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See detailTHE NORDIC TEST SYSTEM FOR VOLTAGE STABILITY ASSESSMENT
Van Cutsem, Thierry ULg

Conference (2014, July)

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See detailNorepinephrine and ephedrine do not counteract the increase in cutaneous microcirculation induced by spinal anaesthesia.
Lecoq, Jean-Pierre ULg; Brichant, Jean-François ULg; Lamy, Maurice ULg et al

in British Journal of Anaesthesia (2010), 105(2), 214-9

BACKGROUND: /st> Neuraxial anaesthesia improves tissue perfusion and tissue oxygen tension. Vasodilation induced by this technique may result in hypotension requiring the administration of vasoactive ... [more ▼]

BACKGROUND: /st> Neuraxial anaesthesia improves tissue perfusion and tissue oxygen tension. Vasodilation induced by this technique may result in hypotension requiring the administration of vasoactive drugs. The use of peripheral vasoconstrictors might counteract the improved tissue perfusion and its potentially beneficial effects. We therefore investigated the effect of i.v. norepinephrine and ephedrine on skin perfusion using laser-Doppler flowmetry (LDF) in patients during spinal anaesthesia. METHODS: /st> Skin blood flow expressed in perfusion units (PU) provided by LDF was measured simultaneously at the foot and the manubrium levels in 44 patients during spinal anaesthesia with a sensory level below T5. Norepinephrine infusion was then titrated to normalize mean arterial pressure (MAP) in 23 patients (Group NOR). Ephedrine (max. 10 mg) was administered in 21 patients (Group EPH). Changes in relative PU were compared between the two sites of measurements in each group during drug administration. The same doses of norepinephrine were assessed in 11 normal volunteers to assure comparable vasoreactivity at the foot and manubrium levels. RESULTS: /st> Spinal anaesthesia resulted in a 10% decrease in MAP (P<0.001), an increase in relative PU values at the foot level (P<0.001), and a decrease at the sternum level (P<0.05). Norepinephrine and ephedrine produced a significant increase in relative PU values at the foot level when compared with the sternum level (NOR: P=0.02; EPH: P=0.0035). In volunteers, norepinephrine decreased cutaneous perfusion similarly at the manubrium and foot levels. CONCLUSIONS: /st> Improved skin perfusion induced by spinal anaesthesia was not counteracted by the use of norepinephrine or ephedrine. [less ▲]

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See detailNorepinephrine induces multiple 2nd degree atrio-ventricular blocks in healthy conscious horses
Sandersen, Charlotte ULg; Peters, F; Pequito, M et al

in Pflügers Archives - European journal of Physiology (2005)

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See detailNORINE: a database of nonribosomal peptides.
Caboche, Segolene; Pupin, Maude; Leclere, Valerie et al

in Nucleic acids research (2008), 36(Database issue), 326-31

Norine is the first database entirely dedicated to nonribosomal peptides (NRPs). In bacteria and fungi, in addition to the traditional ribosomal proteic biosynthesis, an alternative ribosome-independent ... [more ▼]

Norine is the first database entirely dedicated to nonribosomal peptides (NRPs). In bacteria and fungi, in addition to the traditional ribosomal proteic biosynthesis, an alternative ribosome-independent pathway called NRP synthesis allows peptide production. It is performed by huge protein complexes called nonribosomal peptide synthetases (NRPSs). The molecules synthesized by NRPS contain a high proportion of nonproteogenic amino acids. The primary structure of these peptides is not always linear but often more complex and may contain cycles and branchings. In recent years, NRPs attracted a lot of attention because of their biological activities and pharmacological properties (antibiotic, immunosuppressor, antitumor, etc.). However, few computational resources and tools dedicated to those peptides have been available so far. Norine is focused on NRPs and contains more than 700 entries. The database is freely accessible at http://bioinfo.lifl.fr/norine/. It provides a complete computational tool for systematic study of NRPs in numerous species, and as such, should permit to obtain a better knowledge of these metabolic products and underlying biological mechanisms, and ultimately to contribute to the redesigning of natural products in order to obtain new bioactive compounds for drug discovery. [less ▲]

