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See detailNovel (co)polymers by cobalt-mediated radical polymerization
Debuigne, Antoine ULg; Piette, Yasmine ULg; Poli, Rinaldo et al

Poster (2009, April 24)

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See detailNovel 2-oxo-2H-benzopyran derivatives as inhibitors of human leukocyte elastase
Pochet, L.; Doucet, C.; Pirotte, Bernard ULg et al

Poster (1998, September)

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See detailA novel 24-base pair deletion in the coding region of CCR5 in an African population
Karasi, Jean Claude ULg

in AIDS (2007), 21(1), 111-113

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See detailA novel AIP mutation related to familial isolated pituitary adenomas (FIPA)
Bilbao, I.; Alvarez coca, M.; Daly, Adrian ULg et al

in Abstract book - The Endocrine Society's 93rd Annual Meeting (2011)

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See detailA novel AIP mutation related to familial isolated pituitary adenomas (FIPA)
Bilbao Garay, I.; Alvarez Coca, M.; Daly, A. et al

in Endocrine Abstracts - 13th European Congress of Endocrinology (2011)

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See detailNovel aliphatic polyesters based on functional cyclic (di)esters
Lou, Xudong; Detrembleur, Christophe ULg; Jérôme, Robert ULg

in Macromolecular Rapid Communications (2003), 24(2), 161-172

Recent progress in the chemical synthesis of novel aliphatic polyesters via ring-opening polymerization of functional cyclic (di)esters are reviewed in this article. Syntheses of these functional ... [more ▼]

Recent progress in the chemical synthesis of novel aliphatic polyesters via ring-opening polymerization of functional cyclic (di)esters are reviewed in this article. Syntheses of these functional aliphatic polyesters are being classified into three groups according to the structure of the cyclic monomers: (i) cyclic diesters, (ii) morpholine-2,5-dione derivatives, and (iii) cyclic esters. Progress in the synthesis and polymerization of monomers in each category is reported with an emphasis on controlled synthesis. The recent achievements have enabled the synthesis of a variety of novel aliphatic polyesters, including hydrophilic, halogenated, and unsaturated polyesters. [less ▲]

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See detailNovel amphiphilic copolymers and design of smart nanoparticles for drug delivery systems
Cajot, Sébastien ULg; Danhier, F.; Lautram, N. et al

Poster (2011, April 29)

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See detailNovel Amphiphilic copolymers and design of smart nanoparticule for triggered drug delivery systems
Cajot, Sébastien ULg; Jérôme, Christine ULg

Poster (2009, June 14)

Over the last decade, polymer micelles attracted an increasing interest in drug pharmaceutical research because they could be used as efficient drug delivery systems. Micelles of amphiphilic block ... [more ▼]

Over the last decade, polymer micelles attracted an increasing interest in drug pharmaceutical research because they could be used as efficient drug delivery systems. Micelles of amphiphilic block copolymers are supramolecular core-shell type assemblies of tens of nanometers in diameter. In principle, the micelles core is usually constructed with biodegradable hydrophobic polymers such as aliphatic polyesters, e.g. poly(epsilon-caprolactone) (PCL), which serves as a reservoir for the incorporation of various lipophilic drugs. Water soluble poly(ethylene oxide) (PEO) is most frequently used to build the micelle corona because it is very efficient in preventing protein adsorption at surfaces and in stabilizing the micelles in the blood compartment, giving rise to particles invisible to the body defence system (so-called stealthy or long circulating particles). Improvements of such simple systems however, rely on the development of novel chemistries and materials by advanced macromolecular engineering techniques. The tumour targeting of a cytotoxic agent refers to the passive accumulation of polymer nanocarriers to solid tumours (EPR effect) followed by active internalization in tumor cells. The internalization of the drug is required for cell death because most cytotoxic drugs act intracellularly. Accordingly, polymer micelles are usually modified by specific ligands. However, these ligands can decrease the micelles stealthiness and stability. No-specific ligands can be used if their exposition is modulated by the pH decrease typical of tumour tissues. Lipophilic drugs are generally incorporated in the hydrophobic core of the micelles. The release of the drug is ruled by diffusion and degradation of the biodegradable polymer used as reservoir. Even if micelles get a high stability in aqueous media thanks to their low critical micellar concentration, the dissociation of micelles is not always preserved when they are injected in the blood compartment. The cross-linking of the core of micelles by disulfide bridges will provide the stability of micelles after the administration and will release the drugs intracellularly by enzymatic breaking of disulfide bridges. This work consists in the development of new macromolecular architectures for the targeting of tumour cells. pH sensitive copolymers able to micellize so as non-specific ligand like biotin is exposed on their surface in response to pH decrease typical for tumour tissues will be synthesized by the incorporation of pH-sensitive linkers like hydrazone or imine benzoïc linkers. In addition, the core of these new micelles will be cross-linked by disulfide bridges to prevent dissociation around healthy cells and trigger the drug release inside tumour cells. [less ▲]

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See detailNovel amphiphilic degradable copolymers for drug deivery systems
Van Butsele, Kathy; Freichels, Hélène ULg; Rieger, Jutta et al

Poster (2007, August 31)

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See detailNovel amphiphilic mikto-arm star-shaped copolymers for the preparation of PLA-based nanocarriers
Cajot, Sébastien ULg; Riva, Raphaël ULg; Billiet, Leen et al

in Macromolecular Symposia (2011), 309/310(1), 111-122

Three-arm (A2B) and four-arm (A2B2) star-shaped copolymers based on biocompatible and biodegradable hydrophobic poly(ε-caprolactone) (PCL) (A arms) and biocompatible and bioeliminable hydrophilic poly ... [more ▼]

