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See detailNovel use of lipopeptide preparations
Deleu, Magali ULg; Brans, Alain; Brasseur, Robert ULg et al

Patent (2004)

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See detailNovel Variations of the Asymmetric Catalytic Dihydroxylation of olefins
Colaux, Catherine ULg; Krief, Alain

Poster (2000, December)

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See detailA novel virus blinding assay using confocal microscopy: demonstration that the intracellular and extracellular vaccinia virions bind to different cellular receptors
Vanderplasschen, Alain ULg; Smith, G. L.

in Journal of Virology (1997), 71

Vaccinia virus (VV) produces two antigenically and structurally distinct infectious virions, intracellular mature virus (IMV) and extracellular enveloped virus (EEV), which bind to unidentified and ... [more ▼]

Vaccinia virus (VV) produces two antigenically and structurally distinct infectious virions, intracellular mature virus (IMV) and extracellular enveloped virus (EEV), which bind to unidentified and possibly different cellular receptors. Studies of VV binding have been hampered by having two infectious virions and by the rupture of the EEV outer membrane in the majority of EEV virions during purification. To overcome these problems, we have developed a novel approach to study VV binding that is based on confocal microscopy and does not require EEV purification. In this assay, individual virus particles adsorbed to the cell are simultaneously distinguished and quantified by double immunofluorescence labelling with antibody markers for EEV and IMV. By this method, we show unequivocally that IMV and EEV bind to different cellular receptors. Three independent observations allow this conclusion. First, the efficiencies with which IMV and EEV bind to different cell lines are unrelated; second, cell surface digestion with some enzymes affects IMV and EEV binding differently; and third, the binding of a monoclonal antibody to cells prevents IMV binding but not EEV binding. This technique may be widely applicable for studying the binding of different viruses. [less ▲]

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See detailNovel xylanases and their use
Georis, Jacques; Dauvrin, Thierry; Hoyoux, Anne et al

Patent (2005)

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See detailNovel, Highly Efficient and Selective Ruthenium Catalysts for the Synthesis of Vinyl Esters from Carboxylic Acids and Alkynes
Nicks, Francois ULg; Aznar, Rozario; Sainz, Daniel et al

in European Journal of Organic Chemistry (2009), 2009(29), 5020-5027

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See detailLas novelas de la rebelión zapatista
Vanden Berghe, Kristine ULg

Book published by Peter Lang (2012)

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See detailNovelties in the multifaceted miconazole effects on skin disorders.
Quatresooz, Pascale ULg; Vroome, Valérie; Borgers, Marcel et al

in Expert Opinion on Pharmacotherapy (2008), 9(11), 1927-34

BACKGROUND: Miconazole nitrate is a time-honored antifungal of the imidazole class. OBJECTIVE: To revisit the various aspects of action of the drug in a dermatologic setting. METHOD: Review of the current ... [more ▼]

BACKGROUND: Miconazole nitrate is a time-honored antifungal of the imidazole class. OBJECTIVE: To revisit the various aspects of action of the drug in a dermatologic setting. METHOD: Review of the current peer-reviewed publications. RESULTS/CONCLUSION: Miconazole essentially inhibits 14alpha-demethylase, an enzyme required for the biosynthesis of ergosterol, which is the main sterol constituent of fungal cell membranes. Hence, toxic methylated sterols accumulate. Synthesis of triglycerides and phospholipids is also affected. In addition, miconazole also exhibits other ancillary mechanisms of action that probably participate in the therapeutic efficacy of the drug. The oxidative and peroxidative enzyme activities are altered leading to an intracellular build up of a toxic concentration of hydrogen peroxide. This may contribute to the deterioration of subcellular organelles and to cell necrosis. Farnesol synthesis is stimulated in Candida spp. leading to the prevention of yeast-to-mycelium formation. Overall, miconazole is fungistatic through its effect on ergosterol biosynthesis, but it may also have a fungicidal effect against a number of fungal species due to its effect on hydrogen peroxide accumulation. In addition, miconazole is active against a series of Gram-positive bacteria and has been shown to help the repair of the skin barrier function and to help mitigate some inflammatory cell reactions (such as in acne). To conclude, miconazole exerts multi-pronged effects both against pathogenic fungi and on skin physiology. [less ▲]

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See detailNovii etap issledovaniya stoyanki Kulbulak (po materialam raskopok 2009 g.)
Kolobova, K.A.; Flas, Damien ULg; Krivoshapkin, A. et al

in Issledovaniya pervobitnoï arkheologii Evrazii (2010)

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See detailNoviy verkhniepaleolititseckiy pamyatnik v doline reki Akhangaran (Uzbekistan)
Derevianko, A.P.; Kolobova, K.A.; Islamov, U.I. et al

in Problems of archaeology, ethnography and anthropology of Siberia and adjacent territories: material of the 15th annual session of the Institute of Archaeology and Ethnography, SBRAS (2007)

