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See detailModena e la cittadinanza globale
Martiniello, Marco ULg

Scientific conference (2003, June 05)

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See detailModerate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors
Mangin, Floriane; Dilly, Sébastien ULg; Joly, Benoît ULg et al

in Bioorganic & Medicinal Chemistry Letters (2012)

The selectivity for 5-HT1A versus D4 receptors is significantly increased when the basic side chain of WAY-100635 is replaced by a 4-phenylpiperazine (3e) or a 4-phenyl-1,2,3,6-tetrahydropyridine moiety ... [more ▼]

The selectivity for 5-HT1A versus D4 receptors is significantly increased when the basic side chain of WAY-100635 is replaced by a 4-phenylpiperazine (3e) or a 4-phenyl-1,2,3,6-tetrahydropyridine moiety (3i). The 4-phenyl-1,2,3,6-tetrahydropyridine compounds (3i-l) have a higher affinity for 5-HT1A receptors than do the corresponding unsubstituted phenylpiperazine analogues (3e-h). Compounds 3e and 3i appear to be selective for 5-HT1A receptors over other relevant receptors and still behave as neutral antagonists. [less ▲]

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See detailModerate deflection analysis of shelles of revolution, using cylindrical components of the displacement
Debongnie, Jean-François ULg

Report (1984)

This paper is devoted to the analysis of shells of revolution, using cylindrical components of the displacement. This procedure, as coupled with a Fourier expansion by respect of the azimuth, permits the ... [more ▼]

This paper is devoted to the analysis of shells of revolution, using cylindrical components of the displacement. This procedure, as coupled with a Fourier expansion by respect of the azimuth, permits the generation of finite elements in which rigid body are represented exactly, even in the case of doubly curved shells. [less ▲]

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See detailModerate deglection analysis of shells of revolution, using cartesian components of the displacement
Debongnie, Jean-François ULg

Report (1985)

This paper is devoted to the analysis of shells of revolution, using cylindrical components of the displacement. This procedure, coupled with a Fourier expansion by respect of the azimuth, permits the ... [more ▼]

This paper is devoted to the analysis of shells of revolution, using cylindrical components of the displacement. This procedure, coupled with a Fourier expansion by respect of the azimuth, permits the generation of finite elements in which rigid body displacements are represented exactly, even in the case of doubly curved shells. [less ▲]

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See detailModerate hypothermia during cardiopulmonary bypass increases intramyocardial synthesis of heat shock protein 72.
Qing, Ma; Vazquez-Jimenez, Jaime F; Schumacher, Kathrin et al

in Journal of Thoracic and Cardiovascular Surgery (The) (2002), 124(4), 724-31

OBJECTIVES: This study was undertaken to test the hypothesis that the myocardial protective effect of moderate hypothermia during cardiopulmonary bypass involves upward regulation of heat shock protein 72 ... [more ▼]

OBJECTIVES: This study was undertaken to test the hypothesis that the myocardial protective effect of moderate hypothermia during cardiopulmonary bypass involves upward regulation of heat shock protein 72. METHODS: Sixteen young pigs were randomly assigned to a temperature regimen during standardized cardiopulmonary bypass of normothermia or moderate hypothermia (temperatures 37 degrees C and 28 degrees C, respectively, n = 8 per group). Myocardial probes were sequentially sampled from the right ventricle before and during bypass and 6 hours after bypass. Messenger RNA encoding for heat shock protein 72 was assessed by competitive reverse transcriptase-polymerase chain reaction, and heat shock protein 72 synthesis was assessed by Western blot and immunohistochemical methods. Induction of apoptosis was assessed by gene expression of apoptosis-regulating proteins (Bcl-xL, Bak, and Fas) according to competitive reverse transcriptase polymerase chain reaction. Apoptotic cells were identified with an in situ apoptosis-detection kit (terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling) in combination with morphologic criteria. Necrotic cells were detected by standard histologic methods. RESULTS: Moderate hypothermia rather than normothermia was associated with earlier and higher gene expression and synthesis of heat shock protein 72 in the myocardium during and after cardiac surgery. In the hypothermia group both heat shock protein 72 and the messenger RNA encoding it were detected as soon as 30 minutes after initiation of bypass and before aortic clamping, whereas in the normothermia group they were not detected before aortic clamping. Immunohistochemical methods showed localization of heat shock protein 72 in the cardiomyocytes, endothelial cells, and macrophages. Although the percentage of necrotic cells in the myocardium was lower in the hypothermic group, the induction of apoptosis regulatory proteins and the percentage of apoptotic cells did not differ between the groups. CONCLUSIONS: These results suggest that the myocardial protective effect of moderate hypothermia during cardiopulmonary bypass involves upward regulation of heat shock protein 72 and inhibition of necrosis but not of apoptosis. [less ▲]