Three-arm (A2B) and four-arm (A2B2) star-shaped copolymers based on biocompatible and biodegradable hydrophobic poly(ε-caprolactone) (PCL) (A arms) and biocompatible and bioeliminable hydrophilic poly(ethylene oxide) (PEO) (B arms) were synthesized by the coupling of an ω-azide terminated PEO chains with PCL chain bearing one (A2B) or two (A2B2) alkyne functions at the middle of the chain by the copper mediated azide-alkyne cycloaddition (CuAAC). The amphiphilic behavior of these different stars was confirmed by micellization experiments in water followed by dynamic light scattering and transmission electron microscopy analyses. The efficiency to stabilize PLA nanoparticles was investigated in function of the stars structure. [less ▲]

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See detailA novel and template-free method for the spontaneous formation of aluminosilicate macro-channels with mesoporous walls
Léonard, Alexandre ULg; Su, B.-L.

in Chemical Communications (2004), 10(14), 1674-1675

A simple and template-free synthesis pathway was developed leading to hierarchical meso-macroporous aluminosilicates made of an assembly of macro-channels with openings between 0.5 and 2.0 μm and ... [more ▼]

A simple and template-free synthesis pathway was developed leading to hierarchical meso-macroporous aluminosilicates made of an assembly of macro-channels with openings between 0.5 and 2.0 μm and mesoporous walls. [less ▲]

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See detailNovel antiangiogenic effects of the bisphosphonate compound zoledronic acid
Wood, J.; Bonjean, K.; Ruetz, S. et al

in Journal of Pharmacology and Experimental Therapeutics (2002), 302(3), 1055-1061

Bisphosphonate drugs inhibit osteoclastic bone resorption and are widely used to treat skeletal complications in patients with tumor-induced osteolysis. We now show that zoledronic acid, a new generation ... [more ▼]

Bisphosphonate drugs inhibit osteoclastic bone resorption and are widely used to treat skeletal complications in patients with tumor-induced osteolysis. We now show that zoledronic acid, a new generation bisphosphonate with a heterocyclic imidazole substituent, is also a potent inhibitor of angiogenesis. In vitro, zoledronic acid inhibits proliferation of human endothelial cells stimulated with fetal calf serum, basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (IC50 values 4.1, 4.2, and 6.9 muM, respectively), and modulates endothelial cell adhesion and migration. In cultured aortic rings and in the chicken egg chorioallantoic membrane assay, zoledronic acid reduces vessel sprouting. When administered systemically to mice, zoledronic acid potently inhibits the angiogenesis induced by subcutaneous implants impregnated with bFGF [ED50, 3 mug/kg (7.5 nmol/kg) s.c.]. These findings indicate that zoledronic acid has marked antiangiogenic properties that could augment its efficacy in the treatment of malignant bone disease and extend its potential clinical use to other diseases with an angiogenic component. [less ▲]

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See detailNovel antiangiogenic peptide agents and their therapeutic and diagnostic use
Weiner, Richard I.; Martial, Joseph ULg; Struman, Ingrid ULg et al

Patent (2008)

The current invention concerns novel antiangiogenic peptides which correspond to about 10 to about 150 consecutive amino acids of N-terminal sequences of human growth hormones, human placental lactogen ... [more ▼]

The current invention concerns novel antiangiogenic peptides which correspond to about 10 to about 150 consecutive amino acids of N-terminal sequences of human growth hormones, human placental lactogen, human growth hormone variant hGH-V, and prolactin, and their use in inhibiting angiogenesis and in the diagnosis of diseases of human pregnancy involving abnormalities of placental vascularization. [less ▲]

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See detailNovel applications of lactoperoxydase system against pathogens of cultivated plants
Jijakli, Haissam ULg; Bafort, Françoise ULg; perraudin, J.P

Conference (2010, June)

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See detailA novel approach for extracting time-delays from lightcurves of lensed quasar images
Burud, I.; Magain, Pierre ULg; Sohy, Sandrine ULg et al

in Astronomy and Astrophysics (2001), 380

We present a new method to estimate time delays from light curves of lensed quasars. The method is based on chi [SUP]2[/SUP] minimization between the data and a numerical model light curve. A linear ... [more ▼]

We present a new method to estimate time delays from light curves of lensed quasars. The method is based on chi [SUP]2[/SUP] minimization between the data and a numerical model light curve. A linear variation can be included in order to correct for slow long-term microlensing effects in one of the lensed images. An iterative version of the method can be applied in order to correct for higher-order microlensing effects. The method is tested on simulated light curves. When higher-order microlensing effects are present, the time delay is best constrained with the iterative method. Analysis of a published data set for the lensed double Q 0957+561 yields results in agreement with other published estimates. [less ▲]

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See detailA Novel Approach to Design Chitosan-Polyester Materials for Biomedical Applications
Akopova, Tatiana A.; Demina, Tatiana S.; Shchegolikhin, Alexander N. et al

in International Journal of Polymer Science (2012), 2012

Detailed reference viewed: 10 (3 ULg)
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See detailA novel approach to the study of familial influences on evoked cortical responses in migraine.
Schoenen, Jean ULg; Sandor, P. S.

in Cephalalgia : An International Journal of Headache (1999), 19 Suppl 24

Detailed reference viewed: 7 (1 ULg)