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See detailA new Barremian (Early Cretaceous) ichthyosaur from western Russia
Fischer, Valentin ULg; Masure, Edwige; Arkhangelsky, Maxim et al

in Journal of Vertebrate Paleontology (2011), 31(5), 1010-1025

A new ophthalmosaurid ichthyosaur, Sveltonectes insolitus gen. et sp. nov., is described from a sub-complete and three-dimensionally preserved specimen from the late Barremian of western Russia. This new ... [more ▼]

A new ophthalmosaurid ichthyosaur, Sveltonectes insolitus gen. et sp. nov., is described from a sub-complete and three-dimensionally preserved specimen from the late Barremian of western Russia. This new taxon is supported by 11 cranial, dental, and postcranial autapomorphies, and is also characterized by features previously considered as autapomorphic for some other Ophthalmosauridae, such as a processus narialis on the prefrontal and relatively long hindfins with pre- and postaxial accessory digits. We conducted a new phylogenetic analysis of Thunnosauria, which supports a ‘Stenopterygius-origin’ for Ophthalmosauridae. Sveltonectes is regarded as the sister taxon of Aegirosaurus, which shares a similar skull roof construction. Contrary to most other Cretaceous ichthyosaurs, Sveltonectes is characterized by delicate and sharply pointed teeth, confirming that the Ophthalmosauridae were ecologically highly diversified during the Early Cretaceous [less ▲]

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See detailNew Basic Membrane-Destabilizing Peptides For Plasmid-Based Gene Delivery In Vitro And In Vivo
Rittner, K.; Benavente, A.; Bompard-Sorlet, A. et al

in Molecular Therapy (2002), 5(2), 104-14

We have designed new basic amphiphilic peptides, ppTG1 and ppTG20 (20 amino acids), and evaluated their efficiencies in vitro and in vivo as single-component gene transfer vectors. ppTG1 and ppTG20 bind ... [more ▼]

We have designed new basic amphiphilic peptides, ppTG1 and ppTG20 (20 amino acids), and evaluated their efficiencies in vitro and in vivo as single-component gene transfer vectors. ppTG1 and ppTG20 bind to nucleic acids and destabilize liposomes consisting of 1-palmitoyl-2-oleoylphosphatidylcholine (POPC) and cholesterol (3:1 mol/mol) at pH 5 and pH 7. Complexes of plasmid DNA and ppTG1 gave rise to efficient transfection in a variety of human and murine cell lines at low charge ratios ([+/-] between 1 and 2). In cell culture experiments, such vectors were superior to the membrane-destabilizing peptide KALA. In comparison with cationic lipid-, dendrimer-, and polymer-based transfection agents like Superfect, polyethylenimine (PEI), and Lipofectin, ppTG1 vectors showed good transfection efficiencies, especially at low DNA doses. Moreover, we demonstrated for the first time successful gene transfer in living animals with a single-component peptide vector. In the mouse, intravenous injection of a luciferase expression plasmid complexed with ppTG1 or ppTG20 led to significant gene expression in the lung 24 hours after injection. Structure-function studies with ppTG1, ppTG20, and sequence variants suggest that the high gene transfer activity of these peptides is correlated with their propensity to exist in alpha-helical conformation, which seems to be strongly influenced by the nature of the hydrophobic amino acids. [less ▲]

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See detailA new benzotriazole-mediated stereoflexible gateway to hetero-2,5-diketopiperazines
Monbaliu, Jean-Christophe ULg; Hansen, Finn; Beagle, Lucas et al

in Chemistry : A European Journal (2011), 18

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See detailNew Biological Investigations on 3-Bromophenyl 6-Acetoxymethyl-2-oxo-2H-1-Benzopyran-3-Carboxylate as Anti-angiogenic Agent
Hemmer, M.; Kempen, Isabelle; De Tullio, Pascal ULg et al

in Drug Development Research (2010), 71

The development of blood vessels inside tumors is required to provide the nutrients and oxygen needed for tumor growth and to allow the spread of cancer cells at a distance to form metastasis ... [more ▼]