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See detailModerate hypothermia during cardiopulmonary bypass reduces myocardial cell damage and myocardial cell death related to cardiac surgery.
Vazquez-Jimenez, J. F.; Qing, M.; Hermanns, B. et al

in Journal of the American College of Cardiology (2001), 38(4), 1216-23

OBJECTIVES: The goal of this study was to test the hypothesis that moderate hypothermia during cardiopulmonary bypass (CPB) provides myocardial protection by enhancing intra-myocardial anti-inflammatory ... [more ▼]

OBJECTIVES: The goal of this study was to test the hypothesis that moderate hypothermia during cardiopulmonary bypass (CPB) provides myocardial protection by enhancing intra-myocardial anti-inflammatory cytokine balance. BACKGROUND: Moderate hypothermia during experimental CPB stimulates production of interleukin-10 (IL10) and blunts release of tumor necrosis factor-alpha (TNFalpha). METHODS: Twelve young pigs were assigned to a temperature (T degrees ) regimen during CPB: moderate hypothermia (T degrees : 28 degrees C; n = 6) and normothermia (T degrees : 37 degrees C; n = 6). Intra-myocardial TNFalpha- and IL10-messenger RNA were detected by competitive reverse transcriptase polymerase chain reaction and quantification of cytokine synthesis by Western blot. Levels of cardiac troponin I (cTnI) in cardiac lymph and in arterial and coronary venous blood were examined during and after CPB. Myocardial cell damage was assessed by histologic and ultrastructural anomalies of tissue probes taken 6 h after CPB. RESULTS: Synthesis of IL10 was significantly higher, while that of TNFalpha was significantly lower, in pigs that were in moderate hypothermia during surgery than in the others. In contrast with normothermia, moderate hypothermia was also associated with significantly lower cumulative cardiac lymphatic flow during and after CPB, significantly lower lymphatic cTnI concentrations after CPB, significantly lower percentages of myocardial cell necrosis and a significantly lower score of ultrastructural anomalies of myocardial cells. While the percentage of apoptotic cells was not different between groups, the apoptosis/necrosis ratio tended to be higher in animals that were in moderate hypothermia during surgery. In all animals, TNFalpha synthesis correlated positively while IL10 production correlated negatively with necrosis and total cell death, respectively. CONCLUSIONS: Our results suggest that moderate hypothermia during CPB provides myocardial protection by enhancing intra-myocardial anti-inflammatory cytokine balance. [less ▲]

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See detailModerate patient-prosthesis mismatch can impact on mortality after aortic valve replacement
Dumesnil, J. G.; Magne, Julien ULg; Girerd, N. et al

in Heart (2009), 95(7), 592

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See detailA moderate transfusion regimen may reduce iron loading in beta-thalassemia major without producing excessive expansion of erythropoiesis.
Cazzola, M.; Borgna-Pignatti, C.; Locatelli, F. et al

in Transfusion (1997), 37(2), 135-40

BACKGROUND: Hypertransfusion with a baseline hemoglobin of 10 to 12 g per dL is still considered by many to be the mainstay of conservative therapy for beta-thalassemia major. However, this regimen is ... [more ▼]

BACKGROUND: Hypertransfusion with a baseline hemoglobin of 10 to 12 g per dL is still considered by many to be the mainstay of conservative therapy for beta-thalassemia major. However, this regimen is frequently associated with manifestations of transfusion iron overload, despite regular chelation therapy with subcutaneous desferoxamine. STUDY DESIGN AND METHODS: To verify whether a transfusion regimen with a target pretransfusion hemoglobin level between 9 and 10 g per dL can allow a significant reduction in blood consumption, while still effectively suppressing erythropoiesis, the records were reviewed of 32 beta-thalassemia major patients, who were maintained at a pretransfusion hemoglobin of 11.3 +/- 0.5 g per dL between 1981 and 1986. These patients were switched at the beginning of 1987 to a transfusion regimen with pretransfusion hemoglobin of 9.4 +/- 0.4 g per dL. The degree of erythroid marrow activity was evaluated in these patients and in 32 subjects with beta-thalassemia intermedia through the simple measurement of serum transferrin receptor. RESULTS: After the adoption of the moderate transfusion regimen, transfusion requirements decreased from 137 +/- 26 to 104 +/- 23 mL per kg per year of red cells (p < 0.0001), and mean serum ferritin decreased from 2448 +/- 1515 to 1187 +/- 816 micrograms per L (p < 0.0001), with one-half of patients achieving serum ferritin levels lower than 1000 micrograms per L. The proportion of patients having spontaneous pubertal development increased significantly (p < 0.01), as a result of less iron-related gonadotropin insufficiency. At the lower pretransfusion hemoglobin, erythroid marrow activity did not exceed two to three times normal levels in most subjects. CONCLUSION: As compared with hypertransfusion, moderate transfusion may allow more effective prevention of iron loading, with higher likelihood of spontaneous pubertal development and without producing excessive expansion of erythropoiesis. [less ▲]

