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See detailMitochondrion- and endoplasmic reticulum-induced SK channel dysregulation as a potential origin of the selective neurodegeneration in Parkinson’s disease
Drion, Guillaume ULg; Sepulchre, Rodolphe ULg; Seutin, Vincent ULg

in Wellstead, Peter; Cloutier, Mathieu (Eds.) The Systems Biology of Parkinson's Disease (2012)

Mitochondrial dysfunction and metabolic issues are known to have strong implications in the pathogenesis of Parkinson’s disease (PD). But it is also known that the neuronal loss leading to PD symptoms is ... [more ▼]

Mitochondrial dysfunction and metabolic issues are known to have strong implications in the pathogenesis of Parkinson’s disease (PD). But it is also known that the neuronal loss leading to PD symptoms is selective for particular areas of the brain. In particular, the characteristic motor symptoms of PD are mainly due to abnormal neuronal activity in the basal ganglia, through the degeneration of substantia nigra pars compacta (SNc), but not ventral tegmental area (VTA), dopaminergic (DA) neurons. How a metabolic dysfunction triggers such a selective loss is considered from a range of perspectives in several contributions to this volume. The aim of this chapter is to investigate the potential role of small conductance calcium-activated potassium (SK) channels in this selective degeneration. Based on a recently proposed model and experimental data, we underline the fundamental role of SK channels in regulating the excitability of SNc DA neurons. The fact that SK channels do not play this regulating role in VTA DA neurons suggests the hypothesis that one reason for the preferential vulnerability of SNc DA neurons in Parkinson’s disease is that SK channels, which have a profound influence on their firing physiologically, are dysregulated by a dysfunction of mitochondria and/or endoplasmic reticulum. [less ▲]

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See detailMitogen-Activated Lymphocytes: A Good Model for Characterising Lung Cyp1a1 Inducibility
Lambert, Vincent ULg; Todaro, Anna ULg; Kremers, Pierre ULg et al

in European Journal of Epidemiology (1997), 13(2), 177-83

The CYP1A1 hyperinducibility phenotype occurring in some 10% of the human population corresponds to a higher risk of developing lung cancer. This study was undertaken to assess whether the inducibility ... [more ▼]

The CYP1A1 hyperinducibility phenotype occurring in some 10% of the human population corresponds to a higher risk of developing lung cancer. This study was undertaken to assess whether the inducibility factor, generally evaluated on mitogen-activated lymphocytes after PAH induction, represents correctly the lung situation. Optimal experimental conditions were determined for evaluating, on both lymphocytes and lung tissue explants, the inducibility factor, defined as the ratio of EROD activity (CYP1A1-specific) to cytochrome c reductase activity (unaffected by PAH induction). Paired results for lymphocytes and lung tissue samples from 10 lung cancer patients were compared. A good correlation was observed between lymphocyte and lung tissue inducibilities (R = 0.809; p = 0.005). In conclusion, mitogen-activated lymphocyte inducibility is indicative of lung tissue inducibility and constitutes a good marker for evaluating individual PAH inducibilities. [less ▲]

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See detailMitoproteome plasticity of rat brown adipocytes in response to cold acclimation
Navet, Rachel ULg; Mathy, Grégory ULg; Douette, Pierre ULg et al

in Journal of Proteome Research (2007), 6(1), 25-33

Cold acclimation induces an adaptative increase in respiration in brown adipose tissue (BAT). A comparative analysis by two-dimensional differential in-gel electrophoresis of mitochondrial protein ... [more ▼]

Cold acclimation induces an adaptative increase in respiration in brown adipose tissue (BAT). A comparative analysis by two-dimensional differential in-gel electrophoresis of mitochondrial protein patterns found in rat control and cold-acclimated BAT was performed. A total of 58 proteins exhibiting significant differences in their abundance was unambiguously identified. Proteins implicated in the major catabolic pathways were up-regulated as were ATP synthase and mitofilin. Moreover, these results support the fact that adipocytes can balance their ATP synthesis and their heat production linked to UCP1-sustained uncoupling. [less ▲]

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See detailmitotic cycling of radial glial cells of the fetal murine cerebral wall: a combined autoradiographic and immunohistochemical study.
Misson, Jean-Paul ULg; Edwards, Michael; Yamamoto, M. et al

in Developmental Brain Research (1988), 38

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See detailMitotic spindle: focus on the function of huntingtin
Godin, Juliette ULg; Humbert, Sandrine

in International Journal of Biochemistry & Cell Biology (2011), 43(6), 852-856

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See detailMitral regurgitation after transcatheter aortic valve replacement: Does the prosthesis matter?
Unger, Philippe; Dedobbeleer, Chantal; Vanden Eynden, Frederic et al

in International Journal of Cardiology (2013)

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See detailMitral regurgitation in patients with aortic stenosis undergoing valve replacement.
Unger, P.; Dedobbeleer, C.; Van Camp, G. et al

in Heart (2009)

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See detailMitral regurgitation in patients with systolic heart failure: more than a bystander
Lancellotti, Patrizio ULg; Dulgheru, R.

in Revista Espanola de Cardiologia (2011)

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See detailMitral repair versus replacement for ischemic mitral regurgitation comparison of short-term and long-term survival
Magne, Julien ULg; Girerd, N.; Sénéchal, M. et al

in Circulation (2009), 120(SUPPL. 1), 104-111

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See detailMitral valve annuloplasty and papillary muscle relocation oriented by 3-dimensional transesophageal echocardiography for severe functional mitral regurgitation.
Fattouch, Khalil; Murana, Giacomo; Castrovinci, Sebastiano et al

in Journal of Thoracic and Cardiovascular Surgery (The) (2012), 143(4 Suppl), 38-42

