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See detailReduced levels of reactive oxygen species correlate with inhibition of apoptosis, rise in thioredoxin expression and increased bovine leukemia virus proviral loads.
Bouzar, Amel ULg; Boxus, Mathieu ULg; Florins, ARNAUD-FRANCOIS ULg et al

in Retrovirology (2009), 6

BACKGROUND: Bovine Leukemia virus (BLV) is a deltaretrovirus that induces lymphoproliferation and leukemia in ruminants. In ex vivo cultures of B lymphocytes isolated from BLV-infected sheep show that ... [more ▼]

BACKGROUND: Bovine Leukemia virus (BLV) is a deltaretrovirus that induces lymphoproliferation and leukemia in ruminants. In ex vivo cultures of B lymphocytes isolated from BLV-infected sheep show that spontaneous apoptosis is reduced. Here, we investigated the involvement of reactive oxygen species (ROS) in this process. RESULTS: We demonstrate that (i) the levels of ROS and a major product of oxidative stress (8-OHdG) are reduced, while the thioredoxin antioxidant protein is highly expressed in BLV-infected B lymphocytes, (ii) induction of ROS by valproate (VPA) is pro-apoptotic, (iii) inversely, the scavenging of ROS with N-acetylcysteine inhibits apoptosis, and finally (iv) the levels of ROS inversely correlate with the proviral loads. CONCLUSION: Together, these observations underline the importance of ROS in the mechanisms of inhibition of apoptosis linked to BLV infection. [less ▲]

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See detailA reduced order data assimilation scheme coupled with a two-way nested model. Application to the Ligurian Sea
Barth, Alexander ULg; Alvera Azcarate, Aïda ULg; Beckers, Jean-Marie ULg et al

Conference (2004, April)

A system of nested models is coupled with a data assimilation module. The system is composed by a low resolution model (1/4 ) covering the whole Mediterranean Sea, an intermediate resolution model (1/20 ... [more ▼]

A system of nested models is coupled with a data assimilation module. The system is composed by a low resolution model (1/4 ) covering the whole Mediterranean Sea, an intermediate resolution model (1/20 ) of the Liguro-Provençal basin and a high resolution model (1/60 ) simulating the fine mesoscale structures in the Ligurian Sea. Boundary conditions and the averaged fields (feedback) are exchanged between two successive nesting levels. A reduced order, optimal interpolation data assimilation scheme was implemented. The state vector is composed by temperature, salinity and sea surface elevation. Novel in the present approach is that these variables from the three nested model grids are assembled to one multigrid state vector. This implementation allows to take into account the correlation of the variables across the nested model grids in order to avoid for example artificial gradients after an assimilation cycle. The eigenvectors of the covariance matrix are constructed by an EOF analysis of the free model run. Cross-grid correlations especially in the overlapping domains are thus consistently represented. Horizontal correlations over long distances are suppressed by multiplying each error mode with a set of radial Gaussian functions. This procedure increases considerably the rank of the covariance matrix but ensures the local impact of each observation. Sea surface temperature (SST, from the DLR EOWEB), sea surface height (SSH, from the CLS) and CTD profiles (SIRENA cruise from SACLANT Center and cruises from the MEDAR/Medatlas database) are assimilated into the model. In overlapping model grids the measurements are related to the highest resolution grid. Since the SSH has a resolution of 1/8 , the surface elevation of the Ligurian Sea and the Liguro-Provençal model are filtered in order to be coherent with the space scales present in the observations. Starting from the 1st January 1998 the low and intermediate resolution models are spun up for 18 months. The initial conditions for the Ligurian Sea are interpolated from the intermediate resolution model. The three models are then integrated until August 1999. During this period SST, SSH and the CTD profiles are assimilated. The results are compared with a free model run. In particular the model forecast just before the assimilation step are compared with the observations. The model forecast and the measurements are then independent and the difference is a measure of the model forecast skill and the impact of the previous assimilation cycles. [less ▲]

