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See detailPhonological short-term memory networks following recovery from Landau and Kleffner syndrome
Majerus, Steve ULg; Laureys, Steven ULg; Collette, Fabienne ULg et al

in Human Brain Mapping (2003), 19(3), 133-144

Landau-Kleffner syndrome (LKS) is a rare acquired aphasia occurring in otherwise healthy children, together with spike-wave discharges predominating over superior temporal regions and activated by sleep ... [more ▼]

Landau-Kleffner syndrome (LKS) is a rare acquired aphasia occurring in otherwise healthy children, together with spike-wave discharges predominating over superior temporal regions and activated by sleep. Although the outcome of language abilities is variable, a residual impairment in verbal short-term memory (STM) is frequent. This STM deficit might be related to the persistent dysfunction of those temporal lobe regions where epileptic discharges were observed during the active phase of the disorder. We tested this hypothesis by measuring brain activation during immediate serial recall of lists of 4 words, compared to single word repetition, using H(2) (15)O positron emission tomography (PET), in 3 LKS patients after recovery and in 14 healthy controls. The patients (TG, JPH, and DC) had shown abnormally increased or decreased glucose metabolism in left or right superior temporal gyrus (STG) at different stages during the active phase of their disease. At the time of this study, the patients were 6-10 years from the active phase of LKS. Results showed that Patients JPH and DC had impaired performance in the STM condition, whereas TG showed near normal performance. PET data showed that JPH and DC activated significantly less than controls left and right posterior STG. TG, having near normal STM performance, showed increased activity in the posterior part of the right STG. These data suggest that impaired verbal STM at late outcome of LKS might indeed be related to a persistent decrease of activity in those posterior superior temporal gyri that were involved in the epileptic focus during the active phase. [less ▲]

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See detailLa phonologie et la mémoire en classe de français langue seconde
Lucchini, Silvia ULg

Conference given outside the academic context (2003)

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See detailPhonologie, lexique et métaphonologie dans le syndrome de l'X-fragile et le syndrome de Down
Pierart, Bernadette; Comblain, Annick ULg

Conference (1998, May 28)

La présentation passe en revue les résultats d'enfants trisomiques 21 et x-fragile aux épreuves proposée dans la nouvelle batterie d'évaluation du langage ISADYLE. La recherche sur ISADYLE poursuit 4 ... [more ▼]

La présentation passe en revue les résultats d'enfants trisomiques 21 et x-fragile aux épreuves proposée dans la nouvelle batterie d'évaluation du langage ISADYLE. La recherche sur ISADYLE poursuit 4 objectifs : - (a) construire une batterie longue de langage oral, destinée à l' examen approfondi des dysfonctionnements du langage de l'enfant ; - (b) construire une batterie courte de langage oral, à partir des items statistiquement les plus discriminants ; - (c) réaliser des étalonnages corrects sur échantillons proportionnels stratifiés en Belgique francophone, ce qui répond également aux besoins de la sécurité sociale en matière de logopédie de l'enfant; - (d) constituer une banque de données longitudianles et transversales sur le lanngage oral de 1200 enfants de 3 à 12 ans [less ▲]

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See detailPhonology and syntax in French children with SLI: A longitudinal study
Parisse, Christophe; Maillart, Christelle ULg

in Clinical Linguistics & Phonetics (2007), 21(11-12, NOV-DEC), 945-951

Maillart and Parisse found out that French children with specific language impairment (SLI) presented strong difficulties in phonology when compared with normally-developing children matched by MLU (NLD ... [more ▼]

Maillart and Parisse found out that French children with specific language impairment (SLI) presented strong difficulties in phonology when compared with normally-developing children matched by MLU (NLD). Some of the youngest children from this study were followed to provide developmental information about their language deficit. Children were tested again in the same way as before (free spontaneous production) and matched by MLU against other NLD children. The previous phonological analysis was extended to include syntax as well as phonology. Percentage of words correct was computed for both phonology and syntax. An analysis of covariance (ANCOVA) was performed with children's age as covariate. Results showed a significant difference between SLI and NLD children for phonology but not for syntax. There was a trend that showed that the difference between SLI and NLD children tended to increase with age. The same analysis was performed separately for 9 frequent syntactic categories for phonology and for syntax. A significant difference was found for prepositions, nouns, subject pronouns, and verbs in phonology. Effects were found for determiners and prepositions in syntax. As well as confirming the importance of phonological difficulties in SLI, our results call for a developmental theory of phonological and syntactic deficits in SLI, where differences between SLI and NLD grow with age and where there is a timing difference between phonology (earlier) and syntax (later). [less ▲]