The development of blood vessels inside tumors is required to provide the nutrients and oxygen needed for tumor growth and to allow the spread of cancer cells at a distance to form metastasis. Angiogenesis is also implicated in ocular diseases like age-related macular degeneration. The present work describes the potential anti-angiogenic properties of a coumarinic derivative, 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate (IK9), previously described as a potent inhibitor of HT 1080 fibrosarcoma cell invasion in vitro and tumor growth in vivo. In vivo, ex vivo, and in vitro models were used to delineate the anti-angiogenic properties of IK9. The anti-angiogenic effect of IK9 was demonstrated in vivo in a choroidal neovascularization mice model and additionally ex vivo in a rat aortic ring assay where it was more active than the known matrix metalloproteinase inhibitor Ro 28-2653. IK9 did not affect apoptosis, proliferation, or endothelial cell invasiveness in vitro. These findings suggest a complex mechanism of action of the compound via direct or indirect effects on endothelial cell properties. This study identifies IK9 as a new potent inhibitor of angiogenesis and suggests its potential use as a therapeutic agent. [less ▲]

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See detailNew biomarkers of Crohn's disease: serum biomarkers and development of diagnostic tools
Meuwis, Marie-Alice ULg; Fillet, Marianne ULg; Chapelle, Jean-Paul ULg et al

in Expert Review of Molecular Diagnostics (2008), 8

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See detailNew bisphosphonates for the treatment of osteoporosis : concerns and hopes
Reginster, Jean-Yves ULg

in Revue du Rhumatisme (English ed.) (1996), 63(7-8), 461-464

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See detailNew bounds on trilinear R-parity violation from lepton flavor violating observables
Dreiner, H. K.; Nickel, K.; Staub, F. et al

in Physical Review. D, Particles, Fields, Gravitation, and Cosmology (2012), 86

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See detailNew C++ version of the Liège intranuclear cascade model in Geant4
Mancusi, D.; Boudard, A.; Cugnon, Joseph ULg et al

in Proceedings of SNA + MC 2013 - Joint International Conference on Supercomputing in Nuclear Applications + Monte Carlo (2014)

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See detailNew capabilities of the INCL4.6 model implemented into high-energy transport codes
Leray, S.; Boudard, A.; Braunn, B. et al

in Proceedings of Shielding Aspects of Accelerators, Targets and Irradiation Facilities 2011 (2013)

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See detailNew capabilities of the Liège intranuclear-cascade model for particle-transport codes
Mancusi, D.; Boudard, A.; Cugnon, Joseph ULg et al

in Proceedings of SNA + MC 2013 - Joint International Conference on Supercomputing in Nuclear Applications + Monte Carlo (2014)

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See detailNew carbohydrate-active enzymes identified by screening two metagenomic libraries derived from the soil of a winter wheat field
Stroobants, Aurore ULg; Portetelle, Daniel ULg; Vandenbol, Micheline ULg

in Journal of Applied Microbiology (2014)

Aims Soils are rich, diversified environments where β-glucosidases abound because of their importance in organic matter degradation. The aim of this work was to discover new β-glucosidases by constructing ... [more ▼]

Aims Soils are rich, diversified environments where β-glucosidases abound because of their importance in organic matter degradation. The aim of this work was to discover new β-glucosidases by constructing two metagenomic DNA libraries from soil samples collected in winter and spring from a field of winter wheat. Methods and Results Both libraries were screened on esculin-supplemented medium so as to isolate candidates showing β-glucosidase activity. Candidate analysis revealed seven putative β-glycosidases and two putative glycosyltransferases, displaying 25 to 82% identity to known enzymes. The putative β-glycosidases belong to families GH1, GH3 and GH20 and the two putative glycosyltransferases, probably, to new families. In characterization tests performed on bacteria in suspension or spread on agar plates, some candidates appeared to hydrolyse several natural and synthetic substrates. These tests also highlighted interesting industrial characteristics, such as the activity of four β-glycosidases under alkaline conditions and the esculin-hydrolysing activity of a β-glucosidase candidate in the presence of glucose. Conclusions Seven putative β-glycosidases and two putative glycosyltransferases were found by functional screening of two metagenomic DNA libraries derived from agricultural soil. Significance and Impact of the Study This study has identified β-glycosidases and putative glycosyltransferases that have or may have interesting industrial characteristics. [less ▲]

