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See detailNew hypothesis on the conformation of the PAF receptor from studies on the geometry of selected platelet-activating-factor antagonists
Batt, Jean-Pierre; Lamouri, Aazdine; Tavet, Fabrice et al

in Journal of Lipid Mediators (1991), 4(3), 343-346

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See detailNew identifications of Fe III in the spectra of early B stars.
Swings, Polydore ULg; Edlén, B.; Grandjean, J.

in Astrophysical Journal (1939), 90

Starting from their laboratory measurements, the authors are able to show that about one hundred lines observed in the spectra cf early B-type stars are due to Fe III. The ionization potential of Fe III ... [more ▼]

Starting from their laboratory measurements, the authors are able to show that about one hundred lines observed in the spectra cf early B-type stars are due to Fe III. The ionization potential of Fe III is 30.48 volts. [less ▲]

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See detailNew illumination technique for IR-video guided patch-clamp recording from neurons in slice cultures on biomembrane
Alix, Philippe ULg; Winterer, J; Muller, W

in Journal of Neuroscience Methods (2003), 128

Slice cultures on biomembrane are the method of choice for studying Ca2 -dependent plastic changes occurring over several days to weeks. Using IR-differential interference contrast, good visualization of ... [more ▼]

Slice cultures on biomembrane are the method of choice for studying Ca2 -dependent plastic changes occurring over several days to weeks. Using IR-differential interference contrast, good visualization of neurons in biomembrane slice cultures has been achieved despite a negative optical effect of the biomembrane, but epifluorescence imaging requires removal of a Wollaston prism and the analyzer. Here, we describe a novel illumination method to overcome this problem. Using optic fiber illumination at a shallow angle from the top of the slice culture, with or without additional illumination from the bottom, we obtained good cellular resolution of neurons in biomembrane slice cultures as well as in acute slices with an infrared-video camera. With this technique, we demonstrate visually guided whole-cell patch-clamp recording of Na - and K -currents as well as combination of whole-cell recording with fluorescence imaging of hippocampal and entorhinal cortex neurons in biomembrane slice cultures. Our inexpensive method should prove very useful for studying in vitro effects of long-term manipulations on membrane currents and intracellular Ca2 -signaling. # 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailNew Immigrants and Democratic Society. Minority Integrations in Western Societies
Martiniello, Marco ULg

in International Migration Review (1993), 27(101), 204-205

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See detailNew Improvements in the Enantioselective Synthesis of 2-[18F]Fluoro-L-Tyrosine and 6-[18F]Fluoro-L-Dopa
Libert, Lionel ULg; Lemaire, Christian ULg; Denoël, Thibaut ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2009, July), 52(S1), 196

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See detailNew in situ generated ruthenium catalysts bearing N-heterocyclic carbene ligands for the ring-opening metathesis polymerization of cyclooctene
Delaude, Lionel ULg; Szypa, Magdalena; Demonceau, Albert ULg et al

in Advanced Synthesis & Catalysis (2002), 344(6-7), 749-756

New 1,3-diarylimidazol(in)ium chlorides bearing phenyl, 1-naphthyl, 4-biphenyl, 2-tolyl, 2,6-dimethylphenyl, and 3,5-dimethylphenyl substituents were synthesized. They were combined with [RuCl2 (p-cymene ... [more ▼]

New 1,3-diarylimidazol(in)ium chlorides bearing phenyl, 1-naphthyl, 4-biphenyl, 2-tolyl, 2,6-dimethylphenyl, and 3,5-dimethylphenyl substituents were synthesized. They were combined with [RuCl2 (p-cymene)](2) and potassium tert-butoxide or sodium hydride to generate the corresponding ruthenium-N-heterocyclic carbene complexes in situ. Catalyst precursors derived from imidazol(in)ium salts bearing the 2,4,6-trimethylphenyl (mesityl) and the 2,6-diisopropylphenyl groups were also prepared. The catalytic activity of all these species in the photoinduced ring-opening metathesis polymerization of cyclooctene was investigated. The C4-C5 double bond in the imidazole ring of the N-heterocyclic carbene ligands was not crucial to achieve high catalytic efficiencies. The presence or the absence of alkyl groups on the ortho positions of the phenyl rings had a more pronounced influence. Blocking all the ortho positions was a requisite for obtaining efficient catalysts. Failure to do so probably results in the ortho-metallation of the carbene ligand, thereby altering the coordination sphere of the ruthenium active centers. [less ▲]

