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See detailLD-based haplotype encoding scheme with iterative pruning principal component analysis (ipPCA) to retrieve population substructures
Chaichoompu, Kridsadakorn ULg; Fouladi, Ramouna ULg; Wangkumhang, Pongsakorn et al

Poster (2014, April 29)

Objective To identify and differentiate between subpopulations using a rich set of genetic markers, as using reduced sets of genetic markers for these purposes can become challenging, especially when ... [more ▼]

Objective To identify and differentiate between subpopulations using a rich set of genetic markers, as using reduced sets of genetic markers for these purposes can become challenging, especially when similar geographic regions are involved or when spurious patterns are likely to exist. Method Single Nucleotide Polymorphisms (SNPs) are commonly used to capture variations between populations and often genome-wide SNP data are pruned based on linkage disequilibrium (LD) patterns. Notably, haplotype composition and the pattern of LD between markers may vary between larger populations but may also play a role within more confined geographic regions. Indeed, knowledge about haplotypes in unrelated individuals can reveal useful information about genetic ancestry. Here, we use iterative pruning principal component analysis (ipPCA) [1] to identify and characterize subpopulations in an unsupervised way. As input data, either pruned genome-wide SNP data are used (using PLINK 1.9 with the "indep-pairwise" option, window size = 100k, r2 < 0.25) or multilocus haplotype information derived from the genome-wide SNP panel (using BEAGLE 3.3.2 to infer haplotype). These approaches are applied to real-life data from 992 Thai individuals [2]. Result Preliminary results indicate that ipPCA applied to pruned SNP data or ipPCA that explicitly uses multilocus information (haplotypes) give complementary information about population substructure for geographically confined populations such as the Thai samples in this study. Both methods address different aspects of population structure. Detailed simulation studies are needed to identify the optimal scenarios for haplotype-based ipPCA. Conclusion In this work, we propose to combine an LD-based haplotype encoding scheme with the ipPCA machinery to retrieve fine population substructures. Despite the complexities that are associated with haplotype inference, added value can be obtained when the LD structure between SNPs is exploited in the search for relevant population strata. References 1. Intarapanich, A., et al., Iterative pruning PCA improves resolution of highly structured populations. BMC Bioinformatics, 2009. 10: p. 382. 2. Wangkumhang, P., et al., Insight into the peopling of Mainland Southeast Asia from Thai population genetic structure. PLoS One, 2013. 8(11): p. e79522. [less ▲]

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See detailLDSO: A program to simulate pedigrees and molecular information under various evolutionary forces
Ytournel, F.; Teyssèdre, S.; Roldan, D. et al

in Journal of Animal Breeding & Genetics (2012), 129(5), 417-421

Simulations are a major tool to evaluate new statistical methods and optimize experimental designs in the genomic era. However, this can only be achieved when the simulations are close enough to reality ... [more ▼]

Simulations are a major tool to evaluate new statistical methods and optimize experimental designs in the genomic era. However, this can only be achieved when the simulations are close enough to reality, as well as diverse enough to be realistic. For mapping studies, it is thus critical to re-create as much as possible the forces generating linkage (mutation, random drift, changes in population sizes, selection and pedigree structure) and the mechanisms producing trait genetic architecture (additivity, dominance, epistasis). We present here a computer program (ldso) simulating these phenomena. Optional outputs provide statistics on the linkage disequilibrium (LD) structure and the identity by descent between chromosomal segments, facilitating further data analyses. Furthermore, ldso enables the simulation of genomic data in known pedigrees, which sticks as precisely as possible to recent population history and structures of the long-range LD, allowing optimization of fine-mapping strategies. © 2012 Blackwell Verlag GmbH. [less ▲]

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See detailLe _Syntactic Reference Corpus of Medieval French_: Structure, outils et exploitation
Mazziotta, Nicolas ULg

in Dister, Anne; Longrée, Dominique; Purnelle, Gérald (Eds.) 11es Journées internationales d'Analyse statistique des Données Textuelles (JADT) (2012)

Detailed reference viewed: 19 (0 ULg)
See detailLe bail et la pratique notariale : récents développements
Kohl, Benoît ULg

Scientific conference (2009, February)

Detailed reference viewed: 92 (2 ULg)
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See detailLe balbuzard pêcheur: histoire d'une sauvegarde
de Bellefroid, Marie-des-Neiges; Berny, Philippe; Corallo, Christian et al

Book published by Catiche productions (2013)

Ce grand rapace ayant frôlé l'extinction, le balbuzard voit ses effectifs se reconstituer progressivement grâce à des actions de protection de ses habitats mais aussi un programme d'études scientifiques ... [more ▼]

Ce grand rapace ayant frôlé l'extinction, le balbuzard voit ses effectifs se reconstituer progressivement grâce à des actions de protection de ses habitats mais aussi un programme d'études scientifiques: baguage, suivi des couples nicheurs, alimentation... [less ▲]

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See detailLe Bio entre qualité spécifique et qualité différenciée
Stassart, Pierre M ULg

Conference (2002)

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See detailLe bloc officiel et résidentiel: phase 1
Van der Stede, Véronique ULg

in Lebeau, Marc; Suleiman, Antoine (Eds.) Tell Beydar, Five Seasons of Excavations (1995-1999), A Preliminary Report (2003)

 Cet article est consacré au palais mis au jour à Tell Beydar, une cité-état du 3e millénaire av. n. è. localisée dans le nord-est de la Syrie. Le lecteur y trouvera une description détaillée du bâtiment ... [more ▼]

