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See detailAn investigation on thermal performance of a low cost apartment in hot humid climate of Danang
Nguyen, Anh Tuan ULg; Reiter, Sigrid ULg

in Energy and Buildings (2012), 47

Low cost apartment has recently become one of the essential state policies to deal with rapid urbanisation and population boom in Vietnam. Thermal performance of a low cost apartment in Danang was ... [more ▼]

Low cost apartment has recently become one of the essential state policies to deal with rapid urbanisation and population boom in Vietnam. Thermal performance of a low cost apartment in Danang was examined using building simulation approach. The simulated results created by COMFIE were first calibrated by comparing them with measured data. The statistical indicators CV(RMSE) and NMBE as well as linear regression analysis were applied to assess the calibration. The calibrated model was then used to perform whole year simulations in which various ventilation and design strategies were applied. Thermal comfort potentials of these strategies were graphically defined by Brager’s adaptive comfort model from which the efficiency of each strategy was quantitatively determined. In the present paper, details of the calibration approach, assessment of simulated results and comparison of the findings were discussed. Results of these analyses revealed many notable findings which are in good agreement with those obtained from other publications. The limitation and recommendations for further study are also outlined. [less ▲]

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See detailInvestigation on Water Productivity of Winter Wheat Based on MODIS and SEBAL in the Huang-Huai-Hai Plain, China
Yang, Jian-ying; HUO, Zhi-guo; Wu, Ding-rong et al

in Chinese Journal of Agrometeorology (in press)

Understanding how the productivity of water can be increased is widely accepted to be a high priority where water resources are currently scarce and/or over-exploited in China. As the primary data source ... [more ▼]

Understanding how the productivity of water can be increased is widely accepted to be a high priority where water resources are currently scarce and/or over-exploited in China. As the primary data source, MODIS remote sensing, statistics, meteorological data, crop growth period data and ground truth-data from Jan. 2011 to Dec. 2012 were used in actual evapotranspiration estimation, yields rasterizing, and water productivity calculation for winter wheat in the Huang-Huai-Hai Plain (3H Plain). The statistical data were synthesized to calculate district-state-level land productivity, which is then further extrapolated to pixel-level values using a MODIS NDVI image, based on a crop dominance map. Spatial variation of crop water productivity was investigated in order to reveal the key factors of crop water productivity. In addition, the relationship between water productivity and actual evapotranspiration and in subsequence yield for winter wheat was discussed in 3H Plain. The main results indicated that the SEBAL is suitable for estimating evapotranspiration in winter wheat based on the comparation between evapotranspiration measured by Yucheng (in Shandong province). The regional average value of water productivity for winter wheat was detected to be 1.21kg·m-3, with the higher value in Beijing, Tianjin, north part of Shandong province and south part of Hebei province. The pronounced relationship of spatial correlation of the yield and water productivity for winter wheat indicated that the increasing yield governed the increment of water productivity for winter wheat in the coastal land-farming-fishing area (zone1), low plain-hydropenia irrigable land and dry land zone (zone2) and basin- irrigable land and dry land (zone5). The increasing water productivity for winter wheat was recognized to be controlled by rather the increment of yield than the reduction of actual evapotranspiration for winter wheat in the piedmont plain-irrigable land (zone2). Whereas, the pronounced relationship of negative correlation of water productivity and actual evapotranspiration for winter wheat described that only the reduction of actual evapotranspiration was responsible for the increment of water productivity for winter wheat in hill-wet hot paddy-paddy field (zone6). The results is expected to provide a basis information for agricultural water management, improvement of crop water productivity and choice of adaptive mechanism under climate change in Huang-Huai-Hai plain. [less ▲]

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See detailInvestigation structurale par RMN 2D appliquée à l’analyse d’oligo- et poly-saccharides
Goffin, Dorothée ULg

Scientific conference (2008)

Dans cet exposé, diverses expériences 2D sont décrites et appliquées à l'analyse structurale d'oligosaccharides de structures proches. L'apport de chaque type d'expérience et les informations obtenues ... [more ▼]

Dans cet exposé, diverses expériences 2D sont décrites et appliquées à l'analyse structurale d'oligosaccharides de structures proches. L'apport de chaque type d'expérience et les informations obtenues sont mises en évidence afin de déterminer à la fois l'anomérie, le type de résidu et de liaisons ainsi que leur séquence. [less ▲]