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See detailNorinomlarda Yabanci Cisim Reoksyonlari. Foreign Bodies into Neuromas.
LEJEUNE, G; CARLIER, Alain ULg; BRAHY, R et al

in Turk Otorino Larengoloji Bulteni (1978), 3

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See detailThe norite-mangerite relationships in the Bjerkreim-Sokndal layered lopolith (SW Norway)
Duchesne, Jean-Clair ULg; Denoiseux, Bruno; Hertogen, Jan

in Lithos (1987), 20

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See detailTHE NORMAL ANATOMICAL DEVELOPMENT OF THE FOAL FOOT DESCRIBED WITH MULTI DETECTOR COMPUTED TOMOGRAPHY (MDCT)
Van Thielen, B.; Murray, R.; Van Dooren, J. P. et al

Poster (2010)

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See detailNormal anatomy and anatomical pitfalls of the distal extremity of the horse with Multi Detector Computed Tomography (MDCT)
Van Thielen, B.; Murray, R.; Van Dooren, J. P. et al

in European Veterinary Conference De Voorjaarsdagen Proceedings (2010)

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See detailNormal and aberrant biological self-assembly: Insights from studies of human lysozyme and its amyloidogenic variants
Dumoulin, Mireille ULg; Kumita, Janet; Dobson, Christopher M

in Accounts of Chemical Research (2006), 39

Studies of lysozyme have played a major role over several decades in defining the general principles underlying protein structure, folding, and stability. Following the discovery some 10 years ago that ... [more ▼]

Studies of lysozyme have played a major role over several decades in defining the general principles underlying protein structure, folding, and stability. Following the discovery some 10 years ago that two mutational variants of lysozyme are associated with systemic amyloidosis, these studies have been extended to investigate the mechanism of amyloid fibril formation. This Account describes our present knowledge of lysozyme folding and misfolding, and how the latter can give rise to amyloid disease. It also discusses the significance of these studies for our general understanding of normal and aberrant protein folding in the context of human health and disease. [less ▲]

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See detailNormal and frictional forces between surfaces bearing polyelectrolyte brushes
Raviv, Uri; Giasson, Suzanne; Kampf, Nir et al

in Langmuir (2008), 24(16), 8678-8687

Normal and shear forces were measured as a function of surface separation, D, between hydrophobized mica surfaces bearing layers of a hydrophobic−polyelectrolytic diblock copolymer, poly(methyl ... [more ▼]

Normal and shear forces were measured as a function of surface separation, D, between hydrophobized mica surfaces bearing layers of a hydrophobic−polyelectrolytic diblock copolymer, poly(methyl methacrylate)-block-poly(sodium sulfonated glycidyl methacrylate) copolymer (PMMA-b-PSGMA). The copolymers were attached to each hydrophobized surface by their hydrophobic PMMA moieties with the nonadsorbing polyelectrolytic PSGMA tails extending into the aqueous medium to form a polyelectrolyte brush. Following overnight incubation in 10−4 w/v aqueous solution of the copolymer, the strong hydrophobic attraction between the hydrophobized mica surfaces across water was replaced by strongly repulsive normal forces between them. These were attributed to the osmotic repulsion arising from the confined counterions at long-range, together with steric repulsion between the compressed brush layers at shorter range. The corresponding shear forces on sliding the surfaces were extremely low and below our detection limit (±20−30 nN), even when compressed down to a volume fraction close to unity. On further compression, very weak shear forces (130 ± 30 nN) were measured due to the increase in the effective viscous drag experienced by the compressed, sliding layers. At separations corresponding to pressures of a few atmospheres, the shearing motion led to abrupt removal of most of the chains out of the gap, and the surfaces jumped into adhesive contact. The extremely low frictional forces between the charged brushes (prior to their removal) is attributed to the exceptional resistance to mutual interpenetration displayed by the compressed, counterion-swollen brushes, together with the fluidity of the hydration layers surrounding the charged, rubbing polymer segments. [less ▲]