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See detailPhonon band structure and electron-phonon interactions in metallic nanowires
Verstraete, Matthieu ULg; Gonze, Xavier

in Physical Review. B : Condensed Matter (2006), 74

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See detailPhonon spectroscopy in a Bi2Te3 nanowire array
Bessas, Dimitrios; Toellner, William; Aabdin, Zainul et al

in NANOSCALE (2013), 5(21), 10629-10635

The lattice dynamics in an array of 56 nm diameter Bi2Te3 nanowires embedded in a self-ordered amorphous alumina membrane were investigated microscopically using Te-125 nuclear inelastic scattering. The ... [more ▼]

The lattice dynamics in an array of 56 nm diameter Bi2Te3 nanowires embedded in a self-ordered amorphous alumina membrane were investigated microscopically using Te-125 nuclear inelastic scattering. The element specific density of phonon states is measured on nanowires in two perpendicular orientations and the speed of sound is extracted. Combined high energy synchrotron radiation diffraction and transmission electron microscopy was carried out on the same sample and the crystallinity was investigated. The nanowires grow almost perpendicular to the c-axis, partly with twinning. The average speed of sound in the 56 nm diameter Bi2Te3 nanowires is similar to 7% smaller with respect to bulk Bi2Te3 and a decrease in the macroscopic lattice thermal conductivity by similar to 13% due to nanostructuration and to the reduced speed of sound is predicted. [less ▲]

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See detailPhosphate derivatives of thiamine and Na-channel in conducting membranes
Schoffeniels, Ernest; Dandrifosse, Guy ULg; Bettendorff, Lucien ULg

in Journal of Neurochemistry (1984), 43

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See detailPhosphate mineral associations in the Cema pegmatite (San Luis Province, Argentina) : Paragenesis, chemistry and significance in the pegmatite evolution
Roda-Robles, Encarnacion ULg; Galliski, Miguel; Roquet, M. B. et al

in Estudios Geologicos (2009), 19(2), 300-304

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See detailPhosphate mineral formation in Lake Baïkal sediments and implications for paleoclimate
Fagel, Nathalie ULg; Alleman, L. Y.; André, Luc et al

Poster (2003)

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See detailPhosphate mineral occurrences in Lake Baïkal sediments : Paleo-environment or diagenesis record ?
Fagel, Nathalie ULg; Alleman, L. Y.; André, Luc et al

Poster (2003)

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See detailThe phosphate minerals assemblages from Jocão pegmatite, Minas Gerais, Brazil.
Baijot, Maxime ULg; Hatert, Frédéric ULg; Philippo, S

in PEG2013 – 6th International Symposium on Granitic Pegmatites, Abstract book, (2013)

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See detailPhosphatidylinositol 3,4,5-trisphosphate modulation in Ship2-deficient mouse embryonic fibroblasts
Blero, D.; Zhang, J.; Pesesse, X. et al

in FEBS Journal (2005), 272

SHIP2, the ubiquitous SH2 domain containing inositol 5-phosphatase, includes a series of protein interacting domains and has the ability to dephosphorylate phosphatidylinositol 3,4,5-trisphosphate [PtdIns ... [more ▼]

SHIP2, the ubiquitous SH2 domain containing inositol 5-phosphatase, includes a series of protein interacting domains and has the ability to dephosphorylate phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] in vitro. The present study, which was undertaken to evaluate the impact of SHIP2 on PtdIns(3,4,5)P3 levels, was performed in a mouse embryonic fibroblast (MEF) model using SHIP2 deficient (– ⁄ –) MEF cells derived from knockout mice. PtdIns(3,4,5)P3 was upregulated in serum stimulated – ⁄ – MEF cells as compared to +⁄+ MEF cells. Although the absence of SHIP2 had no effect on basal PtdIns(3,4,5)P3 levels, we show here that this lipid was significantly upregulated in SHIP2 – ⁄ – cells but only after short-term (i.e. 5–10 min) incubation with serum. The difference in PtdIns(3,4,5)P3 levels in heterozygous fibroblast cells was intermediate between the +⁄+ and the – ⁄ – cells. In our model, insulin-like growth factor-1 stimulation did not show this upregulation. Serum stimulated phosphoinositide 3-kinase (PI 3-kinase) activity appeared to be comparable between +⁄+ and – ⁄ – cells. Moreover, protein kinase B, but not mitogen activated protein kinase activity, was also potentiated in SHIP2 deficient cells stimulated by serum. The upregulation of protein kinase B activity in serum stimulated cells was totally reversed in the presence of the PI 3-kinase inhibitor LY-294002, in both +⁄+ and – ⁄ – cells. Altogether, these data establish a link between SHIP2 and the acute control of PtdIns(3,4,5)P3 levels in intact cells [less ▲]

