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See detailMultimodal evaluation of gait and stride dynamics in relapsing and progressive forms of multiple sclerosis
Belachew, Shibeshih ULg; Pierard, Sébastien ULg; PHAN BA, Remy ULg et al

in Proceedings of the Belgian Royal Academies of Medicine (2012), 1

Ambulation measures are being increasingly recognized as highly relevant to the quantification of multiple sclerosis (MS) severity and response to treatment. Feet paths are highly informative for gait ... [more ▼]

Ambulation measures are being increasingly recognized as highly relevant to the quantification of multiple sclerosis (MS) severity and response to treatment. Feet paths are highly informative for gait analysis and we have recently designed a new system, which captures the position of the feet in real time. We use several range laser scanners (RLS) to analyze a horizontal slice of the scene in which each foot is considered as a point, and the vertical movements are ignored. Neat ambulation measures may be easily extracted such as walking speed, distance between feet over time, swing phase duration, and gait asymmetry in specific settings of walking recommendations. Our RLS platform is much cheaper than existing sensor-based and motion capture systems and may be more convenient for the development of multicentric clinical trials settings since patients can be easily and rapidly assessed without tags or sensors in the hallway of an outpatient clinic. We use 4 BEA LZR-i100 RLS arranged in a corridor of at least 10m long and 4m width, devoid of obstacle. The scanned plane is chosen to be located at 15 cm above the floor, which is right above the tibio-tarsal joint of the ankle in a barefoot configuration for adult individuals in stance phase. We expect further studies to validate and empower the meaning of non-intrusive RLS-derived gait measures that should pave the ground for major improvements in the way we will assess the efficacy of disease-modifying treatments (DMTs), physical therapy and symptomatic interventions on walking impairment, ataxia and fatigability in MS. RLS-derived gait measures may also reveal to be crucial in the near future for the development of treatments that would specifically target progressive forms of MS. [less ▲]

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See detailMultimodal neuroimaging in patients with disorders of consciousness showing "functional hemispherectomy".
Bruno, Marie-Aurélie ULg; Fernandez-Espejo, D.; Lehembre, Remy ULg et al

in Progress in Brain Research (2011), 193

Beside behavioral assessment of patients with disorders of consciousness, neuroimaging modalities may offer objective paraclinical markers important for diagnosis and prognosis. They provide information ... [more ▼]

Beside behavioral assessment of patients with disorders of consciousness, neuroimaging modalities may offer objective paraclinical markers important for diagnosis and prognosis. They provide information on the structural location and extent of brain lesions (e.g., morphometric MRI and diffusion tensor imaging (DTI-MRI) assessing structural connectivity) but also their functional impact (e.g., metabolic FDG-PET, hemodynamic fMRI, and EEG measurements obtained in "resting state" conditions). We here illustrate the role of multimodal imaging in severe brain injury, presenting a patient in unresponsive wakefulness syndrome (UWS; i.e., vegetative state, VS) and in a "fluctuating" minimally conscious state (MCS). In both cases, resting state FDG-PET, fMRI, and EEG showed a functionally preserved right hemisphere, while DTI showed underlying differences in structural connectivity highlighting the complementarities of these neuroimaging methods in the study of disorders of consciousness. [less ▲]

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See detailMultimodality blood conservation strategy in cardiac surgery with cardiopulmonary bypass: the CHU of Liege experience
ERPICUM, Marie ULg; BLAFFART, Francine ULg; DEFRAIGNE, Jean ULg et al

Poster (2012, November 20)

This study presents the transfusion rates of cardiac surgery patients and describes the in-house strategy of blood conservation applied in a single centre

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See detailMultimodality blood conservation strategy in cardiac surgery with cardiopulmonary bypass : the CHU of Liège experience
ERPICUM, Marie ULg; BLAFFART, Francine ULg; DEFRAIGNE, Jean ULg et al

Poster (2012, September 29)

Introduction: The aim of this study is to analyze the transfusion rates of cardiac surgery patients in a single centre following an in-house strategy of blood conservation. Methods: The data of all adult ... [more ▼]