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See detailInvestigational insulin secretagogues for type 2 diabetes.
SCHEEN, André ULg

in Expert opinion on investigational drugs (2016), 25(4), 405-22

INTRODUCTION: Insulin secretory defects are a key feature in the pathophysiology of type 2 diabetes (T2D). Classical insulin-secreting agents such as sulfonlyureas stimulate insulin secretion independent ... [more ▼]

INTRODUCTION: Insulin secretory defects are a key feature in the pathophysiology of type 2 diabetes (T2D). Classical insulin-secreting agents such as sulfonlyureas stimulate insulin secretion independent of glucose and cause hypoglycemia. Despite the advantages offered by incretin-based therapies, there is still a medical need for developing new insulin secretagogues for treating T2D. AREA COVERED: This article discusses: the new advances in the field of incretin-based therapies, glucokinase (GK) activators, free fatty acid receptor (FFAR) or G protein-coupled receptor (GPR) agonists (GPR40, GPR119, GPR120), imeglimin and some other insulin secretagogues with diverse mechanisms of action still in preclinical development. EXPERT OPINION: New insulin secretagogues should offer major advantages over sulfonylureas and gliptins. The challenge is to avoid uncontrolled insulin secretion and minimize the risk of hypoglycemia, to protect cells from progressive loss of mass and function for a better durability of glucose control, and to offer a good safety profile. Numerous approaches are in development. However, it is too early to decide whether one new pharmacological class will emerge as a clinically useful insulin secretagogue in the near feature. [less ▲]

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See detailInvestigations around an unrecognized genre: case study on speech captions in private tombs
Motte, Aurore ULg

Conference (2016, May 05)

Since the Old Kingdom, speech captions, generally known as “Reden und Rufe”, are found in the decorative program of private tombs. These captions are dialogs between workers in the “daily life” scenes ... [more ▼]

Since the Old Kingdom, speech captions, generally known as “Reden und Rufe”, are found in the decorative program of private tombs. These captions are dialogs between workers in the “daily life” scenes. They appear in several topics, such as fishing, butchery, crafts, ... Quite surprisingly, they have never been studied exhaustively since their first mention in 1918 in Egyptological literature. My first goal is twofold: to show precisely where and when they are found, and what exactly defines “Reden und Rufe” as a genre. Besides, a chronological scope of nearly 2,300 years allows me to highlight diachronic, diatopic, and diastratic variations. It is particularly evident in New Kingdom and Late Period tombs, where “Égyptien de Tradition” features are found next to “vernacular” ones. It has long been taken for granted, incorrectly, that these speeches were written in an idiom very close to colloquial. This first comprehensive study aims to determine which state(s) of language is/are used. [less ▲]

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See detailInvestigations of migraine
Nappi, G.; Sandrini, G.; Schoenen, Jean ULg

in Ekbom, K. (Ed.) Migraine in General Practice: basic concepts (1993)

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See detailInvestigations of the GCxGC-HRMS coupling
Focant, Jean-François ULg; Patterson Jr

Conference (2010, June)

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See detailInvestigations of typical stellar spectra with high dispersion. I. Table of lines in α Cygni.
Struve, Otto; Swings, Polydore ULg

in Astrophysical Journal (1941), 94

This paper contains a new table of wave lengths of absorption lines in the spectrum of α Cygni between λ 3862 and λ 6590.

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See detailInvestigations on a Level Set based approach for the optimization of flexible components in multibody systems with a fixed mesh grid
Tromme, Emmanuel ULg; Bruls, Olivier ULg; Van Miegroet, Laurent ULg et al

in Proceedings of The 6th Asian Conference on Multibody Dynamics: Shanghai (China), 26-30 aout 2012 (2012, August)

This paper considers the optimization of flexible components in mechanical systems thanks to a "fully integrated" optimization method which includes a flexible multibody system simulation based on ... [more ▼]