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See detailModeration
Küpper, Achim ULg

Scientific conference (2012, October 10)

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See detailModerator : Prosthetic Session
Van Heusden, Alain ULg

Conference (2009)

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See detailModeratrice
Parra Santamaria, Lusmiriam Andrea ULg

Conference (2009)

This Forum has been organised in order to discuss different approaches for the bilateral Colombia-Venezuela's conflict that had taken place during the gouvernements of Alvaro Uribe and Hugo Chavez ... [more ▼]

This Forum has been organised in order to discuss different approaches for the bilateral Colombia-Venezuela's conflict that had taken place during the gouvernements of Alvaro Uribe and Hugo Chavez. Several secteors of the society participated in it. We had academics (from different universities in the city), the local journal's president, the Chief of research of the Central Bank (local office in Cartagena). [less ▲]

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See detailModern approaches to Corpus Linguistics
Longrée, Dominique ULg

Conference (2010)

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See detailModern aspecs of treatment of decompression sickness
Lamy, Maurice ULg; Hanquet, M. M.

in Acta Anaesthesiologica Belgica (1973), 24(3), 215-29

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See detailModern electrophysiological methods for brain-computer interfaces.
Grave de Peralta Menendez, Rolando; Noirhomme, Quentin ULg; Cincotti, Febo et al

in Computational Intelligence & Neuroscience (2007)

Modern electrophysiological studies in animals show that the spectrum of neural oscillations encoding relevant information is broader than previously thought and that many diverse areas are engaged for ... [more ▼]

Modern electrophysiological studies in animals show that the spectrum of neural oscillations encoding relevant information is broader than previously thought and that many diverse areas are engaged for very simple tasks. However, EEG-based brain-computer interfaces (BCI) still employ as control modality relatively slow brain rhythms or features derived from preselected frequencies and scalp locations. Here, we describe the strategy and the algorithms we have developed for the analysis of electrophysiological data and demonstrate their capacity to lead to faster accurate decisions based on linear classifiers. To illustrate this strategy, we analyzed two typical BCI tasks. (1) Mu-rhythm control of a cursor movement by a paraplegic patient. For this data, we show that although the patient received extensive training in mu-rhythm control, valuable information about movement imagination is present on the untrained high-frequency rhythms. This is the first demonstration of the importance of high-frequency rhythms in imagined limb movements. (2) Self-paced finger tapping task in three healthy subjects including the data set used in the BCI-2003 competition. We show that by selecting electrodes and frequency ranges based on their discriminative power, the classification rates can be systematically improved with respect to results published thus far. [less ▲]

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See detailModern három dimenziós konformális craniospinalis besugárzási technika.
Sebestyén, Z.; Kovács, P.; GULYBAN, Akos ULg et al

in Magyar Onkologia (2011), 55(3), 187-192

The main problem of craniospinal irradiation (CSI) is the matching of the fields. The use of a suitable technique is very important because matching of the fields is necessary to use for the optimal ... [more ▼]

The main problem of craniospinal irradiation (CSI) is the matching of the fields. The use of a suitable technique is very important because matching of the fields is necessary to use for the optimal cancer irradiation of the long planning target volume (PTV). Since 2007, 8 patients have received CT-based, 3D-planned conformal CSI in our Institute. Patient immobilization was made in prone position in a vacuum bed, using skull and pelvis masks. Organ-at-risk (OAR) contours were made by radiographers. PTV was contoured by radiation oncologists. The prescribed dose to the PTV was 36 Gy with 1.8 Gy dose per fraction. In the planning process the following aspects were taken under consideration: all points of the PTV had to receive at least 95% of the prescribed dose (according to ICRU 50, 62); at junction field edges the overlapping parts were eliminated using a multisegmental technique, where the adjacent segment ends of the neighbouring fields were shifted two times 2 cm, so that the three equally weighted segments used in one field had 2-2 cm distance from each other. In the CSI planning the shape of the patient and so the length of the PTV has made a big emphasis on determining the number of field matching. Thus in some cases instead of two, only one field matching was sufficient - this could be achieved by increasing the source-to-skin distance (SSD) of the fields. The verification made with a solid-water phantom justified the precision of the field matching. The offset used at junction field edges in between one treatment facilitates the verification of field matching - and so the patient positioning. Thus the possibility of having overdosed regions could be reduced, which was very important from a radiation biological point of view. [less ▲]

