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See detailOptimization of the encapsulation of Thrombin Receptor Agonist Peptide in PLGA microbeads
Stashevskaya, K; Grandfils, Christian ULg; Markvicheva, E et al

Conference (2004, September 24)

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See detailOptimization of the encapsulation of Thrombin Receptor Agonist Peptide in PLGA microbeads
Stashevskaya, Kira; Grandfils, Christian ULg; Markvicheva, E. et al

Conference (2004, March 04)

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See detailOptimization of the expression of heterologous P450 hydroperoxide lyase in Escherichia coli
Delcarte, J.; Jacques, P.; Fauconnier, Marie-Laure ULg et al

Poster (2001, September 11)

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See detailOptimization of the formation of vinyldithiins, a therapeutic compound from garlic
DETHIER, Bérénice ULg; Hanon, Emilien; Fauconnier, Marie-Laure ULg

in Pulkrabova, Jana; Tomaniova, Monika; Godulova, Vanda (Eds.) et al Chemical reactions in food: book of abstracts (2012, November 14)

Garlic has been used worldwide for centuries for its taste, but also for its health benefits. The therapeutic compounds are mostly organosulfurs, and can be formed when an enzyme, alliinase, gets in ... [more ▼]

Garlic has been used worldwide for centuries for its taste, but also for its health benefits. The therapeutic compounds are mostly organosulfurs, and can be formed when an enzyme, alliinase, gets in contact with its substrate, alliin. Both are separated in an entire cell, and react when the plant is damaged. The product of the enzymatic reaction, allicin, turns quickly into different molecules with potential beneficial effects. The way garlic is processed has a major influence on the released products. Indeed, an aqueous or oily medium, as far as the temperature, can emphasize the formation of specific compounds. Vinyldithiins are one of the active molecules, and are part of the garlic’s organoleptic properties. Their effects against obesity have been recently proven. This study aims to describe the conditions of vinyldithiins formation, as well as its extraction, purification and analyse. Vinyldithiins are mostly produced when garlic is crushed in edible oil, at low temperature. Extraction conditions (garlic/oil ratio, oil and garlic source, temperature and extraction time) were optimized. Analysis of the results were performed by HPLC.Finally, a purification process was set up. These results allow better knowledges on vinyldithiins formation that can be applied in garlic-based nutraceuticals. They might also lead to new uses of garlic in the production of highly valuable compounds. [less ▲]

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See detailOptimization of the formation of vinyldithiins, therapeutic compounds from garlic
DETHIER, Bérénice ULg; Hanon, Emilien; Maayoufi, Said et al

in European Food Research & Technology (2013), 237(1), 83-88

Allyl sulfides, ajoenes and vinyldithiins are the three main groups of volatile organosulfur compounds that are formed when garlic is crushed. The manner garlic is processed (nature of the extraction ... [more ▼]

Allyl sulfides, ajoenes and vinyldithiins are the three main groups of volatile organosulfur compounds that are formed when garlic is crushed. The manner garlic is processed (nature of the extraction medium, temperature…) has a major influence on their relative proportion and the amounts produced. It has been proven recently that the vinyldithiins are at the origin of garlic’s capacity to prevent adipocytes development. Their incorporation in garlic-based nutraceuticals is thus particularly interesting. In this context, this work aims to optimize the production of vinyldithiins from garlic. After having determined the best garlic origin (Spanish) and the best oil for the extraction (olive or sunflower oil), the extraction conditions were optimized (1/2 (w/w garlic oil), 37 °C, 6 h) and 133 mg of vinyldithiins was obtained from 100 g of fresh garlic. Carrying out the extraction under microwave irradiation allowed increasing the yield 3.6-fold (yield 486 mg of vinyldithiins from 100 g of fresh garlic). This study may also contribute to the development of new garlic derived high value products by enhancing the comprehension of their formation. [less ▲]

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See detailOptimization of the formulation and post-treatment of stainless steel for rapid manufacturing
Vaneetveld, Grégory ULg; Clarinval, A. M.; Dormal, T. et al

in Journal of Materials Processing Technology (2008), 196(1-3), 160-164

Rapid prototyping process called Optoform shapes functional parts from a photocurable paste. This paste contains metal powder, resin, UV photoinitiator and wetting agent. After processing on the Optoform ... [more ▼]

