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See detailInnate lymphocyte and dendritic cell cross-talk: a key factor in the regulation of the immune response.
Reschner, Anca ULiege; Hubert, Pascale ULiege; Delvenne, Philippe ULiege et al

in Clinical & Experimental Immunology (2008), 152(2), 219-26

Dendritic cells (DC) are specialized in the presentation of antigens and the initiation of specific immune responses. They have been involved recently in supporting innate immunity by interacting with ... [more ▼]

Dendritic cells (DC) are specialized in the presentation of antigens and the initiation of specific immune responses. They have been involved recently in supporting innate immunity by interacting with various innate lymphocytes, such as natural killer (NK), NK T or T cell receptor (TCR)-gammadelta cells. The functional links between innate lymphocytes and DC have been investigated widely and different studies demonstrated that reciprocal activations follow on from NK/DC interactions. The cross-talk between innate cells and DC which leads to innate lymphocyte activation and DC maturation was found to be multi-directional, involving not only cell-cell contacts but also soluble factors. The final outcome of these cellular interactions may have a dramatic impact on the quality and strength of the down-stream immune responses, mainly in the context of early responses to tumour cells and infectious agents. Interestingly, DC, NK and TCR-gammadelta cells also share similar functions, such as antigen uptake and presentation, as well as cytotoxic and tumoricidal activity. In addition, NK and NK T cells have the ability to kill DC. This review will focus upon the different aspects of the cross-talk between DC and innate lymphocytes and its key role in all the steps of the immune response. These cellular interactions may be particularly critical in situations where immune surveillance requires efficient early innate responses. [less ▲]

Detailed reference viewed: 81 (24 ULiège)
See detailInnate lymphocytes in human papillomavirus (HPV)-associated cervical cancers
Renoux, V; Bisig, B; Thiry, Marc ULiege et al

Poster (2009)

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See detailInnate lymphocytes in human papillomavirus (HPV)-associated cervical cancers
Renoux, V; Bisig, B; Thiry, Marc ULiege et al

Poster (2009)

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See detailInnate signaling by mycolate esters of the cell wall of Mycobacterium tuberculosis and relevance for the development of adjuvants for subunit vaccines
Tima, Giresse ULiege

Doctoral thesis (2017)

Tuberculosis remains among the most deadly health threats to humankind. This povertyrelated disease, caused by bacteria of the Mycobacterium tuberculosis complex, kills each year more than 1.5 million ... [more ▼]

Tuberculosis remains among the most deadly health threats to humankind. This povertyrelated disease, caused by bacteria of the Mycobacterium tuberculosis complex, kills each year more than 1.5 million people. It is estimated that a further 2 billion individuals are latently infected with M. tuberculosis. Most of them will never develop any clinical symptoms, although 5 to 10% of these latently infected individuals are at risk to develop TB in their lifetime. During the last decades the situation worsened because of deteriorating socioeconomic conditions, the increased incidence of drug-resistant M.tuberculosis strains and the co-infection with HIV (a major risk factor for development of TB). Currently only one vaccine is available against TB, the Bacille of Calmette and Guérin (BCG). However, its efficacy is extremely variable against the contagious form of TB - pulmonary TB - in adults and adolescents (ranging from 0 to 80%). Therefore, to control and eliminate TB, a better vaccine, efficient drug treatments and more rapid and cheaper diagnostic techniques are needed. In this PhD thesis we have attempted to provide additional information to reach this goal. Indeed, we investigated the inflammatory and adjuvant potential of mycolate esters homologous of those found in the cell wall of M. tuberculosis. These mycolate esters vary in terms of sugar (trehalose, glucose and arabinose) and lipid (alpha-, methoxy-, keto-, wax-ester MAs) moieties. TDM, TMM, GMM and AraMM were found to be potent activators of BMDCs in vitro. This activation was shown to be dependent on the Mincle pathway. Our results demonstrated that the classes of MAs bound to sugar do not consistently impact the level of pro-inflammatory and adjuvant responses induced. Rather, the nature of the sugar and the number of acyl chains bound to it seem to dictate the affinity of the glycolipid for Mincle receptor in vitro. In vivo, we observed that TDM, TMM and GMM induce similar immune responses characterized by a production of antigen-specific IFN-γ and IL-17A. The immune responses induced by AraMM are dependent on the type of formulation. Indeed, AraMM in emulsion does not induce substantial level of Th1 while AraMM in DDA liposome induces Th1 immune response. This study increases our knowledge on host-pathogen interactions during M. tuberculosis infection by identifying the receptor involved in the recognition of several PAMPs. Furthermore, we showed that the activation of this receptor by these mycolate esters triggers the induction of protective Th1 and Th17 immune responses [less ▲]

