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See detailNonresponsive Generalized Bacterial Infection Associated with Systemic Lupus Erythematosus in a Beauceron
Clercx, Cécile ULg; Mc Entee, Kathleen ULg; Gilbert, S. et al

in Journal of the American Animal Hospital Association (1999), 35(3, May-Jun), 220222224-8

A case of concurrent canine systemic lupus erythematosus (SLE) and generalized bacterial infection in a six-year-old female Beauceron is reported. The dog presented with purulent nasal and ocular ... [more ▼]

A case of concurrent canine systemic lupus erythematosus (SLE) and generalized bacterial infection in a six-year-old female Beauceron is reported. The dog presented with purulent nasal and ocular discharges, skin lesions (including seborrhea, hyperkeratotic areas, and papules as well as ecchymoses around the eyes, on both sides of the pinnae, and on the vulva), generalized lymph node enlargement, a mitral murmur, and lameness. Later, facial swelling, a retrobulbar abscess, and a cough also developed. Occurrence of a generalized bacterial infection was established by culture of group-C, beta-hemolytic Streptococcus from the throat, the mouth, a biopsy site (popliteal lymph node area), the retrobulbar abscess, and the lung. The diagnosis of SLE was based on the clinical signs and particularly on the occurrence of antinuclear antibody (ANA) and antidoublestranded-desoxyribonucleic acid (ds-DNA) antibody. Interestingly, the latter type of antibodies were also detected in two young female puppies whelped by this dog. Salient histological findings included an extreme cell depletion of the lymph nodes and spleen and severe pneumonitis and peribronchiolitis. The results of this case indicate that a definite diagnosis of canine SLE can, at times, be made on the basis of the presence of serum ANA and ds-DNA antibodies. [less ▲]

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See detailNonribosomal peptides producing strains isolated from Bikalga and Soumbala fermented condiments of Burkina Faso
Savadogo, Aly; Chollet, Marlène; Tapi, Arthur et al

Conference (2009)

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See detailNonrigid registration and multimodality image fusion for 3D image-guided neurochirurgical planning and navigation
Verly, Jacques ULg; Vigneron, Lara M.; Petitjean, Nicolas et al

Conference (2004)

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See detailNonrigid registration and multimodality image fusion for 3D image-guided neurosurgery
Verly, Jacques ULg; Vigneron, Lara M.; Mercenier, Julien et al

Conference (2004)

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See detailA nonsense mutation in cGMP-dependent type II protein kinase (PRKG2) causes dwarfism in American Angus cattle.
Koltes, James E; Mishra, Bishnu P; Kumar, Dinesh et al

in Proceedings of the National Academy of Sciences of the United States of America (2009), 106(46), 19250-5

Historically, dwarfism was the major genetic defect in U.S. beef cattle. Aggressive culling and sire testing were used to minimize its prevalence; however, neither of these practices can eliminate a ... [more ▼]

Historically, dwarfism was the major genetic defect in U.S. beef cattle. Aggressive culling and sire testing were used to minimize its prevalence; however, neither of these practices can eliminate a recessive genetic defect. We assembled a 4-generation pedigree to identify the mutation underlying dwarfism in American Angus cattle. An adaptation of the Elston-Steward algorithm was used to overcome small pedigree size and missing genotypes. The dwarfism locus was fine-mapped to BTA6 between markers AFR227 and BM4311. Four candidate genes were sequenced, revealing a nonsense mutation in exon 15 of cGMP-dependant type II protein kinase (PRKG2). This C/T transition introduced a stop codon (R678X) that truncated 85 C-terminal amino acids, including a large portion of the kinase domain. Of the 75 mutations discovered in this region, only this mutation was 100% concordant with the recessive pattern of inheritance in affected and carrier individuals (log of odds score = 6.63). Previous research has shown that PRKG2 regulates SRY (sex-determining region Y) box 9 (SOX9)-mediated transcription of collagen 2 (COL2). We evaluated the ability of wild-type (WT) or R678X PRKG2 to regulate COL2 expression in cell culture. Real-time PCR results confirmed that COL2 is overexpressed in cells that overexpressed R678X PRKG2 as compared with WT PRKG2. Furthermore, COL2 and COL10 mRNA expression was increased in dwarf cattle compared with unaffected cattle. These experiments indicate that the R678X mutation is functional, resulting in a loss of PRKG2 regulation of COL2 and COL10 mRNA expression. Therefore, we present PRKG2 R678X as a causative mutation for dwarfism cattle. [less ▲]