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See detailA new in vitro model of Microsporum canis dermatophytosis in reconstituted feline skin
Tabart, J.; Baldo, Aline ULg; Vermout, S. et al

Conference (2006)

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See detailA new in-silico method for determination of helical transmembrane domains based on the PepLook scan: application to IL-2Rbeta and IL-2Rgammac receptor chains.
Charlois, Yan; Lins, Laurence ULg; Brasseur, Robert ULg

in BMC Structural Biology (2011), 11

BACKGROUND: Modeling of transmembrane domains (TMDs) requires correct prediction of interfacial residues for in-silico modeling and membrane insertion studies. This implies the defining of a target ... [more ▼]

BACKGROUND: Modeling of transmembrane domains (TMDs) requires correct prediction of interfacial residues for in-silico modeling and membrane insertion studies. This implies the defining of a target sequence long enough to contain interfacial residues. However, too long sequences induce artifactual polymorphism: within tested modeling methods, the longer the target sequence, the more variable the secondary structure, as though the procedure were stopped before the end of the calculation (which may in fact be unreachable). Moreover, delimitation of these TMDs can produce variable results with sequence based two-dimensional prediction methods, especially for sequences showing polymorphism. To solve this problem, we developed a new modeling procedure using the PepLook method. We scanned the sequences by modeling peptides from the target sequence with a window of 19 residues. RESULTS: Using sequences whose NMR-structures are already known (GpA, EphA1 and Erb2-HER2), we first determined that the hydrophobic to hydrophilic accessible surface area ratio (ASAr) was the best criterion for delimiting the TMD sequence. The length of the helical structure and the Impala method further supported the determination of the TMD limits. This method was applied to the IL-2Rbeta and IL-2Rgamma TMD sequences of Homo sapiens, Rattus norvegicus, Mus musculus and Bos taurus. CONCLUSIONS: We succeeded in reducing the variation in the TMD limits to only 2 residues and in gaining structural information. [less ▲]

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See detailNew indications for radiotherapy: primary liver cancer and secondary liver oligometastases
JANVARY, Zsolt Levente ULg; JANSEN, Nicolas ULg; MARTINIVE, Philippe ULg et al

in Belgian Journal of Medical Oncology [=BJMO] (2011), 5(1), 8-13

Surgery is considered to be the standard treatment for intrahepatic malignancies, primary <br />cancers and metastatic lesions. However, a great many patients are not eligible for surgical <br ... [more ▼]

Surgery is considered to be the standard treatment for intrahepatic malignancies, primary <br />cancers and metastatic lesions. However, a great many patients are not eligible for surgical <br />intervention. Modern stereotactic radiotherapy has the potential to be an effective alternative <br />treatment modality with low toxicity for patients with primary hepatocellular carcinoma <br />and liver oligometastases. In this paper we intend to review the current status and published <br />experiences in the field of liver irradiation. [less ▲]

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See detailNew indole aldehydic alkaloids of Strychnos variabilis
Tits, Monique ULg; Angenot, Luc ULg; Tavernier, Dirk

in Tetrahedron Letters (1980), 21

Two isomeric pairs of novel indoline aldehydic alkaloids have been isolated from the root barks of Strychnos variabillis. The isomerism finds its origin in the facile isomerisation of C16 and is set up ... [more ▼]

Two isomeric pairs of novel indoline aldehydic alkaloids have been isolated from the root barks of Strychnos variabillis. The isomerism finds its origin in the facile isomerisation of C16 and is set up rapidly at room temperature. So, they could be the biogenetic starting point of two series of alkaloids which have a different stereochemistry for C16: the "retuline" series and the epimer "isoretuline" series. [less ▲]

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See detailNew Industrial Product Performance: Models and Empirical Analysis
Choffray, Jean-Marie ULg; Lilien, Gary L.; Yoon, Eusang

in Woodside, A. (Ed.) Advances in Business Marketing (1988)

In this chapter we review methods that are used to evaluate the likely sales level for new industrial products and discuss the relation between those methods and what we know about innovation diffusion ... [more ▼]

In this chapter we review methods that are used to evaluate the likely sales level for new industrial products and discuss the relation between those methods and what we know about innovation diffusion. Our model-based methodology can be used to help plan entry stratégies as well as to forecast market penetration. [less ▲]