Detailed reference viewed: 21 (3 ULiège)
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See detailInnate sound production in the cichlid Oreochromis niloticus
Longrie, Nicolas ULiege; Fine, M. L.; Parmentier, Eric ULiege

in Journal of Zoology (2008), 275

The mouthbrooding cichlid Oreochromis niloticus is one of the world’s best-studied fish and is raised extensively for aquaculture. Although it is a common behavioural model, its acoustic communication has ... [more ▼]

The mouthbrooding cichlid Oreochromis niloticus is one of the world’s best-studied fish and is raised extensively for aquaculture. Although it is a common behavioural model, its acoustic communication has been neglected. Because of extensive parental care, the species is a good candidate for vocal learning. In male O. niloticus, we investigated for the first time sound production in agonistic interactions during nest construction. Males produce short-duration (250– 400 ms), often double-pulse sounds. Most energy is below 200 Hz and includes three main low-frequency peaks although energy extends beyond 1 kHz. Males (separated as eggs and raised in isolation) produce similar sounds in the same context as parental fish, indicating that the ability to produce sounds and the basic properties of the sounds are innate. [less ▲]

Detailed reference viewed: 81 (16 ULiège)
See detailL'inné et l'a priori. Aspets du savoir premier chez Descartes et Kant
Dubouclez, Olivier ULiege

Master of advanced studies dissertation (2002)

Detailed reference viewed: 17 (0 ULiège)
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See detailThe inner debris disc of Vega as seen by CHARA/FLUOR
Absil, Olivier ULiege

Scientific conference (2006, July 21)

Using the FLUOR near-infrared beam combiner installed at the CHARA Array (Mt Wilson, CA), we have obtained high-precision interferometric measurements of Vega, a prototypical debris-disk star known to be ... [more ▼]

Using the FLUOR near-infrared beam combiner installed at the CHARA Array (Mt Wilson, CA), we have obtained high-precision interferometric measurements of Vega, a prototypical debris-disk star known to be surrounded by large amounts of cold dust at 80-100 AU in a ring-like structure. The combination of short and long baselines has allowed us to separately resolve the stellar photosphere and its immediate neighbourhood inside by the FLUOR field-of-view of 1’’ (~8 AU at the distance of Vega). Our observations show a significant deficit in visibility at short baselines with respect to the expected visibility of a simple uniform disk stellar model, suggesting the presence of an extended source of emission around Vega. We propose that the visibility deficit is most likely due to the presence of hot circumstellar dust in the inner part of the debris disk, with a flux ratio of 1.29+/-0.19% between the integrated dust emission and the stellar photosphere in K band (2.15 microns). Using this piece of information together with archival photometric and interferometric data in the near- and mid-infrared, we derive the expected physical properties of the dust grains by modelling their infrared Spectral Energy Distribution. Small, highly refractive grains are suspected to be located at only a few 0.1 AU from Vega, with a total mass of about 1e-7 Earth mass. Their presence is thought to be an indicator of major dynamical perturbations currently ongoing in the Vega system. [less ▲]

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See detailThe inner debris disk of Vega as seen by CHARA/FLUOR
Absil, Olivier ULiege

Scientific conference (2006, May 25)

Using the FLUOR beam-combiner installed at the CHARA Array (Mt Wilson, CA), we have obtained high-precision visibility measurements of Vega, one of the prototypic debris-disk stars, known to be surrounded ... [more ▼]