Rapid prototyping process called Optoform shapes functional parts from a photocurable paste. This paste contains metal powder, resin, UV photoinitiator and wetting agent. After processing on the Optoform machine, a post-treatment is applied (debinding+sintering). During the post-treatment, the residual carbon coming from the resin modifies the composition of the metal and its melting point. This modification affects densification mechanisms, which leads to a residual porosity that lowers mechanical characteristics. We will present theoretical consideration leading to the optimization of the formulation. To improve the process, bimodal powder is used and thermal treatment is adapted. (c) 2007 Elsevier B.V. All rights reserved. [less ▲]

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See detailOptimization of the LC enantioseparation of chiral pharmaceuticals using cellulose tris(4-chloro-3-methylphenylcarbamate) as chiral selector and polar non-aqueous mobile phases
Dossou, Katina Sourou Sylvestre ULg; Chiap, Patrice ULg; Chankvetadze, Bezhan et al

in Journal of Separation Science (2010), 33

The resolving power of a new commercial polysaccharide-based chiral stationary phase, Sepapak-4, with cellulose tris(4-chloro-3-methylphenylcarbamate) coated on silica microparticles as chiral selector ... [more ▼]

The resolving power of a new commercial polysaccharide-based chiral stationary phase, Sepapak-4, with cellulose tris(4-chloro-3-methylphenylcarbamate) coated on silica microparticles as chiral selector, was evaluated toward the enantioseparation of ten basic drugs with widely different structures and hydrophobic properties, using ACN as the main component of the mobile phase. A multivariate approach (experimental design) was used to screen the factors (temperature, n-hexane content, acidic and basic additives) likely to influence enantioresolution. Then, the optimization was performed using a face-centered central composite design. Complete enantioseparation could be obtained for almost all tested chiral compounds, demonstrating the high chiral discrimination ability of this chiral stationary phase using polar organic mobile phases made up of ACN and containing an acidic additive (TFA or formic acid), 0.1% diethylamine and n-hexane. These results clearly illustrate the key role of the nature of the acidic additive in the mobile phase. [less ▲]

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See detailOptimization of the liquid chromatography enantioseparation of chiral acidic compounds using cellulose tris(3-chloro-4-methylphenylcarbamate) as chiral selector and polar organic mobile phases.
Dossou, K. S. S.; Farcas, Elena ULg; Servais, Anne-Catherine ULg et al

in Journal of Chromatography. A (2012), 1234

The LC enantioseparation of chiral acidic and zwitterionic drugs selected as model compounds was optimized using chlorine containing cellulose based chiral stationary phases and polar organic mobile ... [more ▼]

The LC enantioseparation of chiral acidic and zwitterionic drugs selected as model compounds was optimized using chlorine containing cellulose based chiral stationary phases and polar organic mobile phases. The main solvent of the mobile phase was acetonitrile, the temperature was settled at 25 degrees C and a stationary phase with cellulose tris(3-chloro-4-methylphenylcarbamate) as chiral selector (3-Cl-4-Me-PC) was selected. In the screening step, the nature and concentration of both acidic and basic additives were found to have a significant effect on retention, selectivity and resolution. Acetic acid (AcA) was selected as acidic additive for the optimization step since it could lead to the enantioseparation of more acidic compounds than trifluoroacetic acid (TFA) and formic acid (FA), while among the three basic additives tested, diethylamine (DEA) most often gave better results with respect to enantioresolution and selectivity than butylamine (BuA) and triethylamine (TEA). The optimization was performed using a central composite face-centered design with two factors, namely the concentration of acetic acid (0.1-0.3%) and the concentration of DEA (0.01-0.1%) in the mobile phase. On the basis of the results obtained in the screening and optimization steps, a strategy for the rapid development of methods for the enantioseparation of acidic or neutral compounds was proposed. [less ▲]

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See detailOptimization of the operating conditions of an existing biomass CHP plant with respect to pollutants levels
Sartor, Kevin ULg; Restivo, Yannick ULg; Ngendakumana, Philippe ULg et al

in Proceedings of 21st Biomass Conference and Exhibition (2013, June 03)

While small and medium size biomass combined heat and power plants (i.e., up to 5 MW of electrical rated power) represent an attractive option to exploit locally available biomass resources at low cost ... [more ▼]

