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See detailThe mayonnaise droplet
Terwagne, Denis ULg; Gilet, Tristan ULg; Vandewalle, Nicolas ULg et al

Conference (2009, November 23)

A compound drop is made of a millimetric water drop encapsulated by an oil shell. They are obtained by merging one drop of each component (water and oil). Afterwards, they are laid on a high viscosity oil ... [more ▼]

A compound drop is made of a millimetric water drop encapsulated by an oil shell. They are obtained by merging one drop of each component (water and oil). Afterwards, they are laid on a high viscosity oil bath which is vertically vibrated. When the forcing acceleration is higher than a given threshold, compound drops can bounce on the surface. We show that above a second threshold some oil contained in the shell enters in the inner water droplet. In a second experiment, we drop the compound droplet on the oil bath at rest. We can determine the range of impact speed in which capillary waves developed on the surface are able to generate an oil drop (coming from the shell) in the water drop. When the bouncing trajectories of the droplets are analyzed a correlation between the emulsion threshold and the static analysis can be made. [less ▲]

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See detailThe mayonnaise droplet
Terwagne, Denis ULg; Gilet, Tristan ULg; Vandewalle, Nicolas ULg et al

Poster (2009, September)

Compound drops are made of a millimetric water drop encapsulated by an oil shell. They are laid on a high viscosity oil bath which is vertically vibrated. When the forcing acceleration is higher than a ... [more ▼]

Compound drops are made of a millimetric water drop encapsulated by an oil shell. They are laid on a high viscosity oil bath which is vertically vibrated. When the forcing acceleration is higher than a given threshold, compound drops can bounce on the surface. We show that above an another threshold a double emulsion occurs in the drop. We measured this emulsion threshold for various size and water/oil volume ratio of the compound drop. [less ▲]

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See detailThe mayonnaise droplet
Terwagne, Denis ULg; Mack, Nicolas; Dorbolo, Stéphane ULg et al

in Chaos (2009)

Detailed reference viewed: 56 (21 ULg)
See detailThe mazer physics
Bastin, Thierry ULg

Conference (2003)

Detailed reference viewed: 9 (2 ULg)
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See detailMazindol in the treatment of Parkinson's disease.
Delwaide, P. J.; Schoenen, Jean ULg; Martinelli, P.

in Archives of Neurology (1983), 40(13), 788-90

Mazindol, a drug that blocks the reuptake of dopamine, was studied in the treatment of Parkinson's disease in both a pilot study (12 patients) and a controlled trial (11 patients). The patients had stage ... [more ▼]

Mazindol, a drug that blocks the reuptake of dopamine, was studied in the treatment of Parkinson's disease in both a pilot study (12 patients) and a controlled trial (11 patients). The patients had stage II or III disease, according to the classification of Hoehn and Yahr. Both studies showed that mazindol possessed anti-parkinsonian properties and that the improvement was statistically significant. The therapeutic effect was moderate, but could be of value for patients in the early stages of the disease. The drug was well tolerated; only two patients had side effects. [less ▲]

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See detailMBD du laboratoire à la clinique
CAVALIER, Etienne ULg

Conference (2015, February 02)

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See detailmbmdr: an R package for exploring gene-gene interactions associated with binary or quantitative traits
Calle, M. Luz; Urrea, Victor; Van Steen, Kristel ULg

in Bioinformatics (2010), 26(17), 2198-2199

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See detailMBO en Aandeelhouder
Corhay, Albert ULg; Herst, Arthur; Tourani Rad, Alireza

in Bedrifskunde (1994), 4

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See detailMcCune-Albright Syndrome: A Detailed Pathological And Genetic Analysis of Disease Effects in an Adult Patient.
Vasilev, Vladimir; Daly, Adrian ULg; THIRY, Albert ULg et al

in The Journal of clinical endocrinology and metabolism (2014)

Context: McCune Albright syndrome (MAS) is a clinical association of endocrine and non-endocrine anomalies caused by post-zygotic mutation of the GNAS1 gene, leading to somatic activation of the ... [more ▼]

Context: McCune Albright syndrome (MAS) is a clinical association of endocrine and non-endocrine anomalies caused by post-zygotic mutation of the GNAS1 gene, leading to somatic activation of the stimulatory alpha subunit of G protein (Gsalpha). Important advances have been made recently in describing pathological characteristics of many MAS-affected tissues, particularly pituitary, testicular and adrenal disease. Other rarer disease related features are emerging. Objective: To study pathological and genetic findings of MAS on a tissue-by-tissue basis in classically and non classically affected tissues. Design: A comprehensive autopsy and genetic analysis Setting: Tertiary referral University Hospital Patients: Adult male patient with MAS and severe disease burden including gigantism Intervention(s): Clinical, hormonal and radiographic studies; gross and microscopic pathology analyses, conventional PCR and droplet digital PCR analyses of affected and non affected tissues Main Outcome Measure: Pathological findings, presence of GNAS1 mutations Results: The patient was diagnosed with MAS syndrome at six years of age based on the association of cafe-au-lait spots and radiological signs of polyostotic fibrous dysplasia. Gigantism developed and hyperprolactinemia, hypogonadotropic hypogonadism and hyperparathyroidism were diagnosed throughout adult period. The patient died at the age of 39 from pulmonary embolism. A detailed study revealed mosaiscism for the p.R201C GNAS mutation distributed across many endocrine and non-endocrine tissues. These genetically implicated tissues included rare or previously undescribed disease associations including primary hyperparathyroidism, and hyperplasia of the thymus and endocrine pancreas. Conclusions: This comprehensive pathological study of a single patient highlights the complex clinical profile of MAS and illustrates important advances in understanding the characteristics of somatic GNAS1 related pathology across a wide range of affected organs. [less ▲]

