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See detailInnovative Learning for Collaborative Design in Ergonomics
Folcher, Viviane; Zreik, Khaldoun; Ben Rajeb, Samia ULiege et al

in Stouffs, Rudy; Sariyildiz, Sevil (Eds.) Computation and Performance (2013)

The proposed article deals with introducing collaborative architectural design into the training of ergonomists at the Master 2 level. The collaborative design workshop aims to confront ergonomists with ... [more ▼]

The proposed article deals with introducing collaborative architectural design into the training of ergonomists at the Master 2 level. The collaborative design workshop aims to confront ergonomists with the difficulties any design project involves, and which challenge architects, designers, engineers and so on: collaboration between people with different skills and different expertise; powerful time constraints; need for their work to converge; working together and/or at a distance; sharing documents; decision-making, etc. The article will present a short review of work carried out in the domains of architecture and design, and of the contribution of ergonomics within architectural projects. We shall then present the workshop’s educational aims, and give details of the way it functioned. Finally, observation results will be presented and discussed. [less ▲]

Detailed reference viewed: 41 (3 ULiège)
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See detailAn innovative lens surface functionalization to control Posterior Capsular Opacification
Huang, Yi-Shiang ULiege

Poster (2014, May 26)

Cataract is the opacity of the lens, causing impairment of vision or even blindness and the surgery is still the only available treatment today. The intraocular lens (IOL) is a polymer implant designed to ... [more ▼]

Cataract is the opacity of the lens, causing impairment of vision or even blindness and the surgery is still the only available treatment today. The intraocular lens (IOL) is a polymer implant designed to replace the natural lens in the cataract surgery. However, the bio-inert materials could not satisfy the unmet need in the secondary cataract control. Posterior capsular opacification (PCO, or Secondary Cataract), characterized by a thick and cloudy layer of lens epithelial cells (LECs), is the most common postoperative complication. For the present study, a bioactive molecule is immobilized onto the conventional acrylic hydrophilic polymer pHEMA (Poly(2-hydroxyethyl methacrylate)) using oxygen plasma treatment followed by dip-coating deposition. The RGD peptide sequence, being well-known for its ability to promote cellular attachment by binding to integrin receptors, is designed to stimulate the adhesion of LECs on the IOL. The data have shown the peptide immobilized biomaterial not only exhibits similar optical and physical properties, but also reveals enhanced bio-logical properties in cell adhesion and cell morphology maintenance. By means of surface functionalization of IOL to stimulate LECs adhesion, the secondary cataract could be controlled. [less ▲]

Detailed reference viewed: 46 (0 ULiège)
See detailInnovative materials improving energy efficiency of buildings
Dewalque, Jennifer ULiege; Denayer, Jessica ULiege; Schrijnemakers, Audrey ULiege et al

Conference (2014, July 01)

Detailed reference viewed: 41 (17 ULiège)
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See detailInnovative method for the detection of bovine blood products in feedingstuffs
Lecrenier, Marie-Caroline ULiege; Marbaix, Hélène; Veys, Pascal et al

Poster (2014, October)

Detailed reference viewed: 12 (1 ULiège)
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See detailInnovative Method for the Detection of Bovine Blood Proteins in Feedingstuffs
Lecrenier, Marie-Caroline ULiege; Marbaix, Hélène; Veys, Pascal et al

Poster (2015, October)

Detailed reference viewed: 13 (1 ULiège)
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See detailInnovative Methodology for the Definition of Design Spaces of Chromatographic Methods
Rozet, Eric ULiege; Debrus, B; Lebrun, Pierre ULiege et al

Conference (2013, June 06)

As defined by ICH [1] and FDA, Quality by Design (QbD) stands for “a systematic approach to development that begins with predefined objectives and emphasizes product and process understanding and process ... [more ▼]