OBJECTIVE: The study of the mitral valve apparatus and its modifications during functional mitral regurgitation (FMR) is better revealed by 3-dimensional (3D) transesophageal echocardiography (TOE). To ... [more ▼]

OBJECTIVE: The study of the mitral valve apparatus and its modifications during functional mitral regurgitation (FMR) is better revealed by 3-dimensional (3D) transesophageal echocardiography (TOE). To plan mitral valve repair by annuloplasty and papillary muscle (PPM) relocation, we proposed a valve repair procedure oriented by the new main features obtained by real-time 3D TOE reconstruction of the mitral valve apparatus. METHODS: Since January 2008, 25 patients with severe FMR before mitral valve repair were examined. Mean coaptation depth and mean tenting area were 1.3 +/- 0.2 cm and 3.2 +/- 0.5 cm(2), respectively. Intraoperative 2D and 3D TOE were performed, followed by a 3D offline reconstruction of the mitral valve apparatus. A schematic mitral valve apparatus model was obtained. A geometric model like a truncated cone was traced in according to the preoperative measurements. The size of the prosthetic ring was selected preoperatively according to the anterior leaflet surface. The expected truncated cone after annuloplasty was retraced. A conventional normal coaptation depth about 0.6 cm was used to detect the new position of the PPM tips. RESULTS: Offline reconstruction of the mitral valve apparatus and respective truncated cone were feasible in all patients. The expected position of the PPM tips desirable to reach a normal tenting area with a coaptation depth 0.6 cm or less was obtained in all patients. After surgery, all parameters were calculated and no statistically significant difference was found compared with the expected data. CONCLUSIONS: PPM relocation plus ring annuloplasty reduce mitral valve tenting and may improve mitral valve repair results for patients with severe FMR. This technique may be easily and precisely guided by preoperative offline 3D echocardiographic mitral valve reconstruction. [less ▲]

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See detailMitral valve dynamics in a closed-loop model of the cardiovascular system
Paeme, Sabine ULg; Chase, J. Geoffrey; Hann, christopher et al

in Archives des Maladies du Coeur et des Vaisseaux. Pratique (2009, December), hors série 1

A cardiovascular and circulatory system (CVS) model has been validated in silico, and in several animal model studies. It accounts for valve dynamics by means of Heaviside function to simulate “open on ... [more ▼]

A cardiovascular and circulatory system (CVS) model has been validated in silico, and in several animal model studies. It accounts for valve dynamics by means of Heaviside function to simulate “open on pressure, close on flow” law. Thus, it does not consider the real time scale of the valve aperture and thus doesn’t fully capture valve dysfunction. This work describes a new coupled model of the cardiovascular system that accounts for progressive mitral valve aperture. Simulations show good correlation with physiologically expected results for healthy or diseased valves. The large number of valve model parameters indicates a need for emerging, lighter and minimal mitral valve models that are readily identifiable to achieve full benefit in real-time use. These results suggest a further use of this model to track, diagnose and control valves pathologies. [less ▲]

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See detailMitral valve dynamics in a closed-loop model of the cardiovascular system
Paeme, Sabine ULg; Chase, J. Geoffrey; Hann, Christopher et al

Poster (2009, December 17)

A cardiovascular and circulatory system (CVS) model has been validated in silico, and in several animal model studies. It accounts for valve dynamics by means of Heaviside function to simulate “open on ... [more ▼]

A cardiovascular and circulatory system (CVS) model has been validated in silico, and in several animal model studies. It accounts for valve dynamics by means of Heaviside function to simulate “open on pressure, close on flow” law. Thus, it does not consider the real time scale of the valve aperture and thus doesn’t fully capture valve dysfunction. This research couples the CVS model with a model describing the progressive aperture of the mitral valve. [less ▲]

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See detailMITRAL VALVE REGURGITATION
LANCELLOTTI, Patrizio ULg; MAGNE, Julien

in ZAMORANO, JOSE LUIS; BAX, JEROEN; KNUUTI, JUHANI (Eds.) et al THE ESC TEXTBOOK OF CARDIOVASCULAR IMAGING - SECOND EDITION (2015)

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See detailMitteldevonische Sporen Aus Der Bohrung Schwarzbachtal 1.
Streel, Maurice ULg; Paproth, E

in Senckenbergiana Lethaea (1982), 63(4), 175-181

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See detailDie mittelniederländischen Nachdichtungen Hoffmanns von Fallersleben
Vromans, Joseph ULg

in Hipp, H. (Ed.) Niederlandistik und Germanistik. Tangenten und Schnittpunkte. Festschrift für Gerhard Worgt zum 65. Geburtstag (1993)

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See detailMix stability as a criterion for optimizing the granular composition to improve concrete durability – an application
Willem, Xavier; Courard, Luc ULg; Darimont, Anne ULg et al

in Marchand, J.; Bissonnette, B.; Gagné, R. (Eds.) et al Advances in Concrete through Science and Engineering (2006, September)

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See detailMixed IBD families: A distinct entity within IBD
Pierik, M.; Van Steen, Kristel ULg; Joossens, M. et al

in Gastroenterology (2007), 132(4), 450-450

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See detailA mixed integer nonlinear programming bi-objective model for intermodal network design
Mostert, Martine ULg; Caris, An; Limbourg, Sabine ULg

Conference (2015, February 05)

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