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See detailNormal and pathological aging and memory
Bastin, Christine ULg

Scientific conference (2012)

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See detailNormal and shear forces between a polyelectrolyte brush and a solid surface
Kampf, Nir; Gohy, Jean-François; Jérôme, Robert ULg et al

in Journal of Polymer Science. Part B, Polymer Physics (2005), 43(2), 193-204

The diblock copolymer poly(methyl methacrylate)-b-poly(sodium sulfonated glycidyl methacrylate) (PMMA-b-PSGMA) was end-attached by its hydrophobic block (PMMA) onto mica hydrophobized by a stearic ... [more ▼]

The diblock copolymer poly(methyl methacrylate)-b-poly(sodium sulfonated glycidyl methacrylate) (PMMA-b-PSGMA) was end-attached by its hydrophobic block (PMMA) onto mica hydrophobized by a stearic trimethylammonium iodide (STAI) layer, to form a polyelectrolyte brush immersed in water. With a surface force balance (SFB), we extended earlier measurements between two such brush layers for the case of normal and shear forces at different shear rates, surface separation, and compressions between one mica surface coated with STAI or a STAI-diblock layer against a bare mica surface. After coating one of the surfaces with STAI, a long range attraction that results in a jump into an adhesive flat contact between the hydrophobic and hydrophilic surfaces was observed. A very different behavior was seen after forming the polyelectrolyte brush on the STAI-coated surface. The long range attraction was replaced by repulsion, accompanied by very low friction during shear (ca. three orders of magnitude lower than with adsorbed polyelectrolytes). On further compression, a weak attraction to the adhesive contact was observed. From the final surface-surface contact separation, we deduce that most of the polyelectrolyte diblock brush layer was squeezed out from the gap, leaving the STAI layer and a small amount of the polymer attached to the surface. Stick-sliding behavior was seen while applying shear, suggesting a dissipation mechanism caused by the trapped polyelectrolyte. [less ▲]

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See detailNormal Electro- and Vectorcardiographic Data in the Growing Friesian Calf Using a Semi-Orthogonal Lead System
Amory, Hélène ULg; Genicot, B; Rollin, Frédéric ULg et al

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1993), 40(2), 81-92

This study derives normal values for electro- and vectorcardiographic parameters, as generated by the Holmes semi-orthogonal lead system, in healthy growing calves. Sixty-four electrocardiograms were ... [more ▼]

This study derives normal values for electro- and vectorcardiographic parameters, as generated by the Holmes semi-orthogonal lead system, in healthy growing calves. Sixty-four electrocardiograms were recorded from healthy Friesian calves aged from one week to one year. Waveform and duration were analysed and compared in the X-, Y- and Z-leads. The modal P, QRS and T tridimensional vectors were graphically constructed and their magnitude and orientation were calculated. The duration of waves and intervals were similar to data previously reported in the bovine species. Differences from data reported in other species were attributed to heart rate. The duration of waves and QT and ST intervals significantly lengthened with the decrease in heart rate which occurred during growth. PR interval significantly lengthened with physical maturation, and this change was independent of the decrease in heart rate. The magnitude and the orientation of the spatial modal vectors were approximately similar to the few data previously reported in cattle and in other ungulates and were not affected by somatic growth [less ▲]

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See detailLe normal et le pathologique Compte-rendu de la table ronde des XV es Journées francophones d’électro-neuromyographie (15-17 mars 2006, Grenoble)
Labarre-Vila, Annick; Fournier, Emmanuel; Jabre, Joe F et al

in Lettre du Neurologue (La) : le Courrier du Spécialiste (2009)

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See detailNormal female puberty in a developmental perspective.
BOURGUIGNON, Jean-Pierre ULg; Juul, Anders

in Endocrine Development (2012), 22

Puberty is unique in the sense that its onset shows an extraordinary individual variability of about 5 years, the basis of which being still elusive despite research efforts to understand the reason why ... [more ▼]