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See detailA new case of consensual decision: collective movement in earthworms
Zirbes, Lara ULg; Deneubourg, Jean-Louis; Brostaux, Yves ULg et al

in Ethology (2010), 115

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See detailA new case of gravitational lensing
Surdej, Jean ULg; Magain, Pierre ULg; Swings, J.-P. et al

in Nature (1987), 329

The authors have begun a systematic search from ESO for gravitational lens systems in a selected sample of highly luminous quasars; M[SUB]V[/SUB] < -29.0. They give a brief description of their first ... [more ▼]

The authors have begun a systematic search from ESO for gravitational lens systems in a selected sample of highly luminous quasars; M[SUB]V[/SUB] < -29.0. They give a brief description of their first identified gravitational lens system UM673 = Q0142-100 = PHL3703. It consists of two images, A (m[SUB]R[/SUB] = 16.9) and B (m[SUB]R[/SUB] = 19.1), separated by 2.2 arc s at a redshift z[SUB]q[/SUB] = 2.719. The lensing galaxy (m[SUB]R[/SUB] â 19, Z[SUB]L[/SUB] â 0.49) has also been found. It lies very near the line connecting the two QSO images, â ¡0.8 arc s from the fainter one. A value M[SUB]0[/SUB] â 2.4×10[SUP]11[/SUP]M_sun; for the mass of the lensing galaxy and Deltat â 7 weeks for most likely travel-time difference between the two light paths to the QSO are found (assuming H[SUB]0[/SUB] = 75 km s[SUP]-1[/SUP]Mpc[SUP]-1[/SUP], q[SUB]0[/SUB] = 0). [less ▲]

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See detailNew catalysis for fast bulk ring-opening polymerization of lactide monomers
Degée, Philippe; Dubois, Philippe ULg; Jérôme, Robert ULg et al

in Macromolecular Symposia (1999), 144

The ring-opening polymerization of lactides has been studied in bulk using either 2-ethylhexanoic acid tin(II) salt, Sn(Oct)2, or aluminum triisopropoxide, Al(OiPr)3, as the initiator over a wide range of ... [more ▼]

The ring-opening polymerization of lactides has been studied in bulk using either 2-ethylhexanoic acid tin(II) salt, Sn(Oct)2, or aluminum triisopropoxide, Al(OiPr)3, as the initiator over a wide range of temperature and monomer-to-initiator molar ratio, A high increase in the bulk polymerization rate has been observed when the initiator was added with an equimolar amount of a Lewis base, such as triphenylphosphine and 4-picoline (C6H7N) added to Sn(Oct)2 and Al(OiPr)3, respectively Melt stable polylactides of high molecular weight and reasonably narrow molecular weight distribution have been accordingly prepared. The use of the Sn(Oct)2. equimolar combination has allowed for reaching an acceptable balance between propagation and depolymerization rates, so that the polymerization is fast enough to be performed through a continuous single-stage process in a twin-screw extruder A global activation mechanism is proposed and discussed by comparison with both investigated initiation systems. [less ▲]

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See detailA new CCD camera for the Echelec spectrograph.
Gilliotte, A.; Magain, Pierre ULg

in The Messenger (1987), 50

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See detailNEW CHALLENGES FOR 21ST CENTURY COMPETITION AUTHORITIES
Petit, Nicolas ULg

E-print/Working paper (2012)

This paper discusses challenges for competition authorities in the 21st century. Those challenges were identified on the basis of a statistical review of the articles published since January 2011 in five ... [more ▼]

This paper discusses challenges for competition authorities in the 21st century. Those challenges were identified on the basis of a statistical review of the articles published since January 2011 in five major antitrust law journals. The assumption underlying this literature review is that the topics that statistically attract the most the attention from contemporary antitrust scholars are those that will likely constitute the main challenges for 21st century competition authorities. [less ▲]

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See detailNew challenges for feature selection in data mining and knowledge discovery
Saeys, Yvan; Liu, Huan; Inza, Inaki et al

in Journal of Machine Learning Research (2008), 4

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