This paper considers the optimization of flexible components in mechanical systems thanks to a "fully integrated" optimization method which includes a flexible multibody system simulation based on nonlinear finite elements. This approach permits to better capture the effects of dynamic loading under service conditions. This process is challenging because most state-of-the-art studies in structural optimization have been conducted under (quasi-)static loading conditions or vibration design criteria and also because this ``fully integrated" optimization method is not a simple extension of static optimization techniques. The present paper proposes an approach based on a Level Set description of the geometry. This method leads to an intermediate level between shape and topology optimizations. Gradient-based optimization methods are adopted for their convergence speed. Numerical applications are conducted on the optimization of a connecting rod of a reciprocating engine with cyclic dynamic loading to show the feasibility and the promising results of this approach. [less ▲]

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See detailInvestigations on Both Chemical Composition and Insecticidal Activities on Essential Oils of Vepris heterophylla (Rutaceae) from Two Localities of Northern Cameroon Towards Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae)
Ngamo, Tinkeu L.S.; Noudjou, W.Félicité; Ngassoum, Martin B. et al

in Research Journal of Biological Sciences (2007), 2(1), 57-61

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See detailInvestigations on Cationic Exchange Capacity and Unused Bed Zone according to operational conditions in a Fixed Bed Reactor for water lead removal by a natural zeolite.
Fanfan, Pierre Naïder; Mabon, Nicolas; Thonart, Philippe ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2006), 10(2), 93-99

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See detailInvestigations on physical and textural properties of Arctic first-year sea ice in the Amundsen Gulf, Canada, November 2007–June 2008 (IPY-CFL system study)
Carnat, Gauthier; Papakyriakou, Timothy; Geilfus, Nicolas-Xavier ULg et al

in Journal of Glaciology (2013), 59(217),

We report sea-ice temperature and bulk salinity measurements as well as textural analysis from 33 first-year drift- and fast-ice stations sampled between November 2007 and June 2008 in the southern ... [more ▼]

We report sea-ice temperature and bulk salinity measurements as well as textural analysis from 33 first-year drift- and fast-ice stations sampled between November 2007 and June 2008 in the southern Beaufort Sea–Amundsen Gulf, Canadian Arctic, during the International Polar Year Circumpolar Flaw Lead (IPY-CFL) system study. We use this significant dataset to investigate the halothermodynamic evolution of sea ice from growth to melt. A strong desalination phase is observed over a small time window in the spring. Using calculated proxies of sea-ice permeability (brine volume fraction) and of the intensity of brine convection (Rayleigh number) we demonstrate that this phase corresponds to full-depth gravity drainage initiated by a restored connectivity of the brine network with warming in the spring. Most stations had a textural sequence typical of Arctic first-year ice, with granular ice overlying columnar ice. Unusual textural features were observed sporadically: sandwiched granular ice, platelet ice and draped platelet ice. We suggest that turbulence in leads and double diffusion in strong brine plumes following the refreeze of cracks are plausible mechanisms for the formation of these textures. [less ▲]

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See detailInvestigations on PrP and PrPres in porcine brain and in stimufol preparations
Degand, Guy ULg; Remy, Benoit; Fotsing, Lucas ULg et al

in Proceedings: 20th Annual Meeting A.E.T.E (2004)

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See detailInvestigations on Surra-induced lymphopoenia in a murine model
Antoine-Moussiaux, Nicolas ULg; Cornet, Anne ULg; Cornet, et al

Conference (2009, March)

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See detailInvestigations on the development of the health status of harbour seals in the year of the PDV seal die-off in 2002
Siebert, Ursula; Fonfara, Sonja; Hasselmeier, Ilka et al

Poster (2004, March 31)

More than 21,500 harbour seals were killed by Phocine Distempter Virus in the North Sea and adjacent waters in 2002. Of those more than 3,340 seals were found dead on the coast of Schleswig-Holstein ... [more ▼]