 Cet article est consacré au palais mis au jour à Tell Beydar, une cité-état du 3e millénaire av. n. è. localisée dans le nord-est de la Syrie. Le lecteur y trouvera une description détaillée du bâtiment, une analyse du système de circulation ainsi qu’une évaluation des possibilités d’éclairage de l’édifice et de celles de restitution d’un étage. Il se termine par une analyse fonctionnelle des pièces et replace le bâtiment dans le contexte de l’architecture palatiale du Bronze ancien. [less ▲]

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See detailLe Brésil et ses ambitions séculaires au statut de puissance
Santander, Sébastian ULg

Scientific conference (2010, April 30)

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See detailLe caillou de Spinoza (à propos de Médias et Censure)
Durand, Pascal ULg

Article for general public (2004)

Detailed reference viewed: 183 (6 ULg)
See detailLe calcaire
Gerrienne, Philippe ULg

in Environnement (1988), 5/88

Detailed reference viewed: 12 (0 ULg)
See detailLe Calendrier et son Histoire
Biémont, Emile ULg

in Bulletin de la Classe des Sciences. Académie Royale de Belgique (1996), 6e série(VII), 15-71

Detailed reference viewed: 16 (3 ULg)
See detailLe Cambro-Ordovicien du Massif de Stavelot et sa couverture de Dévonien inférieur
Lamens, J.; Steemans, Philippe ULg; Vanguestaine, M.

Conference (1988)

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See detailLe cancer de la prostate
GERARD, Xavier ULg

Scientific conference (2011, November)

Detailed reference viewed: 46 (3 ULg)
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See detailLe capital osseux : une épargne qui débute au berceau
Halkin, V; Reginster, Jean-Yves ULg

in L'agenda Pédiatrie (2000), 22

Detailed reference viewed: 10 (1 ULg)
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See detailLe caricaturiste offre sinon la réalité, du moins l’illusion d’une liberté
Durand, Pascal ULg; Vaute, Paul

Article for general public (2002)

Detailed reference viewed: 25 (1 ULg)
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See detailLE CAS CLINIQUE DU MOIS Cas rare d’endométriose urétérale neuf ans après une hystérectomie
Bawin, Isabelle ULg; Troisfontaines, E; Nisolle, Michelle ULg

in Revue Médicale de Liège (2013), 68(7-8), 378-381

Ureteral endometriosis is a rare entity, espe- cially when it occurs in the postmenopausal period. In certain circumstances, this severe disease can cause obstruction, leading to ureterohydronephrosis and ... [more ▼]

Ureteral endometriosis is a rare entity, espe- cially when it occurs in the postmenopausal period. In certain circumstances, this severe disease can cause obstruction, leading to ureterohydronephrosis and, finally, to a progressive and often silent loss of renal function. The symptomatology is variable and non specific, making pre- operative diagnosis difficult. The treatment is mainly surgical. Its aim is the relief of obstruction to preserve the renal function. We report the case of a 39 year old patient, hysterect- omised for endometriosis nine years earlier, who developed a recurrence demonstrated by ureteral endometriosis and revealed by ureterohydronephrosis. Robot-assisted lapa- roscopic ureterolysis allowed a complete resection of the lesion and resolved the obstruction. No recurrence of ure- terohydronephrosis was found at the fifth and ninth postop- erative month ultrasonographic controls. [less ▲]

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See detailLE CAS CLINIQUE DU MOIS Cas rare d’endométriose urétérale neuf ans après une hystérectomie
Bawin, I; Troisfontaines, E; Nisolle, Michelle ULg

in Revue Médicale de Liège (2012), 67

Ureteral endometriosis is a rare entity, espe- cially when it occurs in the postmenopausal period. In certain circumstances, this severe disease can cause obstruction, leading to ureterohydronephrosis and ... [more ▼]

Ureteral endometriosis is a rare entity, espe- cially when it occurs in the postmenopausal period. In certain circumstances, this severe disease can cause obstruction, leading to ureterohydronephrosis and, finally, to a progressive and often silent loss of renal function. The symptomatology is variable and non specific, making pre- operative diagnosis difficult. The treatment is mainly surgical. Its aim is the relief of obstruction to preserve the renal function. We report the case of a 39 year old patient, hysterect- omised for endometriosis nine years earlier, who developed a recurrence demonstrated by ureteral endometriosis and revealed by ureterohydronephrosis. Robot-assisted lapa- roscopic ureterolysis allowed a complete resection of the lesion and resolved the obstruction. No recurrence of ure- terohydronephrosis was found at the fifth and ninth postop- erative month ultrasonographic controls. [less ▲]

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See detailLE CAS CLINIQUE DU MOIS Le syndrome miroir : à propos d’un cas
Touhami, O.; CHANTRAINE, Frédéric ULg; DELBECQUE, Katty ULg et al

in Revue Médicale de Liège (2013), 68(9), 440-443

Mirror syndrome is a rare entity describing the association of foetal hydrops and maternal symptoms as general oedema and excessive weight gain mimicking preec- lampsia. We report the case of a patient ... [more ▼]

Mirror syndrome is a rare entity describing the association of foetal hydrops and maternal symptoms as general oedema and excessive weight gain mimicking preec- lampsia. We report the case of a patient who developed symptoms of oedema, weight gain, headache and biological hemodilution associated with foetal hydrops due to a com- plex congenital heart defect. This symptomatology spontane- ously resolved after foetal expulsion. Mirror or Ballantyne’s syndrome needs to be identified on time and well differenti- ated from preeclampsia. Its consequences may involve the maternal and foetal prognosis. [less ▲]

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See detailLe casier judiciaire du mineur
Seron, Vincent ULg

Conference given outside the academic context (2012)

Detailed reference viewed: 37 (8 ULg)