As defined by ICH [1] and FDA, Quality by Design (QbD) stands for “a systematic approach to development that begins with predefined objectives and emphasizes product and process understanding and process control, based on sound science and quality risk management”. A risk–based QbD–compliant approach is proposed for the robust development of analytical methods. This methodology based on Design of Experiments (DoE) to study the experimental domain models the retention times at the beginning, the apex and the end of each peak corresponding to the compounds of a mixture and uses the separation criterion (S) rather than the resolution (RS) as a Critical Quality Attribute. Stepwise multiple linear regressions are used to create the models. The estimated error is propagated from the modelled responses to the separation criterion (S) using Monte Carlo simulations in order to estimate the predictive distribution of the separation criterion (S) over the whole experimental domain. This allows finding ranges of operating conditions that will guarantee a satisfactory quality of the method in its future use. These ranges define the Design Space (DS) of the method. In chromatographic terms, the chromatograms processed at operating conditions within the DS will assuredly show high quality, with well separated peaks and short run time, for instance. This Design Space can thus be defined as the subspace, necessarily encompassed in the experimental domain (i.e. the knowledge space), within which the probability for the criterion to be higher than an advisedly selected threshold is higher than a minimum quality level. Precisely, the DS is defined as “the multidimensional combination and interaction of input variables (e.g., material attributes) and process parameters that have been demonstrated to provide assurance of quality” [1]. Therefore, this DS defines a region of operating conditions that provide prediction of assurance of quality rather than only quality as obtained with traditional mean response surface optimisation strategies. For instance, in the liquid chromatography there is a great difference in e.g. predicting a resolution (RS) higher than 1.5 vs. predicting that the probability for RS to be higher than 1.5 (i.e. P(RS> 1.5)) is high. The presentation of this global methodology will be illustrated for the robust optimisation and DS definition of several liquid chromatographic methods dedicated to the separation of different mixtures: pharmaceutical formulations, API and impurities/degradation products, plant extracts, separation of enantiomers, … [less ▲]

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See detailInnovative methodology to transfer conventional GC-MS heroin profiling to UHPLC-MS/MS
Debrus, Benjamin ULiege; Broséus, Julian; Guillarme, Davy et al

in Analytical and Bioanalytical Chemistry (2011), 399(8), 2719-2730

Nowadays, in forensic laboratories, heroin profiling is frequently carried out by gas chromatography coupled with mass spectrometry (GC-MS). This analytical technique is well established, provides good ... [more ▼]

Nowadays, in forensic laboratories, heroin profiling is frequently carried out by gas chromatography coupled with mass spectrometry (GC-MS). This analytical technique is well established, provides good sensitivity and reproducibility, and allows the use of large databases. Despite those benefits, recently introduced analytical techniques, such as ultra-high-pressure liquid chromatography (UHPLC), could offer better chromatographic performance, which needs to be considered to increase the analysis throughput for heroin profiling. With the latter, chromatographic conditions were optimized through commercial modeling software and two atmospheric pressure ionization sources were evaluated. Data obtained from UHPLC–MS/MS were thus transferred, thanks to mathematical models to mimic GC-MS data. A calibration and a validation set of representative heroin samples were selected among the database to establish a transfer methodology and assess the models’ abilities to transfer using principal component analysis and hierarchical classification analysis. These abilities were evaluated by computing the frequency of successful classification of UHPLC–MS/MS data among GC-MS database. Seven mathematical models were tested to adjust UHPLC–MS/MS data to GC-MS data. A simplified mathematical model was finally selected and offered a frequency of successful transfer equal to 95%. [less ▲]

Detailed reference viewed: 169 (31 ULiège)
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See detailInnovative methods for the determination of the taxonomic origin of processed animal proteins in feed.
Veys, Pascal; Ngo Njembe, M.; Lecrenier, Marie-Caroline ULiege et al

Poster (2015, November)

The use of animal by-products in feed depends on their nature defined by the type of tissue or body parts and the species of origin. Currently, the detection of unauthorised processed animal proteins ... [more ▼]