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See detailReduced Organ Failure with Effective Glycemic Control
Preiser, JC; Chase, JG; Pretty, CG et al

in Intensive Care Medicine (2010), 36 (Suppl 2)

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See detailReduced organ failure with effective glycemic control
Preiser, Jean-Charles; Chase, J. G.; Pretty, C. G. et al

in Intensive Care Medicine (2010), 36(2), 173-173

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See detailReduced proviral loads during primo-infection of sheep by Bovine Leukemia virus attenuated mutants.
Debacq, Christophe; Sanchez Alcaraz, Maria Teresa; Mortreux, Franck et al

in Retrovirology (2004), 1(1),

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See detailReduced risk of back pain following teriparatide treatment: a meta-analysis
Nevitt, M. C.; Chen, P. Q.; Dore, R. K. et al

in Osteoporosis International (2006), 17(2), 273-280

Vertebral fractures are the most common osteoporotic fracture and may result in back pain with functional limitations and diminished quality of life. Teriparatide [rhPTH (1-34)] has been shown to increase ... [more ▼]

Vertebral fractures are the most common osteoporotic fracture and may result in back pain with functional limitations and diminished quality of life. Teriparatide [rhPTH (1-34)] has been shown to increase bone mass and reduce the risk of vertebral and other osteoporotic fractures. The aim of this study was to evaluate the effects of teriparatide on the risk of back pain in patients with osteoporosis. A systematic review of the literature was performed, and five trials were identified and included in our analyses. All trials were randomized, double-blinded, and parallel with either new vertebral fracture (n =1) or bone mineral density as the primary endpoint (n =4). Four studies were in postmenopausal women with osteoporosis, and one was in men with idiopathic or hypogonadal osteoporosis. Two trials were placebo controlled, two trials were alendronate controlled, and one trial involved teriparatide plus hormone replacement therapy versus hormone replacement therapy alone. Reports of back pain, defined as new or worsened back pain after initiating the study drug, were obtained from adverse event databases, and the risk of back pain was analyzed using a multivariate Cox proportional hazards model. Results were not statistically heterogeneous (P =0.60) across trials, and there were no differences between groups administered teriparatide 20 or 40 mcg/day doses (P =0.64). The rates of back pain, moderate or severe back pain, and severe back pain per 100 patient-years were numerically lower in the teriparatide versus comparator groups in each study. Compared with the pooled comparator, patients in the pooled teriparatide group had reduced risk for any back pain [relative risk, 0.66 (95% CI, 0.55-0.80)], moderate or severe back pain [relative risk, 0.60 (95% CI, 0.48-0.75)] and severe back pain [relative risk, 0.44 (95% CI, 0.28-0.68)]. Separate meta-analyses comparing teriparatide versus placebo or antiresorptive drugs gave similar results. In conclusion, patients randomized to teriparatide had a reduced risk of new or worsening back pain compared to patients randomized to placebo, hormone replacement therapy or alendronate. [less ▲]

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See detailReduced Slow-Wave Rebound during Daytime Recovery Sleep in Middle-Aged Subjects
Lafortune, Marjolaine; Gagnon, Jean-François; Latreille, Véronique et al

in PLoS ONE (2012), 7(8), 43224

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See detailReduced specificity of autobiographical memory and of personal projection in the future in alcoholics
Blairy, Sylvie ULg; Neumann, Aurore; Vanlofvelde, Cécile

Poster (2007, July)

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See detailReduced Sperm Counts In Guppies (Poecilia Reticulata) Following Exposure To Low Levels Of Tributyltin And Bisphenol A
Haubruge, Eric ULg; Petit, François ULg; Gage, Mjg.

