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See detailLessons to be learned from varicella-zoster virus
Rentier, Bernard ULg; Piette, Jacques ULg; Baudoux, Laurence et al

in Veterinary Microbiology (1996), 53(1-2), 55-66

Varicella-zoster virus (VZV) is an alphaherpesvirus responsible for two human diseases: chicken pox and shingles. The virus has a respiratory port of entry. After two successive viremias, it reaches the ... [more ▼]

Varicella-zoster virus (VZV) is an alphaherpesvirus responsible for two human diseases: chicken pox and shingles. The virus has a respiratory port of entry. After two successive viremias, it reaches the skin where it causes typical lesions. There, it penetrates the peripheral nervous system and it remains latent in dorsal root ganglia. It is still debatable whether VZV persists in neurons or in satellite cells. During latency, VZV expresses a limited set of transcripts of its immediate early (IE) and early (E) genes but no protein has been detected. Mechanisms of reactivation from ganglia have not been identified. However, dysfunction of the cellular immune system appears to be involved in this process. The cell-associated nature of VZV has made it difficult to identify a temporal order of gene expression, but there appears to be a cascade mechanism as for HSV-1. The lack of high titre cell-free virions or recombination mutants has hindered so far the understanding of VZV gene functions. Five genes, ORFs 4, 10, 61, 62, and 63 that encode regulatory proteins could be involved in VZV latency. ORF4p activates gene promoters with basal activities. ORF10p seems to activate the ORF 62 promoter. ORF61p has trans-activating and trans-repressing activities. The major IE protein ORF62p, a virion component, has DNA-binding and regulatory functions, transactivates many VZV promoters and even regulates its own expression. ORF63p is a nuclear IE protein of yet unclear regulatory functions, abundantly expressed very early in infection. We have established an animal model of VZV latency in the rat nervous system, enabling us to study the expression of viral mRNA and protein expression during latency, and yielding results similar to those found in humans. This model is beginning to shed light on the molecular events in VZV persistent infection and on the regulatory mechanisms that maintain the virus in a latent stage in nerve cells. [less ▲]

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See detailLet the Country Grow
Maiorano, Diego ULg

in Economic and Political Weekly (2013), XLVIII(22),

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See detail"Let's Stick Together (c'mon c'mon)": Decumul enkel mogelijk bij gezamenlijke vervolging van natuurlijke en rechtspersoon?
Franssen, Vanessa ULg; Van Dyck, S.

in Nullum Crimen : Tijdschrift voor Straf- en Strafprocesrecht [= NC] (2011)

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See detailLet's Talk Ambiguity: Citizen science in new and emerging technologies
Van Oudheusden, Michiel ULg

Conference (2014, July 04)

Citizen science (CS) is a fairly new concept that is rapidly gaining traction in the industrialized democratic world. Although it is often likened to public participation in science, CS takes on many ... [more ▼]

Citizen science (CS) is a fairly new concept that is rapidly gaining traction in the industrialized democratic world. Although it is often likened to public participation in science, CS takes on many forms and orientations. In this presentation, I link CS developments and practices to the advent of new and emerging technologies (NEST), such as bio- and nanotechnologies. I draw on three Flemish cases of CS linked to NEST to illustrate how CS co-evolves with Flemish and European policy shifts towards responsible innovation governance. The cases serve to highlight how various conceptions of CS enact divergent rationales for public involvement in science and promote competing visions of the volatile relationship between science and society. The clash of CS perspectives within and through NEST produces a highly ambiguous innovation context that is simultaneously characterized by excitement and (pre)caution; public and formal expertise; policy dictates and public dialogue; and deterministic and constructionist views of innovation. How implicated actors (policymakers, scientists, citizens, and other stakeholders) make sense of, and deal with, these ambiguities is one of the key challenges CS faces today. [less ▲]

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See detailLet’s work together
Chatelus, Renaud ULg; Sevini, Filippo

in WorldECR (2016), issue 47

Export control systems are complex by nature. They involve many national stakeholders. A typical national export controlapparatus requires the cooperation of between seven and 15 governmental ministries ... [more ▼]