The use of animal by-products in feed depends on their nature defined by the type of tissue or body parts and the species of origin. Currently, the detection of unauthorised processed animal proteins (PAPs) is based on light microscopy and PCR methods. Light microscopy identifies structures on the basis of their morphology and enables identification of particles (such as bones, cartilages, muscle fibres,…) while PCR is able to detect and identify the presence of specific animal DNA in feed. Nevertheless, for some scenarios, even combined, these methods do not succeed in determining the taxonomic origin of the PAPs. A typical example is that of an aquafeed containing authorised porcine PAP together with dairy products: the analysis will conclude of the potential presence of ruminant PAP. Therefore, there is a need for developing methods allowing a taxonomic characterisation of visual structures such as bones fragments and muscle fibres. For the characterisation of bones, NIRM has yet demonstrated its potential. However the limitation of NIRM is when the presence of bones is reduced or absent. This study investigated the potential of NIRM for the determination of the taxonomic origin of muscle fibres. The NIRM was experimented on 2 porcine PAPs vs. 6 ruminant PAPs and 7 fishmeals all of industrial origin. Results showed that NIRM allows differentiating muscle fibres from different taxonomic origins: fish, ruminant and pig. In addition to this taxonomic classification, results also reveal differences inside taxonomic clusters of PAPs (e.g among different ruminant PAPs and porcine PAPs). The results obtained on this type of meals are promising and offer new perspectives. Tests on adulterated feeds need to be performed by NIRM prior to validation. [less ▲]

Detailed reference viewed: 27 (4 ULiège)
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See detailInnovative modelling of 3D unsaturated flow in porous media by coupling independent models for vertical and lateral flows
Paulus, Raphaël ULiege; Dewals, Benjamin ULiege; Erpicum, Sébastien ULiege et al

in Journal of Computational & Applied Mathematics (2013), 246

Detailed reference viewed: 72 (32 ULiège)
See detailInnovative multilayered nanofibers for wound dressing application
Croisier, Florence ULiege; Detrembleur, Christophe ULiege; Jérôme, Christine ULiege

Poster (2012, April 18)

Chitosan is a natural polymer derived from the chitin of crustacean or mushroom shells, that intrinsically presents haemostatic, mucoadhesive, antimicrobial and immunostimulant properties. This ... [more ▼]

Chitosan is a natural polymer derived from the chitin of crustacean or mushroom shells, that intrinsically presents haemostatic, mucoadhesive, antimicrobial and immunostimulant properties. This polysaccharide has shown a great potential for biomedical and pharmaceutical applications, on account of its remarkable compatibility with physiological medium. Besides, it is degraded in a physiological environment into non-toxic products, which make chitosan an outstanding candidate for short- to medium-term applications. In this respect, nanometric fibers are highly interesting as their assembly mimics the skin extracellular matrix structure. Such nanofibrous materials can be prepared by electrospinning (ESP). This technique uses a high voltage to create an electrically charged jet of polymer solution or melt which leads to fibers formation. Depending on the polymer characteristics (a.o. molecular weight, solution viscosity and conductivity) and processing conditions (electric potential, distance between syringe-capillary and collection plate, concentration, flow rate), polymer fibers ranging from nanometers to a few microns in diameter can be obtained and subsequently used as potential scaffolds, a.o. to form a temporary, artificial extracellular matrix. In the present study, electrospinning technique was combined with layer-by-layer deposition method (LBL) - a well-known method for surface coating, based on electrostatic interactions - in order to prepare multilayered chitosan-based nanofibers. The antibacterial properties of the obtained material were then assessed, and the presence of a multilayered deposit was confirmed by several techniques. (Future) possibilities for valorization: These multilayered chitosan-based nanofibers present great prospects for the preparation of new biomedical scaffolds - such as wound dressings that could improve skin regeneration. [less ▲]

Detailed reference viewed: 84 (6 ULiège)
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See detailAn innovative non-animal chitosan hydrogel is able to restore the rheology of osteoarthritis synovial fluid ex vivo
Henrotin, Yves ULiege; Rocasalbas, Guillem; Chausson, Mickaël et al

Poster (2016, September)

Detailed reference viewed: 45 (2 ULiège)
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See detailAn innovative non-animal chitosan hydrogel is able to restore the rheology of osteoarthritis synovial fluid ex vivo
Henrotin, Yves ULiege; Rocasalbas, Guillem; Chausson, Mickaël et al

in Osteoarthritis and Cartilage (2017, April)

Detailed reference viewed: 31 (2 ULiège)
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See detailInnovative PCR without DNA extraction for African sickle cell disease diagnosis.
Detemmerman, L.; Olivier, S.; BOURS, Vincent ULiege et al

in Hematology (Amsterdam, Netherlands) (2017)

