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See detailLe NPI NH chez des sujets âgés déments et non déments
Ylieff, Michel ULg; Di Notte, David; Missotten, Pierre ULg et al

Poster (2006, September)

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See detailNPM Under Pressure: An Inquiry in Theory
Esposito, Giovanni ULg

Conference (2014)

This theoretical inquiry is undertaken on the basis of the problematization methodology proposed by Alvesson et Sandberg (2011) and deriving from a critical approach to management studies. In this paper ... [more ▼]

This theoretical inquiry is undertaken on the basis of the problematization methodology proposed by Alvesson et Sandberg (2011) and deriving from a critical approach to management studies. In this paper, problematization is adopted not only to question the fundamental assumptions of New Public Management (NPM) theory, but also to develop alternative assumptions to be explored in order to highlight a new way of approaching the managerial practices of public organizations. Starting from the in-house level of assumptions, NPM theoretical body has been gradually deconstructed by progressively increasing the level of abstraction and reaching the field level of assumption. The assumption’s content at each level of abstraction has been determined thanks to a continuum comparison between NPM and the Public Value Theory (PVT) school of thought. Because of its status of challenging theory, PVT has played the role of a theoretical reagent added to NPM system of thought in order to bring about a theoretical reaction enabling to spotlight problematic assumptions and generate further research questions. Such a “theoretical reaction” has shown that NPM is a functionalist theory based on a rationalistic approach to public organizations which are conceived as machines whose proper functioning depends on efficiency improvements to be achieved by means of a planning mode of management. [less ▲]

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See detailThe NREGA - Tackling Poverty in India
Maiorano, Diego ULg

Learning material (2013)

This is a presentation on the Mahatma Gandhi National Rural Employment Guarantee Act. This presenatation was prepared for the students of the course "Strategies to Tackle Poverty" of the University of ... [more ▼]

This is a presentation on the Mahatma Gandhi National Rural Employment Guarantee Act. This presenatation was prepared for the students of the course "Strategies to Tackle Poverty" of the University of Liège (2013/14). [less ▲]

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See detailNREM slow wave oscillation rebound after sleep deprivation : effect of aging
Lafortune, M; Viens, I; Poirier, G et al

Poster (2010, June)

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See detailNSAIDS : not just COX-2 inhibitors ?
Henrotin, Yves ULg

in Intern Clin Pract Series (2002), 19

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See detailNSAIDs in the acute treatment of migraine: A review of clinical and experimental data
Párdutz, Arpad; Schoenen, Jean ULg

in Pharmaceuticals (2010), 3

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See detailNSAIDs in the management of musculoskeletal conditions: a comparative meta-analysis of the efficacy/safety profile of piroxicam
Richy, Florent; Scarpignato, Carmalo; Lanas, Angel et al

in Arthritis and Rheumatism (2007, September), 56(number 9 (suppl.)), 599-600

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See detailNt-3 Has a Tropic Effect on Process Outgrowth by Postnatal Auditory Neurones in Vitro
Malgrange, Brigitte ULg; Lefebvre, P. P.; Martin, Didier ULg et al

in Neuroreport (1996), 7(15-17), 2495-9

CONFOCAL analysis of early postnatal auditory neurones in a bicompartmental culture system was used to test for chemoattractant properties of NGF, BDNF and NT-3 on neuronal process outgrowth. NT-3 exerted ... [more ▼]

CONFOCAL analysis of early postnatal auditory neurones in a bicompartmental culture system was used to test for chemoattractant properties of NGF, BDNF and NT-3 on neuronal process outgrowth. NT-3 exerted a strong tropic effect on neuritic outgrowth from auditory neurones in this system. BDNF and NGF did not have any tropic activity that directed processes outgrowth from auditory neurones. However, BDNF was important for the support of neuronal survival in NGF-treated cultures and for neuritogenesis in NT-3-treated cultures. Since NT-3 has been identified as both a survival factor and a chemotropic agent for auditory neurones, it is likely that this neurotrophin will be a useful therapeutic agent in the treatment of damaged cochleae for the recovery of hearing. [less ▲]