Introduction: The aim of this study is to analyze the transfusion rates of cardiac surgery patients in a single centre following an in-house strategy of blood conservation. Methods: The data of all adult patients undergoing normothermic cardiac surgery with cardiopulmonary bypass (CPB) over a 1 year period were retrospectively collected (n=491). Management protocols were described. The transfusion rates of allogeneic blood components were recorded: red blood cells (RBC), fresh frozen plasma (FFP) and platelets (PT), as well as the number of units transfused. The timing of transfusion was categorized: during CPB (peroperative period), within the first 48 postoperative hours after wean out CPB (early postoperative period) and during the hospitalisation from surgery until discharge (hospitalisation). The hematocrit values were recorded during CPB, 10 minutes after wean out CPB, after the first 48 postoperative hours and at discharge from hospital. Results: Two hundred and forty-eight patients (50%) received an allogeneic blood component transfusion during hospitalisation. One hundred and twenty-one patients (25%) received RBC during the operative period; the median of units transfused was 2(1-2).The lowest hematocrit value during CPB was 21(19-24) % in median. A cell salvage device was used in each case: the median volume of washed red blood cells transfused was 678(512-891) mL. The median hematocrit value after CPB was 23(21-25) %. One hundred and sixty-five patients (34%) were transfused in the early postoperative period: 27% received RBC, 18% received FFP and 18% received PT. The median of units transfused was 2(1-3) for RBC, 4(2-6) for FFP and 1(1-2) for PT. The median hematocrit value after 48 hours was 32(29-34) % and 32(30-35) % at discharge. Conclusion: The transfusion rates observed in this series are relatively high compared with the literature. Improvements will be made in our practice and protocols management in order to decrease the need of transfusion. This detailed audit of the transfusion practices in our cardiac surgery centre would be helpful to value the effectiveness of further improvements. [less ▲]

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See detailMultimodality staging of lung cancer
THULKAR; NAMUR, Gauthier ULg; HUSTINX, Roland ULg et al

in PET Clinics (2011), 6

Lung cancer is among the most common and lethal cancers around the world. Most lung cancers are directly attributed to smoking. Common histologic subtypes of lung carcinomas are squamous cell carcinoma ... [more ▼]

Lung cancer is among the most common and lethal cancers around the world. Most lung cancers are directly attributed to smoking. Common histologic subtypes of lung carcinomas are squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. These carcinomas have similar presentations and are primarily treated surgically. Hence, these are usually classified as non-small cell lung carcinoma. Small cell lung carcinoma is an aggressive neuroendocrine tumor with a generally poor prognosis. It usually presents with massive mediastinal lymphadenopathy and widespread metastases at initial diagnosis, and is usually treated with chemotherapy and radiotherapy; surgery has little role.Cough, dyspnea and hemoptysis are the consistent clinical features of most lung cancers. Advances tumors with pleural, chest wall, or mediastinal invasion produce a variety of additional clinical features such as chest pain, brachial plexus neuropathy, Horner syndrome, phrenic or recurrent laryngeal nerve palsy, dysphagia, or superior vena cava syndrome. Sone of the lung cancers are detected as small pulmonary nodules in asymptomatic individuals. [less ▲]

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See detailMultimodular Penicillin-Binding Proteins: An Enigmatic Family of Orthologs and Paralogs
Goffin, Colette ULg; Ghuysen, Jean-Marie ULg

in Microbiology & Molecular Biology Reviews (1998), 62(4), 1079-1093

The monofunctional penicillin-binding DD-peptidases and penicillin-hydrolyzing serine beta-lactamases diverged from a common ancestor by the acquisition of structural changes in the polypeptide chain ... [more ▼]

The monofunctional penicillin-binding DD-peptidases and penicillin-hydrolyzing serine beta-lactamases diverged from a common ancestor by the acquisition of structural changes in the polypeptide chain while retaining the same folding, three-motif amino acid sequence signature, serine-assisted catalytic mechanism, and active-site topology. Fusion events gave rise to multimodular penicillin-binding proteins (PBPs). The acyl serine transferase penicillin-binding (PB) module possesses the three active-site defining motifs of the superfamily; it is linked to the carboxy end of a non-penicillin-binding (n-PB) module through a conserved fusion site; the two modules form a single polypeptide chain which folds on the exterior of the plasma membrane and is anchored by a transmembrane spanner; and the full-size PBPs cluster into two classes, A and B. In the class A PBPs, the n-PB modules are a continuum of diverging sequences; they possess a five-motif amino acid sequence signature, and conserved dicarboxylic amino acid residues are probably elements of the glycosyl transferase catalytic center. The PB modules fall into five subclasses: A1 and A2 in gram-negative bacteria and A3, A4, and A5 in gram-positive bacteria. The full-size class A PBPs combine the required enzymatic activities for peptidoglycan assembly from lipid-transported disaccharide-peptide units and almost certainly prescribe different, PB-module specific traits in peptidoglycan cross-linking. In the class B PBPs, the PB and n-PB modules cluster in a concerted manner. A PB module of subclass B2 or B3 is linked to an n-PB module of subclass B2 or B3 in gram-negative bacteria, and a PB module of subclass B1, B4, or B5 is linked to an n-PB module of subclass B1, B4, or B5 in gram-positive bacteria. Class B PBPs are involved in cell morphogenesis. The three motifs borne by the n-PB modules are probably sites for module-module interaction and the polypeptide stretches which extend between motifs 1 and 2 are sites for protein-protein interaction. The full-size class B PBPs are an assortment of orthologs and paralogs, which prescribe traits as complex as wall expansion and septum formation. PBPs of subclass B1 are unique to gram-positive bacteria. They are not essential, but they represent an important mechanism of resistance to penicillin among the enterococci and staphylococci. Natural evolution and PBP- and beta-lactamase-mediated resistance show that the ability of the catalytic centers to adapt their properties to new situations is limitless. Studies of the reaction pathways by using the methods of quantum chemistry suggest that resistance to penicillin is a road of no return. [less ▲]