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See detailA new inhibition task for young children: The “Real Size Animal” task
Catale, Corinne ULg; Meulemans, Thierry ULg

in Books of Conference Abstract: The 9th European Conference on Psychological Assessment (2007)

In neuropsychology, inhibition deficits underlie a variety of cognitive and behavioural dysfunctions and are reported in numerous developmental and acquired disorders (such as Attention Deficit and ... [more ▼]

In neuropsychology, inhibition deficits underlie a variety of cognitive and behavioural dysfunctions and are reported in numerous developmental and acquired disorders (such as Attention Deficit and Hyperactivity Disorders–ADHD). Despite a large body of literature regarding inhibition functioning in adult’s neuropsychology, developmental studies on inhibition remained for a long time scarce. Furthermore, most inhibition tools were originally developed for adults and are of limited interest in children – particularly in pre-school children. In this study, we present a new computerized measure of inhibition suitable to young children. This task includes three conditions. The two first conditions assess speed processing and require children to decide quickly, by pressing a response-key, [1] the real size of animals (bird =small) and [2] the on screen size of black rectangles (big or small). The third condition measures inhibition and requires deciding the real size of animals displayed in congruent (big elephant) or incongruent size (big bird) on the screen. Sixty children without neurological disorders and twelve ADHD children aged from 4 to 10 took part in this study. Our aims were to examine the developmental curve of inhibition abilities and to determine the task’s sensitivity in ADHD children. Results show that this task is particularly suitable to preschooler children and provides a good measure of inhibition development (p<.01). Furthermore, this task appears sensitive to inhibition’s disturbances in ADHD children (p<.05). In conclusion, these preliminary results support the validity of this measure to assess inhibition control in young children and its clinical interest in ADHD children. [less ▲]

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See detailNew inhibitors of serine proteinases
Jiang, K. Y.; Schynts, M.; Fesquet, S. et al

Poster (1993, June)

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See detailNew initiator system for the "living" anionic polymerization of tert-alkyl acrylates
Fayt, Roger; Forte, C.; Jacobs, C. et al

in Macromolecules (1987), 20(6), 1442-1444

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See detailNew initiator system for the anionic polymerization of (meth)acrylates in toluene. IV. Random copolymerization of (meth)acrylates in toluene initiated by s-Buli ligated by lithium silanolates
Zune, Catherine; Zundel, Thomas; Dubois, Philippe ULg et al

in Journal of Polymer Science. Part A, Polymer Chemistry (1999), 37(14), 2525-2535

Copolymerization of binary mixtures of alkyl (meth)acrylates has been initiated in toluene by a mixed complex of lithium silanolate (s-BuMe2SiOLi) and s-BuLi (molar ratio > 21) formed in situ by reaction ... [more ▼]

Copolymerization of binary mixtures of alkyl (meth)acrylates has been initiated in toluene by a mixed complex of lithium silanolate (s-BuMe2SiOLi) and s-BuLi (molar ratio > 21) formed in situ by reaction of s-BuLi with hexamethylcyclotrisiloxane (D3). Fully acrylate and methacrylate copolymers, i.e., poly(methyl acrylate-co-n-butyl acrylate), poly(methyl methacrylate-co-ethyl methacrylate), poly(methyl methacrylate-co-n-butyl methacrylate), poly(methyl methacrylate-co-n-butyl methacrylate), poly(isobornyl methacrylate-co-n-butyl methacrylate), poly(isobornyl methacrylate-co-n-butyl methacrylate) of a rather narrow molecular weight distribution have been synthesized. However, copolymerization of alkyl acrylate and methyl methacrylate pairs has completely failed, leading to the selective formation of homopoly(acrylate). As result of the isotactic stereoregulation of the alkyl methacrylate polymerization by the s-BuLi/s-BuMe2SiOLi initiator, highly isotactic random and block copolymers of (alkyl) methacrylates have been prepared and their thermal behavior analyzed. The structure of isotactic poly(ethyl methacrylate-co-methyl methacrylate) copolymers has been analyzed in more detail by Nuclear Magnetic Resonance (NMR). [less ▲]

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See detailThe new inotropic phosphodiesterase inhibitors. The use of positive inotropic drugs in intensive care medicine
EL ALLAF, D; D'Orio, Vincenzo ULg; CARLIER, J

in Archives Internationales de Physiologie et de Biochimie (1984), 92

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See detailNew insight in the Lymnaeids intermediate host of Fasciola hepatica in Belgium
Caron, Yannick ULg

