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See detailInterférométrie RSO et analyses géomorphométriques à caractère tectonique en Jordanie.
Cornet, Yves ULg; De Rauw, Dominique ULg; Ozer, André ULg et al

in Dubois, J. M.; Bernier, M.; Fortin, J. P. (Eds.) et al Série Actualité scientifique - La réalité de terrain en télédétection: pratiques et méthodes (1998)

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See detailInterferon Response Factor 3 is essential for house dust mite-induced airway allergy
Marichal, Thomas ULg; Bedoret, Denis; Mesnil, Claire ULg et al

in Journal of Allergy and Clinical Immunology (The) (2010), 126(4), 836-844

IRF3, mainly known as a central orchestrator of antiviral responses, is required for proallergic functions of dendritic cells in response to aeroallergens. Thus, this study demonstratively identifies a ... [more ▼]

IRF3, mainly known as a central orchestrator of antiviral responses, is required for proallergic functions of dendritic cells in response to aeroallergens. Thus, this study demonstratively identifies a new pathway potentially implicated in the etiology of airway allergy [less ▲]

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See detailInterferon Response Factor 3 is essential for house dust mite-induced airway allergy
Marichal, Thomas ULg; Bedoret, Denis; Mesnil, Claire et al

Conference (2011, May)

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See detailInterferon Response Factor 3 is required for airway allergy to house dust mite in mice
Marichal, Thomas ULg; Bedoret Denis; Mesnil, Claire ULg et al

in Short Book of the Annual Congress of the Euopean Respiratory Society (ERS), Barcelone (2010, September)

Detailed reference viewed: 22 (4 ULg)
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See detailInterferon Response Factor-3 is essential for house dust mite-induced airway allergy
Marichal, Thomas ULg; Bedoret Denis; Mesnil Claire et al

in Proceedings of the Belgian Thoracic Society Annual Meeting (2011, May 23)

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See detailInterferon-induced Sus scrofa Mx1 blocks endocytic traffic of incoming influenza A virus particles
Palm, Mélanie; Garigliany, Mutien-Marie ULg; Cornet, François ULg et al

in Veterinary Research (2010), 41(3), 29

The interferon-induced Mx proteins of vertebrates are dynamin-like GTPases, some isoforms of which can additionally inhibit the life cycle of certain RNA viruses. Here we show that the porcine Mx1 protein ... [more ▼]

The interferon-induced Mx proteins of vertebrates are dynamin-like GTPases, some isoforms of which can additionally inhibit the life cycle of certain RNA viruses. Here we show that the porcine Mx1 protein (poMx1) inhibits replication of influenza A virus and we attempt to identify the step at which the viral life cycle is blocked. In infected cells expressing poMx1, the level of transcripts encoding the viral nucleoprotein is significantly lower than normal, even when secondary transcription is prevented by exposure to cycloheximide. This reveals that a pretranscriptional block participates to the anti-influenza activity. Binding and internalization of incoming virus particles are normal in the presence of poMx1 but centripetal traffic to the late endosomes is interrupted. Surprisingly but decisively, poMx1 significantly alters binding of early endosome autoantigen 1 to early endosomes and/or early endosome size and spatial distribution. This is compatible with impairment of traffic of the endocytic vesicles to the late endosomes. [less ▲]

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See detailThe Interferon-Inducible Mouse Apolipoprotein L9 and Prohibitins Cooperate to Restrict Theiler's Virus Replication.
Kreit, Marguerite; Vertommen, Didier; Gillet, Laurent ULg et al

in PloS one (2015), 10(7), 0133190

Apolipoprotein L9b (Apol9b) is an interferon-stimulated gene (ISG) that has antiviral activity and is weakly expressed in primary mouse neurons as compared to other cell types. Here, we show that both ... [more ▼]

Apolipoprotein L9b (Apol9b) is an interferon-stimulated gene (ISG) that has antiviral activity and is weakly expressed in primary mouse neurons as compared to other cell types. Here, we show that both Apol9 isoforms (Apol9b and Apol9a) inhibit replication of Theiler's murine encephalomyelitis virus (TMEV) but not replication of vesicular stomatitis virus (VSV), Murid herpesvirus-4 (MuHV-4), or infection by a lentiviral vector. Apol9 genes are strongly expressed in mouse liver and, to a lesser extent, in pancreas, adipose tissue and intestine. Their expression is increased by type I interferon and viral infection. In contrast to genuine apolipoproteins that are involved in lipid transport, ApoL9 has an intracytoplasmic localization and does not seem to be secreted. The cytoplasmic localization of ApoL9 is in line with the observation that ApoL9 inhibits the replication step of TMEV infection. In contrast to human ApoL6, ApoL9 did not sensitize cells to apoptosis, in spite of the presence of a conserved putative BH3 domain, required for antiviral activity. ApoL9a and b isoforms interact with cellular prohibitin 1 (Phb1) and prohibitin 2 (Phb2) and this interaction might contribute to ApoL9 antiviral activity. Knocking down Phb2 slightly increased TMEV replication, irrespective of ApoL9 overexpression. The antiviral activity of prohibitins against TMEV contrasts with the pro-viral activity of prohibitins observed for VSV and reported previously for Dengue 2 (DENV-2), Chikungunya (CHIKV) and influenza H5N1 viruses. ApoL9 is thus an example of ISG displaying a narrow antiviral range, which likely acts in complex with prohibitins to restrict TMEV replication. [less ▲]