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See detailMultinational Compagnies, Social Responsibility and Human Resource Manager
Robert, Jocelyne ULg; Goemans, Adeline; Delhez, Gauthier

Conference (2014, July 16)

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See detailLes multinationales de l’information face à l’État : l'exemple des agences de presse anglo-saxonnes
Geuens, Geoffrey ULg

Conference given outside the academic context (2003)

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See detailMultinationales et droit de la propriété intellectuelle – Le cas des savoirs traditionnels
Neyrinck, Norman ULg

in Brüls, Christine (Ed.) Les Multinationales (2012)

The present contribution provides an overview of various issues susceptible to arise in the international management of intellectual property right. Chapter I deals with patents and describes, on the one ... [more ▼]

The present contribution provides an overview of various issues susceptible to arise in the international management of intellectual property right. Chapter I deals with patents and describes, on the one hand, a variety of legal options (novelty, exhaustivity, mandatory licensing, ...) that States can take to influence the management of patent portfolios abroad and, on the other hand, the forum shopping strategies that multinationals may implement to take advantage from the rules that favor them most. Chapter II deals with traditional knowledge issues and lists the various methods of protection – whether defensive or offensive – that States may implement to prevent free exploitation of traditional knowledge abroad. Sui generis regimes, trade secrecy, unjust enrichment and extra contractual liability are discussed. Various examples are given. [less ▲]

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See detailMULTIOBJECTIVE DESIGN OF CONTROL CHARTS
Faraz, Alireza ULg; Heuchenne, Cédric ULg

in International Conference on Applied Statistics 2011 : Ljubljana 24-29 September 2011 (2011, September 24)

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See detailMultiobjective Genetic Algorithm Approach to the Economic Statistical Design of Control Charts with an application to Xbar and S2 charts
Faraz, Alireza ULg; Saniga, Erwin

in Quality and Reliability Engineering International (2013), 29(3), 407-415

Control charts are the primary tools of statistical process control. These charts may be designed by using a simple rule suggested by Shewhart, by a statistical criterion, an economic criterion or a joint ... [more ▼]

Control charts are the primary tools of statistical process control. These charts may be designed by using a simple rule suggested by Shewhart, by a statistical criterion, an economic criterion or a joint economic-statistical criterion. Each method has its strengths and weaknesses. One weakness of the methods of design listed above is their lack of flexibility and adaptability, a primary objective of practical mathematical models. In this paper, we explore multi objective models as an alternative for the methods listed above. These provide a set of optimal solutions rather than a single optimal solution and thus allow the user to tailor their solution to the temporal imperative of a specific industrial situation. We present a solution to a well known industrial problem and compare optimal multi objective designs to economic designs, statistical designs, economic statistical designs and heuristic designs. [less ▲]

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See detailMultiparametric observation and analysis of the Sea
Alvera Azcarate, Aïda ULg; Poulain, Pierre-Marie

in Ocean Dynamics (2011)

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See detailMultiparametric observations and analysis in the Bay of Calvi (Corsica), an ideal site for studying the human activity effects and climate changes in the Mediterranean Sea; STARESO
Gobert, Sylvie ULg; Alvera Azcarate, Aïda ULg; Barth, Alexander ULg et al

Conference (2010, May)

STARESO (Station de REcherche Sous marine et Océanographique) is the marine and oceanographic research station of the University of Liège (Belgium) managed by the French company STARESO S.A.. Constructed ... [more ▼]