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See detailMCDA applied to the architectural sketch design: an aid to conception of the building envelope
Colson, Gérard ULg; Hauglustaine, Jean-Marie ULg

in Papiers de recherche / Working papers - Faculté d'Economie, de Gestion et de Sciences sociales (2000), (G.E.M.M.E n°0008), 13

In the conception of the building envelope, the sketch design is a crucial moment of the architectural design. The first drawing gives a concrete expression to the project author's first choices regarding ... [more ▼]

In the conception of the building envelope, the sketch design is a crucial moment of the architectural design. The first drawing gives a concrete expression to the project author's first choices regarding a set of requirements and preferences, as expressed by the multiple stakholders of the project, namely: the building owner, users, public authorities and the design team surrounding the architect. The present study explores a Multiple Criteria Decision Aid procedure (MCDA), an aid to help stakeholders improve this stage of the sketch design. The methodology is built close to the usual design process. This paper presents design and decision aid intertwined procedures and briefly describes the softwares involed: AMCE and EsQUIsE. The decision aid process is a first attempt to address the architectural sketch design challenge. The reader is expected to react to the suggested presentation of this still open MCDA problem. [less ▲]

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See detailMCDA applied to the architectural sketch design: an aid to conception of the building envelope
Colson, Gérard ULg; Hauglustaine, Jean-Marie ULg

in Colorni, A.; Paruccini, M.; Roy, B. (Eds.) A-MCD-A - Aide Multicritère à la Décision - Multiple Criteria Decision Aiding (2001)

In the conception of the building envelope, the sketch design is a crucial moment of the architectural design. The first drawing gives a concrete expression to the project author's first choices regarding ... [more ▼]

In the conception of the building envelope, the sketch design is a crucial moment of the architectural design. The first drawing gives a concrete expression to the project author's first choices regarding a set of requirements and preferences, as expressed by the multiple stakeholders of the project, namely: the building owner, users, public authorities and the design team surrounding the architect. The present study explores a Multiple Criteria Decision Aid procedure (MCDA), an aid to help stakeholders improve this stage of the sketch design. The methodology is built close to the usual design process. This paper presents design and decision aid intertwined procedures and briefly describes the softwares involved: AMCE and EsQUIsE. The decision aid process is a first attempt to address this architectural sketch design challenge. The reader is expected to react to the suggested presentation of this still open MCDA problem. [less ▲]

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See detailMCF-7/BOS cells membrane proteome: comparison of two isolation methods using mass spectrometry
Bertrand, Virginie ULg; Massart, Anne-Cécile ULg; De Pauw-Gillet, Marie-Claire ULg et al

Poster (2009)

Membrane proteins play an important role in biological processes but their isolation and quantification using classical techniques is often limited due to their poor solubility and relatively low ... [more ▼]

Membrane proteins play an important role in biological processes but their isolation and quantification using classical techniques is often limited due to their poor solubility and relatively low abundance. These membrane markers have to be accessible to antibodies and should be potential therapeutic targets. The tests were conducted on MCF-7 / BOS cell line, immortal and easier to cultivate. The goal of this work is to obtain a pure membrane fraction to facilitate the analysis of the sample. To isolate transmembrane proteins, we compared two methods. The first one used different extraction cycles characterized by different buffers to isolate membrane proteins. The second method labelled accessible extracellular domains at the surface of MCF-7 cells with biotin prior to differential centrifugation. [less ▲]

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See detailMCF-7/BOS cells membrane proteome: comparison of two isolation methods using mass spectrometry
Bertrand, Virginie ULg; Massart, Anne-Cécile ULg; De Pauw-Gillet, Marie-Claire ULg et al

Poster (2009)

Membrane proteins (MP) play an important role in biological processes. Isolation and quantification of these MP using classical techniques is often limited due to their poor solubility and relatively low ... [more ▼]