OBJECTIVES: Hemoglobin (Hb) disorders consist of thalassemia and Hb structural variants, of which the major forms are associated with severe anemia and/or vascular occlusion. Current diagnostic techniques ... [more ▼]

OBJECTIVES: Hemoglobin (Hb) disorders consist of thalassemia and Hb structural variants, of which the major forms are associated with severe anemia and/or vascular occlusion. Current diagnostic techniques are highly accurate and mostly based on isoelectric focusing, high-performance liquid chromatography or mass spectrometry, which often require advanced laboratory equipment. In sub-Saharan Africa, the Hb disorders are mainly associated to the pathological variants hemoglobin S (HbS) and HbC. Unfortunately, until now, it is not easy to get a diagnosis of these disorders in this area. In this study, we tested the performance of a new molecular diagnostic tests on qualified samples. METHODS: The Human Hb S/C Lamp assay is a new polymerase chain reaction test able to detect HbS, HbC and HbA alleles without DNA extraction, directly on fresh or frozen blood samples, or on dried blood spots (DBS). In this study, we compared the genotyping of 248 blood samples (56 whole blood and 192 DBS) with this LAMP assay to the routine diagnostic methods performed in the genetics lab at the university hospital of Liege. RESULTS: Our results show that the LAMP method can detect HbS and HbC with an accuracy of 100%. Moreover, this test can be used for the neonatal screening because we did not observe any interference with fetal Hb. DISCUSSION: To our knowledge, this method is the only molecular assay that can be performed directly on dried blood cards without DNA extraction, lowering handling, turnaround time and costs. [less ▲]

Detailed reference viewed: 25 (1 ULiège)
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See detailInnovative polyelectrolytes/poly(ionic liquid)s for energy and environment
Ajjan, Fátima N.; Ambrogi, Martina; Tiruye, Girum Ayalneh et al

in Polymer International (2017), 66(8), 1119-1126

This manuscript presents the work carried out within the European Project RENAISSANCE-ITN, which was dedicated to the development of innovative polyelectrolytes for energy and environmental applications ... [more ▼]

This manuscript presents the work carried out within the European Project RENAISSANCE-ITN, which was dedicated to the development of innovative polyelectrolytes for energy and environmental applications. Within the project different types of innovative polyelectrolytes were synthesized such as poly(ionic liquid)s coming from renewable or natural ions, thiazolium cations, cathechol functionalities or from a new generation of cheap deep-eutectic monomers. Further, macromolecular architectures such as new poly(ionic liquid) block copolymers and new (semi)conducting polymer/polyelectrolyte complexes were also developed. As the final goal, the application of these innovative polymers in energy and environment was investigated. Important advances in energy storage technologies included the development of new carbonaceous materials, new lignin/conducting polymer biopolymer electrodes, new iongels and single-ion conducting polymer electrolytes for supercapacitors and batteries and new poly(ionic liquid) binders for batteries. On the other hand, the use of the innovative polyelectrolytes into sustainable environmental technologies led to the development of new liquid and dry water, new materials for water cleaning technologies such as floculants, oil absorbers, new recyclable organocatalysts platform and multifunctional polymer coatings with antifouling and antimicrobial properties. All in all this article demonstrates the potential of the poly(ionic liquid)s for high-value applications in Energy & Enviromental areas. [less ▲]

Detailed reference viewed: 113 (25 ULiège)
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See detailAn innovative procedure for smoothing parameter selection
Frasso, Gianluca ULiege; Eilers, Paul H.C.

in Proceedings of 46th scientific meeting of the Italian Statistical Society (2012, June)

Smoothing with penalized splines calls for an automatic method to select the size of the penalty parameter λ. We propose a not well known smoothing parameter selection procedure: the L-curve method. AIC ... [more ▼]

Smoothing with penalized splines calls for an automatic method to select the size of the penalty parameter λ. We propose a not well known smoothing parameter selection procedure: the L-curve method. AIC and (generalized) cross validation represent the most common choices in this kind of problems even if they indicate light smoothing when the data represent a smooth trend plus correlated noise. In those cases the L-curve is a computationally efficient alternative and robust alternative. [less ▲]

