndrome. Muscle function was assessed electrophysiologically. Vascular, cellular and tissue inflammation was assessed by staining of intercellular adhesion molecule-1 (ICAM-1) and by determination of the activity of myeloperoxidase (MPO) in neutrophils and tissue oedema. Compartment syndrome impaired skeletal muscle function and increased the expression of ICAM-1, activity of MPO and muscle weight increased significantly. Pretreatment with vitamin C preserved muscle function and reduced the expression of ICAM-1, infiltration of the neutrophils and oedema. [less ▲]

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See detailOrales Chondroïtinsulfat bei Arthrose
WANG, François-Charles ULg; Collignon, Laurent; REGINSTER, Jean-Yves ULg et al

in Litera Rheumatologica (1992)

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See detailOralité et comicité
Defays, Jean-Marc ULg

in Actes du XXI Congrès international de linguistique et de philologie romanes (1998)

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