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See detailThe nth order moment W(n)D of a resonance doublet P Cygni line profile
Surdej, Jean ULg; Hutsemekers, Damien ULg

in Astronomy and Astrophysics (1990), 233

The theory of the nth order moment W(n)D of a P Cygni line profile due to a resonance doublet line transition is developed here in the framework of the Sobolev approximation. It is shown that, in the ... [more ▼]

The theory of the nth order moment W(n)D of a P Cygni line profile due to a resonance doublet line transition is developed here in the framework of the Sobolev approximation. It is shown that, in the optically thick approximation, the asymptotic value W(n)D,t is entirely dependent on both the doublet separation and the type of the velocity field characterizing the expanding atmosphere. The most useful P Cygni profiles seem to be those which are unsaturated. [less ▲]

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See detailLe Nucléaire... Une énergie dans le vent? - Ciné-débat autour du film d'Alain de Halleux, Welcome to Fukushima
Parotte, Céline ULg

Speech (2014)

Ciné-débat autour du film Welcome to Fukushima en présence du réalisateur, Alain de Halleux et avec Pierre Dewallef, chargé de cours à la faculté des Sciences Appliquées dans le département d’aérospatiale ... [more ▼]

Ciné-débat autour du film Welcome to Fukushima en présence du réalisateur, Alain de Halleux et avec Pierre Dewallef, chargé de cours à la faculté des Sciences Appliquées dans le département d’aérospatiale et mécanique – ULg Céline Parotte, assistante-doctorante au Centre de recherche Spiral – ULg Pablo Servigne, animateur et chercheur en éducation permanente à l’asbl Barricade Débat animé par Jérôme Jamin,co-directeur de la Maison des Sciences de l'Homme-ULg Organisation : la Maison des Sciences de l'Homme (ULg), l'asbl Barricade et la Coopérative Courant d'Air, sous l'impulsion de Laurence Farine (membre de TerreMaCulture) et avec le soutien de Réjouisciences. [less ▲]

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See detailNuclear (scintigraphic) methods and FDG-PET in rheumatoid osteoarthritis
Ribbens, Clio ULg; Hustinx, Roland ULg

in Bruno, Michael A.; Mosher, Timothy J.; Gold, Gary E. (Eds.) Arthritis in Color. Advance Imaging of Arthritis. (2009)

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See detailNuclear bodies and compartmentalization of pre-mRNA splicing factors in higher plants
Docquier, Sarah; Tillemans, Vinciane ULg; Deltour, Roger et al

in Chromosoma (2004), 112(5), 255-266

We studied the fine structural organization of nuclear bodies in the root meristem during germination of maize and Arabidopsis thaliana using electron microscopy (EM). Cajal bodies (CBs) were observed in ... [more ▼]

We studied the fine structural organization of nuclear bodies in the root meristem during germination of maize and Arabidopsis thaliana using electron microscopy (EM). Cajal bodies (CBs) were observed in quiescent embryos as well as germinating cells in both species. The number and distribution of CBs were investigated. To characterize the nuclear splicing domains, immunofluorescence labelling with antibodies against splicing factors (U2B" and m3G-snRNAs) and in situ hybridisation (with U1/U6 antisense probes) were performed combined with confocal microscopy. Antibodies specific to the Arabidopsis SR splicing factor atRSp31 were produced. AtRSp31 was detected in quiescent nuclei and in germinating cells. This study revealed an unexpected nuclear speckled organization of atRSp31 in root epidermal cells where micro clusters of interchromatin granules were also observed by EM. Therefore, we examined the distribution of green fluorescent protein (GFP)-tagged atRSp31 in living cells after Agrobacterium-mediated transient expression. When expressed transiently, atRSp31-GFP exhibited a speckled distribution in leaf cells. Treatments with -amanitin, okadaic acid, staurosporine or heat-shock induced the speckles to reorganize. Furthermore, we have generated stable Arabidopsis transgenics expressing atRSp31-GFP. The distribution of the fusion protein was identical to the endogenous atRSp31. Three-dimensional time-lapse confocal microscopy showed that speckles were highly dynamic domains over time. [less ▲]