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See detailLes interférons de type 1 et leur fonction antivirale
Leroy, Michael; Desmecht, Daniel ULg

in Annales de Médecine Vétérinaire (2006), 150(2), 73-107

Type I interferons are part of the innate immune system involved in the first line defense against invasion, replication and spreading of pathogens such as viruses. Through specific membrane or ... [more ▼]

Type I interferons are part of the innate immune system involved in the first line defense against invasion, replication and spreading of pathogens such as viruses. Through specific membrane or intracellular receptors, virus entry induces the expression of type I interferons which stimulates the cells through an autocrine and paracrine manner. Interferons are polypeptides that stimulate cells through membrane receptors. They induce a cascade of events leading to the synthesis of many proteins some of which having specific antiviral properties. The most characterized are the MX proteins, the 2’5’ oligoadenylate synthetase/ ribonuclease L pathway and the double-stranded RNA-dependent protein kinase R system. Recently, the protein ISG20 has been involved in the specific antiviral function of type I interferons. The interferons act on multiple steps of the viral cycle including penetration, decapsidation, mRNA transcription, protein synthesis, genome replication, assembling and excretion of viral particles. Nowadays, due to their major efficiency, type I interferons are used in therapeutics against some viral infections and cancers. [less ▲]

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See detailInterfollicular fibrosis and organohalogens in the thyroid of the harbour porpoise (phocoena phocoena) of the British and Belgian coasts
Schnitzler, Joseph ULg; Das, Krishna ULg; Beineke, Andreas et al

Conference (2005, October 27)

Previous studies have described high levels of polychlorobiphenyls (PCB), p,p`-dichlordiphenyl-dichlorethen (DDT), p,p`-dichlordiphenyl-trichlorethan (DDE) and polybrominated diphenylether (PBDE) in the ... [more ▼]

Previous studies have described high levels of polychlorobiphenyls (PCB), p,p`-dichlordiphenyl-dichlorethen (DDT), p,p`-dichlordiphenyl-trichlorethan (DDE) and polybrominated diphenylether (PBDE) in the blubber of the harbour porpoise (Phocoena phocoena) from the North Sea raising the question of a potential endocrine disruption in this species. In the present study, the thyroids of 36 harbour porpoises from the British and the Belgian coast have been collected for histological and immunohistological investigations. The number and mean diameter of follicles and the relative distribution of follicular, connective and vascular tissues (%) were quantified in the thyroid of each individual. Then, the relationship between the thyroid morphometry data and previously described organic compounds (namely PCB, DDT, DDE and PBDE) was investigated using factor analysis and multiple regressions. The results of this work were compared to the previous study of harbour porpoises from the German (North and Baltic Seas), Norwegian and Icelandic coasts. Thyroid morphology was similar between the harbour porpoises from the British and Belgian coast. Compared to the previous study, the thyroids differed strongly between sampling sites. Porpoises from the German (North and Baltic Seas) and Norwegian coasts displayed a high percentage of connective tissues between 30 and 38% revealing severe inter-follicular fibrosis. The thyroids of Icelandic coasts displayed only a light inter-follicular fibrosis (percentage of connective tissue of 3%). The thyroids of the porpoises from the British and Belgian coasts occupied an intermediary place with a moderate fibrosis (percentage of connective tissue of 10%). A relation between mean diameter of follicles and the body size and mass suggesting a downward trend of activity of the thyroid with increasing body size and mass and thus, the age of the porpoises. A correlation-based principal component analysis (PCA) revealed one principal components explaining 69% of the total variance. The variables PCB, PBDE, DDT, and DDE compounds loaded highest on PC1. Our results pointed out a relationship between PCBs, PBDE, DDE and DDT (PC1) compounds and interfollicular fibrosis in the thyroids of harbour porpoises from the German coast of the Baltic Sea. The present report supports the hypothesis of a contaminant-induced thyroid fibrosis in harbour porpoises raising the question of the long term-viability in highly polluted areas [less ▲]