Membrane proteins (MP) play an important role in biological processes. Isolation and quantification of these MP using classical techniques is often limited due to their poor solubility and relatively low abundance. These membrane proteins enclosed markers which could be potential therapeutic targets. These potential therapeutic targets have to be accessible to antibodies and need to be presented in the plasmic membrane. Assays were conducted on MCF-7 / BOS cell line, immortal and easier to cultivate. The goal of this work is to obtain an enriched membrane fraction to facilitate the analysis of the sample and to simplify the complex proteins mixture. To isolate transmembrane proteins, we compared two methods. The first one used different extraction cycles characterized by different buffers to isolate membrane proteins. The second method labelled accessible extracellular domains at the surface of MCF-7 cells with biotin prior to differential centrifugation. The obtained enriched membrane proteome was digested with trypsin and/or Lysyl Endopeptidase. Obtained peptides were separated by 2D-HPLC chromatography and on-line analysed ion trap mass spectrometer, the Esquire HCT. [less ▲]

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See detailMCI conversion to dementia and the APOE genotype : A prediction study with FDG-PET
Mosconi, L.; Perani, D.; Sorbi, S. et al

in Neurology (2004), 63(12), 2332-2340

Objectives: To investigate whether the combination of fluoro-2-deoxy-D-glucose (FDG) PET measures with the APOE genotype would improve prediction of the conversion from mild cognitive impairment (MCI) to ... [more ▼]

Objectives: To investigate whether the combination of fluoro-2-deoxy-D-glucose (FDG) PET measures with the APOE genotype would improve prediction of the conversion from mild cognitive impairment (MCI) to Alzheimer disease ( AD). Method: After 1 year, 8 of 37 patients with MCI converted to AD (22%). Differences in baseline regional glucose metabolic rate (rCMRglc) across groups were assessed on a voxel-based basis using a two-factor analysis of variance with outcome (converters [n = 8] vs nonconverters [n = 29]) and APOE genotype (E4 carriers [E4+] [n = 16] vs noncarriers [E4-] [n = 21]) as grouping factors. Results were considered significant at p < 0.05, corrected for multiple comparisons. Results: All converters showed reduced rCMRglc in the inferior parietal cortex (IPC) as compared with the nonconverters. Hypometabolism in AD-typical regions, that is, temporoparietal and posterior cingulate cortex, was found for the E4+ as compared with the E4- patients, with the E4+/converters (n = 5) having additional rCMRglc reductions within frontal areas, such as the anterior cingulate (ACC) and inferior frontal (IFC) cortex. For the whole MCI sample, IPC rCMRglc predicted conversion to AD with 84% overall diagnostic accuracy (p = 0.003). Moreover, ACC and IFC rCMRglc improved prediction for the E4+ group, yielding 100% sensitivity, 90% specificity, and 94% accuracy (p < 0.0005), thus leading to an excellent discrimination. Conclusion: Fluoro-2-deoxy-D-glucose-PET measures may improve prediction of the conversion to Alzheimer disease, especially in combination with the APOE genotype. [less ▲]

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See detailMcLuhan, trente ans après
Durand, Pascal ULg

Scientific conference (1999, December 17)

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See detailMcLuhan, trente ans après
Durand, Pascal ULg

in Quaderni : la Revue de la Communication (1999), 37

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See detailMcLuhan, trente ans après
Durand, Pascal ULg

in Quaderni : la Revue de la Communication (1999), 37

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See detailMdm2 promotes systemic lupus erythematosus and lupus nephritis
Sayyed, Sufyan Ali ULg

in Journal of the American Society of Nephrology [=JASN] (2011), 22(11), 2016

Detailed reference viewed: 17 (1 ULg)
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See detailMDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation.
Shostak, Kateryna ULg; Patrascu, F.; Göktuna, Serkan ULg et al

in Cell death and differentiation (2014), 5(21), 811-24

Restoration of p53 tumor suppressor function through inhibition of its interaction and/or enzymatic activity of its E3 ligase, MDM2, is a promising therapeutic approach to treat cancer. However, because ... [more ▼]

Restoration of p53 tumor suppressor function through inhibition of its interaction and/or enzymatic activity of its E3 ligase, MDM2, is a promising therapeutic approach to treat cancer. However, because the MDM2 targetome extends beyond p53, MDM2 inhibition may also cause unwanted activation of oncogenic pathways. Accordingly, we identified the microtubule-associated HPIP, a positive regulator of oncogenic AKT signaling, as a novel MDM2 substrate. MDM2-dependent HPIP degradation occurs in breast cancer cells on its phosphorylation by the estrogen-activated kinase TBK1. Importantly, decreasing Mdm2 gene dosage in mouse mammary epithelial cells potentiates estrogen-dependent AKT activation owing to HPIP stabilization. In addition, we identified HPIP as a novel p53 transcriptional target, and pharmacological inhibition of MDM2 causes p53-dependent increase in HPIP transcription and also prevents HPIP degradation by turning off TBK1 activity. Our data indicate that p53 reactivation through MDM2 inhibition may result in ectopic AKT oncogenic activity by maintaining HPIP protein levels.Cell Death and Differentiation advance online publication, 31 January 2014; doi:10.1038/cdd.2014.2. [less ▲]

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See detailMDRD equation for GFR estimation : analytical limitations
Cavalier, Etienne ULg; Delanaye, Pierre ULg; Krzesinski, Jean-Marie ULg et al

Conference (2007, March 23)

Detailed reference viewed: 112 (1 ULg)