Using the FLUOR beam-combiner installed at the CHARA Array (Mt Wilson, CA), we have obtained high-precision visibility measurements of Vega, one of the prototypic debris-disk stars, known to be surrounded by a large amount of cold dust in a ring-like structure at 80-100 AU. The combination of short and long baselines has allowed us to separately resolve the stellar photosphere and the close environment of the star (<8 AU). Our observations show a significant deficit in square visibility at short baselines with respect to the expected visibility of a simple UD stellar model (dV2 ~ 2%), suggesting the presence of an extended source of emission around Vega. The sparse (u,v) plane coverage does not allow the discrimination between a point source and an extended circumstellar emission as the source of the extended emission. However, we show that the presence of a point-like source within the FLUOR field-of-view (1" in radius, i.e., 7.8 AU at the distance of Vega) is highly unlikely. The excess emission is most likely due to the presence of hot circumstellar dust in the inner part of Vega's debris disk, with a flux ratio of 1.29 +/- 0.19% between the integrated dust emission and the stellar photosphere. Complementing this result with archival photometric data in the near- and mid-infrared and taking into account a realistic photospheric model for the rapidly rotating Vega, we derive the expected physical properties of the circumstellar dust by modelling its Spectral Energy Distribution. The inferred properties suggest that the Vega system could be currently undergoing major dynamical perturbations. [less ▲]

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See detailThe Inner Debris Structure in the Fomalhaut Planetary System
Su, Kate Y. L.; Rieke, George H.; Defrere, Denis ULiege et al

in Astrophysical Journal (2016), 818

Fomalhaut plays an important role in the study of debris disks and small bodies in other planetary systems. The proximity and luminosity of the star make key features of its debris, like the water ice ... [more ▼]

Fomalhaut plays an important role in the study of debris disks and small bodies in other planetary systems. The proximity and luminosity of the star make key features of its debris, like the water ice line, accessible. Here we present ALMA cycle 1, 870 μm (345 GHz) observations targeted at the inner part of the Fomalhaut system with a synthesized beam of 0.″45 × 0.″37 (˜3 AU linear resolution at the distance of Fomalhaut) and an rms of 26 μJy beam[SUP]-1[/SUP]. The high angular resolution and sensitivity of the ALMA data enable us to place strong constraints on the nature of the warm excess revealed by Spitzer and Herschel observations. We detect a point source at the star position with a total flux consistent with thermal emission from the stellar photosphere. No structures that are brighter than 3σ are detected in the central 15 AU × 15 AU region. Modeling the spectral energy distribution using parameters expected for a dust-producing planetesimal belt indicates a radial location in the range of ˜8-15 AU. This is consistent with the location where ice sublimates in Fomalhaut, i.e., an asteroid-belt analog. The 3σ upper limit for such a belt is <1.3 mJy at 870 μm. We also interpret the 2 and 8-13 μm interferometric measurements to reveal the structure in the inner 10 AU region as dust naturally connected to this proposed asteroid belt by Poynting-Robertson drag, dust sublimation, and magnetically trapped nanograins. Fomalhaut is a triple system; here we refer to the Fomalhaut planetary system as the one around the primary star Fomalhaut A. [less ▲]

Detailed reference viewed: 46 (2 ULiège)
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See detailInner patterns and front propagation of dynamic random impurity model
Vandewalle, Nicolas ULiege; Ausloos, Marcel ULiege

in Physical Review Letters (1996), 77(3), 510-513

We investigate a simple model, the so-called dynamic epidemic model, for the evolution of an advancing interface through a medium containing mobile impurities. A short range repulsion between the front ... [more ▼]

We investigate a simple model, the so-called dynamic epidemic model, for the evolution of an advancing interface through a medium containing mobile impurities. A short range repulsion between the front and the impurities leads to an aggregation process along the front, and to the trapping of aggregates. The amplitude of this self-organization for collective impurity trapping is analyzed in two dimensions. A relationship exists between individual motion and the aggregation of particles. The results indicate that self-organizing features are different behind and on the front. [less ▲]

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See detailThe inner structure of early-type galaxies in the Illustris simulation
Xu, Dandan; Springel, Volker; Sluse, Dominique ULiege et al

in Monthly Notices of the Royal Astronomical Society (2017), 469

Early-type galaxies provide unique tests for the predictions of the cold dark matter cosmology and the baryonic physics assumptions entering models for galaxy formation. In this work, we use the Illustris ... [more ▼]