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See detailInterfollicular fibrosis in the thyroid of the harbour porpoise: An endocrine disruption?
Das, Krishna ULg; Vossen, Arndt; Tolley, Kristal et al

in Archives of Environmental Contamination & Toxicology (2006), 51

Previous studies have described high levels of polychlorobiphenyls (PCB), polybrominated diphenylether (PBDE), toxaphene, ,p0-dichlorodiphenyltrichloroethane (DDT), and ,p0 ... [more ▼]

Previous studies have described high levels of polychlorobiphenyls (PCB), polybrominated diphenylether (PBDE), toxaphene, ,p0-dichlorodiphenyltrichloroethane (DDT), and ,p0-dichlorodiphenyldichloroethylene (DDE) in the blubber of the harbour porpoise from the North Sea raising the question of a potential endocrine disruption in this species. In the present study, the thyroids of 57 harbour porpoises from the German and Danish (North and Baltic Seas), Norwegian, and Icelandic coasts have been collected for histological and immunohistological investigations. The number of follicles and the relative distribution of follicles, connective, and solid tissues (%) were quantified in the thyroid of each individual. Then, the potential relationship between the thyroid morphometry data and previously described organic compounds (namely, PCB, PBDE, toxaphene, DDT, and DDE) was investigated using factor analysis and multiple regressions. Thyroid morphology differed strongly between ampling sites. Porpoises from the German (North and Baltic Seas) and Norwegian coasts displayed a high percentage of connective tissues between 30 and 38% revealing severe interfollicular fibrosis and a high number of large follicles (diameter >200 lm). A correlation-based principal component analysis (PCA) revealed two principal components explaining 85.9% of the total variance. The variables PCB, PBDE, DDT, and DDE compounds loaded highest on PC1 whereas toxaphene compound loaded most on PC2. Our results pointed out a relationship between PC1 (PCBs, PBDE, DDE, and DDT compounds) and interfollicular fibrosis in the harbour porpoise thyroids. Such an association is not alone sufficient for a cause–effect relationship but supports the hypothesis of a contaminant-induced thyroid fibrosis in harbour porpoises raising the question of the longterm viability in highly polluted areas. [less ▲]

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See detailIntergenerational conflict in the first trilogy of Nuruddin Farah
Bajou, Issam ULg

Conference (2014, April)

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See detailIntergenerational physical activity: Effects of a three-month intervention bringing together older adults and elementary school children
Mouton, Alexandre ULg; Renier, Tom ULg; Cloes, Marc ULg

in Revista Espaňola de Educación Física y Deportes (2015, July), 410-S

For the first time in history, children are projected to have a shorter life expectancy than their parents (Olshansky et al., 2005). Besides, older adults are the less active population group (Sun et al ... [more ▼]

For the first time in history, children are projected to have a shorter life expectancy than their parents (Olshansky et al., 2005). Besides, older adults are the less active population group (Sun et al., 2013). Intergenerational PA has the potential to increase PA and quality of life (QoL) among those two age-groups but research in the field is still very limited (Flora & Faulkner, 2007). Accordingly, the aim of this study was to examine the impact of an intergeneration PA intervention on self-reported PA and Qol among older adults and elementary school children. At baseline, two intergenerational groups were formed: (Gr1) 11 older adults (63.91±7.62 years) and a class of 18 children (4.81±0.37 years); (Gr2) 9 older adults (68.67±7.25) and a class of 13 children (7.16±0.38years). Those groups took part in a three-month intergenerational intervention including one weekly session of PA practiced in the school context. Assessments were performed before (T0), during (satisfaction level), after the intervention (T1) and after a three months’ follow-up period (T2). PA and Qol were respectively assessed with the QAPPA and the SF-36 among older adults, and with adapted versions of the PAQ-C and the AUQUEI among children. Older adults’ physical fitness was also assessed with the SFT battery test. Participation rate was relatively high in both groups during PA sessions (Gr1: 81.48% older adults and 93.21% children; Gr2: 83.33% older adults and 91.45% children). At T1, Only 1 older adult (Gr1) dropped out of the study, as 9 children (group 1) and 6 children (group 2) dropped out due to the failure of the parents to complete and return the children’s questionnaires. Preliminary results of the SFT exposed significant improvements of the upper limbs strength in both groups (p<0.05). Further analyses will inform about effects on PA and Qol. [less ▲]

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See detailIntergenerational transmission within the family
Roskam, I.; Stievenart, Marie ULg

in Psychologica Belgica (2013), 53(3), 3-5

In this special issue, we wanted to gather a diverse range of psychological points of view concerning the question of intergenerational transmission within the family. It was on this topic that we asked ... [more ▼]

In this special issue, we wanted to gather a diverse range of psychological points of view concerning the question of intergenerational transmission within the family. It was on this topic that we asked for contributions from systemic family therapists and developmentalists. It is such an important topic from both a research and a clinical perspective that our colleagues were full of enthusiasm for the project. [less ▲]