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See detailModern look at a pathology of the millenium : abdominal aortic aneurysms.
Limet, Raymond ULg; Sakalihasan, Natzi ULg

in Bulletins et Mémoires de l’Académie Royale de Médecine de Belgique (2008), 163(5), 205-11

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See detailModern techniques for flood risk analysis: quasi-3D simulations in a GIS environment
Archambeau, Pierre ULg; Erpicum, Sébastien ULg; Dewals, Benjamin ULg et al

in Geophysical Research Abstracts (2005), 7(09348),

Human beings have continuously attempted to adapt their environment to their needs. However, many natural phenomena still remain challenging to control and the populations must undergo sometimes heavily ... [more ▼]

Human beings have continuously attempted to adapt their environment to their needs. However, many natural phenomena still remain challenging to control and the populations must undergo sometimes heavily damaging consequences. It is consequently essential to study these phenomena in order to assess their potential hazards. In particular, the scope of the present paper focus on floods. The intense floods met these last years showed the importance of this phenomenon as well as its many devastating effects. Thanks to recent important breakthroughs, both in the field of conceptual and numerical modelling of complex flows and in the calculation power of computers, it is henceforth possible to study the effects of potential floods on the basis of numerical simulations, with an accuracy never reached beforehand. The Laboratory of Applied Hydrodynamics and Hydraulic Constructions (HACH) of the University of Liege has always made this kind of study one of its core competencies, thanks to • the development of modern and powerful modelling tools (quasi-three dimensional software for flow simulation by finite volume), • the use of a broad range of data enabling a proper representation of the studied fields (topography, occupation of the ground...) • the systematic validation of simulation results. These tools are currently intensively used within the framework of a general study of the flood-prone zones of the Walloon area of Belgium, which corresponds to more than 800 km of rivers. [less ▲]

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See detailModernidades múltiples y crítica social de las tecnologías
Delvenne, Pierre ULg; Erpicum, Martin ULg; Hupet, Pierre et al

in Cuadernos sobre Relaciones Internacionales, Regionalismo y Desarrollo (2009), 4(7), 65-90

Although, the links between the ideologies of progress and technological developments are often strong, we are currently observing amore and more virulent social criticism of these evolutions’ ... [more ▼]

Although, the links between the ideologies of progress and technological developments are often strong, we are currently observing amore and more virulent social criticism of these evolutions’ consequences. This paper,written by four European and Latin American researchers, addresses the way as sciences and technology issues are criticised and dealt with in Europe in the framework of “TechnologyAssessment” (TA) offices. Then, important for the authors is to consider that although TA practices proved to be efficient in a European context, such a tool may not be transferable as such in another context. Relying on the concept of “multiplemodernities”, they focus on Latin America to stress the usefulness of building an adapted local TA capacity, through an interactive process of co-construction by the practitionners and various stakeholders, including the public. [less ▲]

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See detailLa modernisation de l'administration publique : gérer le changement par/avec/malgré les identités ?
Rondeaux, Giseline ULg

Conference (2008, November)

Au sein de la problématique de la modernisation de l’administration publique, notre propos s’intéresse à l’existence de liens entre un processus de réforme mis en oeuvre dans une administration, et les ... [more ▼]