While small and medium size biomass combined heat and power plants (i.e., up to 5 MW of electrical rated power) represent an attractive option to exploit locally available biomass resources at low cost, the corresponding investment per unit of rated power significantly rises when the installed power decreases. In these cases, secondary pollutant emissions control measures are most of the time not economically viable and primary emissions control must be used alone to avoid the formation of undesired compounds such as $NO_x$ and $SO_x$. Primary control measures require the careful optimization of fuel quality and combustion process. For plant operators, being able to accommodate biomass quality changes in order to minimize the fuel cost can be of great importance in order to guarantee the profitability of the plant. This contribution is dedicated to the development of zero-dimensional (input-output) combustion simulation model able to predict the pollutants emissions resulting from complete and incomplete combustion with respect to varying combustion operation (ambient temperature, humidity, fumes recirculation,..). This tool is intended to be integrated in global simulation model of the CHP plant and the attached district heating network installed on the University campus in Liège. Doing so, the plant operation can be optimized with respect to economic as well as environmental and energetic aspects (3E approach) thus ensuring the sustainability of the approach. [less ▲]

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See detailOptimization of the PML in the Discrete Context for Wave-Like Problems
Modave, Axel ULg; Delhez, Eric ULg; Geuzaine, Christophe ULg

Conference (2011, July 18)

The Perfectly Matched Layer (PML) is widely used for unbounded problems. However its performances depend critically on both an absorption coefficient and the numerical method. The coefficient is generally ... [more ▼]

The Perfectly Matched Layer (PML) is widely used for unbounded problems. However its performances depend critically on both an absorption coefficient and the numerical method. The coefficient is generally tuned by using optimization procedures. In this talk we will present some efficient profiles of the coefficient that overcome every tuning in discrete contexts. These profiles and others will be compared by using benchmarks with different numerical methods. [less ▲]

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See detailOptimization of the Production of the Amyloidogenic Variants of Human Lysozyme
Menzer, Linda ULg; Tocquin, Pierre ULg; Dony, Nicolas et al

Poster (2008, February 16)

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See detailOptimization of the separation of beta-blockers by ion-pair capillary electrophoresis in non-aqueous media using univariate and multivariate approaches
Servais, Anne-Catherine ULg; Fillet, Marianne ULg; Chiap, Patrice ULg et al

in Journal of Separation Science (2002), 25(15-17), 1087-1095

The separation of four beta-blocking drug substances (atenolol, sotalol, betaxolol, and metoprolol) selected as model basic analytes has been investigated in non-aqueous capillary electrophoresis (NACE ... [more ▼]

The separation of four beta-blocking drug substances (atenolol, sotalol, betaxolol, and metoprolol) selected as model basic analytes has been investigated in non-aqueous capillary electrophoresis (NACE) using the principle of ion-pair formation. Camphorsulphonate was selected as the counter-ion in a background electrolyte (BGE) made up of formate buffer in a mixture of acetonitrile/methanol or acetonitrile/ethanol. The influence on resolution of the concentration of the counter-ion, the nature and proportion of the organic solvents, as well as the concentration of the ionic components of the BGE was first studied by a univariate approach. An experimental design was then applied to estimate possible quadratic effects and first-order interactions. To identify the most important factors affecting the separation of the four beta-blockers, a two-level fractional factorial design with 16 experimental points was applied as a screening test. A three factor Box-Behnken design with 12 experimental points was used to predict and optimize the selectivity. Finally the optimal conditions obtained by the univariate and the multivariate, approaches were compared. [less ▲]

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See detailOptimization of the service start time for an elementary shortest path problem with time windows
Arda, Yasemin ULg; Crama, Yves ULg; Kucukaydin, Hande ULg

E-print/Working paper (2014)

We investigate an elementary shortest path problem with resource constraints where a single capacitated vehicle, initially located at a depot, must serve a set of customers while respecting their ... [more ▼]

We investigate an elementary shortest path problem with resource constraints where a single capacitated vehicle, initially located at a depot, must serve a set of customers while respecting their individual time windows. When the vehicle visits a customer, it delivers the customer's demand and collects a revenue in return for the delivery. The vehicle can start its trip at any desired time. The transportation cost is a function of both the total distance traveled and the duration of the assigned trip. The objective is to determine the service start time from the depot, the subset of customers to be served, and the trip to be performed so as to minimize the total loss, which is calculated as the di erence between the transportation cost and the revenue collected from the customers. We develop two exact dynamic programming algorithms which can deal with an in nite number of Pareto-optimal states arising from the fact that the starting time and the duration of the trip act like continuous decision variables. We report computational results obtained with these algorithms and with a faster heuristic for the elementary shortest path problem. We also examine the performance of these algorithms when they are used to solve the pricing subproblem arising in the framework of a column generation algorithm for a related vehicle routing problem with time windows. [less ▲]