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See detailPhosphoinositide phosphatases in a network of signaling reactions
Blero, D.; Payrastre, B.; Schurmans, Stéphane ULg et al

in Pflügers Archiv : European Journal of Physiology (2007), 455

Phosphoinositide phosphatases dephosphorylate the three positions (D-3, 4 and 5) of the inositol ring of the poly-phosphoinositides. They belong to different families of enzymes. The PtdIns(3,4)P(2) 4 ... [more ▼]

Phosphoinositide phosphatases dephosphorylate the three positions (D-3, 4 and 5) of the inositol ring of the poly-phosphoinositides. They belong to different families of enzymes. The PtdIns(3,4)P(2) 4-phosphatase family, the tumour suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), SAC1 domain phosphatases and myotubularins belong to the tyrosine protein phosphatases superfamily. They share the presence of a conserved cysteine residue in the consensus CX(5)RT/S. Another family consists of the inositol polyphosphate 5-phosphatase isoenzymes. The importance of these phosphoinositide phosphatases in cell regulation is illustrated by multiple examples of their implications in human diseases such as Lowe syndrome, X-linked myotubular myopathy, cancer, diabetes or bacterial infection [less ▲]

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See detailPhospholipid-Binding And Lecithin-Cholesterol Acyltransferase Activation Properties Of Apolipoprotein-A-I Mutants
Holvoet, P.; Zhao, Za.; Vanloo, B. et al

in Biochemistry (1995), 34(41), 13334-42

Recombinant human apolipoprotein A-I (apo A-I) and three deletion mutants: apo A-I(delta Leu44-Leu126), apo A-I(delta Glu139-Leu170), and apo A-I(delta Ala190-Gln243), purified from the periplasmic space ... [more ▼]

Recombinant human apolipoprotein A-I (apo A-I) and three deletion mutants: apo A-I(delta Leu44-Leu126), apo A-I(delta Glu139-Leu170), and apo A-I(delta Ala190-Gln243), purified from the periplasmic space of Escherichia coli, were studied. The rate of turbidity decrease following mixing of apo A-I(delta Ala190-Gln243) with dimyristoylphosphatidylcholine (DMPC) vesicles at 23 degrees C was 10-fold lower than that of the other apo A-I proteins, confirming that the carboxy-terminal region of apo A-I plays a role in rapid lipid binding. The Stokes radii of reconstituted high-density lipoproteins (rHDL), containing dipalmitoylphosphatidylcholine and cholesterol, were larger for the three apo A-I mutants [6.3 nm for apo A-I(delta Leu44-Leu126), 6.1 nm for apo A-I(delta Glu139-Leu170), and 6.5 nm for apo A-I(delta Ala190-Gln243)] than for intact apo A-I (5.0 nm). The mutant rHDL all contained 4 apo A-I molecules per particle as compared to 2 for intact apo A-I. Circular dichroism measurements revealed 8 alpha-helices per apo A-I molecule, 5 per apo A-I(delta Leu44-Leu126), 6 per apo A-I(delta Glu139-Leu170), and 4 per apo A-I(delta Ala190-Gln243) molecule as compared to predicted values of 8, 5, 6, and 6 alpha-helices, respectively. [less ▲]

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See detailPhospholipids quantification in vegetable oil degumming residues by HPLC-ELSD
Pierart, Céline ULg; Danthine, Sabine ULg; Wathelet, B et al

Poster (2008)

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See detailThe phosphoprotein pp135 is an essential constituent of the fibrillar components of nucleoli and of coiled bodies.
Vandelaer, M.; Thiry, Marc ULg

in Histochemistry & Cell Biology (1998), 110(2), 169-77

We examined the distribution of the silver-stainable phosphoprotein, pp135, within Ehrlich tumor and HEp-2 cells by a postembedding Lowicryl immunogold labeling procedure. Identical labeling patterns were ... [more ▼]

We examined the distribution of the silver-stainable phosphoprotein, pp135, within Ehrlich tumor and HEp-2 cells by a postembedding Lowicryl immunogold labeling procedure. Identical labeling patterns were obtained in both cell types. During interphase, gold particles were found not only over the dense fibrillar component but were also evident over the fibrillar centers of nucleoli. By contrast, the granular component did not display any significant label. When rRNA synthesis was inhibited by actinomycin D, the same labeling was observed in segregated nucleoli; both fibrillar components were labeled. Aside from the nucleolar labeling, label was also consistently present in coiled bodies. During metaphase, label was visualized in silver-stainable material of the nucleolus organizing regions. It thus appears that, unlike the two major silver-stained proteins, nucleolin/C23 and B23, pp135 remains located in all major silver-stainable structures during the whole cell cycle. This finding strongly suggests that pp135 could be the component responsible for in situ silver staining. On the other hand, the maintenance of pp135 in the fibrillar centers throughout the cell cycle, like RNA polymerase I, upstream binding factor, and DNA topoisomerase I, suggests that pp135 could be a component involved in transcription of the rRNA genes. [less ▲]

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