STARESO (Station de REcherche Sous marine et Océanographique) is the marine and oceanographic research station of the University of Liège (Belgium) managed by the French company STARESO S.A.. Constructed in 1969, it is located near Calvi (Corsica, Western Mediterranean Sea) in an oligotrophic area chosen for the exceptional quality of its coastal waters STARESO offers to the oceanographers, by diving or with boats, a direct access to the sea. The variety of the accessible ecosystems is remarkable and unique in the Mediterranean basin: -the Bay of Calvi is characterized by healthy and very diverse biocenosis (e.g. Posidonia meadows, rocky and sandy communities, -a steep submarine canyon, with depths greater than 1 000 meters, is accessible in 15 minutes of navigation; -the Liguro-Provençal front, a major hydrologic structure, is situated between 10 and 15 miles of the coast. STARESO is accessible all the year for everybody and is functioning like an oceanographic research vessel. The Station is a platform for all oceanographic disciplines with a scientific expertise widely based on a long tradition of interdisciplinary work, and a direct access to time series of physical, chemical and biological data registered with automated systems and variety of sensors deployed in the Bay of Calvi since 30 years. This platform provides the opportunity to reach coastal, pelagic, benthic, deep systems with a manageable cost and ship requirements in a pristine zone. [less ▲]

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See detailMultipartite entanglement criterion from uncertainty relations
Gillet, Jérémie ULg; Bastin, Thierry ULg; Agarwal, G. S.

Poster (2009)

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See detailMultipartite entanglement criterion from uncertainty relations
Gillet, Jérémie ULg; Bastin, Thierry ULg; Agarwal, G. S.

in Physical Review. A (2008), 78

We formulate an entanglement criterion using Peres-Horodecki positive partial transpose operations combined with the Schrödinger-Robertson uncertainty relation. We show that any pure entangled bipartite ... [more ▼]

We formulate an entanglement criterion using Peres-Horodecki positive partial transpose operations combined with the Schrödinger-Robertson uncertainty relation. We show that any pure entangled bipartite and tripartite state can be detected by experimentally measuring mean values and variances of specific observables. Those observables must satisfy a specific condition in order to be used, and we show their general form in the 2 x 2 (two qubits) dimension case. The criterion is applied on a variety of physical systems including bipartite and multipartite mixed states and reveals itself to be stronger than the Bell inequalities and other criteria. The criterion also work on continuous variable cat states and angular momentum states of the radiation field. [less ▲]

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See detailMultipartite-entanglement monotones and polynomial invariants
Eltschka, Christopher; Bastin, Thierry ULg; Osterloh, Andreas et al

in Physical Review. A (2012), 85

We show that a positive homogeneous function that is invariant under determinant 1 stochastic local operations and classical communication (SLOCC) transformations defines an N-qubit entanglement monotone ... [more ▼]

We show that a positive homogeneous function that is invariant under determinant 1 stochastic local operations and classical communication (SLOCC) transformations defines an N-qubit entanglement monotone if and only if the homogeneous degree is not larger than four. We then describe a common basis and formalism for the N-tangle and other known invariant polynomials of degree four. This allows us to elucidate the relation of the four-qubit invariants defined by Luque and Thibon [Phys. Rev. A 67, 042303 (2003)] and the reduced two-qubit density matrices of the states under consideration, thus giving a physical interpretation for those invariants. We demonstrate that this is a special case of a completely general law that holds for any multipartite system with bipartitions of equal dimension, e.g., for an even number of qudits. [less ▲]

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See detailMultiperiod vehicle loading optimization with stochastic supply
Amand, Guillaume ULg; Arda, Yasemin ULg; Crama, Yves ULg et al

Scientific conference (2011, April 07)

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See detailMultiperiod vehicle loading with stochastic release dates
Pironet, Thierry ULg

Conference (2013, February 08)

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See detailMultiperiod vehicle loading with stochastic release dates
Arda, Yasemin ULg; Crama, Yves ULg; Kronus, David ULg et al

Conference (2012, May 24)

Production scheduling and vehicle routing problems are well-known topics in operations management. Although these tasks are consecutive in the supply chain, few optimization models tackle the associated ... [more ▼]

Production scheduling and vehicle routing problems are well-known topics in operations management. Although these tasks are consecutive in the supply chain, few optimization models tackle the associated issues. A most common situation, in practice, is actually that transportation management is disconnected from production planning: when production items or batches have been completely processed by the manufacturing plant, they become available for shipping, and they are consequently handled by the transportation managers. From a global managerial perspective, and with a view towards coordination of the product flows and customer satisfaction, this is not an ideal process. It is by far preferable, indeed, to set up an integrated production-transportation plan taking into account, among other constraints, the capacity of the plants and the customer due-dates. The present research proposes a methodology to investigate a multi-period vehicle loading problem with deterministic or stochastic information concerning items arrivals from production. Results from related optimization techniques are statistically compared and the benefits of the multi-period and stochastic modeling is demonstrated. Finally, an efficient heuristic is highlighted and is shown to be robust to the deviation from item arrival forecasts. [less ▲]

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