Early-type galaxies provide unique tests for the predictions of the cold dark matter cosmology and the baryonic physics assumptions entering models for galaxy formation. In this work, we use the Illustris simulation to study correlations of three main properties of early-type galaxies, namely the stellar orbital anisotropies, the central dark matter fractions and the central radial density slopes, as well as their redshift evolution since z = 1.0. We find that lower mass galaxies or galaxies at higher redshift tend to be bluer in rest-frame colour, have higher central gas fractions, and feature more tangentially anisotropic orbits and steeper central density slopes than their higher mass or lower redshift counterparts, respectively. The projected central dark matter fraction within the effective radius shows a very mild mass dependence but positively correlates with galaxy effective radii due to the aperture effect. The central density slopes obtained by combining strong lensing measurements with single-aperture kinematics are found to differ from the true density slopes. We identify systematic biases in this measurement to be due to two common modelling assumptions, isotropic stellar orbital distributions and power-law density profiles. We also compare the properties of early-type galaxies in Illustris to those from existing galaxy and strong lensing surveys; we find in general broad agreement but also some tension, which poses a potential challenge to the stellar formation and feedback models adopted by the simulation. [less ▲]

Detailed reference viewed: 16 (1 ULiège)
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See detailInnervation adrénergique de la vessie dans la sénescence. Etude histoenzymologique
Martin, Didier ULiege; TIMMERMANS, L.

Conference (1983, November)

Detailed reference viewed: 33 (1 ULiège)
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See detailL'innocence en pédagogie
Bloom, Benjamin S.; de Landsheere, Gilbert ULiege

in Education : tribune libre d'information et de discussion pédagogiques (1972), mai

Detailed reference viewed: 147 (6 ULiège)
See detailInnocent but paternalistic comments as interference that strikes hard on women
Sarlet, Marie ULiege; Dardenne, Benoît ULiege

Poster (2011, November 14)

Detailed reference viewed: 51 (12 ULiège)
See detailInnocuité du virus recombinant vaccine-rage chez quelques espèces non-cibles
Brochier, B.; Languet, B.; Blancou, J. et al

in Pastoret, Paul-Pierre; Brochier, B.; Thomas, I. (Eds.) et al Vaccination to control rabies in foxes (1988)

Detailed reference viewed: 23 (3 ULiège)
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See detailLes innombrables formes des Mille et une Nuits : quelques éditions, traditions, traductions... et trahisons
Franssen, Elise ULiege

Conference (2011, December 02)

Dans le domaine des études arabes, de nombreux textes attendent encore d’être édités. D’autres l’ont été par le passé, mais ne répondent pas aux principes de l’édition critique moderne. C’est notamment le ... [more ▼]

Dans le domaine des études arabes, de nombreux textes attendent encore d’être édités. D’autres l’ont été par le passé, mais ne répondent pas aux principes de l’édition critique moderne. C’est notamment le cas des Mille et une Nuits. [less ▲]

Detailed reference viewed: 36 (6 ULiège)
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See detailLes innombrables formes des Mille et une Nuits : quelques éditions, traditions, traductions... et trahisons
Franssen, Elise ULiege

in La lettre du Réseau. Une Publication du Réseau des médiévistes belges de langue française (RMBLF) (2012), 2

Detailed reference viewed: 67 (3 ULiège)
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See detailInnovAddict: une entreprise « malade » de la créativité
Crutzen, Nathalie ULiege; Moreau, Charlotte ULiege; Pichault, François ULiege

in Chabault, Didier; Hulin, Annabelle; Soparnot, Richard (Eds.) Cas d'innovations en entreprise - Organisation et stratégie (2014)

Etude de cas montrant le management des tensions dans une entreprise créative

Detailed reference viewed: 153 (15 ULiège)
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See detailInnovating for the Public Good: the Rise of Social Entrepreneurs
Defourny, Jacques ULiege

Conference given outside the academic context (2015)

Detailed reference viewed: 27 (4 ULiège)