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See detailA nonsmooth generalized-alpha scheme for flexible multibody systems with unilateral constraints
Chen, Qiong-zhong; Acary, Vincent; Virlez, Geoffrey ULg et al

in International Journal for Numerical Methods in Engineering (2013), 96(8), 487-511

Mechanical systems are usually subjected not only to bilateral constraints but also to unilateral constraints. Inspired by the generalized-alpha time integration method for smooth flexible multibody ... [more ▼]

Mechanical systems are usually subjected not only to bilateral constraints but also to unilateral constraints. Inspired by the generalized-alpha time integration method for smooth flexible multibody dynamics, this paper presents a nonsmooth generalized-alpha method, which allows a consistent treatment of the nonsmooth phenomena induced by unilateral constraints and an accurate description of the structural vibrations during free motions. Both the algorithm and the implementation are illustrated in detail. Numerical example tests are given in the scope of both rigid and flexible body models, taking account for both linear and nonlinear systems, and comprising both unilateral and bilateral constraints. The extended nonsmooth generalized-alpha method is verified through comparison to the traditional Moreau-Jean method and the fully implicit Newmark method. Results show that the nonsmooth generalized-alpha method benefits from the accuracy and stability property of the classical generalized-alpha method with controllable numerical damping. In particular, when it comes to the analysis of flexible systems, the nonsmooth generalized-alpha method shows much better accuracy property than the other two methods. [less ▲]

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See detailNonspecific airway responsiveness of COPD horses : effects of environmental control
Vandenput, Sandrina ULg; Votion, Dominique ULg; Anciaux, N. et al

in Pflügers Archiv : European Journal of Physiology (1996), 431(6), 324

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See detailNonverbal deficits and interpersonnal regulation in alcoholics
Philippot, P; Kornreich, C; Blairy, Sylvie ULg

in Philippot, P; Coats, E; Feldman, R (Eds.) Nonvernal behavior in clinical context (2003)

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See detailNonvisual responses to light exposure in the human brain during the circadian night
Perrin, Fabien; Peigneux, Philippe ULg; Fuchs, Sonia ULg et al

in Current Biology (2004), 14(20), 1842-6

The brain processes light information to visually represent the environment but also to detect changes in ambient light level. The latter information induces non-image-forming responses and exerts ... [more ▼]

The brain processes light information to visually represent the environment but also to detect changes in ambient light level. The latter information induces non-image-forming responses and exerts powerful effects on physiology such as synchronization of the circadian clock and suppression of melatonin. In rodents, irradiance information is transduced from a discrete subset of photosensitive retinal ganglion cells via the retinohypothalamic tract to various hypothalamic and brainstem regulatory structures including the hypothalamic suprachiasmatic nuclei, the master circadian pacemaker. In humans, light also acutely modulates alertness, but the cerebral correlates of this effect are unknown. We assessed regional cerebral blood flow in 13 subjects attending to auditory and visual stimuli in near darkness following light exposures (>8000 lux) of different durations (0.5, 17, 16.5, and 0 min) during the biological night. The bright broadband polychromatic light suppressed melatonin and enhanced alertness. Functional imaging revealed that a large-scale occipito-parietal attention network, including the right intraparietal sulcus, was more active in proportion to the duration of light exposures preceding the scans. Activity in the hypothalamus decreased in proportion to previous illumination. These findings have important implications for understanding the effects of light on human behavior. [less ▲]

