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Showing results 76408 to 76427 of 95253
  Reduction of apoptosis and proliferation in endometriosisBeliard, Aude  ; Noël, Agnès ; Foidart, Jean-Michel in Fertility and Sterility (2004), 82(1), 80-85 Objective: To evaluate whether endometriosis could be related to an impaired balance between apoptosis and proliferation, two processes which could be modulated by hormonal status. Design ... [more ▼] Objective: To evaluate whether endometriosis could be related to an impaired balance between apoptosis and proliferation, two processes which could be modulated by hormonal status. Design: Immunohistochemical study. Setting: Academic research laboratory. Intervention(s): Endometriotic samples obtained from peritoneum of women aged 26-40 years who were undergoing laparoscopy for pain or infertility. Main Outcome Measure(s): Apoptotic cells were detected with the use of the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay. The production of p53 and bcl-2, estrogen and Progesterone (P) receptors, and cellular proliferation were assessed by immunohistochemistry in eutopic and ectopic endometria from 30 patients with endometriosis throughout the menstrual cycle. Results were compared with those from normal endometria from 15 fertile patients. Result(s): Endometriotic lesions were characterized by reduced TUNEL and p53 stainings and by enhanced bcl-2 staining. No correlation between apoptosis and estrogen receptor or P receptor levels was found. A lower amount of steroid receptor was found in endometriotic tissues, without cyclic modulation, compared with the eutopic endometrium. Conclusion(s): Our results suggest that when endometrial tissue is located at ectopic locations, it differs from eutopic endometrium by its proliferation rate, steroid hormone levels, and markers of apoptosis. A reduced sensitivity of endometriotic cells to apoptosis could promote the dissemination and implantation of these cells to ectopic sites. (C) 2004 by American Society for Reproductive Medicine. [less ▲] Detailed reference viewed: 34 (0 ULg) Reduction of B cell turnover in chronic lymphocytic leukaemia.; ; et al in British Journal of Haematology (2008), 143(2), 240-7 Whether chronic lymphocytic leukaemia (CLL) is a latent or a proliferating disease has been intensively debated. Whilst the dogma that CLL results from accumulation of dormant lymphocytes is supported by ... [more ▼] Whether chronic lymphocytic leukaemia (CLL) is a latent or a proliferating disease has been intensively debated. Whilst the dogma that CLL results from accumulation of dormant lymphocytes is supported by the unresponsiveness of leukaemic cells to antigens and polyclonal activators, recent in vivo kinetic measurements indicate that B lymphocytes do divide at significant rates in CLL. However, an important and still unanswered question is whether CLL cells proliferate faster or slower compared with their normal counterparts. This report addressed directly this point and compared B-cell kinetics in CLL subjects and healthy controls, using a pulse-chase approach based on incorporation of deuterium from 6,6-(2)H(2)-glucose into DNA. We confirmed that B cells proliferated at significant levels in CLL but found that the proliferation rates were reduced compared with healthy subjects (mean 0.47 vs. 1.31%/d respectively, P = 0.007), equivalent to an extended doubling time of circulating B cells (147 d vs. 53 d). In conclusion, CLL B cells proliferate at reduced levels compared with healthy controls. CLL is thus characterized by an aberrant B-cell kinetics with a decrease in cell turnover, an observation that may impact on elaboration of efficient therapeutic strategies. [less ▲] Detailed reference viewed: 38 (12 ULg)Reduction of brain metastases in plasminogen activator inhibitor-1-deficient mice with transgenic ocular tumorsMaillard, Catherine ; ; et alin Carcinogenesis (2008), 29(11), 2236-2242 Plasminogen activator inhibitor-1 is known to play a paradoxical positive role in tumor angiogenesis, but its contribution to metastatic spread remains unclear. We studied the impact of PAI-1 deficiency ... [more ▼] Plasminogen activator inhibitor-1 is known to play a paradoxical positive role in tumor angiogenesis, but its contribution to metastatic spread remains unclear. We studied the impact of PAI-1 deficiency in a transgenic mouse model of ocular tumors originating from retinal epithelial cells and leading to brain metastasis (TRP-1/SV40 Tag mice). PAI-1 deficiency did not affect primary tumor growth or vascularization, but was associated with a smaller number of brain metastases. Brain metastases were found to be differentially distributed between the two genotypes. PAI-1-deficient mice displayed mostly secondary foci expanding from local optic nerve infiltration, whereas wild-type animals displayed more disseminated nodules in the scissura and meningeal spaces. SuperArray GEArray analyses aiming to detect molecules potentially compensating for PAI-1 deficiency demonstrated an increase in fibroblast growth factor-1 (FGF-1) gene expression in primary tumors, which