Conference (2011)

The present work was carried out in the frame of a Belgian Science Policy project (PONDSCAPE -“Towards a sustainable management of pond diversity at the landscape level”). During the summer 2008, 7103 ... [more ▼]

The present work was carried out in the frame of a Belgian Science Policy project (PONDSCAPE -“Towards a sustainable management of pond diversity at the landscape level”). During the summer 2008, 7103 lymnaeids snails were collected from 125 ponds distributed in 5 clusters of 25 ponds each. Each cluster was located in a different geological region of Belgium. These snails belonged to the following species or genus: 2474 Galba truncatula (the main intermediate host of Fasciola hepatica in Belgium) and 4629 Radix sp. Moreover, several biological (presence of trampling and dungs, snail size …) and non biological factors (pH, depth, fences …) were also registered from the different biotopes. DNA was extracted based on Chelex® technique. Then the snail DNAs were screened through a multiplex PCR that amplifies the lymnaeid internal transcribed spacer 2 sequence (500-600 bp) (acting as an internal control) and a 124 bp Fasciola sp. sequence. Lymnaeid snails were found in 93 biotopes (66%). Thirty Galba truncatula (1.31%) and 7 Radix sp. (0.16%) were found positive for Fasciola sp. A classification and regression tree (CART) analysis was performed in an attempt to better understand the relative importance and relationships among the different recorded factors. For example, the geographic localization is one of the best explanatory variables for the abundance of the different snail species and the presence/absence of faecal material is the best explanatory variable for the presence of specific F. hepatica DNA material in the different screened snails. [less ▲]

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See detailA new insight in the structure, composition and functioning of central African moist forests
Fayolle, Adeline ULg; Picard, Nicolas; Doucet, Jean-Louis ULg et al

in Forest Ecology & Management (2014), (329), 195-205

The greater part of the semi-deciduous moist forests of the Congo basin has been given to logging companies for exploitation. In the next decades, very few of these forests will remain intact. In this ... [more ▼]

The greater part of the semi-deciduous moist forests of the Congo basin has been given to logging companies for exploitation. In the next decades, very few of these forests will remain intact. In this paper, we aimed to identify large-scale variations in the structure, composition and functioning of African moist forests that could serve as a baseline for both management and conservation purposes. Commercial forest inventory data were assembled for 49,711 0.5-ha plots, covering an area of more than six million hectares, crossing the borders of Cameroon, Central African Republic and Republic of Congo. Floristic composition was analyzed for a subset of 176 genera reliably identified in the field. Three key functional traits of tropical trees: regeneration guild, leaf phenology, and wood specific gravity, were collected at the species level from various sources, and assigned at the genus level. We first investigated the main variations in forest structure and composition, and identified seven forest types based on these variations. Differences in the percentage of pioneer and deciduous stems, and mean wood specific gravity were tested between forest types. Most of the study area was composed of a mosaic of the structural variations of the forests characterized by the occurrence of Celtis (Ulmaceae) species, which are mostly composed of frequent and abundant genera that formed the common floristic pool of the region. Secondary Musanga (Moraceae) forest is located in repeatedly disturbed areas, along roads and around main cities; mixed Manilkara (Sapotaceae) forest covers a huge area in the southern Central African Republic and in the northern Republic of Congo; and monodominant Gilbertiodendron (Fabaceae) forest is sparsely distributed along rivers. The contrasted structure, composition, and functioning of the forest types imply pronounced differences in population and ecosystem processes, and call for adapted management and conservation strategies. [less ▲]

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See detailNew insight into the concept of ferroelectric correlation volume
Geneste, Gregory; Bousquet, Eric ULg; Ghosez, Philippe ULg

in Journal Of Computational And Theoretical Nanoscience (2008), 5(4), 517-520

Using an effective Hamiltonian derived from first-principles calculations, we discuss the concept of "ferroelectric correlation volume" and show that it cannot be uniquely defined: it is not the size but ... [more ▼]

Using an effective Hamiltonian derived from first-principles calculations, we discuss the concept of "ferroelectric correlation volume" and show that it cannot be uniquely defined: it is not the size but the anisotropic shape of the polar region that is crucial for stabilizing a ferroelectric distortion into a ferroelectric materials. To provide basic understanding of this result, the stability of a polar region is analyzed in term of intra-chain and inter-chain interactions. [less ▲]

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