Detailed reference viewed: 9 (0 ULiège)
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See detailInnovative Proteomics for the Discovery of Systemically Accessible Cancer Biomarkers Suitable for Imaging and Targeted Therapies
Turtoi, Andrei ULiege; De Pauw, Edwin ULiege; Castronovo, Vincenzo ULiege

in American Journal of Pathology (2011), 178(1), 12-18

The discovery of biomarkers that are readily accessible through the circulating blood and are selectively overexpressed in pathological tissues has become a major research objective, particularly in the ... [more ▼]

The discovery of biomarkers that are readily accessible through the circulating blood and are selectively overexpressed in pathological tissues has become a major research objective, particularly in the field of oncology. Indisputably, this group of molecules has a high potential to serve as an innovative tool for effective imaging and targeted cancer therapy approaches. In this attractive therapeutic concept, specific cancer proteins are reached by intravenously administered ligands that are coupled to cytotoxic drugs. Such compounds are able to induce cancer destruction while sparing normal tissues. Owing to the performance of mass spectrometry technology, current high-throughput proteomic analysis allows for the identification of a high number of proteins that are differentially expressed in the cancerous tissues. However, such approaches provide no information regarding the effective accessibility of the biomarkers and, therefore, the possibility for these discovered proteins to be targeted. To bypass this major limitation, which clearly slows the discovery of such biomarkers, innovative methodological strategies have been developed to enrich the clinical specimens before the mass spectrometry analysis. The focus is laid on the group of proteins that are necessarily located either at the exterior face of the plasma membrane or in the extracellular matrix. The present review addresses the current technologies meant for the discovery and analysis of accessible antigens from clinically relevant samples. [less ▲]

Detailed reference viewed: 51 (14 ULiège)
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See detailInnovative semiconducting oxide materials reducing the energy footprint of buildings
Dewalque, Jennifer ULiege; Maho, Anthony ULiege; Spronck, Gilles ULiege et al

Conference (2015, October 26)

In the current energy context, many efforts are devoted to the reduction of the energy footprint of buildings. To meet this challenge, the LCIS-GREENMAT laboratory developes a front edge research in the ... [more ▼]

In the current energy context, many efforts are devoted to the reduction of the energy footprint of buildings. To meet this challenge, the LCIS-GREENMAT laboratory developes a front edge research in the field of advanced materials associated to energy and environment, including structured materials for dye-sensitized solar cells (DSSCs) and electrochromic coatings. DSSCs have been reported by O’Regan and Grätzel in the early nineties as a very promising alternative to conventional photovoltaic silicon devices. Main benefits of these cells are their low cost as well as their mild manufacturing process. In most of the specific literature, DSSCs are made of TiO2 films prepared by doctor-blade or screen-printing of anatase nanoparticles paste. However, due to the random organization of the nanoparticles, pore accessibility by the dye and electrolyte could be incomplete. Moreover, some anatase crystallites could suffer from a lack of connectivity, leading to electron transfer issues. The strategy adopted by our group to improve photovoltaic efficiencies involves a templating-assisted process to prepare highly porous layers with well-ordered and accessible pores as well as improved crystallites connectivity. This talk especially focuses on the templating-assisted synthesis of TiO2 and ZnO semiconducting layers used as photoelectrode in DSSCs. Due to the surface area improvement as well as the perfect control of the pore organization and the pore size, the templating strategy is an effective solution to maximize the adsorption of active dye and the electrolyte infiltration inside the porous network. Besides, in the last few years, there has been increasing interest in electrochromic glazing due to its potential use as an energy-efficient component for buildings, as it could reduce considerably their CO2 emission by decreasing their energy consumption up to 30%. The crucial issues of such devices are the durability, the coloration efficiency and the reversibility upon coloration and bleaching of the electrochromic layers. In order to improve the performances of those electrochromic films, we have investigated a surfactant-assisted deposition process for WO3 layer and the insertion of lithium in the NiO layer. All films have been deposited on FTO glass substrates by ultrasonic spray pyrolysis (USP), which is a low-cost alternative to industrial vacuum processes for manufacturing high quality thin films. The presence of lithium ions in nickel oxide films has shown improved coloration efficiency compared to the undoped films. The higher active surface of surfactant-assisted tungsten oxide films has led to higher reversibility and coloration contrast. [less ▲]

Detailed reference viewed: 136 (20 ULiège)