Puberty is unique in the sense that its onset shows an extraordinary individual variability of about 5 years, the basis of which being still elusive despite research efforts to understand the reason why. Continuing changes in environmental influences and interaction with genetic determinants are suggested by the still evolving pattern of the pubertal process both clinically and mechanistically. For instance, secular trends towards earlier breast development have been observed during the two past decades in some countries, resulting in possible skewing of the age distribution of that pubertal sign with less obvious changes in menarcheal age. Conceptually, puberty and subsequent reproduction appear now to be influenced by conditions not only at the time when they occur, but also during fetal and perinatal life. In addition, these influences can be apparently opposing since early maturation follows fetal malnourishment and postnatal overfeeding. In this review, the semiology and pathophysiology of puberty are discussed in a lifelong developmental perspective. [less ▲]

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See detailNormal mere exposure effect with impaired recognition in Alzheimer's disease
Willems, Sylvie ULg; Adam, Stéphane ULg; Van der Linden, Martial ULg

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2002), 38(1), 77-86

We investigated the mere exposure effect and the explicit memory in Alzheimer's disease (AD) patients and elderly control subjects, using unfamiliar faces. During the exposure phase, the subjects ... [more ▼]

We investigated the mere exposure effect and the explicit memory in Alzheimer's disease (AD) patients and elderly control subjects, using unfamiliar faces. During the exposure phase, the subjects estimated the age of briefly flashed faces. The mere exposure effect was examined by presenting pairs of faces (old and new) and asking participants to select the face they liked. The participants were then presented with a forced-choice explicit recognition task. Controls subjects exhibited above-chance preference and recognition scores for old faces. The AD patients also showed the mere exposure effect but no explicit recognition. These results suggest that the processes involved in the mere exposure effect are preserved in AD patients despite their impaired explicit recognition. The results are discussed in terms of Seamon et al.'s (1995) proposal that processes involved in the mere exposure effect are equivalent to those subserving perceptual priming. These processes would depend on extrastriate areas which are relatively preserved in AD patients. [less ▲]

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See detailNormal MRI-anatomy of the foal foot from birth to seven months of age.
Van Thielen, B.; Busoni, Valeria ULg; Van den Broeck, R. et al

in AVEF Proceedings (2009)

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See detailNormal MRI-anatomy of the foal foot.
Van Thielen, B.; Murray, R.; De Ridder, F. et al

in BEVA Proceedings (2009)

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See detailNormal ongoing pregnancy in rabbit immunised against bovine pregnancy-associated glycoprotein-1 (boPAG-1).
Banga-Mboko, H.; Melo de Sousa, Noelita ULg; El Amiri, B. et al

in Pflügers Archiv : European Journal of Physiology (2000), 440

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See detailNormal ranges for the variability in heart rate in young infants while sleeping
Massin, M. M.; Withofs, Nadia ULg; Maeyns, K. et al

in Cardiology in the Young (2001), 11(6), 619-625

Objective: Measurements of the variability in heart rate are increasingly used as markers of cardiac autonomic activity. We sought to establish the development this variability in healthy young infants ... [more ▼]

Objective: Measurements of the variability in heart rate are increasingly used as markers of cardiac autonomic activity. We sought to establish the development this variability in healthy young infants while sleeping. Patients: We carried out polygraphic studies with electrocardiographic recording in 587 healthy infants aged from 5 to 26 weeks. Methods: We determined several variables over a period of 400 minutes sleeping: mean RR interval, 5 time-domain (SDNN, SDNNi, SDANNi, RMSSD, and pNN50) and 5 frequency-domain indexes (spectral power over 3 regions of interest, total power and low-to-high frequency ratio). Frequency-domain indexes were also assessed separately for the periods of quiet sleep and those of rapid eye movement sleep. Results: Our data showed a significant correlation between the indexes of heart rate variability and the mean RR interval, the breathing rate, and the corrected age of the infants. We also demonstrated the importance of the maturation of the sleeping patterns. Conclusion: These data in a large cohort of healthy infants confirm a progressive maturation of the autonomic nervous system during sleep, and may be used to examine the influence of physiological and pathophysiological factors on autonomic control during polygraphic studies. [less ▲]

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