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See detailNOX3, a superoxide-generating NADPH oxidase of the inner ear
Banfi, Botond; Malgrange, Brigitte ULg; Knisz, Judit et al

in Journal of Biological Chemistry (2004), 279(44), 46065-46072

Reactive oxygen species (ROS) play a major role in drug-, noise-, and age-dependent hearing loss, but the source of ROS in the inner ear remains largely unknown. Herein, we demonstrate that NADPH oxidase ... [more ▼]

Reactive oxygen species (ROS) play a major role in drug-, noise-, and age-dependent hearing loss, but the source of ROS in the inner ear remains largely unknown. Herein, we demonstrate that NADPH oxidase (NOX) 3, a member of the NOX/dual domain oxidase family of NADPH oxidases, is highly expressed in specific portions of the inner ear. As assessed by real-time PCR, NOX3 mRNA expression in the inner ear is at least 50-fold higher than in any other tissues where its expression has been observed ( e. g. fetal kidney, brain, skull). Microdissection and in situ hybridization studies demonstrated that NOX3 is localized to the vestibular and cochlear sensory epithelia and to the spiral ganglions. Transfection of human embryonic kidney 293 cells with NOX3 revealed that it generates low levels of ROS on its own but produces high levels of ROS upon co-expression with cytoplasmic NOX subunits. NOX3-dependent superoxide production required a stimulus in the absence of subunits and upon co-expression with phagocyte NADPH oxidase subunits p47(phox) and p67(phox), but it was stimulus-independent upon co-expression with colon NADPH oxidase subunits NOX organizer 1 and NOX activator 1. Pre-incubation of NOX3-transfected human embryonic kidney 293 cells with the ototoxic drug cisplatin markedly enhanced superoxide production, in both the presence and the absence of subunits. Our data suggest that NOX3 is a relevant source of ROS generation in the cochlear and vestibular systems and that NOX3-dependent ROS generation might contribute to hearing loss and balance problems in response to ototoxic drugs. [less ▲]

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See detailThe NOy budget above Jungfraujoch: long-term evolution, family partition and model comparison
Demoulin, Philippe ULg; Mahieu, Emmanuel ULg; Zander, Rodolphe ULg et al

in Abstracts presented at the NDSC 2001 Symposium: Celebrating 10 years of atmospheric research (2001)

Based on high-resolution solar spectra recorded with FTIR instruments at the University of Liège laboratory located at the Jungfraujoch NDSC station (Swiss Alps, 46.5ºN, 8ºE, altitude 3580 m), the most ... [more ▼]

Based on high-resolution solar spectra recorded with FTIR instruments at the University of Liège laboratory located at the Jungfraujoch NDSC station (Swiss Alps, 46.5ºN, 8ºE, altitude 3580 m), the most important constituents making up the NOy family have been measured consistently since the mid-1980s. They include HNO3, NO, NO2 and ClONO2, which are analyzed in terms of their vertical column abundances above the site. Related trends have been determined and assessed statistically. Among these, only ClONO2 and NO2 reveal significant long-term trends. The combined column evaluation of NOy indicates a rate of change equal to (0.1+/-0.2) %/year, thus statistically undefined and barely consistent with the evolution of the source gas N2O. Trends derived from the observations will be compared critically with those deduced from a long-term run of a 2-D stratospheric model developed at the University of Oslo. The model includes full gaseous chemistry, PSCs and sulfate particles, which vary from year to year. Comparisons with similar data found in the literature are also discussed. [less ▲]

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See detailNoyaux de dattes: étude de la composition physico-chimique et des profils caractéristiques de la fraction lipidique
Besbes, S.; Blecker, Christophe ULg; Deroanne, C. et al

Conference (2004, March 21)

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See detailLes noyaux dʼhabitat en Belgique : situation en 1991 et évolution depuis 1970
Halleux, Jean-Marie ULg; Derwael, F.; Merenne-Schoumaker, Bernadette ULg

in Merenne-Schoumaker, Bernadette; Van der Haegen, H.; Van Hecke, E. (Eds.) Monographie "Urbanisation" 11A. Recensement Général de la Population et des Logements au 1er mars 1991 (1998)

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See detailLes noyaux dʼhabitat en Belgique. Situation en 2001 et évolution depuis 1981
Halleux, Jean-Marie ULg; Baltus, L.; Brück, L. et al

in Van Hecke, E.; Halleux, Jean-Marie; Decroly, J.-M. (Eds.) et al Noyaux dʼhabitat et régions urbaines dans une Belgique urbanisée. Enquête Socio-économique 2001. Monographies (n°9) (2009)

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See detailNoyaux dʼhabitat et régions urbaines dans une Belgique urbanisée. Enquête Socio-économique 2001. Monographies (n°9)
Van Hecke, E.; Halleux, Jean-Marie ULg; Decroly, J.-M. et al

Book published by SPF Economie, PME, Classes moyennes et Energie - Traduit en néerlandais (2009)

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See detailLa nozione di "partecipazione" nella Glossematica di Louis Hjelmslev
Cigana, Lorenzo ULg

Doctoral thesis (2014)

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