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See detailNonword repetition problems in children with specific language impairment: A deficit in accessing long-term linguistic representations?
Leclercq, Anne-Lise ULg; Maillart, Christelle ULg; Majerus, Steve ULg

in Topics in Language Disorders (2013), 33(3), 238-254

Children with specific language impairment (SLI) consistently show poor nonword repetition (NWR) performance. However, the reason for these difficulties remains a matter of intensive debate. Nonword ... [more ▼]

Children with specific language impairment (SLI) consistently show poor nonword repetition (NWR) performance. However, the reason for these difficulties remains a matter of intensive debate. Nonword repetition is a complex psycholinguistic task that heavily relies upon phonological segmentation and phonological knowledge, and even lexical knowledge. This study aims at investigating various linguistic factors that can be at the root of difficulties in children with Specific Language Impairment when repeating nonwords, with the goal of achieving a better understanding of the linguistic processes supporting nonword processing. Linguistic complexity was assessed by manipulating lexicality, syllabic complexity, and perceptual difficulty in NWR tasks. Fifteen children with Specific Language Impairment, 15 typically developing controls matched on both age and performance IQ, and 15 typically developing children matched on lexical knowledge participated in this study. Children with Specific Language Impairment performed overall more poorly than age- and IQ-matched children and lexical age-matched children. Importantly, children with Specific Language Impairment showed lower lexicality and syllabic complexity effects in their NWR performances. These results are compatible with difficulties to retrieve lexical and sublexical phonological knowledge in the context of NWR tasks. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins. [less ▲]

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See detailNoradrenergic control of auditory information processing in female canaries
Appeltants, D.; Del Negro, C.; Balthazart, Jacques ULg

in Behavioural Brain Research (2002), 133(2), 221-235

An ethological procedure, based on the study of the sexual responsiveness of female canaries (Serinus canaria) to song playbacks was used to investigate the function of central noradrenergic inputs in the ... [more ▼]

An ethological procedure, based on the study of the sexual responsiveness of female canaries (Serinus canaria) to song playbacks was used to investigate the function of central noradrenergic inputs in the processing of auditory information. The effects of a noradrenergic denervation on sexual responses was analyzed in females exposed to playbacks of biological relevant auditory stimuli, i.e. sexually stimulating songs, presented alone or masked by auditory distractors. A decrease in behavioral responsiveness was observed as a function of the amount of masking distractors indicating that female canaries have the perceptual ability to discriminate and selectively attend to biologically relevant songs. After the systemic administration of DSP-4, a specific noradrenergic neurotoxin, females exhibited an overall decrease in sexual responsiveness to songs masked or not by distractors. No effect of DSP-4 were detected on the motor activity nor on reproductive behaviors. These results indicate that central noradrenergic inputs modulate the sexual behavior of female canaries by affecting the auditory processing of relevant information contained in sexually stimulating songs. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailThe Norberg angle revisited
Comhaire, F.; Criel, A.; Dassy, C. et al

in American Journal of Veterinary Research (2009), 70(2), 228-235

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See detailTHE NORDIC TEST SYSTEM FOR VOLTAGE STABILITY ASSESSMENT
Van Cutsem, Thierry ULg

Conference (2014, July)

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See detailNorepinephrine and ephedrine do not counteract the increase in cutaneous microcirculation induced by spinal anaesthesia.
Lecoq, Jean-Pierre ULg; Brichant, Jean-François ULg; Lamy, Maurice ULg et al

in British Journal of Anaesthesia (2010), 105(2), 214-9

BACKGROUND: /st> Neuraxial anaesthesia improves tissue perfusion and tissue oxygen tension. Vasodilation induced by this technique may result in hypotension requiring the administration of vasoactive ... [more ▼]