was confirmed by RT-PCR and western blotting. Our data provide the first evidence of a key role for PAI-1 in a spontaneous model of metastasis, and suggest that angiogenic factors, such as FGF-1, may be important for primary tumor growth and may compensate for the absence of PAI-1. They identify PAI-1 and FGF-1 as important targets for combined anti-tumor strategies. [less ▲] Detailed reference viewed: 79 (10 ULg)Reduction of Cumulative Nutritional Deficit and Improvement of Early Growth in Extremely Preterm InfantsSENTERRE, Thibault ; in Pediatric Research (2011), 70(S5), 830 Detailed reference viewed: 11 (1 ULg)Reduction Of Ecosystem Productivity And Respiration During The European Summer 2003 Climate Anomaly: A Joint Flux Tower, Remote Sensing And Modelling Analysis; ; et al in Global Change Biology (2007), 13(3), Detailed reference viewed: 18 (2 ULg)Reduction of mathematical models of signal transduction networks: simulation-based approach applied to EGF receptor signalling; ; et al in IEE Proceedings - Systems Biology (2004), 1(1), 159-169 Biological systems and, in particular, cellular signal transduction pathways are characterised by their high complexity. Mathematical models describing these processes might be of great help to gain ... [more ▼] Biological systems and, in particular, cellular signal transduction pathways are characterised by their high complexity. Mathematical models describing these processes might be of great help to gain qualitative and, most importantly, quantitative knowledge about such complex systems. However, a detailed mathematical description of these systems leads to nearly unmanageably large models, especially when combining models of different signalling pathways to study cross-talk phenomena. Therefore, simplification of models becomes very important. Different methods are available for model reduction of biological models. Importantly, most of the common model reduction methods cannot be applied to cellular signal transduction pathways. Using as an example the epidermal growth factor (EGF) signalling pathway, we discuss how quantitative methods like system analysis and simulation studies can help to suitably reduce models and additionally give new insights into the signal transmission and processing of the cell [less ▲] Detailed reference viewed: 32 (2 ULg)Reduction of Neel temperature of CeIn3 by la doping; ; et al in Journal of Magnetism & Magnetic Materials (2007), 310(2), 300-302 The Neel temperature of heavy fermion material CeIn3 is at 10 K. La doping to Ce site of CeIn3 introduces increase of distance between Ce ions and reduction of number of 4f electron. It is implied the ... [more ▼] The Neel temperature of heavy fermion material CeIn3 is at 10 K. La doping to Ce site of CeIn3 introduces increase of distance between Ce ions and reduction of number of 4f electron. It is implied the reduction of 4f electron number with La doping weakens inter site magnetic interaction. An x-T phase diagram was drawn with Neel temperatures estimated from both electrical resistivity and magnetic susceptibility measurements. (c) 2006 Elsevier B.V. All rights reserved. [less ▲] Detailed reference viewed: 8 (5 ULg)Reduction of nitrogen fertilizer in a pasture grazed with dairy cows : Effects on milk production and on plasma ureaDufrasne, Isabelle ; ; Gielen, Marc et alin Proceedings of the 45th Annual Meeting of E.A.A.P. (1994) Detailed reference viewed: 7 (1 ULg)Reduction of postnatal cumulative nutritional deficit and improvement of growth in extremely preterm infantsSENTERRE, Thibault ; in Acta Paediatrica (2012), 101 Detailed reference viewed: 10 (2 ULg)Reduction of relapse rates by 18-month treatment in chronic hepatitis C. A Benelux randomized trial in 300 patients.; ; et al in Journal of Hepatology (2004), 40(4), 689-695 BACKGROUND/AIMS: Treatment of chronic hepatitis C with interferon can be ineffective due to relapse. We aimed to reduce the 40% relapse rate of 6 months interferon-ribavirin combination therapy by ... [more ▼] BACKGROUND/AIMS: Treatment of chronic hepatitis C with interferon can be ineffective due to relapse. We aimed to reduce the 40% relapse rate of 6 months interferon-ribavirin combination therapy by prolonging treatment to 18 months. METHODS: Three hundred patients with treatment-naive hepatitis C, were randomized to 18 months combination therapy with interferon (3MU tiw) and ribavirin (1000-1200 mg/day), 18 months interferon combined with placebo, or 6 months combination therapy with interferon and ribavirin, in a double blinded manner. All 295 patients who received at least one dose of treatment were included in the intention to treat analysis. RESULTS: At the end of treatment, HCV RNA was undetectable in 55 and 49% of those on 6 and 18 months combination therapy, respectively, versus 26% of those on monotherapy (P<0.001). The relapse rate was 38% for 6 months combination therapy, 38% for 18 months monotherapy, and only 13% for 18 months combination treatment (P=0.002). The sustained response rates were 34% for 6 months combination therapy, 16% for 18 months monotherapy and 43% for 18 months