in Proceedings of the Royal Society B-Biological Sciences (2000), 267(1459),

Detailed reference viewed: 24 (7 ULg)
See detailA reduced-gravity model for the Catalan Sea
Garcia-Ladona, Emilio; Djenidi, Salim ULg

in Journal of Marine Systems (1991), 4

Detailed reference viewed: 3 (2 ULg)
See detailA reduced-gravity model for the Catalan Sea
Garcia-Ladona, Emilio; Djenidi, Salim ULg

in Journal of Marine Systems (1991), 4

Detailed reference viewed: 13 (7 ULg)
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See detailReduced-order modeling and control of lightweight parallel manipulators: Theory and experiments
Bruls, Olivier ULg

Scientific conference (2004, December 16)

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See detailReduced-order modeling of electrostatically-actuated micro-beams
Durieu, Francois; Bruls, Olivier ULg; Rochus, Véronique ULg et al

in Proceedings of the 6th EUROMECH Nonlinear Dynamics Conference (ENOC) (2008)

This paper addresses the compact modeling of MEMS devices with nonlinear electromechanical forces. Ideally, the reduced-order model should only involve one or two generalized coordinates. We show that a ... [more ▼]

This paper addresses the compact modeling of MEMS devices with nonlinear electromechanical forces. Ideally, the reduced-order model should only involve one or two generalized coordinates. We show that a projection method based on the first eigenmode of the linearized unactuated structure is a good choice in terms of simplicity and accuracy. To take into account the influence of distributed electrostatic forces, it is necessary to approximate the nonlinear force in terms of the reduced coordinate. It is shown that a Pad´e approximation of order 2 is very attractive in terms of accuracy and numerical efficiency. [less ▲]

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See detailReduced-order modeling of flexible mechanisms
Bruls, Olivier ULg

Conference (2005, September)

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See detailReduced-order modeling of flexible mechanisms with configuration-dependent dynamics: a modal approach
Bruls, Olivier ULg

Conference (2005, September)

Modern formalisms in multibody dynamics allow a detailed and reliable representation of complex mechanical systems. However, high levels of accuracy and generality can only be reached at the price of more ... [more ▼]

Modern formalisms in multibody dynamics allow a detailed and reliable representation of complex mechanical systems. However, high levels of accuracy and generality can only be reached at the price of more sophisticated models, which require increased computational resources. Reduction techniques have thus been developed in order to build simplified models able to capture the essential dynamics of a flexible mechanism. In this talk, a methodology is proposed to transform an initial high-order Finite Element model into a low-order and explicit model. The reduction method is an extension of the component-mode technique established in linear structural dynamics, which accounts for the nonlinear kinematics of the mechanism. It relies on the original concept of “Global Modal Parameterization”: the motion of the assembled mechanism is described in terms of rigid and flexible modes, which depend on the mechanical configuration. We will show that the reduction procedure leads to a consistent model, with configuration-dependent parameters. The nonlinear variations of those parameters are approximated using a piecewise polynomial interpolation. This strategy is based on an adaptive configuration space inspection algorithm, which minimizes the computational resources to satisfy a specification on the approximation error. Several examples will be considered in the presentation: a four-bar mechanism, a parallel kinematic machine-tool, and a lightweight manipulator. [less ▲]

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See detailReducing apathy and depressive mood in Alzheimer's disease: A case report
Adam, Stéphane ULg; Van der Linden, Martial ULg; Juillerat, Anne-Claude et al

Conference (2000, September 21)

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See detailReducing hazards for humans from animals: emerging and re-emerging zoonoses
Saegerman, Claude ULg; Dal Pozzo, Fabiana ULg; Humblet, Marie-France ULg

in Italian Journal of Public Health (2012), 9(2), 13-24

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See detailReducing human salmonellosis in Belgium from minced pork meat with quantitative risk assessment scenarios
Delhalle, Laurent ULg; Bollaerts, K.; Messens, W. et al

Poster (2008, May)

Detailed reference viewed: 11 (0 ULg)
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See detailReducing leg oedema after femoro-popliteal bypass surgery: a challenge.
Kolh, Philippe ULg

in European Journal of Vascular and Endovascular Surgery (2010), 40(5), 643-4

Detailed reference viewed: 1 (0 ULg)