BACKGROUND: /st> Neuraxial anaesthesia improves tissue perfusion and tissue oxygen tension. Vasodilation induced by this technique may result in hypotension requiring the administration of vasoactive drugs. The use of peripheral vasoconstrictors might counteract the improved tissue perfusion and its potentially beneficial effects. We therefore investigated the effect of i.v. norepinephrine and ephedrine on skin perfusion using laser-Doppler flowmetry (LDF) in patients during spinal anaesthesia. METHODS: /st> Skin blood flow expressed in perfusion units (PU) provided by LDF was measured simultaneously at the foot and the manubrium levels in 44 patients during spinal anaesthesia with a sensory level below T5. Norepinephrine infusion was then titrated to normalize mean arterial pressure (MAP) in 23 patients (Group NOR). Ephedrine (max. 10 mg) was administered in 21 patients (Group EPH). Changes in relative PU were compared between the two sites of measurements in each group during drug administration. The same doses of norepinephrine were assessed in 11 normal volunteers to assure comparable vasoreactivity at the foot and manubrium levels. RESULTS: /st> Spinal anaesthesia resulted in a 10% decrease in MAP (P<0.001), an increase in relative PU values at the foot level (P<0.001), and a decrease at the sternum level (P<0.05). Norepinephrine and ephedrine produced a significant increase in relative PU values at the foot level when compared with the sternum level (NOR: P=0.02; EPH: P=0.0035). In volunteers, norepinephrine decreased cutaneous perfusion similarly at the manubrium and foot levels. CONCLUSIONS: /st> Improved skin perfusion induced by spinal anaesthesia was not counteracted by the use of norepinephrine or ephedrine. [less ▲]

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See detailNorepinephrine induces multiple 2nd degree atrio-ventricular blocks in healthy conscious horses
Sandersen, Charlotte ULg; Peters, F; Pequito, M et al

in Pflügers Archives - European journal of Physiology (2005)

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See detailNORINE: a database of nonribosomal peptides.
Caboche, Segolene; Pupin, Maude; Leclere, Valerie et al

in Nucleic acids research (2008), 36(Database issue), 326-31

Norine is the first database entirely dedicated to nonribosomal peptides (NRPs). In bacteria and fungi, in addition to the traditional ribosomal proteic biosynthesis, an alternative ribosome-independent ... [more ▼]

Norine is the first database entirely dedicated to nonribosomal peptides (NRPs). In bacteria and fungi, in addition to the traditional ribosomal proteic biosynthesis, an alternative ribosome-independent pathway called NRP synthesis allows peptide production. It is performed by huge protein complexes called nonribosomal peptide synthetases (NRPSs). The molecules synthesized by NRPS contain a high proportion of nonproteogenic amino acids. The primary structure of these peptides is not always linear but often more complex and may contain cycles and branchings. In recent years, NRPs attracted a lot of attention because of their biological activities and pharmacological properties (antibiotic, immunosuppressor, antitumor, etc.). However, few computational resources and tools dedicated to those peptides have been available so far. Norine is focused on NRPs and contains more than 700 entries. The database is freely accessible at http://bioinfo.lifl.fr/norine/. It provides a complete computational tool for systematic study of NRPs in numerous species, and as such, should permit to obtain a better knowledge of these metabolic products and underlying biological mechanisms, and ultimately to contribute to the redesigning of natural products in order to obtain new bioactive compounds for drug discovery. [less ▲]

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See detailNorinomlarda Yabanci Cisim Reoksyonlari. Foreign Bodies into Neuromas.
LEJEUNE, G; CARLIER, Alain ULg; BRAHY, R et al

in Turk Otorino Larengoloji Bulteni (1978), 3

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See detailThe norite-mangerite relationships in the Bjerkreim-Sokndal layered lopolith (SW Norway)
Duchesne, Jean-Clair ULg; Denoiseux, Bruno; Hertogen, Jan

in Lithos (1987), 20

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See detailTHE NORMAL ANATOMICAL DEVELOPMENT OF THE FOAL FOOT DESCRIBED WITH MULTI DETECTOR COMPUTED TOMOGRAPHY (MDCT)
Van Thielen, B.; Murray, R.; Van Dooren, J. P. et al

Poster (2010)

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