Au sein de la problématique de la modernisation de l’administration publique, notre propos s’intéresse à l’existence de liens entre un processus de réforme mis en oeuvre dans une administration, et les identités organisationnelles des membres de cette organisation. De tels changements entraînent indubitablement une transformation de multiples aspects de l’administration, tels que ses modes d’organisation, sa politique de GRH, sa manière de concevoir et de remplir ses missions, ses structures, ses référents, etc. Cette transformation suppose la valorisation de modes de fonctionnement, de valeurs et de compétences différents, et a pour résultat un bouleversement de l’identité organisationnelle et des identités professionnelles des membres de cette organisation (Fu et al., 1999; Abrams & Hogg, 1987). Notre objectif est de comprendre et décrire de quelle manière les identités évoluent à la suite de l’introduction de ces nouveaux principes et pratiques dans le contexte de l’administration publique. A partir de données collectées durant deux ans au sein d’un ministère fédéral belge, nous postulons que l’introduction d’une réforme inspirée du New Public Management entraîne une hybridation des logiques identitaires au sein de l’administration publique, mais que par ailleurs, le cours de cette réforme a pu être influencé, à terme, par les logiques identitaires en présence. Au moyen d’une analyse qualitative longitudinale, nous proposons de distinguer 7 profils identitaires, caractérisés par la référence à une logique identitaire (logique de service public, de managérialisme public ou de pragmatisme) et leur positionnement par rapport à leur perception du contexte (congruence ou dissonance). Au travers de notre étude de cas, notre hypothèse d’une co-structuration des identités organisationnelles et du processus de réforme de l’administration nous apparaît comme validée, ainsi qu’en témoigne l’hybridation des logiques identitaires en présence au sein de l’administration étudiée. Nos résultats nous permettent ainsi de supposer une modification des repères identitaires à la suite de la réforme, mais également une réinterprétation de cette réforme au travers du filtre des identités. Notre approche longitudinale révèle par ailleurs les dynamiques identitaires, en identifiant notamment les processus de shift d’un profil à l’autre, et nous conduit à proposer un modèle des dynamiques identitaires contextualisé. Nous sommes également en mesure de montrer quels facteurs produisent (ou sont susceptibles de produire) des shifts identitaires, et le positionnement de chaque profil identitaire à l’égard du changement (1) tel qu’il est vécu et (2) de manière projective. Les facteurs influençant le shift d’un profil identitaire à l’autre sont étroitement liés au concept de motivation. Plusieurs études ont en effet montré la portée de la congruence identitaire (ou identification) sur la construction de l'implication organisationnelle et ses impacts sur les attitudes et comportements des membres de l'organisation, telles que le turnover, la satisfaction, l’implication, la coopération, ou encore l'acceptation du changement (Foreman et Whetten, 2002 ; Ashforth et Mael, 1989 ; Dutton et al. 1994 ; Reger et al., 1998). Ces résultats peuvent conduire à divers prolongements managériaux. En effet, les résultats de notre analyse mettent en évidence l’ampleur des obstacles que les problématiques identitaires peuvent constituer face au changement. Ils font également apparaître des leviers potentiels de changement. Dans la mesure où ils auront pu être identifiés, ces éléments peuvent ultérieurement constituer une base pour le développement d’une approche, de méthodes voire d’outils relatifs à la gestion du changement : utiliser les identités organisationnelles comme indicateur clé voire comme levier de changement. De plus, la diversité des profils identitaires, et leur évolution, amène aussi à réfléchir à des actions managériales différenciées, suivant l’idée qu’il n’existe pas un seul modèle de réduction de la dissonance, et que les leviers à mobiliser pour favoriser la congruence sur le plan identitaire dans un contexte de changement varieront d’un profil à l’autre. Enfin, l’approche interprétative proposée par notre modèle analytique pourrait servi de base pour le développement d’outils de gestion pour encadrer et accompagner les processus de changement au sein d’une organisation. [less ▲]

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See detailModernisation de l’interface citoyen - fonction publique: vers une intégration réfléchie des TIC
Lisein, Olivier ULg

in Pyramides (2003), 7(Printemps), 135-147

Périodique scientifique - Le secteur public connaît, ces dernières années, une profonde et sérieuse remise en question. Nombreux sont ainsi les états où une politique générale de modernisation de la ... [more ▼]

Périodique scientifique - Le secteur public connaît, ces dernières années, une profonde et sérieuse remise en question. Nombreux sont ainsi les états où une politique générale de modernisation de la fonction publique est, ou va être, instaurée. Au centre des préoccupations, le citoyen y bénéficie d’une place de choix: il fait l’objet de nombreuses attentions et peut donc désormais s’attendre à davantage d’égards. Qualité du service et satisfaction de la population deviennent en effet des concepts clés de la fonction publique. Pour atteindre ces objectifs, c’est toute la conception des relations qu’entretiennent citoyen et secteur public qui est revue. Les technologies de l’information et de la communication (TIC) présentent, dans ce cadre, de nombreux atouts. L’interface citoyen - secteur public s’en trouve modernisé avec, comme objectif avoué, une proximité accrue avec la population pour une plus grande satisfaction de celle-ci. Si ce recours aux TIC offre d’indéniables opportunités - tant en termes d’innovation de services que dans la manière dont ceux-ci sont prestés -, il n’en soulève pas moins certaines questions, l’accès aux services étant, pour le citoyen, complètement revu. Sur base d’une analyse critique de la littérature et de l’étude d’un cas concret, notre contribution entend questionner l’implémentation et la gestion des TIC dans l’interface citoyen - fonction publique. [less ▲]

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