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See detailOptimization of thermal material in a flux pump system with high temperature superconductor
Hsu, C. H.; Yan, Y; Hadeler, O. et al

in IEEE Transactions on Applied Superconductivity (2012), 22(3), 7800404

Superconductors are known for the ability to trap magnetic field. A thermally actuated magnetization (TAM) flux pump is a system that utilizes the thermal material to generate multiple small magnetic ... [more ▼]

Superconductors are known for the ability to trap magnetic field. A thermally actuated magnetization (TAM) flux pump is a system that utilizes the thermal material to generate multiple small magnetic pulses resulting in a high magnetization accumulated in the superconductor. Ferrites are a good thermal material candidate for the future TAM flux pumps because the relative permeability of ferrite changes significantly with temperature, particularly around the Curie temperature. Several soft ferrites have been specially synthesized to reduce the cost and improve the efficiency of the TAM flux pump. Various ferrite compositions have been tested under a temperature variation ranging from 77K to 300K. The experimental results of the synthesized soft ferrites-Cu0.3Zn0.7Ti0.04Fe1.96O4, including the Curie temperature, magnetic relative permeability and the volume magnetization (emu/cm3), are presented in this paper. The results are compared with original thermal material, gadolinium, used in the TAM flux pump system.-Cu0.3Zn0.7Ti0.04Fe1.96O4 holds superior characteristics and is believed to be a suitable material for next generation TAM flux pump. © 2011 IEEE. [less ▲]

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See detailOptimization of Yarrowia lipolytica beta-oxidation pathway for lactones production
Waché, Y.; Aguedo, Mario ULg; Nicaud, J.M. et al

Poster (2001, September)

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See detailOptimization of Yarrowia lipolytica's β-oxidation pathway for γ-decalactone production
Waché, Y.; Aguedo, Mario ULg; LeDall, M.-T. et al

in Journal of Molecular Catalysis B : Enzymatic (2002), 19-20

The yeast Yarrowia lipolytica growing on methyl ricinoleate produces various lactones, γ-decalactone, the worthy aroma compound, 3-hydroxy-γ-decalactone without sensorial properties and two decenolides of ... [more ▼]

The yeast Yarrowia lipolytica growing on methyl ricinoleate produces various lactones, γ-decalactone, the worthy aroma compound, 3-hydroxy-γ-decalactone without sensorial properties and two decenolides of various interest. Unfortunately, these three latter lactones are produced at high levels by this yeast, decreasing yields and complicating the extraction of γ-decalactone. In this study, the production of γ-decalactone was increased through a genetic engineering of the strain and the accumulation of the three other lactones was lowered. Theses results show that it is possible to improve the mastering of the complex β-oxidation pathway (the metabolic pathway involved in these bioconversions) by playing on genetic factors. © 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailOptimization on manifolds : methods and applications
Absil, P.-A.; Mahony, R.; Sepulchre, Rodolphe ULg

in Recent Advances in Optimization and its Applications in Engineering (2010)

Summary. This paper provides an introduction to the topic of optimization on manifolds. The approach taken uses the language of differential geometry, however, we choose to emphasise the intuition of the ... [more ▼]

Summary. This paper provides an introduction to the topic of optimization on manifolds. The approach taken uses the language of differential geometry, however, we choose to emphasise the intuition of the concepts and the structures that are important in generating practical numerical algorithms rather than the technical details of the formulation. There are a number of algorithms that can be applied to solve such problems and we discuss the steepest descent and Newton’s method in some detail as well as referencing the more important of the other approaches. There are a wide range of potential applications that we are aware of, and we briefly discuss these applications, as well as explaining one or two in more detail. [less ▲]

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See detailOptimization or Rolling and Floating Lock Gates
Rigo, Philippe ULg; Pircalabu, Eugen ULg; Amrane, Amirouche ULg et al

in PIANC'08 (2008, June)

This paper presents a methodology to minimize the weight of the gate by optimizing simultaneously the height of the floating tanks, the number of their watertight partitions and the gate scantling while ... [more ▼]

This paper presents a methodology to minimize the weight of the gate by optimizing simultaneously the height of the floating tanks, the number of their watertight partitions and the gate scantling while considering the floating stability (Richir et al. 2006) The rolling gate, considered for this lock, has to float to be led into the port for maintenance or repairing operations. Two partitioned floating tanks are used inside the gate. Water ballast can be pumped from the floating tanks to float the structure or to restore the mass equilibrium in case of damage due to boat impact. [less ▲]

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See detailOptimization software : View from Europe
Duysinx, Pierre ULg; Fleury, Claude ULg

in KAMAT, M. P. (Ed.) Structural Optimization Status and Promise (1992)

Detailed reference viewed: 24 (4 ULg)