More than 21,500 harbour seals were killed by Phocine Distempter Virus in the North Sea and adjacent waters in 2002. Of those more than 3,340 seals were found dead on the coast of Schleswig-Holstein. After the second seal die-off had ceased, seals were captured alive for a health check and also stranded seals were examined for their health status. Blood status and chemistry tests were performed, microbiological, parasitological, histological, serological and cytological investigations were conducted. During the first catch after the seal die-off animals seemed to be in clinically good condition although hematological disturbances (leucocytosis as well as leucopenia) were detected. Bacteriologically, Bordetella bronchisptica was isolated, a bacterium which was exclusively cultured during the seal die-off. At later catches hematological values normalized and also the normal bacterial flora was cultured from vagina and anus. The serological investigations for morbillivirus-specific antibodies revealed positive titers in 100% of the seals. Morphologically, there was no evidence for a continuing morbillivirus infection by both, histology and immunocytochemistry. The pathomorphological changes were similar to those before the epizootic including the predominance of parasitic and bacterial bronchopneumonia, emaciation and dermatitis. Contrary to the first seal die-off in 1988/89 an increased number of large skin wounds on the ventral side and infections of the umbilicus were not seen. This may indicate that the seal population in Schleswig-Holstein was generally in better health condition at the second seal die-off compared to the first one. The continued investigations will allow a further assessment of the development of the seal population in the Wadden Sea. [less ▲]

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See detailInvestigations on the mechanisms underlying the thymotropic properties of the growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis.
Goffinet, Lindsay ULg; Bodart, Gwennaëlle ULg; Renard, Chantal et al

Poster (2011, November 18)

Background. The thymus is responsible for thymopoiesis, i.e. the generation of a diverse and self-tolerant T-cell repertoire including self-antigen specific natural regulatory cells. We have shown that ... [more ▼]

Background. The thymus is responsible for thymopoiesis, i.e. the generation of a diverse and self-tolerant T-cell repertoire including self-antigen specific natural regulatory cells. We have shown that two parameters of thymopoiesis, thymic output of new T cells (estimated by sjTREC frequency) and intrathymic proliferation of T-cell precursors (estimated by sj/Dβ TREC ratio) are severely reduced in adult patients with GH deficiency (AGHD) and are restored by GH injections at physiological doses. In patients with AGHD, there is a very positive correlation between sjTREC frequency and plasma concentrations of IGF-1, the principal mediator of GH action (1). Treatment of HIV+ patients with high pharmacological doses of GH is associated with increased thymic mass and output of circulating naïve and total CD4+ T cells (2). In addition, previous studies have suggested thymic epithelial cells (TEC) and/or thymocytes (thymic T cells) could transcribe the GH gene (3). Objectives and hypothesis. These studies analysed the question of GH transcription and regulation in primary cultures of human (h) TEC. We also investigated the hypothesis that the thymotropic properties of the somatotrope GH/IGF-1 axis could be mediated by thymic interleukin 7 (IL-7), which plays a crucial role in promoting V(D)J recombination at the TCR locus. Results. Primary hTEC cultures were treated with natural secretagogues of pituitary GH, GH releasing hormone (GHRH) and ghrelin. Using sensitive RT-qPCR, we detected neither any transcript of GH or GHV (placental GH variant) in cultured hTEC, nor any transcript of PIT1, the specific transcription factor of pituitary GH. Similarly, the protein GH was detected neither in the cytoplasm nor in the supernatant of cultured hTEC. Only at 1 nM, GH treatment enhanced IGF1 transcription by cultured hTEC. Of high interest, treatment with GH, ghrelin and IGF-1 promoted IL7 transcription by cultured hTEC, but only IGF-1 and epidermal growth factor (EGF) markedly stimulated IL-7 secretion by hTEC in a dose- and time-dependent manner. The specificity of IGF-1 action was demonstrated by its inhibition after treatment with αIR3, a monoclonal antibody against the type 1 IGF receptor. Conclusions and perspectives. Since primary cultures of hTEC neither transcribe nor secrete any significant amount of GH, the thymotropic effects of the GH/IGF-1 axis seem to depend only on systemic endocrine GH. Local thymic IGF-1 could partially mediate GH action within the thymus and act upon thymopoiesis in parallel with systemic IGF-1. Most importantly, thymic IL-7 appears to be an important mediator of the thymotropic properties of the GH/IGF-1 axis. Further knowledge in this domain will be gained with the use and supplementation of Ghrh-/- mice that will be soon available in our laboratory. References 1. Morrhaye G. et al., PLoS ONE 2009, 4:e5668. 2. Napolitano LA et al. J Clin Invest 2008, 118:1085. 3. Smaniotto S et al., Endocrinology 2005, 146:3005. 4. Taub DD, Murphy WJ and Longo DL. Curr Opin Pharmacol 2010, 10:408. (Supported by F.R.S.-FNRS and a Pfizer Independent Research Grant.) [less ▲]

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