combination therapy (P<0.05). CONCLUSIONS: Reduction of relapse rates to 15% or less is feasible by prolongation of interferon-ribavirin treatment to 18 months. [less ▲] Detailed reference viewed: 6 (0 ULg)Reduction of Temporalis Exteroceptive Suppression by Peripheral Electrical Stimulation in Migraine and Tension-Type Headaches; Schoenen, Jean in Pain (1994), 59(3), 327-34 Inhibition of the second exteroceptive suppression of temporalis muscle activity (ES2) produced by a preceding electrical stimulus applied at the index was studied in patients suffering from migraine ... [more ▼] Inhibition of the second exteroceptive suppression of temporalis muscle activity (ES2) produced by a preceding electrical stimulus applied at the index was studied in patients suffering from migraine without aura (MO), chronic (CTH) or episodic (ETH) tension-type headache. Each patient group comprised of 12 subjects was compared to a group of healthy controls. Mean duration of unconditioned ES2, measured on 10 averaged rectified responses after labial stimulation at a 0.1 Hz frequency, was reduced in CTH only. From stimulation intensities of 20 mA onward, peripheral-induced inhibition of temporalis ES2 was significantly more pronounced in both subtypes of tension-type headache compared to migraineurs or controls. After an index finger stimulus of 20 mA, temporalis ES2 was abolished in 83% of CTH, 67% of ETH, 25% of MO patients and 8% of controls, whereas unconditioned ES2 was present in all patients. Among 9 ETH patients with normal (> or = 32 msec) unconditioned ES2, 5 had total disappearance of ES2 after a 20 mA index stimulation. These results demonstrate that peripheral conditioning at 20 mA increases the diagnostic sensitivity of ES2 studies. They suggest that the changes observed in tension-type headache are due to hyperexcitability of the reticular nuclei which inhibit the medullary inhibitory interneurons mediating ES2. [less ▲] Detailed reference viewed: 12 (2 ULg)Reduction of the acute bioavailability of metformin by the alpha-glucosidase inhibitor acarbose in normal man.Scheen, André ; ; et alin European Journal of Clinical Investigation (1994), 24 Suppl 3 In a double-blind cross-over study, we investigated a possible influence of the alpha-glucosidase inhibitor acarbose on the bioavailability of the biguanide compound metformin. Each of the six healthy ... [more ▼] In a double-blind cross-over study, we investigated a possible influence of the alpha-glucosidase inhibitor acarbose on the bioavailability of the biguanide compound metformin. Each of the six healthy young male volunteers was randomly allocated during two consecutive 7 day periods to either acarbose (days 1-3: 3 x 50 mg day-1; days 4-7: 3 x 100 mg day-1) or placebo. At day 7 and 14 of the study, the overnight-fasted subjects ingested 1000 mg metformin with the first bite of a standardized breakfast (500 kcal; 60 g carbohydrates) and together with either placebo or 100 mg acarbose. Acarbose significantly (P < 0.05) reduced the meal-induced increase in blood glucose and plasma insulin levels. Acarbose induced a significant (P < 0.05) reduction in early (90, 120, 180 min) serum levels, peak concentrations (Cmax: 1.22 +/- 0.14 vs. 1.87 +/- 0.60 mg l-1) and area under the curve of metformin (AUC 0-540 min: 423 +/- 55 vs. 652 +/- 55 mg min l-1), but did not diminish its 24 h urinary excretion. In conclusion, acarbose significantly reduces the acute bioavailability of metformin in normal subjects. [less ▲] Detailed reference viewed: 25 (0 ULg)The reduction of the stress response by jasmonic acid and putrescine has a beneficial effect on in vitro tuber formation and development of yamKevers, Claire in Plant Abiotic Stress: From Systems Biology to Sustainable Agriculture 4th International Workshop - Cost Action FA0605 17-17 November 2011 (2011) Detailed reference viewed: 13 (2 ULg)Les « réductions » du Paraguay (XVIIe-XVIIIe s.) : la réalisation d’une utopie ?Delfosse, Annick Conference given outside the academic context (2007) Detailed reference viewed: 10 (4 ULg)Réduire l'échec à la transition primaire-secondaire; Lafontaine, Dominique in Education : tribune libre (1988), 212 Detailed reference viewed: 25 (1 ULg)Réduire l'échec à la transition primaire-secondaire; Lafontaine, Dominique in Humanités Chrétiennes (1989), 32(3), 254-266 Detailed reference viewed: 22 (1 ULg)Réduire l'échec au début du secondaireLafontaine, Dominique ; Report (1987) Detailed reference viewed: 3 (0 ULg)Réduire la taille des classes dans l'enseignement fondamental : pour des discriminations vraiment positives...Lafontaine, Dominique in Cahiers du Service de Pédagogie Expérimentale (SPE) (2002), 11-12 Detailed reference viewed: 36 (2 ULg)Réduire les consommations énergétiques des ménages : influence des bâtiments et du transport.Reiter, Sigrid Conference given outside the academic context (2012) Detailed reference viewed: 7 (1 ULg)Réduire les inégalités de santé : quand le dispositif reproduit l'exclusion ?Absil, Gaëtan Conference (2007, June) Detailed reference viewed: 44 (9 ULg) |
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