Export control systems are complex by nature. They involve many national stakeholders. A typical national export controlapparatus requires the cooperation of between seven and 15 governmental ministries, services and agencies, each having its own mandate, constraints and work culture. But export control cannot be seen from a purely national perspective. Export control’s ultimate purpose, overall efficacy, and legal basis are genuinely international. International instruments and bodies, such as Resolution 1540 and its committee, or the various multilateral export control regimes, provide some guidance and opportunities for cooperation. It is, however, far from sufficient for addressing all the cooperation challenges at the national and international levels. Recognising this important need for cooperation, the Nuclear Security Unit of the European Joint Research Centre in Ispra, Italy, organised in March 2015, a three-day innovative EU export control simulation exercise with operatives of 11 Member States, involving standard work processes as well as specific fraud patterns. [less ▲]

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See detailLethal white foal syndrome – Revue de la littérature à partir de 2 cas cliniques
Sandersen, Charlotte ULg; Delguste, Catherine ULg; Cassart, Dominique ULg et al

in Proceedings of the Annual meeting of the French Equine Veterinary Association (AVEF) (2002)

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See detailLets get our city clean
Gosset, Christiane ULg; Trinon, J.

in Case Studies Pack, Volume II, Healthy Cities Symposium (1989)

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See detailLetter to editor-Comparative biochemical analysis after steam pretreatments of lignocellulosic biomass from six combined morphological parts of Williams Cavendish banana plant (Triploid Musa AAA group)
Kamdem, Irenée ULg

in Waste Management & Research : The Journal of the International Solid Wastes & Public Cleansing Association (2015)

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See detailLetter To The Editor
Groß-Hardt, E; Henschke, M; Pfennig, Andreas ULg

in AIChE Journal (2003), 49(6), 1610-1611

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See detailLetter to the Editor.
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Seminars in arthritis and rheumatism (2015), 44(5), 15

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See detailLetter to the Editor: On the term 'interaction' and related phrases in the literature on Random Forests.
Boulesteix, Anne-Laure; Janitza, Silke; Hapfelmeier, Alexander et al

in Briefings in bioinformatics (2014)

In an interesting and quite exhaustive review on Random Forests (RF) methodology in bioinformatics Touw et al. address-among other topics-the problem of the detection of interactions between variables ... [more ▼]

In an interesting and quite exhaustive review on Random Forests (RF) methodology in bioinformatics Touw et al. address-among other topics-the problem of the detection of interactions between variables based on RF methodology. We feel that some important statistical concepts, such as 'interaction', 'conditional dependence' or 'correlation', are sometimes employed inconsistently in the bioinformatics literature in general and in the literature on RF in particular. In this letter to the Editor, we aim to clarify some of the central statistical concepts and point out some confusing interpretations concerning RF given by Touw et al. and other authors. [less ▲]

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See detailLetter: should immunosuppressive therapy be started with adalimumab in Crohn's disease? Authors' reply.
Reenaers, C.; Louis, Edouard ULg; Belaiche, Jacques ULg et al

in Alimentary pharmacology & therapeutics (2013), 37(7), 752-3

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See detailLa letteratura francese del Medioevo
Moreno, Paola ULg

Book published by Il Mulino (1990)

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See detailLetteratura maltese in lingua italiana. "Le disavventure marinaresche" di Fabrizio Cagliola
Aresti, Alessandro ULg

in Letterature &. Quaderni della Facoltà di Lingue e letterature straniere dell’Università di Cagliari (2011), 13

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See detailLettere di Carlo Emilio Gadda
Curreri, Luciano ULg

Article for general public (2013)

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See detailLettere e arte, filologia e storia. Il progetto EpistolART
Moreno, Paola ULg

Conference (2014, May 09)

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See detailLettere. Vita quotidiana e sensibilità religiosa nel Polesine di metà Cinquecento
Moreno, Paola ULg

in Giornale Storico della Letteratura Italiana (2011), CLXXXVIII(622), 310-311

Detailed reference viewed: 31 (8 ULg)