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See detailNUCLEAR DELIVERY OF A THERAPEUTIC PEPTIDE BY LONG CIRCULATING pH-SENSITIVE LIPOSOMES: BENEFITS OVER CLASSICAL VESICLES
Ducat, Emilie; Deprez, Juile; Noël, Agnès ULg et al

Poster (2011, December 06)

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See detailNuclear delivery of a therapeutic peptide by long circulating pH-sensitive liposomes: Benefits over classical vesicles.
Ducat, Emilie ULg; Deprez, Julie ULg; Gillet, Aline ULg et al

in International Journal of Pharmaceutics (2011)

The purpose of this study is to propose a suitable vector combining increased circulation lifetime and intracellular delivery capacities for a therapeutic peptide. Long circulating classical liposomes ... [more ▼]

The purpose of this study is to propose a suitable vector combining increased circulation lifetime and intracellular delivery capacities for a therapeutic peptide. Long circulating classical liposomes [SPC:CHOL:PEG-750-DSPE (47:47:6 molar% ratio)] or pH-sensitive stealth liposomes [DOPE:CHEMS:CHOL:PEG(750)-DSPE (43:21:30:6 molar% ratio)] were used to deliver a therapeutic peptide to its nuclear site of action. The benefit of using stealth pH-sensitive liposomes was investigated and formulations were compared to classical liposomes in terms of size, shape, charge, encapsulation efficiency, stability and, most importantly, in terms of cellular uptake. Confocal microscopy and flow cytometry were used to evaluate the intracellular fate of liposomes themselves and of their hydrophilic encapsulated material. Cellular uptake of peptide-loaded liposomes was also investigated in three cell lines: Hs578t human epithelial cells from breast carcinoma, MDA-MB-231 human breast carcinoma cells and WI-26 human diploid lung fibroblast cells. The difference between formulations in terms of peptide delivery from the endosome to the cytoplasm and even to the nucleus was investigated as a function of time. Characterization studies showed that both formulations possess acceptable size, shape and encapsulation efficiency but cellular uptake studies showed the important benefit of the pH-sensitive formulation over the classical one, in spite of liposome PEGylation. Indeed, stealth pH-sensitive liposomes were able to deliver hydrophilic materials strongly to the cytoplasm. Most importantly, when encapsulated in pH-sensitive stealth liposomes, the peptide was able to reach the nucleus of tumorigenic and non tumorigenic breast cancer cells. [less ▲]

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See detailNuclear Energy: Between Legitimacy and Threat
Michel, Quentin ULg

Conference (2013, December 12)

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See detailNuclear Export Control in the European Union
Michel, Quentin ULg

Learning material (2010)

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See detailNuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance.
Kasler, Herbert G.; Lim, Hyung W.; Mottet, Denis ULg et al

in EMBO Journal (2012)

Histone deacetylase 7 (HDAC7) is a T-cell receptor (TCR) signal-dependent regulator of differentiation that is highly expressed in CD4/CD8 double-positive (DP) thymocytes. Here, we examine the effect of ... [more ▼]

Histone deacetylase 7 (HDAC7) is a T-cell receptor (TCR) signal-dependent regulator of differentiation that is highly expressed in CD4/CD8 double-positive (DP) thymocytes. Here, we examine the effect of blocking TCR-dependent nuclear export of HDAC7 during thymic selection, through expression of a signal-resistant mutant of HDAC7 (HDAC7-DeltaP) in thymocytes. We find that HDAC7-DeltaP transgenic thymocytes exhibit a profound block in negative thymic selection, but can still undergo positive selection, resulting in the escape of autoreactive T cells into the periphery. Gene expression profiling reveals a comprehensive suppression of the negative selection-associated gene expression programme in DP thymocytes, associated with a defect in the activation of MAP kinase pathways by TCR signals. The consequence of this block in vivo is a lethal autoimmune syndrome involving the exocrine pancreas and other abdominal organs. These experiments establish a novel molecular model of autoimmunity and cast new light on the relationship between thymic selection and immune self-tolerance. [less ▲]

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