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See detailThe interglacial carbon cycle
Kleinen, Thomas; Brovkin, Victor; Munhoven, Guy ULg et al

Poster (2011, April 07)

Explaining the difference in carbon cycle dynamics (and hence atmospheric CO2) between various interglacials is an elusive issue. Several biogeochemical mechanisms of different origin are involved in ... [more ▼]

Explaining the difference in carbon cycle dynamics (and hence atmospheric CO2) between various interglacials is an elusive issue. Several biogeochemical mechanisms of different origin are involved in interglacial CO2 dynamics, leading to a CO2 release from the ocean (carbonate compensation, coral growth) compensated by a land carbon uptake (biomass and soil carbon buildup, peat accumulation). The balance between these fluxes of CO2 is delicate and time-dependent, and it is not possible to provide firm constraints on these fluxes from proxy data. The best framework for quantification of all these mechanisms is an Earth System model that includes all necessary physical and biogeochemical components of the atmosphere, ocean, and land. To perform multi-millennial model integrations through the Holocene, Eemian, and MIS11, we use an earth system model of intermediate complexity, CLIMBER-2, coupled to the dynamic global vegetation model LPJ with a recently implemented module for boreal peatland dynamics. During glacial-interglacial cycles, the carbon cycle never is in complete equilibrium due to a number of small but persistent fluxes such as terrestrial weathering. This complicates setting up interglacial experiments as the usual approach to start model integrations from an equilibrium state is not valid any more. In order to circumvent the problem of non-equilibrium initial conditions, the model is initialised with the oceanic biogeochemistry state taken from a transient simulation through the last glacial cycle with CLIMBER-2 only. In this simulation, the CLIMBER-2 model was run through the last glacial cycle with carbon cycle in “offline mode” as interactive components of the physical climate system (atmosphere, ocean, ice sheets) were driven by concentration of greenhouse gases reconstructed from ice cores. Using these initial conditions, we performed coupled climate carbon cycle experiments for the Holocene, the Eemian and MIS11, driven by orbital forcing. Contrary to the results we published previously (Kleinen et al. 2010), peat accumulation was not prescribed, but rather determined dynamically, making this model setup applicable to previous interglacials as well. For the Holocene, our results resemble the carbon cycle dynamics as reconstructed from ice cores quite closely, both for atmospheric CO2 and delta13CO2. These experiments will be presented, analysing the role of different forcing mechanisms. The land surface appears to be an overall sink for CO2, due to carbon accumulation in the soil, as well as peat accumulation, and oceanic contributions due to temperature and circulation changes are quite small. Finally, results for MIS11 and the Eemian will be shown. [less ▲]

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See detailIntergrated Exercices on Environmental Issues : a presentation of an interdisciplinary learning process at the University of Liège
Melard, François ULg

Scientific conference (2007, July 04)

Presentation of an interdisciplinary seminar in a master of environmental Sciences and Management at the University of Liège.

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See detailIntergroup variation in robbing and bartering by long-tailed macaques at Uluwatu Temple (Bali, Indonesia)
Brotcorne, Fany ULg; Giraud, Gwennan; Gunst, Noelle et al

in Primates : Journal of Primatology (2017)

Robbing and bartering (RB) is a behavioral practice anecdotally reported in free-ranging commensal macaques. It usually occurs in two steps: after taking inedible objects (e.g., glasses) from humans, the ... [more ▼]

Robbing and bartering (RB) is a behavioral practice anecdotally reported in free-ranging commensal macaques. It usually occurs in two steps: after taking inedible objects (e.g., glasses) from humans, the macaques appear to use them as tokens, returning them to humans in exchange for food. While extensively studied in captivity, our research is the first to investigate the object/food exchange between humans and primates in a natural setting. During a 4-month study in 2010, we used both focal and event sampling to record 201 RB events in a population of long-tailed macaques (Macaca fascicularis), including four neighboring groups ranging freely around Uluwatu Temple, Bali (Indonesia). In each group, we documented the RB frequency, prevalence and outcome, and tested the underpinning anthropogenic and demographic determinants. In line with the environmental opportunity hypothesis, we found a positive qualitative relation at the group level between time spent in tourist zones and RB frequency or prevalence. For two of the four groups, RB events were significantly more frequent when humans were more present in the environment. We also found qualitative partial support for the male-biased sex ratio hypothesis [i.e., RB was more frequent and prevalent in groups with higher ratios of (sub)adult males], whereas the group density hypothesis was not supported. This preliminary study showed that RB is a spontaneous, customary (in some groups), and enduring population-specific practice characterized by intergroup variation in Balinese macaques. As such, RB is a candidate for a new behavioral tradition in this species. [less ▲]

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